Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1-42 and Hypertension.

Publication ,  Journal Article
Al-Janabi, OM; Brown, CA; Bahrani, AA; Abner, EL; Barber, JM; Gold, BT; Goldstein, LB; Murphy, RR; Nelson, PT; Johnson, NF; Shaw, LM ...
Published in: J Alzheimers Dis
2018

BACKGROUND: Alzheimer's disease (AD) pathology and hypertension (HTN) are risk factors for development of white matter (WM) alterations and might be independently associated with these alterations in older adults. OBJECTIVE: To evaluate the independent and synergistic effects of HTN and AD pathology on WM alterations. METHODS: Clinical measures of cerebrovascular disease risk were collected from 62 participants in University of Kentucky Alzheimer's Disease Center studies who also had cerebrospinal fluid (CSF) sampling and MRI brain scans. CSF Aβ1-42 levels were measured as a marker of AD, and fluid-attenuated inversion recovery imaging and diffusion tensor imaging were obtained to assess WM macro- and microstructural properties. Linear regression analyses were used to assess the relationships among WM alterations, cerebrovascular disease risk, and AD pathology. Voxelwise analyses were performed to examine spatial patterns of WM alteration associated with each pathology. RESULTS: HTN and CSF Aβ1-42 levels were each associated with white matter hyperintensities (WMH). Also, CSF Aβ1-42 levels were associated with alterations in normal appearing white matter fractional anisotropy (NAWM-FA), whereas HTN was marginally associated with alterations in NAWM-FA. Linear regression analyses demonstrated significant main effects of HTN and CSF Aβ1-42 on WMH volume, but no significant HTN×CSF Aβ1-42 interaction. Furthermore, voxelwise analyses showed unique patterns of WM alteration associated with hypertension and CSF Aβ1-42. CONCLUSION: Associations of HTN and lower CSF Aβ1-42 with WM alteration were statistically and spatially distinct, suggesting independent rather than synergistic effects. Considering such spatial distributions may improve diagnostic accuracy to address each underlying pathology.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2018

Volume

66

Issue

3

Start / End Page

1095 / 1104

Location

Netherlands

Related Subject Headings

  • White Matter
  • Peptide Fragments
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Hypertension
  • Humans
  • Female
  • Cerebrovascular Disorders
  • Biomarkers
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Al-Janabi, O. M., Brown, C. A., Bahrani, A. A., Abner, E. L., Barber, J. M., Gold, B. T., … Jicha, G. A. (2018). Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1-42 and Hypertension. J Alzheimers Dis, 66(3), 1095–1104. https://doi.org/10.3233/JAD-180663
Al-Janabi, Omar M., Christopher A. Brown, Ahmed A. Bahrani, Erin L. Abner, Justin M. Barber, Brian T. Gold, Larry B. Goldstein, et al. “Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1-42 and Hypertension.J Alzheimers Dis 66, no. 3 (2018): 1095–1104. https://doi.org/10.3233/JAD-180663.
Al-Janabi OM, Brown CA, Bahrani AA, Abner EL, Barber JM, Gold BT, et al. Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1-42 and Hypertension. J Alzheimers Dis. 2018;66(3):1095–104.
Al-Janabi, Omar M., et al. “Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1-42 and Hypertension.J Alzheimers Dis, vol. 66, no. 3, 2018, pp. 1095–104. Pubmed, doi:10.3233/JAD-180663.
Al-Janabi OM, Brown CA, Bahrani AA, Abner EL, Barber JM, Gold BT, Goldstein LB, Murphy RR, Nelson PT, Johnson NF, Shaw LM, Smith CD, Trojanowski JQ, Wilcock DM, Jicha GA. Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1-42 and Hypertension. J Alzheimers Dis. 2018;66(3):1095–1104.

Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2018

Volume

66

Issue

3

Start / End Page

1095 / 1104

Location

Netherlands

Related Subject Headings

  • White Matter
  • Peptide Fragments
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Hypertension
  • Humans
  • Female
  • Cerebrovascular Disorders
  • Biomarkers