Magnesium-free medium activates seizure-like events in the rat hippocampal slice.

Journal Article (Journal Article)

The effect of magnesium-free medium on the electrical activity in CA3 of the rat hippocampal slice was examined. Magnesium removal resulted in the development of spontaneous and triggered interictal-like bursting, followed by spontaneous ictal-like events and finally periodic clustered bursts. The ictal-like events consisted of a tonic firing phase and a phase of clustered burst discharges resembling the tonic and clonic phases of seizures. The return to normal medium resulted in spontaneous and triggered interictal-like bursts.

Full Text

Duke Authors

Cited Authors

  • Anderson, WW; Lewis, DV; Swartzwelder, HS; Wilson, WA

Published Date

  • November 19, 1986

Published In

Volume / Issue

  • 398 / 1

Start / End Page

  • 215 - 219

PubMed ID

  • 3801897

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(86)91274-6


  • eng

Conference Location

  • Netherlands