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Magnesium-free medium activates seizure-like events in the rat hippocampal slice.

Publication ,  Journal Article
Anderson, WW; Lewis, DV; Swartzwelder, HS; Wilson, WA
Published in: Brain Res
November 19, 1986

The effect of magnesium-free medium on the electrical activity in CA3 of the rat hippocampal slice was examined. Magnesium removal resulted in the development of spontaneous and triggered interictal-like bursting, followed by spontaneous ictal-like events and finally periodic clustered bursts. The ictal-like events consisted of a tonic firing phase and a phase of clustered burst discharges resembling the tonic and clonic phases of seizures. The return to normal medium resulted in spontaneous and triggered interictal-like bursts.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

November 19, 1986

Volume

398

Issue

1

Start / End Page

215 / 219

Location

Netherlands

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Magnesium
  • In Vitro Techniques
  • Hippocampus
  • Electric Stimulation
  • Animals
 

Citation

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Chicago
ICMJE
MLA
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Anderson, W. W., Lewis, D. V., Swartzwelder, H. S., & Wilson, W. A. (1986). Magnesium-free medium activates seizure-like events in the rat hippocampal slice. Brain Res, 398(1), 215–219. https://doi.org/10.1016/0006-8993(86)91274-6
Anderson, W. W., D. V. Lewis, H. S. Swartzwelder, and W. A. Wilson. “Magnesium-free medium activates seizure-like events in the rat hippocampal slice.Brain Res 398, no. 1 (November 19, 1986): 215–19. https://doi.org/10.1016/0006-8993(86)91274-6.
Anderson WW, Lewis DV, Swartzwelder HS, Wilson WA. Magnesium-free medium activates seizure-like events in the rat hippocampal slice. Brain Res. 1986 Nov 19;398(1):215–9.
Anderson, W. W., et al. “Magnesium-free medium activates seizure-like events in the rat hippocampal slice.Brain Res, vol. 398, no. 1, Nov. 1986, pp. 215–19. Pubmed, doi:10.1016/0006-8993(86)91274-6.
Anderson WW, Lewis DV, Swartzwelder HS, Wilson WA. Magnesium-free medium activates seizure-like events in the rat hippocampal slice. Brain Res. 1986 Nov 19;398(1):215–219.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

November 19, 1986

Volume

398

Issue

1

Start / End Page

215 / 219

Location

Netherlands

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Magnesium
  • In Vitro Techniques
  • Hippocampus
  • Electric Stimulation
  • Animals