Overview
Explore the relationship between prolonged febrile convulsions, temporal lobe epilepsy and hippocampal sclerosis; The hypothesis that prolonged febrile convulsions cause hippocampal injury that evolves to sclerosis and then to temporal lobe epilepsy has been promulgated for decades since the advent of surgical treatment of temporal lobe epilepsy. However, this concept has never been addressed with a prospective clinical study. With the availability of magnetic resonance imaging techniques capable of discerning hippocampal edema and measuring hippocampal volume, patients suffering from these seizures can now be studied acutely and chronically to determine if hippocampal injury does occur during them and under what clinical circumstances. We are conducting a longterm study of this phenomenon in cooperation with 5 other medical centers which will prospectively enroll 200 infants presenting with febrile status epilepticus and follow these infants for 10 - 15 years with sequential neuroimaging, electroencephalographic and developmental testing to determine the long term consequences of these infantile seizures.
Current Appointments & Affiliations
Professor Emeritus of Pediatrics
·
2021 - Present
Pediatrics, Neurology,
Pediatrics
Recent Publications
Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study.
Journal Article Epilepsia · June 2024 OBJECTIVE: This study was undertaken to determine whether hippocampal T2 hyperintensity predicts sequelae of febrile status epilepticus, including hippocampal atrophy, sclerosis, and mesial temporal lobe epilepsy. METHODS: Acute magnetic resonance imaging ... Full text Link to item CiteMRI for assessing the impact of febrile status epilepticus and predicting outcomes
Chapter · January 1, 2022 Over the past decade, MRI studies have revealed that febrile status epilepticus (FSE) can lead to acute hippocampal signal changes that likely signify swelling/edema. In some cases, these volume changes, apparent within days, are accompanied by a visibly i ... Full text CitePlasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury.
Journal Article Epilepsia · June 2017 OBJECTIVE: Our aim was to explore the association between plasma cytokines and febrile status epilepticus (FSE) in children, as well as their potential as biomarkers of acute hippocampal injury. METHODS: Analysis was performed on residual samples of childr ... Full text Link to item CiteRecent Grants
Consequences of prolonged febrile seizures in childhood
ResearchCo Investigator · Awarded by Albert Einstein College of Medicine · 2017 - 2022Consequences of prolonged febrile seizures in childhood
ResearchPrincipal Investigator · Awarded by Albert Einstein College of Medicine · 2013 - 2017Best Pharmaceutical for Children Act (BPCA): Use of Meropenem in Infants
Clinical TrialCo Investigator · Awarded by National Institutes of Health · 2007 - 2010View All Grants
Education, Training & Certifications
University of Minnesota, Twin Cities ·
1969
M.D.