Darrell Vincent Lewis Jr.

Darrell Vincent Lewis Jr.
Professor of Pediatrics

Current Research Efforts:
Explore the relationship between prolonged febrile convulsions, temporal lobe epilepsy and hippocampal sclerosis; The hypothesis that prolonged febrile convulsions cause hippocampal injury that evolves to sclerosis and then to temporal lobe epilepsy has been promulgated for decades since the advent of surgical treatment of temporal lobe epilepsy. However, this concept has never been addressed with a prospective clinical study. With the availability of magnetic resonance imaging techniques capable of discerning hippocampal edema and measuring hippocampal volume, patients suffering from these seizures can now be studied acutely and chronically to determine if hippocampal injury does occur during them and under what clinical circumstances. We are conducting a longterm study of this phenomenon in cooperation with 5 other medical centers which will prospectively enroll 200 infants presenting with febrile status epilepticus and follow these infants for 10 - 15 years with sequential neuroimaging, electroencephalographic and developmental testing to determine the long term consequences of these infantile seizures.

Current Appointments & Affiliations

Professor of Pediatrics, Pediatrics, Neurology, Pediatrics 1998

Contact Information

125 Bell Bldg, Durham, NC 27710
Box 3936 Med Ctr, Durham, NC 27710
lewis013@mc.duke.edu (919) 668-0477

Background
Education, Training, & Certifications
- M.D., University of Minnesota, Twin Cities 1969
Duke Appointment History
- Assistant Professor of Medicine, Neurology, Clinical Science Departments 1997 - 2011
- Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 1994 - 2009
- Acting Chief, Division of Neurology in the Department of Pediatrics, Pediatrics, Neurology, Pediatrics 1994 - 1999
- Associate Professor of Pediatrics in the Department of Pediatrics, Pediatrics, Neurology, Pediatrics 1987 - 1997
- Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 1994
- Assistant Professor of Physiology, Immunology, Basic Science Departments 1987 - 1988
- Associate Professor of Pediatrics, Pediatrics, Clinical Science Departments 1986 - 1987
- Assistant Professor of Pediatrics, Pediatrics, Clinical Science Departments 1978 - 1986
- Associate in the Department of Pediatrics, Pediatrics, Clinical Science Departments 1978
Research
Selected Grants
- Consequences of prolonged febrile seizures in childhood 2017 - 2020
- Consequences of prolonged febrile seizures in childhood 2013 - 2017
- Best Pharmaceutical for Children Act (BPCA): Use of Meropenem in Infants awarded by National Institutes of Health 2007 - 2010
- A Linux Cluster Computational Facility for Neuroimaging Research awarded by National Institutes of Health 2009 - 2010
- GHB Tolerance and Dependence awarded by National Institutes of Health 2003 - 2007
- Neuronal degeneration in the cingulate gyrus: NMDA antagonists and anticholinestera 1999 - 2002
- Endogenous Opioids Regulate Ltp Of Inhibition awarded by National Institutes of Health 1998 - 2000
- Endogenous Opioids Regulate LTP of Inhibiton awarded by National Institutes of Health 1998 - 1999
- Endogenous Opioids: Their Role In Ltp In Dentate Gyrus awarded by National Institutes of Health 1991 - 1995
- Endogenous Opiods: Their Role In Ltp In Dentate Gyrus awarded by National Institutes of Health 1991 - 1994
- Gaba-B Mediated Disinhibition In The Dentate Gyrus awarded by National Institutes of Health 1992 - 1994
- Gabab Mediated Disinhibition In The Dentate Gyrus awarded by National Institutes of Health 1991 - 1993
- Gabab Mediated Disinhibition In The Dentate Gyrus awarded by National Science Foundation 1990 - 1993
- Ion Channel Control By Calcium awarded by National Institutes of Health 1987 - 1989
- Control Of Ionic Channels By Intracellular Calcium awarded by National Science Foundation 1985 - 1987
- Neurotransmitter Modulation Of Intracellular Calcium awarded by National Institutes of Health 1984 - 1985
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Gallentine, William B., Shlomo Shinnar, Dale C. Hesdorffer, Leon Epstein, Douglas R. Nordli, Darrell V. Lewis, L Matthew Frank, et al. “Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury.” Epilepsia 58, no. 6 (June 2017): 1102–11. https://doi.org/10.1111/epi.13750.
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  - McClelland, A. C., W. A. Gomes, S. Shinnar, D. C. Hesdorffer, E. Bagiella, D. V. Lewis, J. A. Bello, et al. “Quantitative Evaluation of Medial Temporal Lobe Morphology in Children with Febrile Status Epilepticus: Results of the FEBSTAT Study.” Ajnr Am J Neuroradiol 37, no. 12 (December 2016): 2356–62. https://doi.org/10.3174/ajnr.A4919.
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  - Hesdorffer, Dale C., Shlomo Shinnar, Daniel N. Lax, John M. Pellock, Douglas R. Nordli, Syndi Seinfeld, William Gallentine, et al. “Risk factors for subsequent febrile seizures in the FEBSTAT study.” Epilepsia 57, no. 7 (July 2016): 1042–47. https://doi.org/10.1111/epi.13418.
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  - Chan, Stephen, Jacqueline A. Bello, Shlomo Shinnar, Dale C. Hesdorffer, Darrell V. Lewis, James MacFall, Ruth C. Shinnar, et al. “Hippocampal Malrotation Is Associated With Prolonged Febrile Seizures: Results of the FEBSTAT Study.” Ajr Am J Roentgenol 205, no. 5 (November 2015): 1068–74. https://doi.org/10.2214/AJR.14.13330.
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  - Puranam, Ram S., Xiao Ping He, Lijun Yao, Tri Le, Wonjo Jang, Catherine W. Rehder, Darrell V. Lewis, and James O. McNamara. “Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.” J Neurosci 35, no. 23 (June 10, 2015): 8866–81. https://doi.org/10.1523/JNEUROSCI.3470-14.2015.
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  - Lewis, Darrell, Dale Hesdorffer, Solomon L. Moshé, Shlomo Shinnar, and Shlomo FEBSTAT Study Team. “Reply: To PMID 24318290.” Ann Neurol 76, no. 2 (August 2014): 316–17. https://doi.org/10.1002/ana.24206.
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  - Lewis, Darrell V., Shlomo Shinnar, Dale C. Hesdorffer, Emilia Bagiella, Jacqueline A. Bello, Stephen Chan, Yuan Xu, et al. “Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study.” Ann Neurol 75, no. 2 (February 2014): 178–85. https://doi.org/10.1002/ana.24081.
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  - Hesdorffer, Dale C., Shlomo Shinnar, Darrell V. Lewis, Douglas R. Nordli, John M. Pellock, Solomon L. Moshé, Ruth C. Shinnar, et al. “Risk factors for febrile status epilepticus: a case-control study.” J Pediatr 163, no. 4 (October 2013): 1147-51.e1. https://doi.org/10.1016/j.jpeds.2013.05.038.
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  - Frank, L Matthew, Shlomo Shinnar, Dale C. Hesdorffer, Ruth C. Shinnar, John M. Pellock, William Gallentine, Douglas R. Nordli, et al. “Cerebrospinal fluid findings in children with fever-associated status epilepticus: results of the consequences of prolonged febrile seizures (FEBSTAT) study.” J Pediatr 161, no. 6 (December 2012): 1169–71. https://doi.org/10.1016/j.jpeds.2012.08.008.
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  - Nordli, Douglas R., Solomon L. Moshé, Shlomo Shinnar, Dale C. Hesdorffer, Yoshimi Sogawa, John M. Pellock, Darrell V. Lewis, et al. “Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study.” Neurology 79, no. 22 (November 27, 2012): 2180–86. https://doi.org/10.1212/WNL.0b013e3182759766.
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  - Epstein, Leon G., Shlomo Shinnar, Dale C. Hesdorffer, Douglas R. Nordli, Aaliyah Hamidullah, Emma K. T. Benn, John M. Pellock, et al. “Human herpesvirus 6 and 7 in febrile status epilepticus: the FEBSTAT study.” Epilepsia 53, no. 9 (September 2012): 1481–88. https://doi.org/10.1111/j.1528-1167.2012.03542.x.
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  - Hesdorffer, Dale C., Shlomo Shinnar, Darrell V. Lewis, Solomon L. Moshé, Douglas R. Nordli, John M. Pellock, James MacFall, et al. “Design and phenomenology of the FEBSTAT study.” Epilepsia 53, no. 9 (September 2012): 1471–80. https://doi.org/10.1111/j.1528-1167.2012.03567.x.
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  - Shinnar, Shlomo, Jacqueline A. Bello, Stephen Chan, Dale C. Hesdorffer, Darrell V. Lewis, James Macfall, John M. Pellock, et al. “MRI abnormalities following febrile status epilepticus in children: the FEBSTAT study.” Neurology 79, no. 9 (August 28, 2012): 871–77. https://doi.org/10.1212/WNL.0b013e318266fcc5.
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  - Sharp Collaborative Group, Carolyn. “Study of Heart and Renal Protection (SHARP): randomized trial to assess the effects of lowering low-density lipoprotein cholesterol among 9,438 patients with chronic kidney disease.” Am Heart J 160, no. 5 (November 2010): 785-794.e10. https://doi.org/10.1016/j.ahj.2010.08.012.
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  - Kansagra, Sujay, Nour Ataya, Darrell Lewis, William Gallentine, and Mohamad A. Mikati. “The effect of vagus nerve stimulation therapy on body mass index in children.” Epilepsy Behav 19, no. 1 (September 2010): 50–51. https://doi.org/10.1016/j.yebeh.2010.06.012.
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  - Morey, Rajendra A., Christopher M. Petty, Yuan Xu, Jasmeet Pannu Hayes, H Ryan Wagner, Darrell V. Lewis, Kevin S. Labar, Martin Styner, and Gregory McCarthy. “Rebuttal to Hasan and Pedraza in comments and controversies: "Improving the reliability of manual and automated methods for hippocampal and amygdala volume measurements".” Neuroimage 48, no. 3 (November 15, 2009): 499–500. https://doi.org/10.1016/j.neuroimage.2009.07.013.
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  - Morey, Rajendra A., Christopher M. Petty, Yuan Xu, Jasmeet Pannu Hayes, H Ryan Wagner, Darrell V. Lewis, Kevin S. LaBar, Martin Styner, and Gregory McCarthy. “A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes.” Neuroimage 45, no. 3 (April 15, 2009): 855–66. https://doi.org/10.1016/j.neuroimage.2008.12.033.
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  - Provenzale, James M., Kevan E. vanLandingham, Darrell V. Lewis, Srinivasan Mukundan, and Leonard E. White. “Extrahippocampal involvement in human herpesvirus 6 encephalitis depicted at MR imaging.” Radiology 249, no. 3 (December 2008): 955–63. https://doi.org/10.1148/radiol.2492071917.
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  - Shinnar, S., D. C. Hesdorffer, D. R. Nordli, J. M. Pellock, C. O’Dell, D. V. Lewis, L. M. Frank, et al. “Phenomenology of prolonged febrile seizures: results of the FEBSTAT study.” Neurology 71, no. 3 (July 15, 2008): 170–76. https://doi.org/10.1212/01.wnl.0000310774.01185.97.
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  - Provenzale, James M., Daniel P. Barboriak, Kevan VanLandingham, James MacFall, David Delong, and Darrell V. Lewis. “Hippocampal MRI signal hyperintensity after febrile status epilepticus is predictive of subsequent mesial temporal sclerosis.” Ajr Am J Roentgenol 190, no. 4 (April 2008): 976–83. https://doi.org/10.2214/AJR.07.2407.
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  - Li, Q., C. M. Kuhn, W. A. Wilson, and D. V. Lewis. “Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex.” Neuroscience 150, no. 1 (November 30, 2007): 82–92. https://doi.org/10.1016/j.neuroscience.2007.08.023.
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  - Sathornsumetee, Sith, Laura Schanberg, Egla Rabinovich, Darrell Lewis, and Pedro Weisleder. “Parry-Romberg syndrome with fatal brain stem involvement.” J Pediatr 146, no. 3 (March 2005): 429–31. https://doi.org/10.1016/j.jpeds.2004.10.026.
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  - Lewis, Darrell V. “Losing neurons: selective vulnerability and mesial temporal sclerosis.” Epilepsia 46 Suppl 7 (2005): 39–44. https://doi.org/10.1111/j.1528-1167.2005.00306.x.
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  - Li, Qiang, Shirley Guo-Ross, Darrell V. Lewis, Dennis Turner, Aaron M. White, Wilkie A. Wilson, and H Scott Swartzwelder. “Dietary prenatal choline supplementation alters postnatal hippocampal structure and function.” J Neurophysiol 91, no. 4 (April 2004): 1545–55. https://doi.org/10.1152/jn.00785.2003.
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  - Li, Qiang, Suzanne Clark, Darrell V. Lewis, and Wilkie A. Wilson. “NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity.” J Neurosci 22, no. 8 (April 15, 2002): 3070–80.
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  - Lewis, Darrell V., Daniel P. Barboriak, James R. MacFall, James M. Provenzale, Teresa V. Mitchell, and Kevan E. VanLandingham. “Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions.” Prog Brain Res 135 (2002): 263–78. https://doi.org/10.1016/s0079-6123(02)35025-8.
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  - Verma, A., D. Lewis, K. E. VanLandingham, A. M. Husain, A. H. Friedman, E. Thompson, and R. A. Radtke. “Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy.” Epilepsy Res 47, no. 1–2 (November 2001): 9–15. https://doi.org/10.1016/s0920-1211(01)00289-3.
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  - Wainwright, M. S., P. L. Martin, R. P. Morse, M. Lacaze, J. M. Provenzale, R. E. Coleman, M. A. Morgan, et al. “Human herpesvirus 6 limbic encephalitis after stem cell transplantation.” Ann Neurol 50, no. 5 (November 2001): 612–19. https://doi.org/10.1002/ana.1251.
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  - Jobe, A., D. Lewis, M. Wainwright, and G. R. DeLong. “Three children with a syndrome of obesity and overgrowth, atypical psychosis, and seizures: a problem in neuropsychopharmacology.” J Child Neurol 15, no. 8 (August 2000): 518–28. https://doi.org/10.1177/088307380001500805.
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  - Kassem-Moussa, H., J. M. Provenzale, J. R. Petrella, and D. V. Lewis. “Early diffusion-weighted MR imaging abnormalities in sustained seizure activity.” Ajr Am J Roentgenol 174, no. 5 (May 2000): 1304–6. https://doi.org/10.2214/ajr.174.5.1741304.
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  - Foldvary, N., B. Nashold, E. Mascha, E. A. Thompson, N. Lee, J. O. McNamara, D. V. Lewis, J. S. Luther, A. H. Friedman, and R. A. Radtke. “Seizure outcome after temporal lobectomy for temporal lobe epilepsy: a Kaplan-Meier survival analysis.” Neurology 54, no. 3 (February 8, 2000): 630–34. https://doi.org/10.1212/wnl.54.3.630.
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  - Mott, D. D., Q. Li, M. M. Okazaki, D. A. Turner, and D. V. Lewis. “GABAB-Receptor-mediated currents in interneurons of the dentate-hilus border.” J Neurophysiol 82, no. 3 (September 1999): 1438–50. https://doi.org/10.1152/jn.1999.82.3.1438.
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  - Lewis, D. V. “Febrile convulsions and mesial temporal sclerosis.” Curr Opin Neurol 12, no. 2 (April 1999): 197–201. https://doi.org/10.1097/00019052-199904000-00011.
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  - Tennison, M., P. Kankirawatana, M. Richardson Bowman, R. Greenwood, D. Lewis, and M. Burchinal. “Effect of chronic antiepileptic drug therapy on California achievement test scores.” Journal of Epilepsy 11, no. 4 (July 1, 1998): 208–14. https://doi.org/10.1016/S0896-6974(98)00012-7.
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  - VanLandingham, K. E., E. R. Heinz, J. E. Cavazos, and D. V. Lewis. “Magnetic resonance imaging evidence of hippocampal injury after prolonged focal febrile convulsions.” Ann Neurol 43, no. 4 (April 1998): 413–26. https://doi.org/10.1002/ana.410430403.
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  - Xie, C. W., and D. V. Lewis. “Involvement of cAMP-dependent protein kinase in mu-opioid modulation of NMDA-mediated synaptic currents.” J Neurophysiol 78, no. 2 (August 1997): 759–66. https://doi.org/10.1152/jn.1997.78.2.759.
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  - Mott, D. D., D. A. Turner, M. M. Okazaki, and D. V. Lewis. “Interneurons of the dentate-hilus border of the rat dentate gyrus: morphological and electrophysiological heterogeneity.” J Neurosci 17, no. 11 (June 1, 1997): 3990–4005.
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  - Andrews, P. I., J. O. McNamara, and D. V. Lewis. “Clinical and electroencephalographic correlates in Rasmussen's encephalitis.” Epilepsia 38, no. 2 (February 1997): 189–94. https://doi.org/10.1111/j.1528-1157.1997.tb01096.x.
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  - Brucato, F. H., E. D. Levin, D. D. Mott, D. V. Lewis, W. A. Wilson, and H. S. Swartzwelder. “Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade.” Neuroscience 74, no. 2 (September 1996): 331–39. https://doi.org/10.1016/0306-4522(96)00131-5.
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  - Lewis, D. V., R. J. Thompson, C. C. Santos, W. J. Oakes, R. A. Radtke, A. H. Friedman, N. Lee, and H. S. Swartzwelder. “Outcome of temporal lobectomy in adolescents.” Journal of Epilepsy 9, no. 3 (January 1, 1996): 198–205. https://doi.org/10.1016/0896-6974(96)00013-8.
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  - Lee, N., R. D. Tien, D. V. Lewis, A. H. Friedman, G. J. Felsberg, B. Crain, C. Hulette, A. K. Osumi, J. S. Smith, and K. E. VanLandingham. “Fast spin-echo, magnetic resonance imaging-measured hippocampal volume: correlation with neuronal density in anterior temporal lobectomy patients.” Epilepsia 36, no. 9 (September 1995): 899–904. https://doi.org/10.1111/j.1528-1157.1995.tb01633.x.
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  - Xie, C. W., and D. V. Lewis. “Depression of LTP in rat dentate gyrus by naloxone is reversed by GABAA blockade.” Brain Res 688, no. 1–2 (August 7, 1995): 56–60. https://doi.org/10.1016/0006-8993(95)00510-w.
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  - Xie, C. W., and D. V. Lewis. “Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus.” J Neurosci 15, no. 5 Pt 2 (May 1995): 3788–95.
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  - Brucato, F. H., D. D. Mott, D. V. Lewis, and H. S. Swartzwelder. “GABAB receptors modulate synaptically-evoked responses in the rat dentate gyrus, in vivo.” Brain Res 677, no. 2 (April 24, 1995): 326–32. https://doi.org/10.1016/0006-8993(95)00180-x.
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  - Xie, C. W., and D. V. Lewis. “Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus.” Journal of Neuroscience 15, no. 5 II (January 1, 1995): 3788–95.
  - Xie, C. W., and D. V. Lewis. “Blocking δ opioid receptors unmasks LTP of synaptic inhibition in the dentate gyrus.” Regulatory Peptides 54, no. 1 (November 10, 1994): 73–74. https://doi.org/10.1016/0167-0115(94)90395-6.
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  - Nohria, V., N. Lee, R. D. Tien, E. R. Heinz, J. S. Smith, G. R. DeLong, M. B. Skeen, T. J. Resnick, B. Crain, and D. V. Lewis. “Magnetic resonance imaging evidence of hippocampal sclerosis in progression: a case report.” Epilepsia 35, no. 6 (November 1994): 1332–36. https://doi.org/10.1111/j.1528-1157.1994.tb01807.x.
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  - Tennison, M., R. Greenwood, D. Lewis, and M. Thorn. “Discontinuing antiepileptic drugs in children with epilepsy. A comparison of a six-week and a nine-month taper period.” N Engl J Med 330, no. 20 (May 19, 1994): 1407–10. https://doi.org/10.1056/NEJM199405193302002.
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  - Lee, N., R. A. Radtke, L. Gray, P. C. Burger, T. J. Montine, G. R. DeLong, D. V. Lewis, W. J. Oakes, A. H. Friedman, and J. M. Hoffman. “Neuronal migration disorders: positron emission tomography correlations.” Ann Neurol 35, no. 3 (March 1994): 290–97. https://doi.org/10.1002/ana.410350308.
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  - Tsujino, S., P. Tonin, S. Shanske, V. Nohria, R. M. Boustany, D. Lewis, Y. T. Chen, and S. DiMauro. “A splice junction mutation in a new myopathic variant of phosphoglycerate kinase deficiency (PGK North Carolina).” Ann Neurol 35, no. 3 (March 1994): 349–53. https://doi.org/10.1002/ana.410350316.
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  - Mott, D. D., and D. V. Lewis. “The pharmacology and function of central GABAB receptors.” Int Rev Neurobiol 36 (1994): 97–223. https://doi.org/10.1016/s0074-7742(08)60304-9.
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  - Radtke, R. A., M. W. Hanson, J. M. Hoffman, E. R. Heinz, T. S. Walczak, D. V. Lewis, R. E. Coleman, and A. F. Friedman. “Positron emission tomography: Comparison of clinical utility in temporal lobe and extratemporal epilepsy.” Journal of Epilepsy 7, no. 1 (January 1, 1994): 27–33. https://doi.org/10.1016/0896-6974(94)90116-3.
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  - Tien, R. D., G. J. Felsberg, C. Campi de Castro, A. K. Osumi, D. V. Lewis, A. H. Friedman, B. Crain, and R. A. Radtke. “Complex partial seizures and mesial temporal sclerosis: evaluation with fast spin-echo MR imaging.” Radiology 189, no. 3 (December 1993): 835–42. https://doi.org/10.1148/radiology.189.3.8234712.
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  - Radtke, R. A., M. W. Hanson, J. M. Hoffman, B. J. Crain, T. S. Walczak, D. V. Lewis, C. Beam, R. E. Coleman, and A. H. Friedman. “Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy.” Neurology 43, no. 6 (June 1993): 1088–92. https://doi.org/10.1212/wnl.43.6.1088.
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  - Mott, D. D., C. W. Xie, W. A. Wilson, H. S. Swartzwelder, and D. V. Lewis. “GABAB autoreceptors mediate activity-dependent disinhibition and enhance signal transmission in the dentate gyrus.” J Neurophysiol 69, no. 3 (March 1993): 674–91. https://doi.org/10.1152/jn.1993.69.3.674.
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  - Morrisett, R. A., D. V. Lewis, H. S. Swartzwelder, and W. A. Wilson. “Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus.” Brain Res 600, no. 2 (January 15, 1993): 235–42. https://doi.org/10.1016/0006-8993(93)91378-6.
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  - Lee, E. K., C. Armon, T. M. Duginski, D. V. Lewis, and R. A. Radtke. “False lateralization of scalp EEG seizure onset.” Journal of Epilepsy 6, no. 4 (January 1, 1993): 220–23. https://doi.org/10.1016/0896-6974(93)90004-T.
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  - Jones, L. S., S. Y. Grooms, D. M. Lapadula, and D. V. Lewis. “Protein synthesis inhibition blocks maintenance but not induction of epileptogenesis in hippocampal slice.” Brain Res 599, no. 2 (December 25, 1992): 338–44. https://doi.org/10.1016/0006-8993(92)90410-b.
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  - Walczak, T. S., R. A. Radtke, and D. V. Lewis. “Accuracy and interobserver reliability of scalp ictal EEG.” Neurology 42, no. 12 (December 1992): 2279–85. https://doi.org/10.1212/wnl.42.12.2279.
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  - Xie, C. W., R. A. Morrisett, and D. V. Lewis. “Mu opioid receptor-mediated modulation of synaptic currents in dentate granule cells of rat hippocampus.” J Neurophysiol 68, no. 4 (October 1992): 1113–20. https://doi.org/10.1152/jn.1992.68.4.1113.
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  - Tien, R. D., B. C. Ashdown, D. V. Lewis, M. R. Atkins, and P. C. Burger. “Rasmussen's encephalitis: neuroimaging findings in four patients.” Ajr Am J Roentgenol 158, no. 6 (June 1992): 1329–32. https://doi.org/10.2214/ajr.158.6.1590136.
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  - Mott, D. D., and D. V. Lewis. “GABAB receptors mediate disinhibition and facilitate long-term potentiation in the dentate gyrus.” Epilepsy Res Suppl 7 (1992): 119–34.
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  - Morrisett, R. A., D. Martin, T. A. Oetting, D. V. Lewis, W. A. Wilson, and H. S. Swartzwelder. “Ethanol and magnesium ions inhibit N-methyl-D-aspartate-mediated synaptic potentials in an interactive manner.” Neuropharmacology 30, no. 11 (November 1991): 1173–78. https://doi.org/10.1016/0028-3908(91)90162-5.
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  - Dunckley, H., J. R. Chapman, J. Burke, J. Charlesworth, J. Hayes, E. Haywood, B. Hutchison, L. Ibels, S. Kalowski, and P. Kincaid-Smith. “HLA-DR and -DQ genotyping in anti-GBM disease.” Dis Markers 9, no. 5 (September 1991): 249–56.
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  - Mott, D. D., and D. V. Lewis. “Facilitation of the induction of long-term potentiation by GABAB receptors.” Science 252, no. 5013 (June 21, 1991): 1718–20. https://doi.org/10.1126/science.1675489.
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  - Vedanarayanan, V. V., R. S. Kandt, D. V. Lewis, and G. R. DeLong. “Chronic inflammatory demyelinating polyradiculoneuropathy of childhood: treatment with high-dose intravenous immunoglobulin.” Neurology 41, no. 6 (June 1991): 828–30. https://doi.org/10.1212/wnl.41.6.828.
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  - Chung, M. Y., T. S. Walczak, D. V. Lewis, D. V. Dawson, and R. Radtke. “Temporal lobectomy and independent bitemporal interictal activity: what degree of lateralization is sufficient?” Epilepsia 32, no. 2 (March 1991): 195–201. https://doi.org/10.1111/j.1528-1157.1991.tb05244.x.
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  - Morrisett, R. A., D. D. Mott, D. V. Lewis, H. S. Swartzwelder, and W. A. Wilson. “GABAB-receptor-mediated inhibition of the N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus.” J Neurosci 11, no. 1 (January 1991): 203–9.
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  - Walczak, T. S., D. V. Lewis, and R. Radtke. “Scalp EEG differs in temporal and extratemporal complex partial seizures.” Journal of Epilepsy 4, no. 1 (January 1, 1991): 25–28. https://doi.org/10.1016/0896-6974(91)90118-3.
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  - Xie, C. W., and D. V. Lewis. “Opioid-mediated facilitation of long-term potentiation at the lateral perforant path-dentate granule cell synapse.” J Pharmacol Exp Ther 256, no. 1 (January 1991): 289–96.
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  - Morrisett, R. A., D. D. Mott, D. V. Lewis, W. A. Wilson, and H. S. Swartzwelder. “Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats.” Brain Res Dev Brain Res 56, no. 2 (November 1, 1990): 257–62. https://doi.org/10.1016/0165-3806(90)90090-l.
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  - Jones, L. S., D. M. Lapadula, D. V. Lewis, and M. B. Abou-Donia. “Effects of diisopropyl phosphorofluoridate (DFP) on CA3 and CA1 responses in rat hippocampus.” Mol Chem Neuropathol 13, no. 1–2 (August 1990): 1–16. https://doi.org/10.1007/bf03159904.
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  - Lewis, D. V., L. S. Jones, and D. D. Mott. “Hippocampal epileptiform activity induced by magnesium-free medium: differences between areas CA1 and CA2-3.” Epilepsy Res 6, no. 2 (July 1990): 95–101. https://doi.org/10.1016/0920-1211(90)90083-8.
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  - Mott, D. D., D. V. Lewis, C. M. Ferrari, W. A. Wilson, and H. S. Swartzwelder. “Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus.” Neurosci Lett 113, no. 2 (May 31, 1990): 222–26. https://doi.org/10.1016/0304-3940(90)90307-u.
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  - Lee, P. H., C. W. Xie, D. V. Lewis, W. A. Wilson, C. L. Mitchell, and J. S. Hong. “Opioid-induced epileptiform bursting in hippocampal slices: higher susceptibility in ventral than dorsal hippocampus.” J Pharmacol Exp Ther 253, no. 2 (May 1990): 545–51.
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  - Mott, D. D., A. C. Bragdon, and D. V. Lewis. “Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus.” Neurosci Lett 110, no. 1–2 (March 2, 1990): 131–36. https://doi.org/10.1016/0304-3940(90)90800-o.
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  - Walczak, T. S., R. A. Radtke, J. O. McNamara, D. V. Lewis, J. S. Luther, E. Thompson, W. P. Wilson, A. H. Friedman, and B. S. Nashold. “Anterior temporal lobectomy for complex partial seizures: evaluation, results, and long-term follow-up in 100 cases.” Neurology 40, no. 3 Pt 1 (March 1990): 413–18. https://doi.org/10.1212/wnl.40.3_part_1.413.
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  - Walczak, T. S., R. A. Radtke, J. O. McNamara, D. V. Lewis, J. S. Luther, E. Thompson, W. P. Wilson, A. H. Friedman, and B. S. Nashold. “Anterior temporal lobectomy for complex partial seizures: Evaluation, results, and long-term follow-up in 100 cases.” Neurology 40, no. 3 (January 1, 1990): 413–18.
  - Lewis, D. V., L. S. Jones, and D. D. Mott. “Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice.” Exp Neurol 106, no. 2 (November 1989): 181–86. https://doi.org/10.1016/0014-4886(89)90092-7.
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  - Lewis, D. V., L. S. Jones, and H. S. Swartzwelder. “The effects of baclofen and pertussis toxin on epileptiform activity induced in the hippocampal slice by magnesium depletion.” Epilepsy Res 4, no. 2 (September 1989): 109–18. https://doi.org/10.1016/0920-1211(89)90015-6.
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  - Mott, D. D., A. C. Bragdon, D. V. Lewis, and W. A. Wilson. “Baclofen has a proepileptic effect in the rat dentate gyrus.” J Pharmacol Exp Ther 249, no. 3 (June 1989): 721–25.
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  - Crumrine, P., F. E. Dreifuss, H. Corwin, J. Farwell, J. Milstein, K. Laxer, J. R. Schimschock, et al. “Double-blind, placebo-controlled evaluation of cinromide in patients with the Lennox-Gastaut Syndrome.” Epilepsia 30, no. 4 (1989): 422–29.
  - Wilson, W. A., H. S. Swartzwelder, W. W. Anderson, and D. V. Lewis. “Seizure activity in vitro: a dual focus model.” Epilepsy Res 2, no. 5 (September 1988): 289–93. https://doi.org/10.1016/0920-1211(88)90036-8.
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  - Jones, L. S., and D. V. Lewis. “A calcium-activated, nonselective cationic conductance in Aplysia silent neurons.” Brain Res Bull 20, no. 5 (May 1988): 607–9. https://doi.org/10.1016/0361-9230(88)90220-1.
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  - Lewis, D. V. “Calcium-activated inward spike after-currents in bursting neurone R15 of Aplysia.” J Physiol 395 (January 1988): 285–302. https://doi.org/10.1113/jphysiol.1988.sp016919.
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  - Williams, L. B., E. A. Thompson, and D. V. Lewis. “Intractable complex partial seizures: the "initial motionless stare" and surgical outcome following temporal lobectomy.” Neurology 37, no. 7 (July 1987): 1255–58. https://doi.org/10.1212/wnl.37.7.1255.
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  - Swartzwelder, H. S., D. V. Lewis, W. W. Anderson, and W. A. Wilson. “Seizure-like events in brain slices: suppression by interictal activity.” Brain Res 410, no. 2 (May 5, 1987): 362–66. https://doi.org/10.1016/0006-8993(87)90339-8.
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  - Anderson, W. W., D. V. Lewis, H. S. Swartzwelder, and W. A. Wilson. “Magnesium-free medium activates seizure-like events in the rat hippocampal slice.” Brain Res 398, no. 1 (November 19, 1986): 215–19. https://doi.org/10.1016/0006-8993(86)91274-6.
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  - Jones, L. S., G. J. Evans, W. A. Wilson, and D. V. Lewis. “A novel, calcium-induced triphasic current response in silent, non-bursting Aplysia neurons.” Brain Res 385, no. 1 (October 15, 1986): 46–50. https://doi.org/10.1016/0006-8993(86)91545-3.
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  - Brazy, J. E., and D. V. Lewis. “Changes in cerebral blood volume and cytochrome aa3 during hypertensive peaks in preterm infants.” J Pediatr 108, no. 6 (June 1986): 983–87. https://doi.org/10.1016/s0022-3476(86)80944-1.
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  - Kaplan, P. W., and D. V. Lewis. “Juvenile acute intermittent porphyria with hypercholesterolemia and epilepsy: a case report and review of the literature.” J Child Neurol 1, no. 1 (January 1986): 38–45. https://doi.org/10.1177/088307388600100106.
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  - Lewis, D. V., J. R. Huguenard, W. W. Anderson, and W. A. Wilson. “Membrane currents underlying bursting pacemaker activity and spike frequency adaptation in invertebrates.” Adv Neurol 44 (1986): 235–61.
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  - Huguenard, J. R., K. L. Zbicz, D. V. Lewis, G. J. Evans, and W. A. Wilson. “The ionic mechanism of the slow outward current in Aplysia neurons.” J Neurophysiol 54, no. 2 (August 1985): 449–61. https://doi.org/10.1152/jn.1985.54.2.449.
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  - Brazy, J. E., D. V. Lewis, M. H. Mitnick, and F. F. Jöbsis vander Vliet. “Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observations.” Pediatrics 75, no. 2 (February 1985): 217–25.
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  - Brazy, J. E., D. V. Lewis, M. H. Mitnick, and F. F. Jöbsis-Vander Vliet. “Monitoring of cerebral oxygenation in the intensive care nursery.” Adv Exp Med Biol 191 (1985): 843–48. https://doi.org/10.1007/978-1-4684-3291-6_84.
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  - Lewis, D. V., G. B. Evans, and W. A. Wilson. “Dopamine reduces slow outward current and calcium influx in burst-firing neuron R15 of Aplysia.” J Neurosci 4, no. 12 (December 1984): 3014–20.
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  - Lewis, D. V. “Spike aftercurrents in R15 of Aplysia: their relationship to slow inward current and calcium influx.” J Neurophysiol 51, no. 2 (February 1984): 387–403. https://doi.org/10.1152/jn.1984.51.2.387.
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  - Colmers, W. F., D. V. Lewis, and W. A. Wilson. “Cs+ loading reveals Na+-dependent persistent inward current and negative slope resistance region in Aplysia giant neurons.” J Neurophysiol 48, no. 5 (November 1982): 1191–1200. https://doi.org/10.1152/jn.1982.48.5.1191.
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  - Lewis, D. V., and W. A. Wilson. “Calcium influx and poststimulus current during early adaptation in Aplysia giant neurons.” J Neurophysiol 48, no. 1 (July 1982): 202–16. https://doi.org/10.1152/jn.1982.48.1.202.
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  - Colmers, W. F., D. V. L. Jr, and W. A. Wilson. “Cs⁺ loading reveals Na⁺-dependent persistent inward current and negative slope resistance region in Aplysia giant neurons.” Journal of Neurophysiology 48, no. 5 (1982): 1191–1200.
  - Rothman, S. J., D. V. Lewis, and R. S. Greenwood. “Discontinuation of antiepileptic drugs: Preliminary report of a prospective randomized study of two-year versus four-year seizure-free intervals, and nine-month versus six-week taper schedules.” Epilepsia 23, no. 4 (January 1, 1982).
  - Lewis, D. V., K. L. Zbicz, M. E. Nepp, W. F. Colmers, and W. A. Wilson. “Diphenylhydantoin enhances early adaptation in Aplysia giant neurons.” J Pharmacol Exp Ther 218, no. 1 (July 1981): 41–45.
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  - Lewis, D. V. “Diphenylhydantoin reduces the outward current of the action potential in Aplysia.” Brain Res 207, no. 1 (February 23, 1981): 234–38. https://doi.org/10.1016/0006-8993(81)90700-9.
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  - Dubois, P. J., M. Freemark, D. Lewis, B. P. Drayer, E. R. Heinz, and D. Osborne. “Atypical findings in adrenoleukodystrophy.” Journal of Computer Assisted Tomography 5, no. 6 (January 1, 1981): 888–91. https://doi.org/10.1097/00004728-198112000-00019.
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  - Van Buren, J. M., D. V. Lewis, W. H. Schuette, W. C. Whitehouse, and C. A. Marsan. “Fluorometric monitoring of NADH levels in cerebral cortex: preliminary observations in human epilepsy.” Neurosurgery 2, no. 2 (March 1978): 114–21. https://doi.org/10.1227/00006123-197803000-00007.
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  - Lewis, D. V., N. Mutsuga, W. H. Schuette, and J. Van Buren. “Potassium clearance and reactive gliosis in the alumina gel lesion.” Epilepsia 18, no. 4 (December 1977): 499–506. https://doi.org/10.1111/j.1528-1157.1977.tb04997.x.
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  - Lewis, D. V., and J. M. Freeman. “The electroencephalogram in pediatric practice: its use and abuse.” Pediatrics 60, no. 3 (September 1977): 324–30.
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  - Mutsuga, N., W. H. Schuette, and D. V. Lewis. “The contribution of local blood flow to the rapid clearance of potassium from the cortical extracellular space.” Brain Res 116, no. 3 (November 12, 1976): 431–36. https://doi.org/10.1016/0006-8993(76)90491-1.
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  - Lewis, D. V., and W. H. Schuette. “NADH fluorescence, [K+]0 and oxygen consumption in cat cerebral cortex during direct cortical stimulation.” Brain Res 110, no. 3 (July 16, 1976): 523–35. https://doi.org/10.1016/0006-8993(76)90863-5.
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  - Schuette, W. H., D. V. Lewis, M. O’Connor, and J. M. Van Buren. “The design and operation of a dual-beal long-focal-length fluorometer for monitoring the oxidative metabolism in vivo.” Med Biol Eng 14, no. 2 (March 1976): 235–38. https://doi.org/10.1007/bf02478754.
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  - Lewis, D. V., and W. H. Schuette. “Temperature dependence of potassium clearance in the central nervous system.” Brain Res 99, no. 1 (November 28, 1975): 175–78. https://doi.org/10.1016/0006-8993(75)90623-x.
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  - Lewis, D. V., and W. H. Schuette. “NADH fluorescence and [K+]o changes during hippocampal electrical stimulation.” J Neurophysiol 38, no. 2 (March 1975): 405–17. https://doi.org/10.1152/jn.1975.38.2.405.
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  - Schuette, W. H., W. C. Whitehouse, D. V. Lewis, M. O’Connor, and J. M. Van Buren. “A television fluorometer for monitoring oxidative metabolism in intact tissue.” Med Instrum 8, no. 6 (November 1974): 331–33.
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  - Lewis, D. V., M. J. O’Connor, and W. H. Schuette. “Oxidative metabolism during recurrent seizures in the penicillin treated hippocampus.” Electroencephalogr Clin Neurophysiol 36, no. 4 (April 1974): 347–56. https://doi.org/10.1016/0013-4694(74)90184-9.
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  - O’Connor, M. J., and D. V. Lewis. “Recurrent seizures induced by potassium in the penicillin treated hippocampus.” Electroencephalogr Clin Neurophysiol 36, no. 4 (April 1974): 337–45. https://doi.org/10.1016/0013-4694(74)90183-7.
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  - O’Connor, M. J., D. V. Lewis, and C. J. Herman. “Effects of potassium on oxidative metabolism and seizures.” Electroencephalogr Clin Neurophysiol 35, no. 2 (August 1973): 205–8. https://doi.org/10.1016/0013-4694(73)90178-8.
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  - Christian, S. T., C. W. Gorodetzky, and D. V. Lewis. “Structure-activity relationships of noreperidine congeners on cholinesterase systems in vitro and analgesia in vivo.” Biochem Pharmacol 20, no. 6 (June 1971): 1167–82. https://doi.org/10.1016/0006-2952(71)90347-9.
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  - Lewis, D. V., N. Staley, W. Rogers, and R. F. Edlich. “Studies on the distribution of blood flow in amelanotic melanoma and reticulum cell lymphosarcoma during growth.” Cancer Res 28, no. 8 (August 1968): 1507–12.
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  - Rogers, W., R. F. Edlich, D. V. Lewis, and J. B. Aust. “Tumor blood flow: I. Blood flow in transplantable tumors during growth.” Surg Clin North Am 47, no. 6 (December 1967): 1473–82. https://doi.org/10.1016/s0039-6109(16)38398-0.
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- Book Sections
  - Clark, S., S. Stasheff, D. V. Lewis, D. Martin, and W. A. Wilson. “The NMDA receptor in epilepsy.” In The NMDA Receptor, 2012. https://doi.org/10.1093/acprof:oso/9780192625021.003.0017.
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- Other Articles
  - Purves, D., B. Lotto, and T. Polger. “Reply.” J Cogn Neurosci, September 2000. https://doi.org/10.1162/jocn.2000.12.5.911a.
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