Darrell Vincent Lewis Jr.

Darrell Vincent Lewis Jr.
Professor of Pediatrics

Current Research Efforts:
Explore the relationship between prolonged febrile convulsions, temporal lobe epilepsy and hippocampal sclerosis; The hypothesis that prolonged febrile convulsions cause hippocampal injury that evolves to sclerosis and then to temporal lobe epilepsy has been promulgated for decades since the advent of surgical treatment of temporal lobe epilepsy. However, this concept has never been addressed with a prospective clinical study. With the availability of magnetic resonance imaging techniques capable of discerning hippocampal edema and measuring hippocampal volume, patients suffering from these seizures can now be studied acutely and chronically to determine if hippocampal injury does occur during them and under what clinical circumstances. We are conducting a longterm study of this phenomenon in cooperation with 5 other medical centers which will prospectively enroll 200 infants presenting with febrile status epilepticus and follow these infants for 10 - 15 years with sequential neuroimaging, electroencephalographic and developmental testing to determine the long term consequences of these infantile seizures.

Current Appointments & Affiliations

Professor of Pediatrics, Pediatrics, Neurology, Pediatrics 1998

Contact Information

125 Bell Bldg, Durham, NC 27710
Box 3936 Med Ctr, Durham, NC 27710
lewis013@mc.duke.edu (919) 668-0477

Background
Education, Training, & Certifications
- M.D., University of Minnesota, Twin Cities 1969
Duke Appointment History
- Assistant Professor of Medicine, Neurology, Clinical Science Departments 1997 - 2011
- Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 1994 - 2009
- Acting Chief, Division of Neurology in the Department of Pediatrics, Pediatrics, Neurology, Pediatrics 1994 - 1999
- Associate Professor of Pediatrics in the Department of Pediatrics, Pediatrics, Neurology, Pediatrics 1987 - 1997
- Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 1994
- Assistant Professor of Physiology, Immunology, Basic Science Departments 1987 - 1988
- Associate Professor of Pediatrics, Pediatrics, Clinical Science Departments 1986 - 1987
- Assistant Professor of Pediatrics, Pediatrics, Clinical Science Departments 1978 - 1986
- Associate in the Department of Pediatrics, Pediatrics, Clinical Science Departments 1978
Research
Selected Grants
- Consequences of prolonged febrile seizures in childhood awarded by Albert Einstein College of Medicine 2017 - 2019
- Consequences of prolonged febrile seizures in childhood awarded by Albert Einstein College of Medicine 2013 - 2017
- Best Pharmaceutical for Children Act (BPCA): Use of Meropenem in Infants awarded by National Institutes of Health 2007 - 2010
- A Linux Cluster Computational Facility for Neuroimaging Research awarded by National Institutes of Health 2009 - 2010
- GHB Tolerance and Dependence awarded by National Institutes of Health 2003 - 2007
- Neuronal degeneration in the cingulate gyrus: NMDA antagonists and anticholinestera awarded by US Army Medical Research 1999 - 2002
- Endogenous Opioids Regulate Ltp Of Inhibition awarded by National Institutes of Health 1998 - 2000
- Endogenous Opioids Regulate LTP of Inhibiton awarded by National Institutes of Health 1998 - 1999
- Endogenous Opioids: Their Role In Ltp In Dentate Gyrus awarded by National Institutes of Health 1991 - 1995
- Endogenous Opiods: Their Role In Ltp In Dentate Gyrus awarded by National Institutes of Health 1991 - 1994
- Gaba-B Mediated Disinhibition In The Dentate Gyrus awarded by National Institutes of Health 1992 - 1994
- Gabab Mediated Disinhibition In The Dentate Gyrus awarded by National Institutes of Health 1991 - 1993
- Gabab Mediated Disinhibition In The Dentate Gyrus awarded by National Science Foundation 1990 - 1993
- Ion Channel Control By Calcium awarded by National Institutes of Health 1987 - 1989
- Control Of Ionic Channels By Intracellular Calcium awarded by National Science Foundation 1985 - 1987
- Neurotransmitter Modulation Of Intracellular Calcium awarded by National Institutes of Health 1984 - 1985
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Gallentine, WB, Shinnar, S, Hesdorffer, DC, Epstein, L, Nordli, DR, Lewis, DV, Frank, LM, Seinfeld, S, Shinnar, RC, Cornett, K, Liu, B, Moshé, SL, Sun, S, and FEBSTAT Investigator Team, . "Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury." Epilepsia 58, no. 6 (June 2017): 1102-1111. Full Text
  - McClelland, AC, Gomes, WA, Shinnar, S, Hesdorffer, DC, Bagiella, E, Lewis, DV, Bello, JA, Chan, S, MacFall, J, Chen, M, Pellock, JM, Nordli, DR, Frank, LM, Moshé, SL, Shinnar, RC, Sun, S, and FEBSTAT Study Team, . "Quantitative Evaluation of Medial Temporal Lobe Morphology in Children with Febrile Status Epilepticus: Results of the FEBSTAT Study." Ajnr. American Journal of Neuroradiology 37, no. 12 (December 2016): 2356-2362. Full Text
  - Hesdorffer, DC, Shinnar, S, Lax, DN, Pellock, JM, Nordli, DR, Seinfeld, S, Gallentine, W, Frank, LM, Lewis, DV, Shinnar, RC, Bello, JA, Chan, S, Epstein, LG, Moshé, SL, Liu, B, Sun, S, and FEBSTAT study team, . "Risk factors for subsequent febrile seizures in the FEBSTAT study." Epilepsia 57, no. 7 (July 2016): 1042-1047. Full Text
  - Chan, S, Bello, JA, Shinnar, S, Hesdorffer, DC, Lewis, DV, MacFall, J, Shinnar, RC, Gomes, W, Litherland, C, Xu, Y, Nordli, DR, Pellock, JM, Frank, LM, Moshé, SL, Sun, S, and FEBSTAT Study Team, . "Hippocampal Malrotation Is Associated With Prolonged Febrile Seizures: Results of the FEBSTAT Study." AJR. American journal of roentgenology 205, no. 5 (November 2015): 1068-1074. Full Text
  - Puranam, RS, He, XP, Yao, L, Le, T, Jang, W, Rehder, CW, Lewis, DV, and McNamara, JO. "Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus." The Journal of neuroscience : the official journal of the Society for Neuroscience 35, no. 23 (June 2015): 8866-8881. Full Text
  - Lewis, D, Hesdorffer, D, Moshé, SL, Shinnar, S, and FEBSTAT Study Team, . "Reply: To PMID 24318290." Annals of Neurology 76, no. 2 (August 2014): 316-317. (Letter) Full Text
  - Lewis, DV, Shinnar, S, Hesdorffer, DC, Bagiella, E, Bello, JA, Chan, S, Xu, Y, MacFall, J, Gomes, WA, Moshé, SL, Mathern, GW, Pellock, JM, Nordli, DR, Frank, LM, Provenzale, J, Shinnar, RC, Epstein, LG, Masur, D, Litherland, C, Sun, S, and FEBSTAT Study Team, . "Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study." Annals of neurology 75, no. 2 (February 2014): 178-185. Full Text
  - Frank, LM, Provenzale, J, Shinnar, RC, Epstein, LG, Masur, D, Litherland, C, and Sun, S. "Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT study." Annals of Neurology 75, no. 2 (January 1, 2014): 178-185. Full Text
  - Hesdorffer, DC, Shinnar, S, Lewis, DV, Jr, DRN, Pellock, JM, Moshé, SL, Shinnar, RC, Litherland, C, Bagiella, E, Frank, LM, Bello, JA, Chan, S, Masur, D, Macfall, J, and Sun, S. "Risk factors for febrile status epilepticus: A case-control study." Journal of Pediatrics 163, no. 4 (2013): 1147-1151.e1. Full Text
  - Hesdorffer, DC, Shinnar, S, Lewis, DV, Jr, DRN, Pellock, JM, Moshé, SL, Shinnar, RC, Litherland, C, Bagiella, E, Frank, LM, and al, E. "Risk Factors for Febrile Status Epilepticus: A Case-Control Study." Journal of Pediatrics (2013). Full Text
  - Nordli, DR, Moshé, SL, Shinnar, S, Hesdorffer, DC, Sogawa, Y, Pellock, JM, Lewis, DV, Frank, LM, Shinnar, RC, Sun, S, and FEBSTAT Study Team, . "Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study." Neurology 79, no. 22 (November 7, 2012): 2180-2186. Full Text
  - Shinnar, S, Bello, JA, Chan, S, Hesdorffer, DC, Lewis, DV, Macfall, J, Pellock, JM, Nordli, DR, Frank, LM, Moshe, SL, Gomes, W, Shinnar, RC, Sun, S, and FEBSTAT Study Team, . "MRI abnormalities following febrile status epilepticus in children: the FEBSTAT study." Neurology 79, no. 9 (August 2012): 871-877. Full Text
  - Epstein, LG, Shinnar, S, Hesdorffer, DC, Nordli, DR, Hamidullah, A, Benn, EKT, Pellock, JM, Frank, LM, Lewis, DV, Moshe, SL, Shinnar, RC, and Sun, S. "Human herpesvirus 6 and 7 in febrile status epilepticus: The FEBSTAT study." Epilepsia 53, no. 9 (2012): 1481-1488. Full Text
  - Frank, LM, Shinnar, S, Hesdorffer, DC, Shinnar, RC, Pellock, JM, Gallentine, W, Jr, DRN, Epstein, LG, Moshé, SL, Lewis, DV, and Sun, S. "Cerebrospinal fluid findings in children with fever-associated status epilepticus: Results of the consequences of prolonged febrile seizures (FEBSTAT) study." Journal of Pediatrics 161, no. 6 (2012): 1169-1171.e1. Full Text
  - Hesdorffer, DC, Shinnar, S, Lewis, DV, Moshé, SL, Jr, DRN, Pellock, JM, MacFall, J, Shinnar, RC, Masur, D, Frank, LM, Epstein, LG, Litherland, C, Seinfeld, S, Bello, JA, Chan, S, Bagiella, E, and Sun, S. "Design and phenomenology of the FEBSTAT study." Epilepsia 53, no. 9 (2012): 1471-1480. Full Text
  - Baigent, C, Landray, M, Reith, C, Dasgupta, T, Emberson, J, Herrington, W, Lewis, D, Mafham, M, Collins, R, Bray, C, Chen, Y, Baxter, A, Young, A, Hill, M, Knott, C, Cass, A, Feldt-Rasmussen, B, Fellström, B, Grobbee, R, Grönhagen-Riska, C, Haas, M, Holdaas, H, Hooi, LS, Jiang, L, Kasiske, B, Krairittichai, U, Levin, A, Massy, Z, Tesar, V, Walker, R, Wanner, C, Wheeler, D, Wiecek, A, Majoni, W, Simpson, D, Strony, J, Musliner, T, Agodoa, L, Armitage, J, Chen, Z, Craig, J, De Zeeuw, D, Gaziano, M, Grimm, R, Krane, V, Neal, B, Ophascharoensuk, V, Pedersen, T, Sleight, P, Tobert, J, Tomson, C, Sandercock, P, Keech, A, and Whelton, P. "Study of Heart and Renal Protection (SHARP): Randomized trial to assess the effects of lowering low-density lipoprotein cholesterol among 9,438 patients with chronic kidney disease." American Heart Journal 160, no. 5 (November 1, 2010): 785-794. Full Text
  - Kansagra, S, Ataya, N, Lewis, D, Gallentine, W, and Mikati, MA. "The effect of vagus nerve stimulation therapy on body mass index in children." Epilepsy & Behavior : E&B 19, no. 1 (September 2010): 50-51. Full Text
  - Morey, RA, Petty, CM, Xu, Y, Hayes, JP, Wagner, HR, Lewis, DV, Labar, KS, Styner, M, and McCarthy, G. "Rebuttal to Hasan and Pedraza in comments and controversies: "Improving the reliability of manual and automated methods for hippocampal and amygdala volume measurements"." Neuroimage 48, no. 3 (November 15, 2009): 499-500. Full Text Link to Item
  - Morey, RA, Petty, CM, Xu, Y, Hayes, JP, Wagner, HR, Lewis, DV, LaBar, KS, Styner, M, and McCarthy, G. "A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes." Neuroimage 45, no. 3 (April 2009): 855-866. Full Text
  - Provenzale, JM, vanLandingham, KE, Lewis, DV, Mukundan, S, and White, LE. "Extrahippocampal involvement in human herpesvirus 6 encephalitis depicted at MR imaging." Radiology 249, no. 3 (December 2008): 955-963. Full Text
  - Shinnar, S, Hesdorffer, DC, Nordli, DR, Pellock, JM, O'Dell, C, Lewis, DV, Frank, LM, Moshé, SL, Epstein, LG, Marmarou, A, Bagiella, E, and FEBSTAT Study Team, . "Phenomenology of prolonged febrile seizures: results of the FEBSTAT study." Neurology 71, no. 3 (July 2008): 170-176. Full Text
  - Provenzale, JM, Barboriak, DP, VanLandingham, K, MacFall, J, Delong, D, and Lewis, DV. "Hippocampal MRI signal hyperintensity after febrile status epilepticus is predictive of subsequent mesial temporal sclerosis." AJR Am J Roentgenol 190, no. 4 (April 2008): 976-983. Full Text Link to Item
  - Li, Q, Kuhn, CM, Wilson, WA, and Lewis, DV. "Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex." Neuroscience 150, no. 1 (November 30, 2007): 82-92. Full Text Link to Item
  - Sathornsumetee, S, Schanberg, L, Rabinovich, E, Lewis, D, and Weisleder, P. "Parry-Romberg syndrome with fatal brain stem involvement." J Pediatr 146, no. 3 (March 2005): 429-431. Full Text Link to Item
  - Lewis, DV. "Losing neurons: selective vulnerability and mesial temporal sclerosis." Epilepsia 46 Suppl 7 (2005): 39-44. Full Text Link to Item
  - Li, Q, Guo-Ross, S, Lewis, DV, Turner, D, White, AM, Wilson, WA, and Swartzwelder, HS. "Dietary prenatal choline supplementation alters postnatal hippocampal structure and function." Journal of Neurophysiology 91, no. 4 (April 2004): 1545-1555. Full Text
  - Li, Q, Clark, S, Lewis, DV, and Wilson, WA. "NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 22, no. 8 (April 2002): 3070-3080.
  - Lewis, DV, Barboriak, DP, MacFall, JR, Provenzale, JM, Mitchell, TV, and VanLandingham, KE. "Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions." Prog Brain Res 135 (2002): 263-278. (Review) Link to Item
  - Verma, A, Lewis, D, VanLandingham, KE, Husain, AM, Friedman, AH, Thompson, E, and Radtke, RA. "Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy." Epilepsy Res 47, no. 1-2 (November 2001): 9-15. Link to Item
  - Wainwright, MS, Martin, PL, Morse, RP, Lacaze, M, Provenzale, JM, Coleman, RE, Morgan, MA, Hulette, C, Kurtzberg, J, Bushnell, C, Epstein, L, and Lewis, DV. "Human herpesvirus 6 limbic encephalitis after stem cell transplantation." Ann Neurol 50, no. 5 (November 2001): 612-619. Link to Item
  - Jobe, A, Lewis, D, Wainwright, M, and DeLong, GR. "Three children with a syndrome of obesity and overgrowth, atypical psychosis, and seizures: a problem in neuropsychopharmacology." J Child Neurol 15, no. 8 (August 2000): 518-528. Full Text Link to Item
  - Kassem-Moussa, H, Provenzale, JM, Petrella, JR, and Lewis, DV. "Early diffusion-weighted MR imaging abnormalities in sustained seizure activity." AJR Am J Roentgenol 174, no. 5 (May 2000): 1304-1306. Full Text Link to Item
  - Foldvary, N, Nashold, B, Mascha, E, Thompson, EA, Lee, N, McNamara, JO, Lewis, DV, Luther, JS, Friedman, AH, and Radtke, RA. "Seizure outcome after temporal lobectomy for temporal lobe epilepsy: a Kaplan-Meier survival analysis." Neurology 54, no. 3 (February 2000): 630-634. Full Text
  - Mott, DD, Li, Q, Okazaki, MM, Turner, DA, and Lewis, DV. "GABAB-Receptor-mediated currents in interneurons of the dentate-hilus border." Journal of Neurophysiology 82, no. 3 (September 1999): 1438-1450. Full Text
  - Lewis, DV. "Febrile convulsions and mesial temporal sclerosis." Curr Opin Neurol 12, no. 2 (April 1999): 197-201. (Review) Link to Item
  - Tennison, M, Kankirawatana, P, Richardson Bowman, M, Greenwood, R, Lewis, D, and Burchinal, M. "Effect of chronic antiepileptic drug therapy on California achievement test scores." Journal of Epilepsy 11, no. 4 (July 1, 1998): 208-214. Full Text
  - VanLandingham, KE, Heinz, ER, Cavazos, JE, and Lewis, DV. "Magnetic resonance imaging evidence of hippocampal injury after prolonged focal febrile convulsions." Annals of Neurology 43, no. 4 (April 1998): 413-426. Full Text
  - Xie, CW, and Lewis, DV. "Involvement of cAMP-dependent protein kinase in mu-opioid modulation of NMDA-mediated synaptic currents." Journal of Neurophysiology 78, no. 2 (August 1997): 759-766. Full Text
  - Mott, DD, Turner, DA, Okazaki, MM, and Lewis, DV. "Interneurons of the dentate-hilus border of the rat dentate gyrus: morphological and electrophysiological heterogeneity." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 17, no. 11 (June 1997): 3990-4005. Full Text
  - Andrews, PI, McNamara, JO, and Lewis, DV. "Clinical and electroencephalographic correlates in Rasmussen's encephalitis." Epilepsia 38, no. 2 (February 1997): 189-194. Link to Item
  - Brucato, FH, Levin, ED, Mott, DD, Lewis, DV, Wilson, WA, and Swartzwelder, HS. "Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade." Neuroscience 74, no. 2 (September 1996): 331-339. Link to Item
  - Lewis, DV, Thompson, RJ, Santos, CC, Oakes, WJ, Radtke, RA, Friedman, AH, Lee, N, and Swartzwelder, HS. "Outcome of temporal lobectomy in adolescents." Journal of Epilepsy 9, no. 3 (January 1, 1996): 198-205. Full Text
  - Lee, N, Tien, RD, Lewis, DV, Friedman, AH, Felsberg, GJ, Crain, B, Hulette, C, Osumi, AK, Smith, JS, and VanLandingham, KE. "Fast spin-echo, magnetic resonance imaging-measured hippocampal volume: correlation with neuronal density in anterior temporal lobectomy patients." Epilepsia 36, no. 9 (September 1995): 899-904. Link to Item
  - Xie, CW, and Lewis, DV. "Depression of LTP in rat dentate gyrus by naloxone is reversed by GABAA blockade." Brain Res 688, no. 1-2 (August 7, 1995): 56-60. Link to Item
  - Xie, CW, and Lewis, DV. "Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus." J Neurosci 15, no. 5 Pt 2 (May 1995): 3788-3795. Link to Item
  - Brucato, FH, Mott, DD, Lewis, DV, and Swartzwelder, HS. "GABAB receptors modulate synaptically-evoked responses in the rat dentate gyrus, in vivo." Brain Research 677, no. 2 (April 1995): 326-332. Full Text
  - Xie, CW, and Lewis, DV. "Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus." Journal of Neuroscience 15, no. 5 II (January 1, 1995): 3788-3795.
  - Nohria, V, Lee, N, Tien, RD, Heinz, ER, Smith, JS, DeLong, GR, Skeen, MB, Resnick, TJ, Crain, B, and Lewis, DV. "Magnetic resonance imaging evidence of hippocampal sclerosis in progression: a case report." Epilepsia 35, no. 6 (November 1994): 1332-1336. Link to Item
  - Xie, C-W, and Lewis, DV. "Blocking δ opioid receptors unmasks LTP of synaptic inhibition in the dentate gyrus." Regulatory Peptides 54, no. 1 (November 1994): 73-74. Full Text
  - Lee, N, Radtke, RA, Gray, L, Burger, PC, Montine, TJ, DeLong, GR, Lewis, DV, Oakes, WJ, Friedman, AH, and Hoffman, JM. "Neuronal migration disorders: positron emission tomography correlations." Ann Neurol 35, no. 3 (March 1994): 290-297. Full Text Link to Item
  - Tsujino, S, Tonin, P, Shanske, S, Nohria, V, Boustany, RM, Lewis, D, Chen, YT, and DiMauro, S. "A splice junction mutation in a new myopathic variant of phosphoglycerate kinase deficiency (PGK North Carolina)." Ann Neurol 35, no. 3 (March 1994): 349-353. Full Text Link to Item
  - Mott, DD, and Lewis, DV. "The pharmacology and function of central GABAB receptors." Int Rev Neurobiol 36 (1994): 97-223. (Review) Link to Item
  - Radtke, RA, Hanson, MW, Hoffman, JM, Heinz, ER, Walczak, TS, Lewis, DV, Coleman, RE, and Friedman, AF. "Positron emission tomography: Comparison of clinical utility in temporal lobe and extratemporal epilepsy." Journal of Epilepsy 7, no. 1 (January 1, 1994): 27-33. Full Text
  - Tennison, M, Greenwood, R, Lewis, D, and Thorn, M. "Discontinuing antiepileptic drugs in children with epilepsy: A comparison of a six-week and a nine-month taper period." New England Journal of Medicine 330, no. 20 (1994): 1407-1410.
  - Tien, RD, Felsberg, GJ, Campi de Castro, C, Osumi, AK, Lewis, DV, Friedman, AH, Crain, B, and Radtke, RA. "Complex partial seizures and mesial temporal sclerosis: evaluation with fast spin-echo MR imaging." Radiology 189, no. 3 (December 1993): 835-842. Full Text
  - Radtke, RA, Hanson, MW, Hoffman, JM, Crain, BJ, Walczak, TS, Lewis, DV, Beam, C, Coleman, RE, and Friedman, AH. "Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy." Neurology 43, no. 6 (June 1993): 1088-1092. Link to Item
  - Mott, DD, Xie, CW, Wilson, WA, Swartzwelder, HS, and Lewis, DV. "GABAB autoreceptors mediate activity-dependent disinhibition and enhance signal transmission in the dentate gyrus." Journal of Neurophysiology 69, no. 3 (March 1993): 674-691. Full Text
  - Morrisett, RA, Lewis, DV, Swartzwelder, HS, and Wilson, WA. "Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus." Brain Res 600, no. 2 (January 15, 1993): 235-242. Link to Item
  - Lee, EK, Armon, C, Duginski, TM, Lewis, DV, and Radtke, RA. "False lateralization of scalp EEG seizure onset." Journal of Epilepsy 6, no. 4 (January 1, 1993): 220-223. Full Text
  - Jones, LS, Grooms, SY, Lapadula, DM, and Lewis, DV. "Protein synthesis inhibition blocks maintenance but not induction of epileptogenesis in hippocampal slice." Brain Research 599, no. 2 (December 1992): 338-344. Full Text
  - Walczak, TS, Radtke, RA, and Lewis, DV. "Accuracy and interobserver reliability of scalp ictal EEG." Neurology 42, no. 12 (December 1992): 2279-2285. Link to Item
  - Xie, CW, Morrisett, RA, and Lewis, DV. "Mu opioid receptor-mediated modulation of synaptic currents in dentate granule cells of rat hippocampus." Journal of Neurophysiology 68, no. 4 (October 1992): 1113-1120. Full Text
  - Tien, RD, Ashdown, BC, Lewis, DV, Atkins, MR, and Burger, PC. "Rasmussen's encephalitis: neuroimaging findings in four patients." AJR Am J Roentgenol 158, no. 6 (June 1992): 1329-1332. Full Text Link to Item
  - Mott, DD, and Lewis, DV. "GABAB receptors mediate disinhibition and facilitate long-term potentiation in the dentate gyrus." Epilepsy Research. Supplement 7 (January 1992): 119-134.
  - Morrisett, RA, Martin, D, Oetting, TA, Lewis, DV, Wilson, WA, and Swartzwelder, HS. "Ethanol and magnesium ions inhibit N-methyl-D-aspartate-mediated synaptic potentials in an interactive manner." Neuropharmacology 30, no. 11 (November 1991): 1173-1178. Link to Item
  - Mott, DD, and Lewis, DV. "Facilitation of the induction of long-term potentiation by GABAB receptors." Science 252, no. 5013 (June 21, 1991): 1718-1720. Link to Item
  - Vedanarayanan, VV, Kandt, RS, Lewis, DV, and DeLong, GR. "Chronic inflammatory demyelinating polyradiculoneuropathy of childhood: treatment with high-dose intravenous immunoglobulin." Neurology 41, no. 6 (June 1991): 828-830. Link to Item
  - Chung, MY, Walczak, TS, Lewis, DV, Dawson, DV, and Radtke, R. "Temporal lobectomy and independent bitemporal interictal activity: what degree of lateralization is sufficient?." Epilepsia 32, no. 2 (March 1991): 195-201. Full Text
  - Dunckley, H, Chapman, JR, Burke, J, Charlesworth, J, Hayes, J, Haywood, E, Hutchison, B, Ibels, L, Kalowski, S, Kincaid-Smith, P, Lawrence, S, Lewis, D, Moran, J, Pussell, B, Restifo, A, Stewart, J, Thatcher, G, Walker, R, and Waugh, D. "HLR-DR and -DQ genotyping in anti-GBM disease." Disease Markers 9, no. 5 (1991): 249-256.
  - Morrisett, RA, Mott, DD, Lewis, DV, Swartzwelder, HS, and Wilson, WA. "GABAB-receptor-mediated inhibition of the N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 11, no. 1 (January 1991): 203-209. Full Text
  - Walczak, TS, Lewis, DV, and Radtke, R. "Scalp EEG differs in temporal and extratemporal complex partial seizures." Journal of Epilepsy 4, no. 1 (January 1, 1991): 25-28. Full Text
  - Xie, CW, and Lewis, DV. "Opioid-mediated facilitation of long-term potentiation at the lateral perforant path-dentate granule cell synapse." J Pharmacol Exp Ther 256, no. 1 (January 1991): 289-296. Link to Item
  - Morrisett, RA, Mott, DD, Lewis, DV, Wilson, WA, and Swartzwelder, HS. "Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats." Brain Res Dev Brain Res 56, no. 2 (November 1, 1990): 257-262. Link to Item
  - Jones, LS, Lapadula, DM, Lewis, DV, and Abou-Donia, MB. "Effects of diisopropyl phosphorofluoridate (DFP) on CA3 and CA1 responses in rat hippocampus." Molecular and Chemical Neuropathology 13, no. 1-2 (August 1990): 1-16. Full Text
  - Lewis, DV, Jones, LS, and Mott, DD. "Hippocampal epileptiform activity induced by magnesium-free medium: differences between areas CA1 and CA2-3." Epilepsy Res 6, no. 2 (July 1990): 95-101. Link to Item
  - Mott, DD, Lewis, DV, Ferrari, CM, Wilson, WA, and Swartzwelder, HS. "Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus." Neurosci Lett 113, no. 2 (May 31, 1990): 222-226. Link to Item
  - Lee, PH, Xie, CW, Lewis, DV, Wilson, WA, Mitchell, CL, and Hong, JS. "Opioid-induced epileptiform bursting in hippocampal slices: higher susceptibility in ventral than dorsal hippocampus." J Pharmacol Exp Ther 253, no. 2 (May 1990): 545-551. Link to Item
  - Mott, DD, Bragdon, AC, and Lewis, DV. "Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus." Neurosci Lett 110, no. 1-2 (March 2, 1990): 131-136. Link to Item
  - Walczak, TS, Radtke, RA, McNamara, JO, Lewis, DV, Luther, JS, Thompson, E, Wilson, WP, Friedman, AH, and Nashold, BS. "Anterior temporal lobectomy for complex partial seizures: evaluation, results, and long-term follow-up in 100 cases." Neurology 40, no. 3 Pt 1 (March 1990): 413-418. Link to Item
  - Walczak, TS, Radtke, RA, McNamara, JO, Lewis, DV, Luther, JS, Thompson, E, Wilson, WP, Friedman, AH, and Nashold, BS. "Anterior temporal lobectomy for complex partial seizures: Evaluation, results, and long-term follow-up in 100 cases." Neurology 40, no. 3 (1990): 413-418.
  - Lewis, DV, Jones, LS, and Mott, DD. "Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice." Exp Neurol 106, no. 2 (November 1989): 181-186. Link to Item
  - Lewis, DV, Jones, LS, and Swartzwelder, HS. "The effects of baclofen and pertussis toxin on epileptiform activity induced in the hippocampal slice by magnesium depletion." Epilepsy Res 4, no. 2 (September 1989): 109-118. Link to Item
  - Mott, DD, Bragdon, AC, Lewis, DV, and Wilson, WA. "Baclofen has a proepileptic effect in the rat dentate gyrus." J Pharmacol Exp Ther 249, no. 3 (June 1989): 721-725. Link to Item
  - Crumrine, P, Dreifuss, FE, Corwin, H, Farwell, J, Milstein, J, Laxer, K, Schimschock, JR, Lockman, L, Mattson, RH, Spencer, SS, Jr, CJM, Pellock, JM, Garnett, W, Rothman, SJ, Jr, DVL, Rothner, D, Cruse, RP, Erenberg, G, and Lesser, R. "Double-blind, placebo-controlled evaluation of cinromide in patients with the Lennox-Gastaut Syndrome." Epilepsia 30, no. 4 (1989): 422-429.
  - Wilson, WA, Swartzwelder, HS, Anderson, WW, and Lewis, DV. "Seizure activity in vitro: a dual focus model." Epilepsy Res 2, no. 5 (September 1988): 289-293. Link to Item
  - Jones, LS, and Lewis, DV. "A calcium-activated, nonselective cationic conductance in Aplysia silent neurons." Brain Research Bulletin 20, no. 5 (May 1988): 607-609. Full Text
  - Lewis, DV. "Calcium-activated inward spike after-currents in bursting neurone R15 of Aplysia." J Physiol 395 (January 1988): 285-302. Link to Item
  - Williams, LB, Thompson, EA, and Lewis, DV. "Intractable complex partial seizures: the "initial motionless stare" and surgical outcome following temporal lobectomy." Neurology 37, no. 7 (July 1987): 1255-1258. Link to Item
  - Swartzwelder, HS, Lewis, DV, Anderson, WW, and Wilson, WA. "Seizure-like events in brain slices: suppression by interictal activity." Brain Res 410, no. 2 (May 5, 1987): 362-366. Link to Item
  - Anderson, WW, Lewis, DV, Swartzwelder, HS, and Wilson, WA. "Magnesium-free medium activates seizure-like events in the rat hippocampal slice." Brain Res 398, no. 1 (November 19, 1986): 215-219. Link to Item
  - Jones, LS, Evans, GJ, Wilson, WA, and Lewis, DV. "A novel, calcium-induced triphasic current response in silent, non-bursting Aplysia neurons." Brain Res 385, no. 1 (October 15, 1986): 46-50. Link to Item
  - Brazy, JE, and Lewis, DV. "Changes in cerebral blood volume and cytochrome aa3 during hypertensive peaks in preterm infants." J Pediatr 108, no. 6 (June 1986): 983-987. Link to Item
  - Kaplan, PW, and Lewis, DV. "Juvenile acute intermittent porphyria with hypercholesterolemia and epilepsy: a case report and review of the literature." J Child Neurol 1, no. 1 (January 1986): 38-45. Full Text Link to Item
  - Lewis, DV, Huguenard, JR, Anderson, WW, and Wilson, WA. "Membrane currents underlying bursting pacemaker activity and spike frequency adaptation in invertebrates." Adv Neurol 44 (1986): 235-261. (Review) Link to Item
  - Huguenard, JR, Zbicz, KL, Lewis, DV, Evans, GJ, and Wilson, WA. "The ionic mechanism of the slow outward current in Aplysia neurons." Journal of Neurophysiology 54, no. 2 (August 1985): 449-461. Full Text
  - Brazy, JE, Lewis, DV, Mitnick, MH, and Jöbsis vander Vliet, FF. "Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observations." Pediatrics 75, no. 2 (February 1985): 217-225.
  - Brazy, JE, Lewis, DV, Mitnick, MH, and Jöbsis-Vander Vliet, FF. "Monitoring of cerebral oxygenation in the intensive care nursery." Advances in Experimental Medicine and Biology 191 (January 1985): 843-848.
  - Lewis, DV, Evans, GB, and Wilson, WA. "Dopamine reduces slow outward current and calcium influx in burst-firing neuron R15 of Aplysia." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 4, no. 12 (December 1984): 3014-3020. Full Text
  - Lewis, DV. "Spike aftercurrents in R15 of Aplysia: their relationship to slow inward current and calcium influx." Journal of Neurophysiology 51, no. 2 (February 1984): 387-403. Full Text
  - Colmers, WF, Lewis, DV, and Wilson, WA. "Cs+ loading reveals Na+-dependent persistent inward current and negative slope resistance region in Aplysia giant neurons." Journal of Neurophysiology 48, no. 5 (November 1982): 1191-1200. Full Text
  - Lewis, DV, and Wilson, WA. "Calcium influx and poststimulus current during early adaptation in Aplysia giant neurons." Journal of Neurophysiology 48, no. 1 (July 1982): 202-216. Full Text
  - Colmers, WF, Jr, DVL, and Wilson, WA. "Cs⁺ loading reveals Na⁺-dependent persistent inward current and negative slope resistance region in Aplysia giant neurons." Journal of Neurophysiology 48, no. 5 (1982): 1191-1200.
  - Rothman, SJ, Jr, DVL, and Greenwood, RS. "Discontinuation of antiepileptic drugs: Preliminary report of a prospective randomized study of two-year versus four-year seizure-free intervals, and nine-month versus six-week taper schedules." Epilepsia 23, no. 4 (1982): 437--.
  - Lewis, DV, Zbicz, KL, Nepp, ME, Colmers, WF, and Wilson, WA. "Diphenylhydantoin enhances early adaptation in Aplysia giant neurons." J Pharmacol Exp Ther 218, no. 1 (July 1981): 41-45. Link to Item
  - Lewis, DV. "Diphenylhydantoin reduces the outward current of the action potential in Aplysia." Brain Res 207, no. 1 (February 23, 1981): 234-238. Link to Item
  - Dubois, PJ, Freemark, M, Lewis, D, Drayer, BP, Heinz, ER, and Osborne, D. "Atypical findings in adrenoleukodystrophy." Journal of Computer Assisted Tomography 5, no. 6 (January 1, 1981): 888-891. Full Text
  - Van Buren, JM, Lewis, DV, Schuette, WH, Whitehouse, WC, and Marsan, CA. "Fluorometric monitoring of NADH levels in cerebral cortex: preliminary observations in human epilepsy." Neurosurgery 2, no. 2 (March 1978): 114-121. Link to Item
  - Lewis, DV, Mutsuga, N, Schuette, WH, and Van Buren, J. "Potassium clearance and reactive gliosis in the alumina gel lesion." Epilepsia 18, no. 4 (December 1977): 499-506. Link to Item
  - Lewis, DV, and Freeman, JM. "The electroencephalogram in pediatric practice: its use and abuse." Pediatrics 60, no. 3 (September 1977): 324-330. Link to Item
  - Mutsuga, N, Schuette, WH, and Lewis, DV. "The contribution of local blood flow to the rapid clearance of potassium from the cortical extracellular space." Brain Res 116, no. 3 (November 12, 1976): 431-436. Link to Item
  - Lewis, DV, and Schuette, WH. "NADH fluorescence, [K+]0 and oxygen consumption in cat cerebral cortex during direct cortical stimulation." Brain Res 110, no. 3 (July 16, 1976): 523-535. Link to Item
  - Schuette, WH, Lewis, DV, O'Connor, M, and Van Buren, JM. "The design and operation of a dual-beal long-focal-length fluorometer for monitoring the oxidative metabolism in vivo." Med Biol Eng 14, no. 2 (March 1976): 235-238. Link to Item
  - Lewis, DV, and Schuette, WH. "Temperature dependence of potassium clearance in the central nervous system." Brain Res 99, no. 1 (November 28, 1975): 175-178. Link to Item
  - Lewis, DV, and Schuette, WH. "NADH fluorescence and [K+]o changes during hippocampal electrical stimulation." Journal of Neurophysiology 38, no. 2 (March 1975): 405-417. Full Text
  - Schuette, WH, Whitehouse, WC, Lewis, DV, O'Connor, M, and Van Buren, JM. "A television fluorometer for monitoring oxidative metabolism in intact tissue." Med Instrum 8, no. 6 (November 1974): 331-333. Link to Item
  - Lewis, DV, O'Connor, MJ, and Schuette, WH. "Oxidative metabolism during recurrent seizures in the penicillin treated hippocampus." Electroencephalogr Clin Neurophysiol 36, no. 4 (April 1974): 347-356. Link to Item
  - O'Connor, MJ, and Lewis, DV. "Recurrent seizures induced by potassium in the penicillin treated hippocampus." Electroencephalogr Clin Neurophysiol 36, no. 4 (April 1974): 337-345. Link to Item
  - O'Connor, MJ, Lewis, DV, and Herman, CJ. "Effects of potassium on oxidative metabolism and seizures." Electroencephalogr Clin Neurophysiol 35, no. 2 (August 1973): 205-208. Link to Item
  - Christian, ST, Gorodetzky, CW, and Lewis, DV. "Structure-activity relationships of noreperidine congeners on cholinesterase systems in vitro and analgesia in vivo." Biochem Pharmacol 20, no. 6 (June 1971): 1167-1182. Link to Item
  - Lewis, DV, Staley, N, Rogers, W, and Edlich, RF. "Studies on the distribution of blood flow in amelanotic melanoma and reticulum cell lymphosarcoma during growth." Cancer Res 28, no. 8 (August 1968): 1507-1512. Link to Item
  - Rogers, W, Edlich, RF, Lewis, DV, and Aust, JB. "Tumor blood flow: I. Blood flow in transplantable tumors during growth." The Surgical Clinics of North America 47, no. 6 (December 1967): 1473-1482. Full Text
- Book Sections
  - Clark, S, Stasheff, S, Lewis, DV, Martin, D, and Wilson, WA. "The NMDA receptor in epilepsy." In The NMDA Receptor. March 22, 2012. Full Text
- Other Articles
  - Purves, D, Lotto, B, and Polger, T. "Reply." Journal of cognitive neuroscience 12, no. 5 (September 2000): 911-. Full Text

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