Magnetic resonance imaging evidence of hippocampal sclerosis in progression: a case report.

Journal Article (Journal Article)

A 32-month-old child presented in status epilepticus (SE) involving the left side of the body. Fast spin-echo magnetic resonance imaging (FSE-MRI) with hippocampal volumetry performed < or = 24 h after the seizure showed increased T2 signal of the right hippocampus, but no atrophy. Complex partial seizures (CPS) appeared at age 33 months, and three more episodes of SE occurred between 33 and 37 months of age. Follow-up FSE-MRI at 34 and at 45 months of age demonstrated progressive hippocampal atrophy with resolution of the increased T2 signal. Her CPS became intractable and, at age 51 months, she underwent right temporal lobectomy. In the ensuing 5 months, she has had only one major motor seizure. This case demonstrates that acute increased hippocampal T2 signal intensity can occur soon after SE and hippocampal sclerosis (HS) may become evident within months in the setting of recurrent early childhood SE. This observation may support the hypothesis that early childhood SE can lead to HS. Furthermore, this case suggests that years of temporal lobe CPS may not be necessary for development of HS.

Full Text

Duke Authors

Cited Authors

  • Nohria, V; Lee, N; Tien, RD; Heinz, ER; Smith, JS; DeLong, GR; Skeen, MB; Resnick, TJ; Crain, B; Lewis, DV

Published Date

  • 1994

Published In

Volume / Issue

  • 35 / 6

Start / End Page

  • 1332 - 1336

PubMed ID

  • 7988529

International Standard Serial Number (ISSN)

  • 0013-9580

Digital Object Identifier (DOI)

  • 10.1111/j.1528-1157.1994.tb01807.x


  • eng

Conference Location

  • United States