Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.
Journal Article (Journal Article)
Aneuploidy, resulting from chromosome missegregation during meiosis, is a major cause of human infertility and birth defects. However, its molecular basis remains incompletely understood. Here we have identified a spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic mutation in Mps1, a kinase required for the mitotic checkpoint. These aneuploidies are caused by meiotic error and result in severe developmental defects. Our results reveal Mps1 as a critical regulator of chromosome number in zebrafish, and demonstrate how slight genetic perturbation of a mitotic checkpoint factor can dramatically reduce the fidelity of chromosome segregation during vertebrate meiosis.
Full Text
Duke Authors
Cited Authors
- Poss, KD; Nechiporuk, A; Stringer, KF; Lee, C; Keating, MT
Published Date
- July 1, 2004
Published In
Volume / Issue
- 18 / 13
Start / End Page
- 1527 - 1532
PubMed ID
- 15231734
Pubmed Central ID
- PMC443515
International Standard Serial Number (ISSN)
- 0890-9369
Digital Object Identifier (DOI)
- 10.1101/gad.1182604
Language
- eng
Conference Location
- United States