Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.

Journal Article

Aneuploidy, resulting from chromosome missegregation during meiosis, is a major cause of human infertility and birth defects. However, its molecular basis remains incompletely understood. Here we have identified a spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic mutation in Mps1, a kinase required for the mitotic checkpoint. These aneuploidies are caused by meiotic error and result in severe developmental defects. Our results reveal Mps1 as a critical regulator of chromosome number in zebrafish, and demonstrate how slight genetic perturbation of a mitotic checkpoint factor can dramatically reduce the fidelity of chromosome segregation during vertebrate meiosis.

Full Text

Duke Authors

Cited Authors

  • Poss, KD; Nechiporuk, A; Stringer, KF; Lee, C; Keating, MT

Published Date

  • July 1, 2004

Published In

Volume / Issue

  • 18 / 13

Start / End Page

  • 1527 - 1532

PubMed ID

  • 15231734

International Standard Serial Number (ISSN)

  • 0890-9369

Digital Object Identifier (DOI)

  • 10.1101/gad.1182604

Language

  • eng

Conference Location

  • United States