Loss of hippocampal acetylcholinesterase staining after fornix lesion in the monkey.
Journal Article
Cholinergic denervation of the hippocampal formation has been extensively studied in rodents but not in primates. Therefore we studied the changes in acetylcholinesterase histochemical staining of the hippocampus occurring after bilateral transection of the fornices in the cynomolgus monkey. Animals were sacrificed 1.5, 6, 13, and 23 weeks after surgery. We found a 40-50% reduction in the density of acetylcholinesterase-positive fibers in the four analyzed regions (dentate gyrus, CA3, CA1, and subiculum) 1.5 week after surgery and a 60-80% reduction at longer time intervals. The characteristic diffuse AChE staining found in hippocampi from control animals disappeared after fornix lesion, except in the inner third of the molecular layer of the dentate gyrus. We did not find any evidence of spontaneous cholinergic reinnervation over the 6-month period. Thus, as in rats, fornix lesion produces dramatic changes in hippocampal AChE staining, presumably caused by a massive cholinergic denervation. However, in contrast to rodents, spontaneous reinnervation does not seem to occur in the months following the lesion in primates.
Full Text
Duke Authors
Cited Authors
- Samson, Y; Friedman, AH; Wu, JJ; Davis, JN
Published Date
- October 1991
Published In
Volume / Issue
- 114 / 1
Start / End Page
- 123 - 131
PubMed ID
- 1717308
Pubmed Central ID
- 1717308
International Standard Serial Number (ISSN)
- 0014-4886
Digital Object Identifier (DOI)
- 10.1016/0014-4886(91)90089-u
Language
- eng
Conference Location
- United States