Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation.

Published

Journal Article

BACKGROUND: Medulloblastoma and other types of tumors that gain access to the cerebrospinal fluid can spread throughout the craniospinal axis. The purpose of this study was to devise a simple multi-compartment kinetic model using established tumor cell growth and treatment sensitivity parameters to model the complications of this spread as well as the impact of treatment with craniospinal radiotherapy. METHODS: A two-compartment mathematical model was constructed. Rate constants were derived from previously published work and the model used to predict outcomes for various clinical scenarios. RESULTS: The model is simple and with the use of known and estimated clinical parameters is consistent with known clinical outcomes. Treatment outcomes are critically dependent upon the duration of the treatment break and the radiosensitivity of the tumor. Cross-plot analyses serve as an estimate of likelihood of cure as a function of these and other factors. CONCLUSION: The model accurately describes known clinical outcomes for patients with medulloblastoma. It can help guide treatment decisions for radiation oncologists treating patients with this disease. Incorporation of other treatment modalities, such as chemotherapy, that enhance radiation sensitivity and/or reduce tumor burden, are predicted to significantly increase the probability of cure.

Full Text

Duke Authors

Cited Authors

  • Meyer, JJ; Marks, LB; Halperin, EC; Kirkpatrick, JP

Published Date

  • January 2006

Published In

Volume / Issue

  • 1 /

Start / End Page

  • 48 -

PubMed ID

  • 17187666

Pubmed Central ID

  • 17187666

Electronic International Standard Serial Number (EISSN)

  • 1748-717X

International Standard Serial Number (ISSN)

  • 1748-717X

Digital Object Identifier (DOI)

  • 10.1186/1748-717X-1-48

Language

  • eng