Chutes and Ladders: the search for protein kinases that act on AMPK.

Journal Article (Journal Article;Review)

AMP-activated protein kinase (AMPK), a key regulator of energy homeostasis in mammalian cells, is, in turn, regulated by long-sought upstream protein kinases (AMPKKs). Following the recent identification of the tumor-suppressor kinase LKB1 as an AMPKK, a broader role for AMPK in metabolic economy has been unveiled by a new body of work from three groups that implicates the Ca(2+)/calmodulin-dependent protein kinase kinases as AMPKKs. We suggest that PKE (protein kinase "energy" or "economy") is now an apt name for this kinase, which regulates both cellular and whole-organism energy homeostasis.

Full Text

Duke Authors

Cited Authors

  • Witters, LA; Kemp, BE; Means, AR

Published Date

  • January 2006

Published In

Volume / Issue

  • 31 / 1

Start / End Page

  • 13 - 16

PubMed ID

  • 16356723

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2005.11.009


  • eng

Conference Location

  • England