Chutes and Ladders: the search for protein kinases that act on AMPK.
Publication
, Journal Article
Witters, LA; Kemp, BE; Means, AR
Published in: Trends Biochem Sci
January 2006
AMP-activated protein kinase (AMPK), a key regulator of energy homeostasis in mammalian cells, is, in turn, regulated by long-sought upstream protein kinases (AMPKKs). Following the recent identification of the tumor-suppressor kinase LKB1 as an AMPKK, a broader role for AMPK in metabolic economy has been unveiled by a new body of work from three groups that implicates the Ca(2+)/calmodulin-dependent protein kinase kinases as AMPKKs. We suggest that PKE (protein kinase "energy" or "economy") is now an apt name for this kinase, which regulates both cellular and whole-organism energy homeostasis.
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Published In
Trends Biochem Sci
DOI
ISSN
0968-0004
Publication Date
January 2006
Volume
31
Issue
1
Start / End Page
13 / 16
Location
England
Related Subject Headings
- Protein Serine-Threonine Kinases
- Protein Kinases
- Protein Conformation
- Multienzyme Complexes
- Models, Molecular
- Models, Biological
- Homeostasis
- Energy Metabolism
- Developmental Biology
- Calcium-Calmodulin-Dependent Protein Kinase Kinase
Citation
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Witters, L. A., Kemp, B. E., & Means, A. R. (2006). Chutes and Ladders: the search for protein kinases that act on AMPK. Trends Biochem Sci, 31(1), 13–16. https://doi.org/10.1016/j.tibs.2005.11.009
Witters, Lee A., Bruce E. Kemp, and Anthony R. Means. “Chutes and Ladders: the search for protein kinases that act on AMPK.” Trends Biochem Sci 31, no. 1 (January 2006): 13–16. https://doi.org/10.1016/j.tibs.2005.11.009.
Witters LA, Kemp BE, Means AR. Chutes and Ladders: the search for protein kinases that act on AMPK. Trends Biochem Sci. 2006 Jan;31(1):13–6.
Witters, Lee A., et al. “Chutes and Ladders: the search for protein kinases that act on AMPK.” Trends Biochem Sci, vol. 31, no. 1, Jan. 2006, pp. 13–16. Pubmed, doi:10.1016/j.tibs.2005.11.009.
Witters LA, Kemp BE, Means AR. Chutes and Ladders: the search for protein kinases that act on AMPK. Trends Biochem Sci. 2006 Jan;31(1):13–16.
Published In
Trends Biochem Sci
DOI
ISSN
0968-0004
Publication Date
January 2006
Volume
31
Issue
1
Start / End Page
13 / 16
Location
England
Related Subject Headings
- Protein Serine-Threonine Kinases
- Protein Kinases
- Protein Conformation
- Multienzyme Complexes
- Models, Molecular
- Models, Biological
- Homeostasis
- Energy Metabolism
- Developmental Biology
- Calcium-Calmodulin-Dependent Protein Kinase Kinase