Anthony Ross Means | Scholars@Duke

Anthony Ross Means
Nanaline H. Duke Distinguished Professor Emeritus of Pharmacology, in the School of Medicine

The Means laboratory is interested in the study of cell signaling cascades that regulate cell proliferation, differentiation or function and how alterations in these pathways contribute to disease states. It is hoped that an understanding of these pathways may provide clues to novel targets that may be amenable to the drug discovery process. Current major research projects under investigation include:

1. The cellular mechanisms that govern regulation of CaMKIV, the CaM cascade, which includes CaMKK, CaMK1, CaMKIV and AMPK, and how these calcium-mediated signaling cascade affects cell function fate decisions. Examples of current studies include apoptosis, differentiation, self-renewal of stem cells and central regulation of energy balance.

2. Evaluating the pathways that are involved in regulating cell migration and invasiveness. One project investigates the protein kinase MLK3 and how it is involved in the cascade of events by which small G proteins such as Cdc42, Rac and Rho control directed cell movements via changes in the cytoskeleton.

3. Examining the role of the prolyl isomerase Pin1 in oncogenesis. Studies are focused on the Ras-mediated pathways involving Pin1 that control accumulation of oncoproteins such as Myc and cyclin E and how these pathways participate in human cell transformation and tumorigenesis.

Current Appointments & Affiliations

Nanaline H. Duke Distinguished Professor Emeritus of Pharmacology, in the School of Medicine, Pharmacology & Cancer Biology, Basic Science Departments 2011
Professor Emeritus of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2012

Contact Information

C238a Lev Sci Res Ctr, Durham, NC 27708
Duke Box 3813, Durham, NC 27710
means001@mc.duke.edu (919) 681-6209

Background
Education, Training, & Certifications
- Visiting Scientist, Endocrinology, National Institutes of Health 1969
- Senior Research Associate, Molecular Biology, Southwest Foundation For Biomedical Research 1969
- Fellow of the Australian Research Grants Council, Biochemistry, University of Melbourne (Australia) 1967 - 1968
- Ph.D., University of Texas, Austin 1967
- M.S., Oklahoma State University, Stillwater 1964
- B.S., Oklahoma State University, Stillwater 1963
Previous Appointments & Affiliations
- Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1990 - 2011
- Professor in Medicine, Medicine, Cardiology, Medicine 1999 - 2011
- Nanaline H. Duke Distinguished Professor of Pharmacology, in the School of Medicine, Pharmacology & Cancer Biology, Basic Science Departments 1991 - 2011
- Chair, Department of Pharmacology & CancerBiology, Pharmacology & Cancer Biology, Basic Science Departments 1990 - 2011
- Professor in the Department of Medicine, Medicine, Clinical Science Departments 1994 - 1999
- Acting Chair, Department of Molecular Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1996 - 1997
Academic Positions Outside Duke
- Professor and Vice-Chairman, Baylor University. 1975 - 1990
- Associate Professor, Baylor University. 1972 - 1975
- Assistant Professor, Vanderbilt University. 1969 - 1972
- Assoc. Director, Vanderbilt University. 1969 - 1972
Recognition
Awards & Honors
- Goodman and Gilman Award in Receptor Pharmacology. American Society for Pharmacology and Experimental Therapeutics. 2006
- Fellows. American Academy of Arts and Sciences. 2002
Research
Selected Grants
- NCI Clinical Trials Reporting (CTRP) - Early Adaptors awarded by National Institutes of Health 2010 - 2014
- Hormonal regulation of a Ca2+/AMPK signaling pathway awarded by National Institutes of Health 1984 - 2011
- CaM Kinase Cascades in Endocrine Cells awarded by National Institutes of Health 1997 - 2011
- Biological Roles of the Prolyl Isomerase, PIN1 awarded by National Institutes of Health 1999 - 2011
- NF-kB, CDK4 and JNK in Epidermal Growth Regulation awarded by National Institutes of Health 2005 - 2010
- Structure Function Of Genetic Engineered Calmodulins awarded by National Institutes of Health 1984 - 2002
- same awarded by National Institutes of Health 1995 - 2000
- Same awarded by National Institutes of Health 1998 - 2000
- Heart Failure Specialized Center Of Research awarded by National Institutes of Health 1995 - 1999
- Scor In Heart Failure awarded by National Institutes of Health 1995 - 1999
- Scor In Heart Failure awarded by National Institutes of Health 1995 - 1999
- Mediation Of T-Cell Development Of Cam Kinase Iv awarded by National Institutes of Health 1997 - 1999
- Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Activation And Function Of Human Cam Kinase Iv In T-Cells awarded by National Institutes of Health 1994 - 1998
- Structure/Function Of Genetic Engineered Calmodulins awarded by National Institutes of Health 1984 - 1998
- Cancer Biology awarded by National Institutes of Health 1993 - 1998
- Biology Of The Testis awarded by National Institutes of Health 1996 - 1997
- New Animal Model For Early Onset Nonimmune Diabetes awarded by National Institutes of Health 1990 - 1995
- Scor In Coronary And Vascular Diseases awarded by National Institutes of Health 1992 - 1994
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Anderson, Kristin A., Thomas J. Ribar, Fumin Lin, Pamela K. Noeldner, Michelle F. Green, Michael J. Muehlbauer, Lee A. Witters, Bruce E. Kemp, and Anthony R. Means. “Hypothalamic CaMKK2 contributes to the regulation of energy balance.” Cell Metab 7, no. 5 (May 2008): 377–88. https://doi.org/10.1016/j.cmet.2008.02.011.
    Full Text Link to Item
  - Reineke, Erin L., Minh Lam, Qing Liu, Yu Liu, Kristopher J. Stanya, Kun-Sang Chang, Anthony R. Means, and Hung-Ying Kao. “Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells.” Mol Cell Biol 28, no. 3 (February 2008): 997–1006. https://doi.org/10.1128/MCB.01848-07.
    Full Text Link to Item
  - Illario, Maddalena, Maria L. Giardino-Torchia, Uma Sankar, Thomas J. Ribar, Mario Galgani, Laura Vitiello, Anna Maria Masci, et al. “Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells.” Blood 111, no. 2 (January 15, 2008): 723–31. https://doi.org/10.1182/blood-2007-05-091173.
    Full Text Link to Item
  - Phan, Ryan T., Masumichi Saito, Yukiko Kitagawa, Anthony R. Means, and Riccardo Dalla-Favera. “Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.” Nat Immunol 8, no. 10 (October 2007): 1132–39. https://doi.org/10.1038/ni1508.
    Full Text Link to Item
  - Yeh, Elizabeth S., and Anthony R. Means. “PIN1, the cell cycle and cancer.” Nat Rev Cancer 7, no. 5 (May 2007): 381–88. https://doi.org/10.1038/nrc2107.
    Full Text Link to Item
  - Colomer, J., and A. R. Means. “Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease.” Subcell Biochem 45 (2007): 169–214. https://doi.org/10.1007/978-1-4020-6191-2_7.
    Full Text Link to Item
  - Hurley, Rebecca L., Laura K. Barré, Sumintra D. Wood, Kristin A. Anderson, Bruce E. Kemp, Anthony R. Means, and Lee A. Witters. “Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.” J Biol Chem 281, no. 48 (December 1, 2006): 36662–72. https://doi.org/10.1074/jbc.M606676200.
    Full Text Link to Item
  - Sandquist, Joshua C., Katherine I. Swenson, Kris A. Demali, Keith Burridge, and Anthony R. Means. “Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration.” J Biol Chem 281, no. 47 (November 24, 2006): 35873–83. https://doi.org/10.1074/jbc.M605343200.
    Full Text Link to Item
  - Drogen, Frank van, Olle Sangfelt, Aljona Malyukova, Ludmila Matskova, Elizabeth Yeh, Anthony R. Means, and Steven I. Reed. “Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms.” Mol Cell 23, no. 1 (July 7, 2006): 37–48. https://doi.org/10.1016/j.molcel.2006.05.020.
    Full Text Link to Item
  - Yeh, Elizabeth S., Brian O. Lew, and Anthony R. Means. “The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability.” J Biol Chem 281, no. 1 (January 6, 2006): 241–51. https://doi.org/10.1074/jbc.M505770200.
    Full Text Link to Item
  - Witters, Lee A., Bruce E. Kemp, and Anthony R. Means. “Chutes and Ladders: the search for protein kinases that act on AMPK.” Trends Biochem Sci 31, no. 1 (January 2006): 13–16. https://doi.org/10.1016/j.tibs.2005.11.009.
    Full Text Link to Item
  - Yi, Ping, Ray-Chang Wu, Joshua Sandquist, Jiemin Wong, Sophia Y. Tsai, Ming-Jer Tsai, Anthony R. Means, and Bert W. O’Malley. “Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).” Mol Cell Biol 25, no. 21 (November 2005): 9687–99. https://doi.org/10.1128/MCB.25.21.9687-9699.2005.
    Full Text Link to Item
  - Kitsos, Christine M., Uma Sankar, Maddalena Illario, Josep M. Colomer-Font, Andrew W. Duncan, Thomas J. Ribar, Tannishtha Reya, and Anthony R. Means. “Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance.” J Biol Chem 280, no. 39 (September 30, 2005): 33101–8. https://doi.org/10.1074/jbc.M505208200.
    Full Text Link to Item
  - Hurley, Rebecca L., Kristin A. Anderson, Jeanne M. Franzone, Bruce E. Kemp, Anthony R. Means, and Lee A. Witters. “The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.” J Biol Chem 280, no. 32 (August 12, 2005): 29060–66. https://doi.org/10.1074/jbc.M503824200.
    Full Text Link to Item
  - Pan, Fan, Anthony R. Means, and Jun O. Liu. “Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.” Embo J 24, no. 12 (June 15, 2005): 2104–13. https://doi.org/10.1038/sj.emboj.7600685.
    Full Text Link to Item
  - Chow, Felice A., Kristin A. Anderson, Pamela K. Noeldner, and Anthony R. Means. “The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription.” J Biol Chem 280, no. 21 (May 27, 2005): 20530–38. https://doi.org/10.1074/jbc.M500067200.
    Full Text Link to Item
  - Atchison, Fawn W., and Anthony R. Means. “A role for Pin1 in mammalian germ cell development and spermatogenesis.” Front Biosci 9 (September 1, 2004): 3248–56. https://doi.org/10.2741/1476.
    Full Text Link to Item
  - Joseph, James D., Scott N. Daigle, and Anthony R. Means. “PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans.” J Biol Chem 279, no. 31 (July 30, 2004): 32373–84. https://doi.org/10.1074/jbc.M405415200.
    Full Text Link to Item
  - Anderson, Kristin A., Pamela K. Noeldner, Kelie Reece, Brian E. Wadzinski, and Anthony R. Means. “Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex.” J Biol Chem 279, no. 30 (July 23, 2004): 31708–16. https://doi.org/10.1074/jbc.M404523200.
    Full Text Link to Item
  - Kahl, Christina R., and Anthony R. Means. “Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I.” J Biol Chem 279, no. 15 (April 9, 2004): 15411–19. https://doi.org/10.1074/jbc.M312543200.
    Full Text Link to Item
  - Kahl, Christina R., and Anthony R. Means. “Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts.” Mol Biol Cell 15, no. 4 (April 2004): 1833–42. https://doi.org/10.1091/mbc.e03-10-0730.
    Full Text Link to Item
  - Yeh, Elizabeth, Melissa Cunningham, Hugh Arnold, Dawn Chasse, Teresa Monteith, Giovanni Ivaldi, William C. Hahn, et al. “A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.” Nat Cell Biol 6, no. 4 (April 2004): 308–18. https://doi.org/10.1038/ncb1110.
    Full Text Link to Item
  - Lemrow, Shannon M., Kristin A. Anderson, James D. Joseph, Thomas J. Ribar, Pamela K. Noeldner, and Anthony R. Means. “Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus.” J Biol Chem 279, no. 12 (March 19, 2004): 11664–71. https://doi.org/10.1074/jbc.M312613200.
    Full Text Link to Item
  - Colomer, Josep M., Motomu Terasawa, and Anthony R. Means. “Targeted expression of calmodulin increases ventricular cardiomyocyte proliferation and deoxyribonucleic acid synthesis during mouse development.” Endocrinology 145, no. 3 (March 2004): 1356–66. https://doi.org/10.1210/en.2003-1119.
    Full Text Link to Item
  - Atchison, Fawn W., and Anthony R. Means. “Spermatogonial depletion in adult Pin1-deficient mice.” Biol Reprod 69, no. 6 (December 2003): 1989–97. https://doi.org/10.1095/biolreprod.103.020859.
    Full Text Link to Item
  - Kahl, Christina R., and Anthony R. Means. “Regulation of cell cycle progression by calcium/calmodulin-dependent pathways.” Endocr Rev 24, no. 6 (December 2003): 719–36. https://doi.org/10.1210/er.2003-0008.
    Full Text Link to Item
  - Atchison, Fawn W., Blanche Capel, and Anthony R. Means. “Pin1 regulates the timing of mammalian primordial germ cell proliferation.” Development 130, no. 15 (August 2003): 3579–86. https://doi.org/10.1242/dev.00584.
    Full Text Link to Item
  - Corcoran, Ethan E., James D. Joseph, Justin A. MacDonald, Christopher D. Kane, Timothy A. J. Haystead, and Anthony R. Means. “Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences.” J Biol Chem 278, no. 12 (March 21, 2003): 10516–22. https://doi.org/10.1074/jbc.M210642200.
    Full Text Link to Item
  - Colomer, Josep M., Lan Mao, Howard A. Rockman, and Anthony R. Means. “Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo.” Mol Endocrinol 17, no. 2 (February 2003): 183–92. https://doi.org/10.1210/me.2002-0350.
    Full Text Link to Item
  - Joseph, James D., Elisabeth S. Yeh, Katherine I. Swenson, Anthony R. Means, and Anthony R. Winkler. “The peptidyl-prolyl isomerase Pin1.” Prog Cell Cycle Res 5 (2003): 477–87.
    Link to Item
  - Swenson, Katherine I., Katharine E. Winkler, and Anthony R. Means. “A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization.” Mol Biol Cell 14, no. 1 (January 2003): 156–72. https://doi.org/10.1091/mbc.e02-02-0115.
    Full Text Link to Item
  - Chin, David, and Anthony R. Means. “Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286.” Biochemistry 41, no. 47 (November 26, 2002): 14001–9. https://doi.org/10.1021/bi025640o.
    Full Text Link to Item
  - Kimura, Yoshishige, Ethan E. Corcoran, Koh Eto, Keiko Gengyo-Ando, Masa-Aki Muramatsu, Ryoji Kobayashi, Jonathan H. Freedman, et al. “A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans.” Embo Rep 3, no. 10 (October 2002): 962–66. https://doi.org/10.1093/embo-reports/kvf191.
    Full Text Link to Item
  - Klee, Claude B., and Anthony R. Means. “Keeping up with calcium: conference on calcium-binding proteins and calcium function in health and disease.” Embo Rep 3, no. 9 (September 2002): 823–27. https://doi.org/10.1093/embo-reports/kvf182.
    Full Text Link to Item
  - Yu, Wei, Tae Niwa, Yoshitaka Miura, Fumihiko Horio, Shin Teradaira, Thomas J. Ribar, Anthony R. Means, Yoshimi Hasegawa, Takao Senda, and Ichiro Niki. “Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase.” Lab Invest 82, no. 9 (September 2002): 1229–39. https://doi.org/10.1097/01.lab.0000027921.01548.c5.
    Full Text Link to Item
  - Hamilton, Stephen R., John B. O’Donnell, Andrew Hammet, David Stapleton, Susan A. Habinowski, Anthony R. Means, Bruce E. Kemp, and Lee A. Witters. “AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit.” Biochem Biophys Res Commun 293, no. 3 (May 10, 2002): 892–98. https://doi.org/10.1016/S0006-291X(02)00312-1.
    Full Text Link to Item
  - Flory, Mark R., Mary Morphew, James D. Joseph, Anthony R. Means, and Trisha N. Davis. “Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe.” Cell Growth Differ 13, no. 2 (February 2002): 47–58.
    Link to Item
  - Joseph, James D., and Anthony R. Means. “Calcium binding is required for calmodulin function in Aspergillus nidulans.” Eukaryot Cell 1, no. 1 (February 2002): 119–25. https://doi.org/10.1128/EC.01.1.119-125.2002.
    Full Text Link to Item
  - Anderson, Kristin A., and Anthony R. Means. “Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV.” Mol Cell Biol 22, no. 1 (January 2002): 23–29. https://doi.org/10.1128/MCB.22.1.23-29.2002.
    Full Text Link to Item
  - Zhao, X., A. Ito, C. D. Kane, T. S. Liao, T. A. Bolger, S. M. Lemrow, A. R. Means, and T. P. Yao. “The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking.” J Biol Chem 276, no. 37 (September 14, 2001): 35042–48. https://doi.org/10.1074/jbc.M105086200.
    Full Text Link to Item
  - Wu, J. Y., T. J. Ribar, and A. R. Means. “Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin.” Mol Cell Biol 21, no. 17 (September 2001): 6066–70. https://doi.org/10.1128/MCB.21.17.6066-6070.2001.
    Full Text Link to Item
  - Wang, S. L., T. J. Ribar, and A. R. Means. “Expression of Ca(2+)/calmodulin-dependent protein kinase IV (caMKIV) messenger RNA during murine embryogenesis.” Cell Growth Differ 12, no. 7 (July 2001): 351–61.
    Link to Item
  - Corcoran, E. E., and A. R. Means. “Defining Ca2+/calmodulin-dependent protein kinase cascades in transcriptional regulation.” J Biol Chem 276, no. 5 (February 2, 2001): 2975–78. https://doi.org/10.1074/jbc.R000027200.
    Full Text Link to Item
  - Hook, S. S., and A. R. Means. “Ca(2+)/CaM-dependent kinases: from activation to function.” Annu Rev Pharmacol Toxicol 41 (2001): 471–505. https://doi.org/10.1146/annurev.pharmtox.41.1.471.
    Full Text Link to Item
  - Joseph, J. D., and A. R. Means. “Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans.” J Biol Chem 275, no. 49 (December 8, 2000): 38230–38. https://doi.org/10.1074/jbc.M006422200.
    Full Text Link to Item
  - Wu, J. Y., I. J. Gonzalez-Robayna, J. S. Richards, and A. R. Means. “Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV.” Endocrinology 141, no. 12 (December 2000): 4777–83. https://doi.org/10.1210/endo.141.12.7826.
    Full Text Link to Item
  - Ribar, T. J., R. M. Rodriguiz, L. Khiroug, W. C. Wetsel, G. J. Augustine, and A. R. Means. “Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice.” J Neurosci 20, no. 22 (November 15, 2000): RC107. https://doi.org/10.1523/JNEUROSCI.20-22-j0004.2000.
    Full Text Link to Item
  - Chin, D., and A. R. Means. “Author correction.” Trends Cell Biol 10, no. 10 (October 2000): 428. https://doi.org/10.1016/s0962-8924(00)01837-7.
    Full Text Link to Item
  - Chin, D., and A. R. Means. “Calmodulin: a prototypical calcium sensor.” Trends Cell Biol 10, no. 8 (August 2000): 322–28. https://doi.org/10.1016/s0962-8924(00)01800-6.
    Full Text Link to Item
  - Colomer, J. M., and A. R. Means. “Chronic elevation of calmodulin in the ventricles of transgenic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression.” Mol Endocrinol 14, no. 8 (August 2000): 1125–36. https://doi.org/10.1210/mend.14.8.0496.
    Full Text Link to Item
  - Wu, J. Y., T. J. Ribar, D. E. Cummings, K. A. Burton, G. S. McKnight, and A. R. Means. “Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4.” Nat Genet 25, no. 4 (August 2000): 448–52. https://doi.org/10.1038/78153.
    Full Text Link to Item
  - Wu, J. Y., and A. R. Means. “Ca(2+)/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix.” J Biol Chem 275, no. 11 (March 17, 2000): 7994–99. https://doi.org/10.1074/jbc.275.11.7994.
    Full Text Link to Item
  - Winkler, K. E., K. I. Swenson, S. Kornbluth, and A. R. Means. “Requirement of the prolyl isomerase Pin1 for the replication checkpoint.” Science 287, no. 5458 (March 3, 2000): 1644–47. https://doi.org/10.1126/science.287.5458.1644.
    Full Text Link to Item
  - Kane, C. D., and A. R. Means. “Activation of orphan receptor-mediated transcription by Ca(2+)/calmodulin-dependent protein kinase IV.” Embo J 19, no. 4 (February 15, 2000): 691–701. https://doi.org/10.1093/emboj/19.4.691.
    Full Text Link to Item
  - Means, A. R. “Regulatory cascades involving calmodulin-dependent protein kinases.” Mol Endocrinol 14, no. 1 (January 2000): 4–13. https://doi.org/10.1210/mend.14.1.0414.
    Full Text Link to Item
  - Hu, P. P., B. L. Harvat, S. S. Hook, X. Shen, X. F. Wang, and A. R. Means. “c-Jun enhancement of cyclic adenosine 3',5'-monophosphate response element-dependent transcription induced by transforming growth factor-beta is independent of c-Jun binding to DNA.” Mol Endocrinol 13, no. 12 (December 1999): 2039–48. https://doi.org/10.1210/mend.13.12.0405.
    Full Text Link to Item
  - Chin, D., J. L. Schreiber, and A. R. Means. “Calmodulin kinase II chimeras used to investigate the structural requirements for smooth muscle myosin light chain kinase autoinhibition and calmodulin-dependent activation.” Biochemistry 38, no. 46 (November 16, 1999): 15061–69. https://doi.org/10.1021/bi990883a.
    Full Text Link to Item
  - Mounsey, J. P., K. P. Lu, M. K. Patel, Z. H. Chen, L. T. Horne, J. E. John, A. R. Means, L. R. Jones, and J. R. Moorman. “Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases.” Biochim Biophys Acta 1451, no. 2–3 (September 21, 1999): 305–18. https://doi.org/10.1016/s0167-4889(99)00102-0.
    Full Text Link to Item
  - Hook, S. S., B. E. Kemp, and A. R. Means. “Peptide specificity determinants at P-7 and P-6 enhance the catalytic efficiency of Ca2+/calmodulin-dependent protein kinase I in the absence of activation loop phosphorylation.” J Biol Chem 274, no. 29 (July 16, 1999): 20215–22. https://doi.org/10.1074/jbc.274.29.20215.
    Full Text Link to Item
  - Joseph, J. D., J. Heitman, and A. R. Means. “Molecular cloning and characterization of Aspergillus nidulans cyclophilin B.” Fungal Genet Biol 27, no. 1 (June 1999): 55–66. https://doi.org/10.1006/fgbi.1999.1131.
    Full Text Link to Item
  - Anderson, K. A., R. L. Means, Q. H. Huang, B. E. Kemp, E. G. Goldstein, M. A. Selbert, A. M. Edelman, R. T. Fremeau, and A. R. Means. “Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.” J Biol Chem 273, no. 48 (November 27, 1998): 31880–89. https://doi.org/10.1074/jbc.273.48.31880.
    Full Text Link to Item
  - Means, A. R. “The clash in titin.” Nature 395, no. 6705 (October 29, 1998): 846–47. https://doi.org/10.1038/27557.
    Full Text Link to Item
  - Crenshaw, D. G., J. Yang, A. R. Means, and S. Kornbluth. “The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1.” Embo J 17, no. 5 (August 10, 1998): 1315–27. https://doi.org/10.1093/emboj/17.5.1315.
    Full Text Link to Item
  - Means, A. R. “Citation for the 1998 Gerald D. Aurbach Lecture Award of the Endocrine Society to Dr. JoAnne S. Richards.” Endocr Rev 19, no. 4 (August 1998): 512–13.
    Link to Item
  - Westphal, R. S., K. A. Anderson, A. R. Means, and B. E. Wadzinski. “A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.” Science 280, no. 5367 (May 22, 1998): 1258–61. https://doi.org/10.1126/science.280.5367.1258.
    Full Text Link to Item
  - Chin, D., K. E. Winkler, and A. R. Means. “Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I.” J Biol Chem 272, no. 50 (December 12, 1997): 31235–40. https://doi.org/10.1074/jbc.272.50.31235.
    Full Text Link to Item
  - Anderson, K. A., T. J. Ribar, M. Illario, and A. R. Means. “Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV.” Mol Endocrinol 11, no. 6 (June 1997): 725–37. https://doi.org/10.1210/mend.11.6.0011.
    Full Text Link to Item
  - Means, A. R. “The origin of the special issue.” Mol Endocrinol 11, no. 6 (June 1997): 651–53. https://doi.org/10.1210/mend.11.6.0013.
    Full Text Link to Item
  - Tabernero, L., D. A. Taylor, R. J. Chandross, M. F. VanBerkum, A. R. Means, F. A. Quiocho, and J. S. Sack. “The structure of a calmodulin mutant with a deletion in the central helix: implications for molecular recognition and protein binding.” Structure 5, no. 5 (May 15, 1997): 613–22. https://doi.org/10.1016/s0969-2126(97)00217-7.
    Full Text Link to Item
  - Chin, D., D. J. Sloan, F. A. Quiocho, and A. R. Means. “Functional consequences of truncating amino acid side chains located at a calmodulin-peptide interface.” J Biol Chem 272, no. 9 (February 28, 1997): 5510–13. https://doi.org/10.1074/jbc.272.9.5510.
    Full Text Link to Item
  - Dayton, J. S., M. Sumi, N. N. Nanthakumar, and A. R. Means. “Expression of a constitutively active Ca2+/calmodulin-dependent kinase in Aspergillus nidulans spores prevents germination and entry into the cell cycle.” J Biol Chem 272, no. 6 (February 7, 1997): 3223–30. https://doi.org/10.1074/jbc.272.6.3223.
    Full Text Link to Item
  - Means, A. R., T. J. Ribar, C. D. Kane, S. S. Hook, and K. A. Anderson. “Regulation and properties of the rat Ca2+/calmodulin-dependent protein kinase IV gene and its protein products.” Recent Prog Horm Res 52 (1997): 389–406.
    Link to Item
  - Chin, D., and A. R. Means. “Methionine to glutamine substitutions in the C-terminal domain of calmodulin impair the activation of three protein kinases.” J Biol Chem 271, no. 48 (November 29, 1996): 30465–71. https://doi.org/10.1074/jbc.271.48.30465.
    Full Text Link to Item
  - Zhou, Y., Z. Sun, A. R. Means, P. Sassone-Corsi, and K. E. Bernstein. “cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription.” Proc Natl Acad Sci U S A 93, no. 22 (October 29, 1996): 12262–66. https://doi.org/10.1073/pnas.93.22.12262.
    Full Text Link to Item
  - Dayton, J. S., and A. R. Means. “Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans.” Mol Biol Cell 7, no. 10 (October 1996): 1511–19. https://doi.org/10.1091/mbc.7.10.1511.
    Full Text Link to Item
  - Chatila, T., K. A. Anderson, N. Ho, and A. R. Means. “A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR.” J Biol Chem 271, no. 35 (August 30, 1996): 21542–48. https://doi.org/10.1074/jbc.271.35.21542.
    Full Text Link to Item
  - Jan, C. R., T. J. Ribar, A. R. Means, and G. J. Augustine. “Alterations in calcium channel currents underlie defective insulin secretion in a transgenic mouse.” J Biol Chem 271, no. 26 (June 28, 1996): 15478–85. https://doi.org/10.1074/jbc.271.26.15478.
    Full Text Link to Item
  - Feinmesser, R. L., K. Gray, A. R. Means, and A. Chantry. “HER-2/c-erbB2 is phosphorylated by calmodulin-dependent protein kinase II on a single site in the cytoplasmic tail at threonine-1172.” Oncogene 12, no. 12 (June 20, 1996): 2725–30.
    Link to Item
  - Edelman, A. M., K. I. Mitchelhill, M. A. Selbert, K. A. Anderson, S. S. Hook, D. Stapleton, E. G. Goldstein, A. R. Means, and B. E. Kemp. “Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence.” J Biol Chem 271, no. 18 (May 3, 1996): 10806–10. https://doi.org/10.1074/jbc.271.18.10806.
    Full Text Link to Item
  - Nanthakumar, N. N., J. S. Dayton, and A. R. Means. “Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation.” Prog Cell Cycle Res 2 (1996): 217–28. https://doi.org/10.1007/978-1-4615-5873-6_21.
    Full Text Link to Item
  - Sun, Z., R. L. Means, B. LeMagueresse, and A. R. Means. “Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene.” J Biol Chem 270, no. 49 (December 8, 1995): 29507–14. https://doi.org/10.1074/jbc.270.49.29507.
    Full Text Link to Item
  - Ribar, T. J., C. R. Jan, G. J. Augustine, and A. R. Means. “Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse.” J Biol Chem 270, no. 48 (December 1, 1995): 28688–95. https://doi.org/10.1074/jbc.270.48.28688.
    Full Text Link to Item
  - Meador, W. E., S. E. George, A. R. Means, and F. A. Quiocho. “X-ray analysis reveals conformational adaptation of the linker in functional calmodulin mutants.” Nat Struct Biol 2, no. 11 (November 1995): 943–45. https://doi.org/10.1038/nsb1195-943.
    Full Text Link to Item
  - Sun, Z., and A. R. Means. “An intron facilitates activation of the calspermin gene by the testis-specific transcription factor CREM tau.” J Biol Chem 270, no. 36 (September 8, 1995): 20962–67. https://doi.org/10.1074/jbc.270.36.20962.
    Full Text Link to Item
  - Haribabu, B., S. S. Hook, M. A. Selbert, E. G. Goldstein, E. D. Tomhave, A. M. Edelman, R. Snyderman, and A. R. Means. “Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.” Embo J 14, no. 15 (August 1, 1995): 3679–86. https://doi.org/10.1002/j.1460-2075.1995.tb00037.x.
    Full Text Link to Item
  - Selbert, M. A., K. A. Anderson, Q. H. Huang, E. G. Goldstein, A. R. Means, and A. M. Edelman. “Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.” J Biol Chem 270, no. 29 (July 21, 1995): 17616–21. https://doi.org/10.1074/jbc.270.29.17616.
    Full Text Link to Item
  - Means, A. R. “Through the glass lightly.” Science 267, no. 5204 (March 17, 1995): 1610–11. https://doi.org/10.1126/science.267.5204.1610-c.
    Full Text Link to Item
  - Ribar, T. J., P. N. Epstein, P. A. Overbeek, and A. R. Means. “Targeted overexpression of an inactive calmodulin that binds Ca2+ to the mouse pancreatic beta-cell results in impaired secretion and chronic hyperglycemia.” Endocrinology 136, no. 1 (January 1995): 106–15. https://doi.org/10.1210/endo.136.1.7828519.
    Full Text Link to Item
  - Sun, Z., P. Sassone-Corsi, and A. R. Means. “Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene.” Mol Cell Biol 15, no. 1 (January 1995): 561–71. https://doi.org/10.1128/MCB.15.1.561.
    Full Text Link to Item
  - Edman, C. F., S. E. George, A. R. Means, H. Schulman, and P. Yaswen. “Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells.” Eur J Biochem 226, no. 2 (December 1, 1994): 725–30. https://doi.org/10.1111/j.1432-1033.1994.tb20101.x.
    Full Text Link to Item
  - Matthews, R. P., C. R. Guthrie, L. M. Wailes, X. Zhao, A. R. Means, and G. S. McKnight. “Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.” Mol Cell Biol 14, no. 9 (September 1994): 6107–16. https://doi.org/10.1128/mcb.14.9.6107-6116.1994.
    Full Text Link to Item
  - Rasmussen, C., C. Garen, S. Brining, R. L. Kincaid, R. L. Means, and A. R. Means. “The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.” Embo J 13, no. 16 (August 15, 1994): 3917–24. https://doi.org/10.1002/j.1460-2075.1994.tb06703.x.
    Full Text Link to Item
  - Means, A. R. “Calcium, calmodulin and cell cycle regulation.” Febs Lett 347, no. 1 (June 20, 1994): 1–4. https://doi.org/10.1016/0014-5793(94)00492-7.
    Full Text Link to Item
  - Rasmussen, C., C. Garen, S. Brining, R. L. Kincaid, R. L. Means, and A. R. Means. “The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.” Embo J 13, no. 11 (June 1, 1994): 2545–52. https://doi.org/10.1002/j.1460-2075.1994.tb06544.x.
    Full Text Link to Item
  - Lu, K. P., and A. R. Means. “Expression of the noncatalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans.” Embo J 13, no. 9 (May 1, 1994): 2103–13. https://doi.org/10.1002/j.1460-2075.1994.tb06486.x.
    Full Text Link to Item
  - Lu, K. P., B. E. Kemp, and A. R. Means. “Identification of substrate specificity determinants for the cell cycle-regulated NIMA protein kinase.” J Biol Chem 269, no. 9 (March 4, 1994): 6603–7.
    Link to Item
  - Cruzalegui, F. H., and A. R. Means. “Biochemical characterization of the multifunctional Ca2+/calmodulin-dependent protein kinase type IV expressed in insect cells.” J Biol Chem 268, no. 35 (December 15, 1993): 26171–78.
    Link to Item
  - Meador, W. E., A. R. Means, and F. A. Quiocho. “Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.” Science 262, no. 5140 (December 10, 1993): 1718–21. https://doi.org/10.1126/science.8259515.
    Full Text Link to Item
  - George, S. E., Z. Su, D. Fan, and A. R. Means. “Calmodulin-cardiac troponin C chimeras. Effects of domain exchange on calcium binding and enzyme activation.” J Biol Chem 268, no. 33 (November 25, 1993): 25213–20.
    Link to Item
  - Gao, Z. H., J. Krebs, M. F. VanBerkum, W. J. Tang, J. F. Maune, A. R. Means, J. T. Stull, and K. Beckingham. “Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites.” J Biol Chem 268, no. 27 (September 25, 1993): 20096–104.
    Link to Item
  - Gruver, C. L., F. DeMayo, M. A. Goldstein, and A. R. Means. “Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice.” Endocrinology 133, no. 1 (July 1993): 376–88. https://doi.org/10.1210/endo.133.1.8319584.
    Full Text Link to Item
  - Lu, K. P., S. A. Osmani, A. H. Osmani, and A. R. Means. “Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans.” J Cell Biol 121, no. 3 (May 1993): 621–30. https://doi.org/10.1083/jcb.121.3.621.
    Full Text Link to Item
  - Lu, K. P., S. A. Osmani, and A. R. Means. “Properties and regulation of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans.” J Biol Chem 268, no. 12 (April 25, 1993): 8769–76.
    Link to Item
  - Lu, K. P., and A. R. Means. “Regulation of the cell cycle by calcium and calmodulin.” Endocr Rev 14, no. 1 (February 1993): 40–58. https://doi.org/10.1210/edrv-14-1-40.
    Full Text Link to Item
  - Christenson, M. A., and A. R. Means. “Coordinate regulation of mRNAs from multiple calmodulin genes during myoblast differentiation in vitro.” J Cell Physiol 154, no. 2 (February 1993): 343–49. https://doi.org/10.1002/jcp.1041540218.
    Full Text Link to Item
  - Means, A. R., and F. Cruzalegui. “Differential gene expression from a single transcription unit during spermatogenesis.” Recent Prog Horm Res 48 (1993): 79–97. https://doi.org/10.1016/b978-0-12-571148-7.50007-5.
    Full Text Link to Item
  - Chattopadhyaya, R., W. E. Meador, A. R. Means, and F. A. Quiocho. “Calmodulin structure refined at 1.7 A resolution.” J Mol Biol 228, no. 4 (December 20, 1992): 1177–92. https://doi.org/10.1016/0022-2836(92)90324-d.
    Full Text Link to Item
  - Cruzalegui, F. H., M. S. Kapiloff, J. P. Morfin, B. E. Kemp, M. G. Rosenfeld, and A. R. Means. “Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.” Proc Natl Acad Sci U S A 89, no. 24 (December 15, 1992): 12127–31. https://doi.org/10.1073/pnas.89.24.12127.
    Full Text Link to Item
  - Knighton, D. R., R. B. Pearson, J. M. Sowadski, A. R. Means, L. F. Ten Eyck, S. S. Taylor, and B. E. Kemp. “Structural basis of the intrasteric regulation of myosin light chain kinases.” Science 258, no. 5079 (October 2, 1992): 130–35. https://doi.org/10.1126/science.1439761.
    Full Text Link to Item
  - Birch, K. A., J. S. Pober, G. B. Zavoico, A. R. Means, and B. M. Ewenstein. “Calcium/calmodulin transduces thrombin-stimulated secretion: studies in intact and minimally permeabilized human umbilical vein endothelial cells.” J Cell Biol 118, no. 6 (September 1992): 1501–10. https://doi.org/10.1083/jcb.118.6.1501.
    Full Text Link to Item
  - Meador, W. E., A. R. Means, and F. A. Quiocho. “Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex.” Science 257, no. 5074 (August 28, 1992): 1251–55. https://doi.org/10.1126/science.1519061.
    Full Text Link to Item
  - Bagchi, I. C., B. E. Kemp, and A. R. Means. “Intrasteric regulation of myosin light chain kinase: the pseudosubstrate prototope binds to the active site.” Mol Endocrinol 6, no. 4 (April 1992): 621–26. https://doi.org/10.1210/mend.6.4.1584224.
    Full Text Link to Item
  - Epstein, P. N., T. J. Ribar, G. L. Decker, G. Yaney, and A. R. Means. “Elevated beta-cell calmodulin produces a unique insulin secretory defect in transgenic mice.” Endocrinology 130, no. 3 (March 1992): 1387–93. https://doi.org/10.1210/endo.130.3.1371447.
    Full Text Link to Item
  - Lu, K. P., C. D. Rasmussen, G. S. May, and A. R. Means. “Cooperative regulation of cell proliferation by calcium and calmodulin in Aspergillus nidulans.” Mol Endocrinol 6, no. 3 (March 1992): 365–74. https://doi.org/10.1210/mend.6.3.1584213.
    Full Text Link to Item
  - Bagchi, I. C., Q. H. Huang, and A. R. Means. “Identification of amino acids essential for calmodulin binding and activation of smooth muscle myosin light chain kinase.” J Biol Chem 267, no. 5 (February 15, 1992): 3024–29.
    Link to Item
  - Roth, S. M., D. M. Schneider, L. A. Strobel, M. F. Van Berkum, A. R. Means, and A. J. Wand. “Characterization of the secondary structure of calmodulin in complex with a calmodulin-binding domain peptide.” Biochemistry 31, no. 5 (February 11, 1992): 1443–51. https://doi.org/10.1021/bi00120a022.
    Full Text Link to Item
  - Planas-Silva, M. D., and A. R. Means. “Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2.” Embo J 11, no. 2 (February 1992): 507–17. https://doi.org/10.1002/j.1460-2075.1992.tb05081.x.
    Full Text Link to Item
  - Rasmussen, C. D., K. P. Lu, R. L. Means, and A. R. Means. “Calmodulin and cell cycle control.” J Physiol Paris 86, no. 1–3 (1992): 83–88. https://doi.org/10.1016/s0928-4257(05)80011-7.
    Full Text Link to Item
  - Rasmussen, C. D., and A. R. Means. “Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes.” Cell Motil Cytoskeleton 21, no. 1 (1992): 45–57. https://doi.org/10.1002/cm.970210106.
    Full Text Link to Item
  - VanBerkum, M. F., and A. R. Means. “Three amino acid substitutions in domain I of calmodulin prevent the activation of chicken smooth muscle myosin light chain kinase.” J Biol Chem 266, no. 32 (November 15, 1991): 21488–95.
    Link to Item
  - Roth, S. M., D. M. Schneider, L. A. Strobel, M. F. VanBerkum, A. R. Means, and A. J. Wand. “Structure of the smooth muscle myosin light-chain kinase calmodulin-binding domain peptide bound to calmodulin.” Biochemistry 30, no. 42 (October 22, 1991): 10078–84. https://doi.org/10.1021/bi00106a003.
    Full Text Link to Item
  - Means, A. R., F. Cruzalegui, B. LeMagueresse, D. S. Needleman, G. R. Slaughter, and T. Ono. “A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene.” Mol Cell Biol 11, no. 8 (August 1991): 3960–71. https://doi.org/10.1128/mcb.11.8.3960-3971.1991.
    Full Text Link to Item
  - Means, A. R., I. C. Bagchi, M. F. VanBerkum, and B. E. Kemp. “Regulation of smooth muscle myosin light chain kinase by calmodulin.” Adv Exp Med Biol 304 (1991): 11–24. https://doi.org/10.1007/978-1-4684-6003-2_3.
    Full Text Link to Item
  - Means, A. R., M. F. VanBerkum, I. Bagchi, K. P. Lu, and C. D. Rasmussen. “Regulatory functions of calmodulin.” Pharmacol Ther 50, no. 2 (1991): 255–70. https://doi.org/10.1016/0163-7258(91)90017-g.
    Full Text Link to Item
  - Rasmussen, C. D., R. L. Means, K. P. Lu, G. S. May, and A. R. Means. “Characterization and expression of the unique calmodulin gene of Aspergillus nidulans.” J Biol Chem 265, no. 23 (August 15, 1990): 13767–75.
    Link to Item
  - George, S. E., M. F. VanBerkum, T. Ono, R. Cook, R. M. Hanley, J. A. Putkey, and A. R. Means. “Chimeric calmodulin-cardiac troponin C proteins differentially activate calmodulin target enzymes.” J Biol Chem 265, no. 16 (June 5, 1990): 9228–35.
    Link to Item
  - VanBerkum, M. F., S. E. George, and A. R. Means. “Calmodulin activation of target enzymes. Consequences of deletions in the central helix.” J Biol Chem 265, no. 7 (March 5, 1990): 3750–56.
    Link to Item
  - Olson, N. J., R. B. Pearson, D. S. Needleman, M. Y. Hurwitz, B. E. Kemp, and A. R. Means. “Regulatory and structural motifs of chicken gizzard myosin light chain kinase.” Proc Natl Acad Sci U S A 87, no. 6 (March 1990): 2284–88. https://doi.org/10.1073/pnas.87.6.2284.
    Full Text Link to Item
  - Rasmusen, C. D., and A. R. Means. “Effects of changes in calmodulin levels on cell proliferation.” Environ Health Perspect 84 (March 1990): 31–34. https://doi.org/10.1289/ehp.908431.
    Full Text Link to Item
  - Evans, D. P., R. A. Simonette, C. D. Rasmussen, A. R. Means, and S. P. Tomasovic. “Altered synthesis of the 26-kDa heat stress protein family and thermotolerance in cell lines with elevated levels of calcium-binding proteins.” J Cell Physiol 142, no. 3 (March 1990): 615–27. https://doi.org/10.1002/jcp.1041420323.
    Full Text Link to Item
  - Rasmussen, C. D., and A. R. Means. “Calmodulin, cell growth and gene expression.” Trends Neurosci 12, no. 11 (November 1989): 433–38. https://doi.org/10.1016/0166-2236(89)90092-1.
    Full Text Link to Item
  - Fong, Y. L., W. L. Taylor, A. R. Means, and T. R. Soderling. “Studies of the regulatory mechanism of Ca2+/calmodulin-dependent protein kinase II. Mutation of threonine 286 to alanine and aspartate.” J Biol Chem 264, no. 28 (October 5, 1989): 16759–63.
    Link to Item
  - Slaughter, G. R., and A. R. Means. “Analysis of expression of multiple genes encoding calmodulin during spermatogenesis.” Mol Endocrinol 3, no. 10 (October 1989): 1569–78. https://doi.org/10.1210/mend-3-10-1569.
    Full Text Link to Item
  - Bagchi, I. C., B. E. Kemp, and A. R. Means. “Myosin light chain kinase structure function analysis using bacterial expression.” J Biol Chem 264, no. 27 (September 25, 1989): 15843–49.
    Link to Item
  - Epstein, P. N., P. A. Overbeek, and A. R. Means. “Calmodulin-induced early-onset diabetes in transgenic mice.” Cell 58, no. 6 (September 22, 1989): 1067–73. https://doi.org/10.1016/0092-8674(89)90505-9.
    Full Text Link to Item
  - Heidorn, D. B., P. A. Seeger, S. E. Rokop, D. K. Blumenthal, A. R. Means, H. Crespi, and J. Trewhella. “Changes in the structure of calmodulin induced by a peptide based on the calmodulin-binding domain of myosin light chain kinase.” Biochemistry 28, no. 16 (August 8, 1989): 6757–64. https://doi.org/10.1021/bi00442a032.
    Full Text Link to Item
  - Hanley, R. M., M. E. Payne, F. Cruzalegui, M. A. Christenson, and A. R. Means. “Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain.” Nucleic Acids Res 17, no. 10 (May 25, 1989): 3992. https://doi.org/10.1093/nar/17.10.3992.
    Full Text Link to Item
  - Rasmussen, C. D., and A. R. Means. “The presence of parvalbumin in a nonmuscle cell line attenuates progression through mitosis.” Mol Endocrinol 3, no. 3 (March 1989): 588–96. https://doi.org/10.1210/mend-3-3-588.
    Full Text Link to Item
  - Ono, T., G. R. Slaughter, R. G. Cook, and A. R. Means. “Molecular cloning sequence and distribution of rat calspermin, a high affinity calmodulin-binding protein.” J Biol Chem 264, no. 4 (February 5, 1989): 2081–87.
    Link to Item
  - Slaughter, G. R., M. L. Meistrich, and A. R. Means. “Expression of RNAs for calmodulin, actins, and tubulins in rat testis cells.” Biol Reprod 40, no. 2 (February 1989): 395–405. https://doi.org/10.1095/biolreprod40.2.395.
    Full Text Link to Item
  - Epstein, P. N., M. A. Christenson, and A. R. Means. “Chicken calmodulin promoter activity in proliferating and differentiated cells.” Mol Endocrinol 3, no. 1 (January 1989): 193–202. https://doi.org/10.1210/mend-3-1-193.
    Full Text Link to Item
  - Means, A. R., M. F. VanBerkum, S. E. George, and I. C. Bagchi. “Molecular analysis of calmodulin and smooth muscle myosin light chain kinase.” Adv Exp Med Biol 255 (1989): 135–45. https://doi.org/10.1007/978-1-4684-5679-0_15.
    Full Text Link to Item
  - Ono, T., and A. R. Means. “Calspermin is a testis specific calmodulin-binding protein closely related to Ca2+/calmodulin-dependent protein kinases.” Adv Exp Med Biol 255 (1989): 263–68. https://doi.org/10.1007/978-1-4684-5679-0_29.
    Full Text Link to Item
  - Kemp, B. E., R. B. Pearson, C. House, P. J. Robinson, and A. R. Means. “Regulation of protein kinases by pseudosubstrate prototopes.” Cell Signal 1, no. 4 (1989): 303–11. https://doi.org/10.1016/0898-6568(89)90049-1.
    Full Text Link to Item
  - Rasmussen, C. D., and A. R. Means. “Calmodulin is required for cell-cycle progression during G1 and mitosis.” Embo J 8, no. 1 (January 1989): 73–82. https://doi.org/10.1002/j.1460-2075.1989.tb03350.x.
    Full Text Link to Item
  - Means, A. R., and C. D. Rasmussen. “Calcium, calmodulin and cell proliferation.” Cell Calcium 9, no. 5–6 (December 1988): 313–19. https://doi.org/10.1016/0143-4160(88)90012-7.
    Full Text Link to Item
  - Hurwitz, M. Y., J. A. Putkey, C. B. Klee, and A. R. Means. “Domain II of calmodulin is involved in activation of calcineurin.” Febs Lett 238, no. 1 (September 26, 1988): 82–86. https://doi.org/10.1016/0014-5793(88)80230-8.
    Full Text Link to Item
  - Pearson, R. B., R. E. Wettenhall, A. R. Means, D. J. Hartshorne, and B. E. Kemp. “Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase.” Science 241, no. 4868 (August 19, 1988): 970–73. https://doi.org/10.1126/science.3406746.
    Full Text Link to Item
  - Putkey, J. A., T. Ono, M. F. VanBerkum, and A. R. Means. “Functional significance of the central helix in calmodulin.” J Biol Chem 263, no. 23 (August 15, 1988): 11242–49.
    Link to Item
  - Payne, M. E., Y. L. Fong, T. Ono, R. J. Colbran, B. E. Kemp, T. R. Soderling, and A. R. Means. “Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains.” J Biol Chem 263, no. 15 (May 25, 1988): 7190–95.
    Link to Item
  - Tash, J. S., M. Krinks, J. Patel, R. L. Means, C. B. Klee, and A. R. Means. “Identification, characterization, and functional correlation of calmodulin-dependent protein phosphatase in sperm.” J Cell Biol 106, no. 5 (May 1988): 1625–33. https://doi.org/10.1083/jcb.106.5.1625.
    Full Text Link to Item
  - Hanley, R. M., A. R. Means, B. E. Kemp, and S. Shenolikar. “Mapping of calmodulin-binding domain of Ca2+/calmodulin-dependent protein kinase II from rat brain.” Biochem Biophys Res Commun 152, no. 1 (April 15, 1988): 122–28. https://doi.org/10.1016/s0006-291x(88)80688-0.
    Full Text Link to Item
  - Means, A. R. “Molecular mechanisms of action of calmodulin.” Recent Prog Horm Res 44 (1988): 223–62. https://doi.org/10.1016/b978-0-12-571144-9.50012-0.
    Full Text Link to Item
  - Means, A. R., and S. E. George. “Calmodulin regulation of smooth-muscle myosin light-chain kinase.” J Cardiovasc Pharmacol 12 Suppl 5 (1988): S25–29.
    Link to Item
  - Tash, J. S., and A. R. Means. “cAMP-dependent regulatory processes in the acquisition and control of sperm flagellar movement.” Prog Clin Biol Res 267 (1988): 335–55.
    Link to Item
  - Rasmussen, C. D., and A. R. Means. “Calmodulin is involved in regulation of cell proliferation.” Embo J 6, no. 13 (December 20, 1987): 3961–68. https://doi.org/10.1002/j.1460-2075.1987.tb02738.x.
    Full Text Link to Item
  - Slaughter, G. R., D. S. Needleman, and A. R. Means. “Developmental regulation of calmodulin, actin, and tubulin RNAs during rat testis differentiation.” Biol Reprod 37, no. 5 (December 1987): 1259–70. https://doi.org/10.1095/biolreprod37.5.1259.
    Full Text Link to Item
  - Ikebe, M., M. Stepinska, B. E. Kemp, A. R. Means, and D. J. Hartshorne. “Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments.” J Biol Chem 262, no. 28 (October 5, 1987): 13828–34.
    Link to Item
  - Hanley, R. M., A. R. Means, T. Ono, B. E. Kemp, K. E. Burgin, N. Waxham, and P. T. Kelly. “Functional analysis of a complementary DNA for the 50-kilodalton subunit of calmodulin kinase II.” Science 237, no. 4812 (July 17, 1987): 293–97. https://doi.org/10.1126/science.3037704.
    Full Text Link to Item
  - Berchtold, M. W., P. Epstein, A. L. Beaudet, M. E. Payne, C. W. Heizmann, and A. R. Means. “Structural organization and chromosomal assignment of the parvalbumin gene.” J Biol Chem 262, no. 18 (June 25, 1987): 8696–8701.
    Link to Item
  - Putkey, J. A., S. L. Carroll, and A. R. Means. “The nontranscribed chicken calmodulin pseudogene cross-hybridizes with mRNA from the slow-muscle troponin C gene.” Mol Cell Biol 7, no. 4 (April 1987): 1549–53. https://doi.org/10.1128/mcb.7.4.1549-1553.1987.
    Full Text Link to Item
  - Gregori, L., D. Marriott, J. A. Putkey, A. R. Means, and V. Chau. “Bacterially synthesized vertebrate calmodulin is a specific substrate for ubiquitination.” J Biol Chem 262, no. 6 (February 25, 1987): 2562–67.
    Link to Item
  - Kemp, B. E., R. B. Pearson, V. Guerriero, I. C. Bagchi, and A. R. Means. “The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence.” J Biol Chem 262, no. 6 (February 25, 1987): 2542–48.
    Link to Item
  - Rasmussen, C. D., and A. R. Means. “Calmodulin as a regulator of cell growth and gene expression.” Soc Gen Physiol Ser 42 (1987): 287–93.
    Link to Item
  - Russo, M. A., V. Guerriero, and A. R. Means. “Hormonal regulation of a chicken oviduct messenger ribonucleic acid that shares a common domain with gizzard myosin light chain kinase.” Mol Endocrinol 1, no. 1 (January 1987): 60–67. https://doi.org/10.1210/mend-1-1-60.
    Full Text Link to Item
  - Epstein, P., R. C. Simmen, T. Tanaka, and A. R. Means. “Isolation and structural analysis of the chromosomal gene for chicken calmodulin.” Methods Enzymol 139 (1987): 217–29. https://doi.org/10.1016/0076-6879(87)39088-3.
    Full Text Link to Item
  - Jackson, A. E., K. L. Carraway, M. E. Payne, A. R. Means, D. Puett, and K. Brew. “Association of calmodulin and smooth muscle myosin light chain kinase: application of a label selection technique with trace acetylated calmodulin.” Proteins 2, no. 3 (1987): 202–9. https://doi.org/10.1002/prot.340020305.
    Full Text Link to Item
  - Putkey, J. A., P. V. Donnelly, and A. R. Means. “Bacterial expression vectors for calmodulin.” Methods Enzymol 139 (1987): 303–17. https://doi.org/10.1016/0076-6879(87)39094-9.
    Full Text Link to Item
  - Rasmussen, C. D., R. C. Simmen, E. A. MacDougall, and A. R. Means. “Methods for analyzing bovine papilloma virus-based calmodulin expression vectors.” Methods Enzymol 139 (1987): 642–54. https://doi.org/10.1016/0076-6879(87)39117-7.
    Full Text Link to Item
  - Slaughter, G. R., and A. R. Means. “Use of the 125I-labeled protein gel overlay technique to study calmodulin-binding proteins.” Methods Enzymol 139 (1987): 433–44. https://doi.org/10.1016/0076-6879(87)39104-9.
    Full Text Link to Item
  - Tash, J. S., and A. R. Means. “Ca2+ regulation of sperm axonemal motility.” Methods Enzymol 139 (1987): 808–23. https://doi.org/10.1016/0076-6879(87)39128-1.
    Full Text Link to Item
  - Guerriero, V., M. A. Russo, N. J. Olson, J. A. Putkey, and A. R. Means. “Domain organization of chicken gizzard myosin light chain kinase deduced from a cloned cDNA.” Biochemistry 25, no. 26 (December 30, 1986): 8372–81. https://doi.org/10.1021/bi00374a007.
    Full Text Link to Item
  - Brooks, D. E., A. R. Means, E. J. Wright, S. P. Singh, and K. K. Tiver. “Molecular cloning of the cDNA for androgen-dependent sperm-coating glycoproteins secreted by the rat epididymis.” Eur J Biochem 161, no. 1 (November 17, 1986): 13–18. https://doi.org/10.1111/j.1432-1033.1986.tb10118.x.
    Full Text Link to Item
  - Tash, J. S., H. Hidaka, and A. R. Means. “Axokinin phosphorylation by cAMP-dependent protein kinase is sufficient for activation of sperm flagellar motility.” J Cell Biol 103, no. 2 (August 1986): 649–55. https://doi.org/10.1083/jcb.103.2.649.
    Full Text Link to Item
  - Putkey, J. A., G. F. Draetta, G. R. Slaughter, C. B. Klee, P. Cohen, J. T. Stull, and A. R. Means. “Genetically engineered calmodulins differentially activate target enzymes.” J Biol Chem 261, no. 21 (July 25, 1986): 9896–9903.
    Link to Item
  - Seeholzer, S. H., M. Cohn, J. A. Putkey, A. R. Means, and H. L. Crespi. “NMR studies of a complex of deuterated calmodulin with melittin.” Proc Natl Acad Sci U S A 83, no. 11 (June 1986): 3634–38. https://doi.org/10.1073/pnas.83.11.3634.
    Full Text Link to Item
  - Epstein, P., A. R. Means, and M. W. Berchtold. “Isolation of a rat parvalbumin gene and full length cDNA.” J Biol Chem 261, no. 13 (May 5, 1986): 5886–91.
    Link to Item
  - Brooks, D. E., A. R. Means, E. J. Wright, S. P. Singh, and K. K. Tiver. “Molecular cloning of the cDNA for two major androgen-dependent secretory proteins of 18.5 kilodaltons synthesized by the rat epididymis.” J Biol Chem 261, no. 11 (April 15, 1986): 4956–61.
    Link to Item
  - Foyt, H. L., V. Guerriero, and A. R. Means. “Functional domains of chicken gizzard myosin light chain kinase.” J Biol Chem 260, no. 12 (June 25, 1985): 7765–74.
    Link to Item
  - Babu, Y. S., J. S. Sack, T. J. Greenhough, C. E. Bugg, A. R. Means, and W. J. Cook. “Three-dimensional structure of calmodulin.” Nature 315, no. 6014 (May 2, 1985): 37–40. https://doi.org/10.1038/315037a0.
    Full Text Link to Item
  - Putkey, J. A., G. R. Slaughter, and A. R. Means. “Bacterial expression and characterization of proteins derived from the chicken calmodulin cDNA and a calmodulin processed gene.” J Biol Chem 260, no. 8 (April 25, 1985): 4704–12.
    Link to Item
  - Berchtold, M. W., and A. R. Means. “The Ca2+-binding protein parvalbumin: molecular cloning and developmental regulation of mRNA abundance.” Proc Natl Acad Sci U S A 82, no. 5 (March 1985): 1414–18. https://doi.org/10.1073/pnas.82.5.1414.
    Full Text Link to Item
  - Simmen, R. C., T. Tanaka, K. F. Ts’ui, J. A. Putkey, M. J. Scott, E. C. Lai, and A. R. Means. “The structural organization of the chicken calmodulin gene.” J Biol Chem 260, no. 2 (January 25, 1985): 907–12.
    Link to Item
  - Slaughter, G. R., and A. R. Means. “Quantitation and significance of 125I-calmodulin binding to myosin light chain kinase and phosphorylase distributed on polyacrylamide gels.” Biochem Biophys Res Commun 126, no. 1 (January 16, 1985): 295–303. https://doi.org/10.1016/0006-291x(85)90605-9.
    Full Text Link to Item
  - Foyt, H. L., and A. R. Means. “Characterization and analysis of an apparent autophosphorylation of chicken gizzard myosin light chain kinase.” J Cyclic Nucleotide Protein Phosphor Res 10, no. 2 (1985): 143–55.
    Link to Item
  - Simmen, R. C., A. R. Means, and J. H. Clark. “Estrogen modulation of nuclear matrix-associated steroid hormone binding.” Endocrinology 115, no. 3 (September 1984): 1197–1202. https://doi.org/10.1210/endo-115-3-1197.
    Full Text Link to Item
  - Tash, J. S., S. S. Kakar, and A. R. Means. “Flagellar motility requires the cAMP-dependent phosphorylation of a heat-stable NP-40-soluble 56 kd protein, axokinin.” Cell 38, no. 2 (September 1984): 551–59. https://doi.org/10.1016/0092-8674(84)90509-9.
    Full Text Link to Item
  - Simmen, R. C., B. S. Dunbar, V. Guerriero, J. G. Chafouleas, J. H. Clark, and A. R. Means. “Estrogen stimulates the transient association of calmodulin and myosin light chain kinase with the chicken liver nuclear matrix.” J Cell Biol 99, no. 2 (August 1984): 588–93. https://doi.org/10.1083/jcb.99.2.588.
    Full Text Link to Item
  - Means, A. R., G. R. Slaughter, and J. A. Putkey. “Postreceptor signal transduction by cyclic adenosine monophosphate and the Ca2+-calmodulin complex.” J Cell Biol 99, no. 1 Pt 2 (July 1984): 226s-231s. https://doi.org/10.1083/jcb.99.1.226s.
    Full Text Link to Item
  - Chafouleas, J. G., W. E. Bolton, and A. R. Means. “Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair.” Science 224, no. 4655 (June 22, 1984): 1346–48. https://doi.org/10.1126/science.6203171.
    Full Text Link to Item
  - Deery, W. J., A. R. Means, and B. R. Brinkley. “Calmodulin-microtubule association in cultured mammalian cells.” J Cell Biol 98, no. 3 (March 1984): 904–10. https://doi.org/10.1083/jcb.98.3.904.
    Full Text Link to Item
  - Chafouleas, J. G., L. Lagacé, W. E. Bolton, A. E. Boyd, and A. R. Means. “Changes in calmodulin and its mRNA accompany reentry of quiescent (G0) cells into the cell cycle.” Cell 36, no. 1 (January 1984): 73–81. https://doi.org/10.1016/0092-8674(84)90075-8.
    Full Text Link to Item
  - Stein, J. P., R. P. Munjaal, L. Lagace, E. C. Lai, B. W. O’Malley, and A. R. Means. “Tissue-specific expression of a chicken calmodulin pseudogene lacking intervening sequences.” Proc Natl Acad Sci U S A 80, no. 21 (November 1983): 6485–89. https://doi.org/10.1073/pnas.80.21.6485.
    Full Text Link to Item
  - Putkey, J. A., K. F. Ts’ui, T. Tanaka, L. Lagacé, J. P. Stein, E. C. Lai, and A. R. Means. “Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone.” J Biol Chem 258, no. 19 (October 10, 1983): 11864–70.
    Link to Item
  - Slaughter, G. R., and A. R. Means. “Follicle-stimulating hormone activation of glycogen phosphorylase in the Sertoli cell-enriched rat testis.” Endocrinology 113, no. 4 (October 1983): 1476–85. https://doi.org/10.1210/endo-113-4-1476.
    Full Text Link to Item
  - Lagacé, L., T. Chandra, S. L. Woo, and A. R. Means. “Identification of multiple species of calmodulin messenger RNA using a full length complementary DNA.” J Biol Chem 258, no. 3 (February 10, 1983): 1684–88.
    Link to Item
  - Tash, J. S., and A. R. Means. “Cyclic adenosine 3',5' monophosphate, calcium and protein phosphorylation in flagellar motility.” Biol Reprod 28, no. 1 (February 1983): 75–104. https://doi.org/10.1095/biolreprod28.1.75.
    Full Text Link to Item
  - Chafouleas, J. G., M. E. Riser, L. Lagacé, and A. R. Means. “Production of polyclonal and monoclonal antibodies to calmodulin and utilization of these immunological probes.” Methods Enzymol 102 (1983): 104–10. https://doi.org/10.1016/s0076-6879(83)02011-x.
    Full Text Link to Item
  - Bourguignon, L. Y., M. L. Nagpal, K. Balazovich, V. Guerriero, and A. R. Means. “Association of myosin light chain kinase with lymphocyte membrane-cytoskeleton complex.” J Cell Biol 95, no. 3 (December 1982): 793–97. https://doi.org/10.1083/jcb.95.3.793.
    Full Text Link to Item
  - O’Malley, B. W., J. P. Stein, and A. R. Means. “The evolution of a complex eucaryotic gene.” Metabolism 31, no. 7 (July 1982): 646–53. https://doi.org/10.1016/0026-0495(82)90193-7.
    Full Text Link to Item
  - Tash, J. S., and A. R. Means. “Regulation of protein phosphorylation and motility of sperm by cyclic adenosine monophosphate and calcium.” Biol Reprod 26, no. 4 (May 1982): 745–63. https://doi.org/10.1095/biolreprod26.4.745.
    Full Text Link to Item
  - Chafouleas, J. G., W. E. Bolton, H. Hidaka, A. E. Boyd, and A. R. Means. “Calmodulin and the cell cycle: involvement in regulation of cell-cycle progression.” Cell 28, no. 1 (January 1982): 41–50. https://doi.org/10.1016/0092-8674(82)90373-7.
    Full Text Link to Item
  - Means, A. R., J. S. Tash, J. G. Chafouleas, L. Lagace, and V. Guerriero. “Regulation of the cytoskeleton by Ca2+-calmodulin and cAMP.” Ann N Y Acad Sci 383 (1982): 69–84. https://doi.org/10.1111/j.1749-6632.1982.tb23162.x.
    Full Text Link to Item
  - Means, A. R., and J. G. Chafouleas. “Calmodulin in endocrine cells.” Annu Rev Physiol 44 (1982): 667–82. https://doi.org/10.1146/annurev.ph.44.030182.003315.
    Full Text Link to Item
  - Means, A. R., and J. G. Chafouleas. “Regulation by and of calmodulin in mammalian cells.” Cold Spring Harb Symp Quant Biol 46 Pt 2 (1982): 903–8. https://doi.org/10.1101/sqb.1982.046.01.084.
    Full Text Link to Item
  - Stein, J. P., A. R. Means, and B. W. O’Malley. “Evolution of a complex eukaryotic gene.” Natl Cancer Inst Monogr 60 (1982): 55–61.
    Link to Item
  - Chafouleas, J. G., J. R. Dedman, and A. R. Means. “Radioimmunoassay of calmodulin.” Methods Enzymol 84 (1982): 138–47. https://doi.org/10.1016/0076-6879(82)84012-3.
    Full Text Link to Item
  - Means, A. R., J. S. Tash, and J. G. Chafouleas. “Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells.” Physiol Rev 62, no. 1 (January 1982): 1–39. https://doi.org/10.1152/physrev.1982.62.1.1.
    Full Text Link to Item
  - Means, A. R., L. Lagace, V. Guerriero, and J. G. Chafouleas. “Calmodulin as a mediator of hormone action and cell regulation.” J Cell Biochem 20, no. 4 (1982): 317–30. https://doi.org/10.1002/jcb.240200402.
    Full Text Link to Item
  - Kohnken, R. E., J. G. Chafouleas, D. M. Eadie, A. R. Means, and D. G. McConnell. “Calmodulin in bovine rod outer segments.” J Biol Chem 256, no. 23 (December 10, 1981): 12517–22.
    Link to Item
  - Guerriero, V., D. R. Rowley, and A. R. Means. “Production and characterization of an antibody to myosin light chain kinase and intracellular localization of the enzyme.” Cell 27, no. 3 Pt 2 (December 1981): 449–58. https://doi.org/10.1016/0092-8674(81)90386-x.
    Full Text Link to Item
  - Means, A. R., and J. G. Chafouleas. “Function and regulation of calmodulin in endocrine cells.” J Steroid Biochem 15 (December 1981): 163–69. https://doi.org/10.1016/0022-4731(81)90271-5.
    Full Text Link to Item
  - Van Sickle, M., J. M. Oberwetter, L. Birnbaumer, and A. R. Means. “Developmental changes in the hormonal regulation of rat testis Sertoli cell adenylyl cyclase.” Endocrinology 109, no. 4 (October 1981): 1270–80. https://doi.org/10.1210/endo-109-4-1270.
    Full Text Link to Item
  - Weigel, N. L., J. S. Tash, A. R. Means, W. T. Schrader, and B. W. O’Malley. “Phosphorylation of hen progesterone receptor by cAMP dependent protein kinase.” Biochem Biophys Res Commun 102, no. 1 (September 16, 1981): 513–19. https://doi.org/10.1016/0006-291x(81)91549-7.
    Full Text Link to Item
  - Cunningham, G. R., D. J. Tindall, T. J. Lobl, J. A. Campbell, and A. R. Means. “Steroid structural requirements for high affinity binding to human sex steroid binding protein (SBP).” Steroids 38, no. 3 (September 1981): 243–62. https://doi.org/10.1016/0039-128x(81)90061-1.
    Full Text Link to Item
  - Conn, P. M., J. G. Chafouleas, D. Rogers, and A. R. Means. “Gonadotropin releasing hormone stimulates calmodulin redistribution in rat pituitary.” Nature 292, no. 5820 (July 16, 1981): 264–65. https://doi.org/10.1038/292264a0.
    Full Text Link to Item
  - Maihle, N. J., J. R. Dedman, A. R. Means, J. G. Chafouleas, and B. H. Satir. “Presence and indirect immunofluorescent localization of calmodulin in Paramecium tetraurelia.” J Cell Biol 89, no. 3 (June 1981): 695–99. https://doi.org/10.1083/jcb.89.3.695.
    Full Text Link to Item
  - Munjaal, R. P., T. Chandra, S. L. Woo, J. R. Dedman, and A. R. Means. “A cloned calmodulin structural gene probe is complementary to DNA sequences from diverse species.” Proc Natl Acad Sci U S A 78, no. 4 (April 1981): 2330–34. https://doi.org/10.1073/pnas.78.4.2330.
    Full Text Link to Item
  - Tindall, D. J., J. S. Tash, and A. R. Means. “Factors affecting Sertoli cell function in the testis.” Environ Health Perspect 38 (April 1981): 5–10. https://doi.org/10.1289/ehp.81385.
    Full Text Link to Item
  - Chafouleas, J. G., R. L. Pardue, B. R. Brinkley, J. R. Dedman, and A. R. Means. “Regulation of intracellular levels of calmodulin and tubulin in normal and transformed cells.” Proc Natl Acad Sci U S A 78, no. 2 (February 1981): 996–1000. https://doi.org/10.1073/pnas.78.2.996.
    Full Text Link to Item
  - Tash, J. S., M. J. Welsh, and A. R. Means. “Regulation of protein kinase inhibitor by follicle-stimulating hormone in Sertoli cells in vitro.” Endocrinology 108, no. 2 (February 1981): 427–34. https://doi.org/10.1210/endo-108-2-427.
    Full Text Link to Item
  - Linden, C. D., J. R. Dedman, J. G. Chafouleas, A. R. Means, and T. F. Roth. “Interactions of calmodulin with coated vesicles from brain.” Proc Natl Acad Sci U S A 78, no. 1 (January 1981): 308–12. https://doi.org/10.1073/pnas.78.1.308.
    Full Text Link to Item
  - Means, A. R. “Calmodulin: properties, intracellular localization, and multiple roles in cell regulation.” Recent Prog Horm Res 37 (1981): 333–67. https://doi.org/10.1016/b978-0-12-571137-1.50011-6.
    Full Text Link to Item
  - Means, A. R., J. G. Chafouleas, W. E. Bolton, H. Hidaka, and A. E. Boyd. “Calmodulin regulation during the cell cycle of mammalian cells.” Proc West Pharmacol Soc 24 (1981): 209–12.
    Link to Item
  - Chan, L., A. Dugaiczyk, and A. R. Means. “Molecular cloning of the gene sequences of a major apoprotein in avian very low density lipoproteins.” Biochemistry 19, no. 24 (November 25, 1980): 5631–37. https://doi.org/10.1021/bi00565a027.
    Full Text Link to Item
  - Chan, L., W. A. Bradley, and A. R. Means. “Amino acid sequence of the signal peptide of apoVLDL-II, a major apoprotein in avian very low density lipoproteins.” J Biol Chem 255, no. 21 (November 10, 1980): 10060–63.
    Link to Item
  - Catterall, J. F., J. P. Stein, P. Kristo, A. R. Means, and B. W. O’Malley. “Primary sequence of ovomucoid messenger RNA as determined from cloned complementary DNA.” J Cell Biol 87, no. 2 Pt 1 (November 1980): 480–87. https://doi.org/10.1083/jcb.87.2.480.
    Full Text Link to Item
  - Stein, J. P., J. F. Catterall, P. Kristo, A. R. Means, and B. W. O’Malley. “Ovomucoid intervening sequences specify functional domains and generate protein polymorphism.” Cell 21, no. 3 (October 1980): 681–87. https://doi.org/10.1016/0092-8674(80)90431-6.
    Full Text Link to Item
  - Cook, W. J., J. R. Dedman, A. R. Means, and C. E. Bugg. “Crystallization and preliminary X-ray investigation of calmodulin.” J Biol Chem 255, no. 17 (September 10, 1980): 8152–53.
    Link to Item
  - Means, A. R., and J. R. Dedman. “Calmodulin in endocrine cells and its multiple roles in hormone action.” Mol Cell Endocrinol 19, no. 3 (September 1980): 215–27. https://doi.org/10.1016/0303-7207(80)90052-0.
    Full Text Link to Item
  - Tash, J. S., M. J. Welsh, and A. R. Means. “Protein inhibitor of cAMP-dependent protein kinase: production and characterization of antibodies and intracellular localization.” Cell 21, no. 1 (August 1980): 57–65. https://doi.org/10.1016/0092-8674(80)90114-2.
    Full Text Link to Item
  - Means, A. R., and J. R. Dedman. “Calmodulin--an intracellular calcium receptor.” Nature 285, no. 5760 (May 8, 1980): 73–77. https://doi.org/10.1038/285073a0.
    Full Text Link to Item
  - Lin, C. T., J. R. Dedman, B. R. Brinkley, and A. R. Means. “Localization of calmodulin in rat cerebellum by immunoelectron microscopy.” J Cell Biol 85, no. 2 (May 1980): 473–80. https://doi.org/10.1083/jcb.85.2.473.
    Full Text Link to Item
  - Chan, L., W. A. Bradley, A. Dugaiczyk, and A. R. Means. “Lipoprotein biosynthesis: the avian model.” Ann N Y Acad Sci 348 (1980): 427–28. https://doi.org/10.1111/j.1749-6632.1980.tb21319.x.
    Full Text Link to Item
  - Chan, L., W. A. Bradley, R. L. Jackson, and A. R. Means. “Lipoprotein synthesis in the cockerel liver: effects of estrogen on hepatic polysomal messenger ribonucleic acid activities for the major apoproteins in very loow and high density lipoproteins and for albumin and evidence for precursors to these secretory proteins.” Endocrinology 106, no. 1 (January 1980): 275–83. https://doi.org/10.1210/endo-106-1-275.
    Full Text Link to Item
  - Cook, W. J., C. E. Bugg, J. R. Dedman, and A. R. Means. “Crystallographic studies of calmodulin.” Ann N Y Acad Sci 356 (1980): 365–66. https://doi.org/10.1111/j.1749-6632.1980.tb29629.x.
    Full Text Link to Item
  - Means, A. R., J. R. Dedman, J. S. Tash, D. J. Tindall, M. van Sickle, and M. J. Welsh. “Regulation of the testis sertoli cell by follicle stimulating hormone.” Annu Rev Physiol 42 (1980): 59–70. https://doi.org/10.1146/annurev.ph.42.030180.000423.
    Full Text Link to Item
  - Means, A. R., M. J. Welsh, J. R. Dedman, and J. S. Tash. “FSH stimulation of protein kinase inhibitor: regulation of cellular metabolism.” Adv Cyclic Nucleotide Res 12 (1980): 373–85.
    Link to Item
  - Munjaal, R. P., J. R. Dedman, and A. R. Means. “Isolation of the structural gene for calmodulin.” Ann N Y Acad Sci 356 (1980): 110–18. https://doi.org/10.1111/j.1749-6632.1980.tb29604.x.
    Full Text Link to Item
  - O’Malley, B. W., J. P. Stein, and A. R. Means. “Evolutionary mechanisms for eucaryotic genes.” Cardiovasc Res Cent Bull 19, no. 2 (1980): 41–55.
    Link to Item
  - Lai, E. C., J. P. Stein, J. F. Catterall, S. L. Woo, M. L. Mace, A. R. Means, and B. W. O’Malley. “Molecular structure and flanking nucleotide sequences of the natural chicken ovomucoid gene.” Cell 18, no. 3 (November 1979): 829–42. https://doi.org/10.1016/0092-8674(79)90135-1.
    Full Text Link to Item
  - Chafouleas, J. G., J. R. Dedman, R. P. Munjaal, and A. R. Means. “Calmodulin. Development and application of a sensitive radioimmunoassay.” J Biol Chem 254, no. 20 (October 25, 1979): 10262–67.
    Link to Item
  - Welsh, M. J., J. R. Dedman, B. R. Brinkley, and A. R. Means. “Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus.” J Cell Biol 81, no. 3 (June 1979): 624–34. https://doi.org/10.1083/jcb.81.3.624.
    Full Text Link to Item
  - Catterall, J. F., J. P. Stein, E. C. Lai, S. L. Woo, A. Dugaiczyk, M. L. Mace, A. R. Means, and B. W. O’Malley. “The chick ovomucoid gene contains at least six intervening sequences.” Nature 278, no. 5702 (March 22, 1979): 323–27. https://doi.org/10.1038/278323a0.
    Full Text Link to Item
  - Cunningham, G. R., D. J. Tindall, and A. R. Means. “Differences in steroid specificity for rat androgen binding protein and the cytoplasmic receptor.” Steroids 33, no. 3 (March 1979): 261–76. https://doi.org/10.1016/0039-128x(79)90003-5.
    Full Text Link to Item
  - Tash, J. S., J. R. Dedman, and A. R. Means. “Protein kinase inhibitor in sertoli cell-enriched rat testis. Specific regulation by follicle-stimulating hormone.” J Biol Chem 254, no. 4 (February 25, 1979): 1241–47.
    Link to Item
  - Dedman, J. R., B. R. Brinkley, and A. R. Means. “Regulation of microfilaments and microtubules by calcium and cyclic AMP.” Adv Cyclic Nucleotide Res 11 (1979): 131–74.
    Link to Item
  - Stein, J. P., J. F. Catterall, S. L. Woo, A. R. Means, and B. W. O’Malley. “Molecular cloning of ovomucoid gene sequences from partially purified ovomucoid messenger RNA.” Biochemistry 17, no. 26 (December 26, 1978): 5763–72. https://doi.org/10.1021/bi00619a025.
    Full Text Link to Item
  - Tsai, S. Y., D. R. Roop, M. J. Tsai, J. P. Stein, A. R. Means, and B. W. O’Malley. “Effect of estrogen on gene expression in the chick oviduct. Regulation of the ovomucoid gene.” Biochemistry 17, no. 26 (December 26, 1978): 5773–80. https://doi.org/10.1021/bi00619a026.
    Full Text Link to Item
  - Snow, L. D., H. Eriksson, J. W. Hardin, L. Chan, R. L. Jackson, J. H. Clark, and A. R. Means. “Nuclear estrogen receptor in the avian liver: correlation with biologic response.” J Steroid Biochem 9, no. 11 (November 1978): 1017–26. https://doi.org/10.1016/0022-4731(78)90026-2.
    Full Text Link to Item
  - Dedman, J. R., M. J. Welsh, and A. R. Means. “Ca2+-dependent regulator. Production and characterization of a monospecific antibody.” J Biol Chem 253, no. 20 (October 25, 1978): 7515–21.
    Link to Item
  - Chan, L., R. L. Jackson, and A. R. Means. “Regulation of lipoprotein synthesis. Studies on the molecular mechanisms of lipoprotein synthesis and their regulation by estrogen in the cockerel.” Circ Res 43, no. 2 (August 1978): 209–17. https://doi.org/10.1161/01.res.43.2.209.
    Full Text Link to Item
  - Marcum, J. M., J. R. Dedman, B. R. Brinkley, and A. R. Means. “Control of microtubule assembly-disassembly by calcium-dependent regulator protein.” Proc Natl Acad Sci U S A 75, no. 8 (August 1978): 3771–75. https://doi.org/10.1073/pnas.75.8.3771.
    Full Text Link to Item
  - Tindall, D. J., C. R. Mena, and A. R. Means. “Hormonal regulation of androgen-binding protein in hypophysectomized rats.” Endocrinology 103, no. 2 (August 1978): 589–94. https://doi.org/10.1210/endo-103-2-589.
    Full Text Link to Item
  - Welsh, M. J., J. R. Dedman, B. R. Brinkley, and A. R. Means. “Calcium-dependent regulator protein: localization in mitotic apparatus of eukaryotic cells.” Proc Natl Acad Sci U S A 75, no. 4 (April 1978): 1867–71. https://doi.org/10.1073/pnas.75.4.1867.
    Full Text Link to Item
  - Dedman, J. R., R. L. Jackson, W. E. Schreiber, and A. R. Means. “Sequence homology of the Ca2+-dependent regulator of cyclic nucleotide phosphodiesterase from rat testis with other Ca2+-binding proteins.” J Biol Chem 253, no. 2 (January 25, 1978): 343–46.
    Link to Item
  - Tindall, D. J., G. R. Cunningham, and A. R. Means. “5alpha-Dihydrotestosterone binding to androgen binding protein. Effects of testosterone and other compounds in vivo and in vitro on the number of binding sites measured.” J Biol Chem 253, no. 1 (January 10, 1978): 166–69.
    Link to Item
  - Chan, L., A. R. Means, and B. W. O’Malley. “Steroid hormone regulation of specific gene expression.” Vitam Horm 36 (1978): 259–95. https://doi.org/10.1016/s0083-6729(08)60986-3.
    Full Text Link to Item
  - Cunningham, G. R., D. J. Tindall, C. Huckins, and A. R. Means. “Mechanisms for the testicular hypertrophy which follows hemicastration.” Endocrinology 102, no. 1 (January 1978): 16–23. https://doi.org/10.1210/endo-102-1-16.
    Full Text Link to Item
  - Woo, S. L., T. Chandra, A. R. Means, and B. W. O’Malley. “Ovalbumin gene: purification of the coding strand.” Biochemistry 16, no. 26 (December 27, 1977): 5670–76. https://doi.org/10.1021/bi00645a003.
    Full Text Link to Item
  - Dedman, J. R., J. D. Potter, R. L. Jackson, J. D. Johnson, and A. R. Means. “Physicochemical properties of rat testis Ca2+-dependent regulator protein of cyclic nucleotide phosphodiesterase. Relationship of Ca2+-binding, conformational changes, and phosphodiesterase activity.” J Biol Chem 252, no. 23 (December 10, 1977): 8415–22.
    Link to Item
  - Mills, N. C., N. T. Van, and A. R. Means. “Histones of rat testis chromatin during early postnatal development and their interactions with DNA.” Biol Reprod 17, no. 5 (December 1977): 760–68. https://doi.org/10.1095/biolreprod17.5.760.
    Full Text Link to Item
  - Mills, N. C., and A. R. Means. “Nonhistone chromosomal proteins of the developing rat testis.” Biol Reprod 17, no. 5 (December 1977): 769–79. https://doi.org/10.1095/biolreprod17.5.769.
    Full Text Link to Item
  - Beale, E. G., J. R. Dedman, and A. R. Means. “Isolation and regulation of the protein kinase inhibitor and the calcium-dependent cyclic nucleotide phosphodiesterase regulator in the Sertoli cell-enriched testis.” Endocrinology 101, no. 5 (November 1977): 1621–34. https://doi.org/10.1210/endo-101-5-1621.
    Full Text Link to Item
  - Fakunding, J. L., and A. R. Means. “Characterization and follicle stimulating hormone activation of Sertoli cell cyclic AMP-dependent protein kinases.” Endocrinology 101, no. 5 (November 1977): 1358–68. https://doi.org/10.1210/endo-101-5-1358.
    Full Text Link to Item
  - Chan, L., H. Eriksson, R. L. Jackson, J. H. Clark, and A. R. Means. “Effects of estrogen on very low density lipoproteins (VLDL) synthesis in avian liver slices in vitro: lack of correlation with nuclear estrogen receptors.” J Steroid Biochem 8, no. 11 (November 1977): 1189–91. https://doi.org/10.1016/0022-4731(77)90072-3.
    Full Text Link to Item
  - Beale, E. G., J. R. Dedman, and A. R. Means. “Isolation and characterization of a protein from rat testis which inhibits cyclic AMP-dependent protein kinase and phosdiesterase.” J Biol Chem 252, no. 18 (September 25, 1977): 6322–27.
    Link to Item
  - Van, N. T., J. J. Monahan, S. L. Woo, A. R. Means, and B. W. O’Malley. “Comparative studies on the secondary structure of ovalbumin messenger RNA and its complementary DNA transcript.” Biochemistry 16, no. 18 (September 6, 1977): 4090–4100. https://doi.org/10.1021/bi00637a024.
    Full Text Link to Item
  - Jackson, R. L., H. Y. Lin, J. T. Mao, L. Chan, and A. R. Means. “Estrogen induction of plasma vitellogenin in the cockerel: studies with a phosvitin antibody.” Endocrinology 101, no. 3 (September 1977): 849–57. https://doi.org/10.1210/endo-101-3-849.
    Full Text Link to Item
  - Potter, J. D., J. R. Dedman, and A. R. Means. “Ca2+-dependent regulation of cyclic-AMP phosphodiesterase by parvalbumin.” J Biol Chem 252, no. 16 (August 25, 1977): 5609–11.
    Link to Item
  - Jaffe, R. C., and A. R. Means. “Stability of nuclear triiodothyronine binding sites.” Endocrinology 101, no. 2 (August 1977): 447–52. https://doi.org/10.1210/endo-101-2-447.
    Full Text Link to Item
  - Mills, N. C., T. M. Mills, and A. R. Means. “Morphological and biochemical changes which occur during postnatal development and maturation of the rat testis.” Biol Reprod 17, no. 1 (August 1977): 124–30. https://doi.org/10.1095/biolreprod17.1.124.
    Full Text Link to Item
  - Jackson, R. L., J. R. Dedman, W. E. Schreiber, P. K. Bhatnagar, R. D. Knapp, and A. R. Means. “Identification of epsilon-N-trimethyllysine in a rat testis calcium-dependent regulatory protein of cyclic nucleotide phosphodiesterase.” Biochem Biophys Res Commun 77, no. 2 (July 25, 1977): 723–29. https://doi.org/10.1016/s0006-291x(77)80038-7.
    Full Text Link to Item
  - Tindall, D. J., D. A. Miller, and A. R. Means. “Characterization of androgen receptor in Sertoli cell-enriched testis.” Endocrinology 101, no. 1 (July 1977): 13–23. https://doi.org/10.1210/endo-101-1-13.
    Full Text Link to Item
  - Chan, L., R. L. Jackson, and A. R. Means. “Female steroid hormones and lipoprotein synthesis in the cockerel: effects of progesterone and nafoxidine on the estrogenic stimulation of very low density lipoproteins (VLDL) synthesis.” Endocrinology 100, no. 6 (June 1977): 1636–43. https://doi.org/10.1210/endo-100-6-1636.
    Full Text Link to Item
  - Dedman, J. R., J. D. Potter, and A. R. Means. “Biological cross-reactivity of rat testis phosphodiesterase activator protein and rabbit skeletal muscle troponin-C.” J Biol Chem 252, no. 7 (April 10, 1977): 2437–40.
    Link to Item
  - Dedman, J. R., and A. R. Means. “Characterization of a spectrophotometric assay for cAMP phosphodiesterase.” J Cyclic Nucleotide Res 3, no. 2 (April 1977): 139–52.
    Link to Item
  - Jackson, R. L., H. Y. Lin, L. Chan, and A. R. Means. “Amino acid sequence of a major apoprotein from hen plasma very low density lipoproteins.” J Biol Chem 252, no. 1 (January 10, 1977): 250–53.
    Link to Item
  - Chan, L., S. E. Harris, J. M. Rosen, A. R. Means, and B. W. O’Malley. “Processing of nuclear heterogeneous RNA: recent developments.” Life Sci 20, no. 1 (January 1, 1977): 1–15. https://doi.org/10.1016/0024-3205(77)90123-0.
    Full Text Link to Item
  - Tindall, D. J., and A. R. Means. “Concerning the hormonal regulation of androgen binding protein in rat testis.” Endocrinology 99, no. 3 (September 1976): 809–18. https://doi.org/10.1210/endo-99-3-809.
    Full Text Link to Item
  - Chan, L., R. L. Jackson, B. W. O’Malley, and A. R. Means. “Synthesis of very low density lipoproteins in the cockerel. Effects of estrogen.” J Clin Invest 58, no. 2 (August 1976): 368–79. https://doi.org/10.1172/JCI108481.
    Full Text Link to Item
  - Woo, S. L., R. G. Smith, A. R. Means, and B. W. O’Malley. “The ovalbumin gene. Partial purification of the coding strand.” J Biol Chem 251, no. 13 (July 10, 1976): 3868–74.
    Link to Item
  - Sperry, P. J., S. L. Woo, A. R. Means, and B. W. O’Malley. “Partial purification of a progesterone-inducible messenger RNA (avidin) from hen oviduct.” Endocrinology 99, no. 1 (July 1976): 315–25. https://doi.org/10.1210/endo-99-1-315.
    Full Text Link to Item
  - Van, N. T., J. W. Holder, S. L. Woo, A. R. Means, and B. W. O’Malley. “Secondary structure of ovalbumin messenger RNA.” Biochemistry 15, no. 10 (May 18, 1976): 2054–62. https://doi.org/10.1021/bi00655a005.
    Full Text Link to Item
  - Jackson, R. L., H. U. Lin, L. Chan, and A. R. Means. “Isolation and characterization of the major apolipoprotein from chicken high density lipoproteins.” Biochim Biophys Acta 420, no. 2 (February 20, 1976): 342–49. https://doi.org/10.1016/0005-2795(76)90326-3.
    Full Text Link to Item
  - Means, A. R., J. L. Fakunding, and D. J. Tindall. “Follicle stimulating hormone regulation of protein kinase activity and protein synthesis in testis.” Biol Reprod 14, no. 1 (February 1976): 54–63. https://doi.org/10.1095/biolreprod14.1.54.
    Full Text Link to Item
  - Fakunding, J. L., D. J. Tindall, J. R. Dedman, C. R. Mena, and A. R. Means. “Biochemical actions of follice-stimulating hormone in the sertoli cell of the rat testis.” Endocrinology 98, no. 2 (February 1976): 392–402. https://doi.org/10.1210/endo-98-2-392.
    Full Text Link to Item
  - Means, A. R., J. L. Fakunding, C. Huckins, D. J. Tindall, and R. Vitale. “Follicle-stimulating hormone, the Sertoli cell, and spermatogenesis.” Recent Prog Horm Res 32 (1976): 477–527. https://doi.org/10.1016/b978-0-12-571132-6.50027-0.
    Full Text Link to Item
  - O’Malley, B. W., and A. R. Means. “The mechanism of steroid-hormone regulation of transcription of specific eukaryotic genes.” Prog Nucleic Acid Res Mol Biol 19 (1976): 403–19. https://doi.org/10.1016/s0079-6603(08)60934-4.
    Full Text Link to Item
  - Woo, S. L., J. M. Rosen, C. D. Liarakos, Y. C. Choi, H. Busch, A. R. Means, and A. R. O’Malley. “Physical and chemical characterization of purified ovalbumin messenger RNA.” J Biol Chem 250, no. 17 (September 10, 1975): 7027–39.
    Link to Item
  - Tindall, D. J., R. Vitale, and A. R. Means. “Androgen binding protein as a biochemical marker of formation of the blood-testis barrier.” Endocrinology 97, no. 3 (September 1975): 636–48. https://doi.org/10.1210/endo-97-3-636.
    Full Text Link to Item
  - Rosen, J. M., L. Chan, S. L. Woo, S. E. Harris, A. R. Means, and B. W. O’Malley. “Effect of estrogen on the synthesis and processing of ovalbumin messenger RNA in the chick oviduct.” Brookhaven Symp Biol, no. 26 (July 1975): 320–32.
    Link to Item
  - Harris, S. E., J. M. Rosen, A. R. Means, and B. W. O’Malley. “Use of a specific probe for ovalbumin messenger RNA to quantitate estrogen-induced gene transcripts.” Biochemistry 14, no. 10 (May 20, 1975): 2072–81. https://doi.org/10.1021/bi00681a006.
    Full Text Link to Item
  - Means, A. R., S. Woo, S. E. Harris, and B. W. O’Malley. “Estrogen induction of ovalbumin mRNA: evidence for transcription control.” Mol Cell Biochem 7, no. 1 (April 30, 1975): 33–42. https://doi.org/10.1007/BF01732161.
    Full Text Link to Item
  - O’Malkey, B. W., S. L. Woo, S. E. Harris, J. M. Rosen, and A. R. Means. “Steroid hormone regulation of specific messenger RNA and protein synthesis in eucaryotic cells.” J Cell Physiol 85, no. 2 Pt 2 Suppl 1 (April 1975): 343–56. https://doi.org/10.1002/jcp.1040850403.
    Full Text Link to Item
  - Rosen, J. M., S. L. Woo, J. W. Holder, A. R. Means, and B. W. O’Malley. “Preparation and preliminary characterization of purified ovalbumin messenger RNA from the hen oviduct.” Biochemistry 14, no. 1 (January 14, 1975): 69–78. https://doi.org/10.1021/bi00672a012.
    Full Text Link to Item
  - Means, A. R., and D. J. Tindall. “FSH-induction of androgen binding protein in testes of Sertoli cell-only rats.” Curr Top Mol Endocrinol 2 (1975): 383–98. https://doi.org/10.1007/978-1-4613-4440-7_27.
    Full Text Link to Item
  - Means, A. R. “Early sequence of biochemical events in the action of follicle stimulating hormone on the testis.” Life Sci 15, no. 3 (August 1, 1974): 371–89. https://doi.org/10.1016/0024-3205(74)90337-3.
    Full Text Link to Item
  - Means, A. R., E. MacDougall, T. R. Soderling, and J. D. Corbin. “Testicular adenosine 3':5'-monophosphate-dependent protein kinase. Regulation by follicle-stimulating hormone.” J Biol Chem 249, no. 4 (February 25, 1974): 1231–38.
    Link to Item
  - O’Malley, B. W., and A. R. Means. “Female steroid hormones and target cell nuclei.” Science 183, no. 4125 (February 15, 1974): 610–20. https://doi.org/10.1126/science.183.4125.610.
    Full Text Link to Item
  - O’Malley, B. W., and A. R. Means. “Female steroid hormones and target cell nuclei.” Science (New York, N.Y.) 183, no. 125 (February 1974): 610–20.
  - Means, A. R., and C. Huckins. “Coupled events in the early biochemical actions of FSH on the Sertoli cells of the testis.” Curr Top Mol Endocrinol 1 (1974): 145–65. https://doi.org/10.1007/978-1-4684-2595-6_8.
    Full Text Link to Item
  - O’Malley, B. W., A. R. Means, S. H. Socher, T. C. Spelsberg, F. Chytil, J. P. Comstock, and W. M. Mitchell. “Hormonal control of oviduct growth and differentiation.” Symp Soc Dev Biol 30, no. 0 (1974): 53–77. https://doi.org/10.1016/b978-0-12-612973-1.50009-7.
    Full Text Link to Item
  - Tindall, D. J., W. T. Schrader, and A. R. Means. “The production of androgen binding protein by Sertoli Cells.” Curr Top Mol Endocrinol 1 (1974): 167–75. https://doi.org/10.1007/978-1-4684-2595-6_9.
    Full Text Link to Item
  - Woo, S. L., S. E. Harris, J. M. Rosen, L. Chan, P. J. Sperry, A. R. Means, and B. W. O’Malley. “Use of Sepharose 4B for preparative scale fractionation of eukaryotic messenger RNA's.” Prep Biochem 4, no. 6 (1974): 555–72. https://doi.org/10.1080/00327487408061554.
    Full Text Link to Item
  - Harris, S. E., A. R. Means, W. M. Mitchell, and B. W. O’Malley. “Synthesis of (3H)DNA complementary to ovalbumin messenger RNA: evidence for limited copies of the ovalbumin gene in chick oviduct.” Proc Natl Acad Sci U S A 70, no. 12 (December 1973): 3776–80. https://doi.org/10.1073/pnas.70.12.3776.
    Full Text Link to Item
  - Chan, L., A. R. Means, and B. W. O’Malley. “Rates of induction of specific translatable messenger RNAs for ovalbumin and avidin by steroid hormones.” Proc Natl Acad Sci U S A 70, no. 6 (June 1973): 1870–74. https://doi.org/10.1073/pnas.70.6.1870.
    Full Text Link to Item
  - Means, A. R. “Specific interaction of 3H-FSH with rat testis binding sites.” Adv Exp Med Biol 36, no. 0 (1973): 431–48. https://doi.org/10.1007/978-1-4684-3237-4_20.
    Full Text Link to Item
  - O’Malley, B. W., G. C. Rosenfeld, J. P. Comstock, and A. R. Means. “Steroid hormone induction of a specific translatable messenger RNA.” Nat New Biol 240, no. 97 (November 8, 1972): 45–48. https://doi.org/10.1038/newbio240045a0.
    Full Text Link to Item
  - Comstock, J. P., G. C. Rosenfeld, B. W. O’Malley, and A. R. Means. “Estrogen-induced changes in translation, and specific messenger RNA levels during oviduct differentiation.” Proc Natl Acad Sci U S A 69, no. 9 (September 1972): 2377–80. https://doi.org/10.1073/pnas.69.9.2377.
    Full Text Link to Item
  - Mills, N. C., and A. R. Means. “Sorbitol dehydrogenase of rat testis: changes of activity during development, after hypophysectomy and following gonadotrophic hormone administration.” Endocrinology 91, no. 1 (July 1972): 147–56. https://doi.org/10.1210/endo-91-1-147.
    Full Text Link to Item
  - Means, A. R., J. P. Comstock, G. C. Rosenfeld, and B. W. O’Malley. “Ovalbumin messenger RNA of chick oviduct: partial characterization, estrogen dependence, and translation in vitro.” Proc Natl Acad Sci U S A 69, no. 5 (May 1972): 1146–50. https://doi.org/10.1073/pnas.69.5.1146.
    Full Text Link to Item
  - Rosenfeld, G. C., J. P. Comstock, A. R. Means, and B. W. O’Malley. “A rapid method for the isolation and partial purification of specific eucaryotic messenger RNA's.” Biochem Biophys Res Commun 47, no. 2 (April 28, 1972): 387–92. https://doi.org/10.1016/0006-291x(72)90725-5.
    Full Text Link to Item
  - Means, A. R., and B. W. O’Malley. “Mechanism of estrogen action: early transcriptional and translational events.” Metabolism 21, no. 4 (April 1972): 357–70. https://doi.org/10.1016/0026-0495(72)90081-9.
    Full Text Link to Item
  - Rosenfeld, G. C., J. P. Comstock, A. R. Means, and B. W. O’Malley. “Estrogen-induced synthesis of ovalbumin messenger RNA and its translation in a cell-free system.” Biochem Biophys Res Commun 46, no. 4 (February 25, 1972): 1695–1703. https://doi.org/10.1016/0006-291x(72)90805-4.
    Full Text Link to Item
  - Comstock, J. P., B. W. O’Malley, and A. R. Means. “Stimulation of cell-free polypeptide synthesis by a protein fraction extracted from chick oviduct polyribosomes.” Biochemistry 11, no. 4 (February 15, 1972): 646–52. https://doi.org/10.1021/bi00754a029.
    Full Text Link to Item
  - O’Malley, B. W., G. C. Rosenfeld, J. P. Comstock, and A. R. Means. “Induction of specific translatable messenger RNA's by oestrogen and progesterone.” Acta Endocrinol Suppl (Copenh) 168 (1972): 381–95. https://doi.org/10.1530/acta.0.071s0381.
    Full Text Link to Item
  - Means, A. R., and J. Vaitukaitis. “Peptide hormone "receptors": specific binding of 3 H-FSH to testis.” Endocrinology 90, no. 1 (January 1972): 39–46. https://doi.org/10.1210/endo-90-1-39.
    Full Text Link to Item
  - Means, A. R., J. P. Comstock, and B. W. O’Malley. “Isolation of protein factors from oviduct polysomes which stimulate protein synthesis.” Biochem Biophys Res Commun 45, no. 3 (November 5, 1971): 759–66. https://doi.org/10.1016/0006-291x(71)90482-7.
    Full Text Link to Item
  - Means, A. R. “Concerning the mechanism of FSH action: rapid stimulation of testicular synthesis of nuclear RNA.” Endocrinology 89, no. 4 (October 1971): 981–89. https://doi.org/10.1210/endo-89-4-981.
    Full Text Link to Item
  - Leung, B. S., A. R. Means, and B. W. O’Malley. “Effect of cyclic adenosine 3',5'-monophosphate on the incorporation of 3H-leucine into polypeptides by beef thyroid polysomes in vitro.” Endocrinology 89, no. 1 (July 1971): 70–78. https://doi.org/10.1210/endo-89-1-70.
    Full Text Link to Item
  - Means, A. R., I. B. Abrass, and B. W. O’Malley. “Protein biosynthesis on chick oviduct polyribosomes. I. Changes during estrogen-mediated tissue differentiation.” Biochemistry 10, no. 9 (April 27, 1971): 1561–70. https://doi.org/10.1021/bi00785a009.
    Full Text Link to Item
  - Means, A. R., and B. W. O’Malley. “Protein biosynthesis on chick oviduct polyribosomes. II. Regulation by progesterone.” Biochemistry 10, no. 9 (April 27, 1971): 1570–76. https://doi.org/10.1021/bi00785a010.
    Full Text Link to Item
  - Means, A. R., and B. W. O’Malley. “Assessment of sex steroid action in vitro.” Acta Endocrinol Suppl (Copenh) 153 (1971): 318–36. https://doi.org/10.1530/acta.0.068s318.
    Full Text Link to Item
  - Means, A. R., and P. F. Hall. “Protein biosynthesis in the testis. V. Concerning the mechanism of stimulation by follicle-stimulating hormone.” Biochemistry 8, no. 11 (November 1969): 4293–98. https://doi.org/10.1021/bi00839a011.
    Full Text Link to Item
  - Means, A. R., and C. A. Baker. “Isolation of polyribosomes and characteristics of an amino acid-incorporation system from the liver of a primate (Papio papio).” Biochim Biophys Acta 182, no. 2 (June 17, 1969): 461–68. https://doi.org/10.1016/0005-2787(69)90198-1.
    Full Text Link to Item
  - Means, A. R., P. F. Hall, L. W. Nicol, W. H. Sawyer, and C. A. Baker. “Protein bisoynthesis in the testis. IV. Isolation and properties of polyribosomes.” Biochemistry 8, no. 4 (April 1969): 1488–95. https://doi.org/10.1021/bi00832a026.
    Full Text Link to Item
  - Means, A. R., and P. F. Hall. “Protein biosynthesis in the testis. 3. Dual effect of glucose.” Endocrinology 84, no. 2 (February 1969): 285–97. https://doi.org/10.1210/endo-84-2-285.
    Full Text Link to Item
  - Yokoe, Y., A. R. Means, and P. F. Hall. “The influence of follicle-stimulating hormone on testicular phospholipids.” Biochim Biophys Acta 187, no. 2 (1969): 278–80. https://doi.org/10.1016/0005-2760(69)90040-x.
    Full Text Link to Item
  - Means, A. R., and P. F. Hall. “Protein biosynthesis in the testis. II. Role of adenosine triphosphate (ATP) in stimulation by glucose.” Endocrinology 83, no. 1 (July 1968): 86–96. https://doi.org/10.1210/endo-83-1-86.
    Full Text Link to Item
  - Hamilton, T. H., C. S. Teng, and A. R. Means. “Early estrogen action: nuclear synthesis and accumulation of protein correlated with enhancement of two DNA-dependent RNA polymerase activities.” Proc Natl Acad Sci U S A 59, no. 4 (April 1968): 1265–72. https://doi.org/10.1073/pnas.59.4.1265.
    Full Text Link to Item
  - Means, A. R., and P. F. Hall. “Protein biosynthesis in the testis. I. Comparison between stimulation by FSH and glucose.” Endocrinology 82, no. 3 (March 1968): 597–602. https://doi.org/10.1210/endo-82-3-597.
    Full Text Link to Item
  - Means, A. R., and P. F. Hall. “Effect of FSH on protein biosynthesis in testes of the immature rat.” Endocrinology 81, no. 5 (November 1967): 1151–60. https://doi.org/10.1210/endo-81-5-1151.
    Full Text Link to Item
  - Means, A. R., and T. H. Hamilton. “Early estrogen action: concomitant stimulations within two minutes of nuclear RNA synthesis and uptake of RNA precursor by the uterus.” Proc Natl Acad Sci U S A 56, no. 5 (November 1966): 1594–98. https://doi.org/10.1073/pnas.56.5.1594.
    Full Text Link to Item
  - Ewing, L. L., A. R. Means, C. G. Beames, and R. D. Montgomery. “Biochemical changes in rat testis during postnatal maturation.” J Reprod Fertil 12, no. 2 (October 1966): 295–307. https://doi.org/10.1530/jrf.0.0120295.
    Full Text Link to Item
  - Means, A. R., and T. H. Hamilton. “Evidence for depression of nuclear protein synthesis and concomitant stimulation of nuclear RNA synthesis during early estrogen action.” Proc Natl Acad Sci U S A 56, no. 2 (August 1966): 686–93. https://doi.org/10.1073/pnas.56.2.686.
    Full Text Link to Item
  - Hamilton, T. H., R. J. Moore, A. F. Rumsey, A. R. Means, and A. R. Schrank. “Stimulation of synthesis of ribonucleic acid in sub-apical sections of Avena coleoptile by indolyl-3-acetic acid.” Nature 208, no. 5016 (December 18, 1965): 1180–83. https://doi.org/10.1038/2081180a0.
    Full Text Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Previous Appointments & Affiliations

Academic Positions Outside Duke

Awards & Honors

Selected Grants

Selected Publications

Academic Articles