Scanning electron microscopic study of the airways in normal children and in patients with cystic fibrosis and other lung diseases.

Journal Article (Journal Article)

Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to examine pulmonary tissue from 9 patients with cystic fibrosis (CF), 12 patients with diseases other than CF, and from two surgically resected specimens with no known airways disease. A region of the human airways, the transition zone, was observed between the end of the terminal bronchiole and the type II alveolar cell lining of the respiratory bronchioles. This region was lined predominantly by nonciliated bronchiolar (NCB) cells. Patients with CF exhibited indistinct transition zones, epidermoid metaplasia, large dilated bronchial glands, copious surface mucus, alveolar destruction, and unusual microvilli; no single lesion specific for cystic fibrosis was identified.

Full Text

Duke Authors

Cited Authors

  • Simel, DL; Mastin, JP; Pratt, PC; Wisseman, CL; Shelburne, JD; Spock, A; Ingram, P

Published Date

  • 1984

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 47 - 64

PubMed ID

  • 6542212

International Standard Serial Number (ISSN)

  • 0277-0938

Digital Object Identifier (DOI)

  • 10.3109/15513818409041187


  • eng

Conference Location

  • United States