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The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-alpha and interferon-beta.

Publication ,  Journal Article
Sarzotti, M; Coppenhaver, DH; Singh, IP; Poast, J; Baron, S
Published in: J Interferon Res
June 1989

An interferon (IFN) inducer and immunomodulator, CL246,738 [3,6-bis(2-piperidinoethoxy)acridine trihydrochloride], protected mice from lethal infection with Semliki Forest (SFV) and Banzi (BZV) viruses. A single oral dose of CL246,738 (5-150 mg/kg) administered 24 h before intraperitoneal challenge with SFV or BZV fully protected mice from lethal infection. Dose-dependent levels of circulating IFN peaked at 24 h in the serum and peritoneal fluid of CL246,738-treated mice. The circulating IFN of CL246,738-treated mice consisted of IFN-alpha and was produced by spleen cells. Peritoneal exudate cells (PEC) obtained from CL246,738-treated mice produced IFN-beta. Treatment in vivo with anti-IFN-alpha/beta and anti-IFN-beta reversed the protective effect of CL246,738 against lethal SFV encephalitis.

Duke Scholars

Published In

J Interferon Res

DOI

ISSN

0197-8357

Publication Date

June 1989

Volume

9

Issue

3

Start / End Page

265 / 274

Location

United States

Related Subject Headings

  • Togaviridae Infections
  • Semliki forest virus
  • Peritoneal Cavity
  • Mice
  • Interferon Type I
  • Interferon Inducers
  • Flavivirus
  • Female
  • Encephalitis
  • Dose-Response Relationship, Drug
 

Citation

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Sarzotti, M., Coppenhaver, D. H., Singh, I. P., Poast, J., & Baron, S. (1989). The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-alpha and interferon-beta. J Interferon Res, 9(3), 265–274. https://doi.org/10.1089/jir.1989.9.265
Sarzotti, M., D. H. Coppenhaver, I. P. Singh, J. Poast, and S. Baron. “The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-alpha and interferon-beta.J Interferon Res 9, no. 3 (June 1989): 265–74. https://doi.org/10.1089/jir.1989.9.265.
Sarzotti M, Coppenhaver DH, Singh IP, Poast J, Baron S. The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-alpha and interferon-beta. J Interferon Res. 1989 Jun;9(3):265–74.
Sarzotti, M., et al. “The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-alpha and interferon-beta.J Interferon Res, vol. 9, no. 3, June 1989, pp. 265–74. Pubmed, doi:10.1089/jir.1989.9.265.
Sarzotti M, Coppenhaver DH, Singh IP, Poast J, Baron S. The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-alpha and interferon-beta. J Interferon Res. 1989 Jun;9(3):265–274.

Published In

J Interferon Res

DOI

ISSN

0197-8357

Publication Date

June 1989

Volume

9

Issue

3

Start / End Page

265 / 274

Location

United States

Related Subject Headings

  • Togaviridae Infections
  • Semliki forest virus
  • Peritoneal Cavity
  • Mice
  • Interferon Type I
  • Interferon Inducers
  • Flavivirus
  • Female
  • Encephalitis
  • Dose-Response Relationship, Drug