The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-alpha and interferon-beta.

Journal Article (Journal Article)

An interferon (IFN) inducer and immunomodulator, CL246,738 [3,6-bis(2-piperidinoethoxy)acridine trihydrochloride], protected mice from lethal infection with Semliki Forest (SFV) and Banzi (BZV) viruses. A single oral dose of CL246,738 (5-150 mg/kg) administered 24 h before intraperitoneal challenge with SFV or BZV fully protected mice from lethal infection. Dose-dependent levels of circulating IFN peaked at 24 h in the serum and peritoneal fluid of CL246,738-treated mice. The circulating IFN of CL246,738-treated mice consisted of IFN-alpha and was produced by spleen cells. Peritoneal exudate cells (PEC) obtained from CL246,738-treated mice produced IFN-beta. Treatment in vivo with anti-IFN-alpha/beta and anti-IFN-beta reversed the protective effect of CL246,738 against lethal SFV encephalitis.

Full Text

Duke Authors

Cited Authors

  • Sarzotti, M; Coppenhaver, DH; Singh, IP; Poast, J; Baron, S

Published Date

  • June 1989

Published In

Volume / Issue

  • 9 / 3

Start / End Page

  • 265 - 274

PubMed ID

  • 2545791

Pubmed Central ID

  • 2545791

International Standard Serial Number (ISSN)

  • 0197-8357

Digital Object Identifier (DOI)

  • 10.1089/jir.1989.9.265

Language

  • eng

Conference Location

  • United States