Skip to main content

Marcella Sarzotti-Kelsoe

Research Professor of Integrative Immunobiology
Integrative Immunobiology
DUMC Box 102800, Durham, NC 27710
2812 Erwin Rd., Suite 301, Durham, NC 27705


Ongoing Applied Activities 
•I direct a Global Quality Assurance Program, which I developed and pioneered here at Duke University, to oversee compliance with Good Clinical Laboratory Practice Guidelines in three HIV vaccine trial networks (CHAVI, CAVD, Duke HVTN, EQAPOL, Duke VTEU) involving domestic and international laboratory sites.
•I also direct a Global Proficiency Testing Program for laboratories testing for neutralizing antibody function in individuals infected with HIV or vaccinated against HIV. The Program was launched in 2009.
•I provide assistance and oversight for endpoint assay standardization, qualification and validation, as well as for the QSU of the GMP facility at DHVI, which will manufacture HIV vaccine products for first-in-man Phase I trials.

Past Basic Research
•Development of T cell responses in neonates.
•Neonatal T cell receptor Vβ repertoire diversity in the peripheral T cell pool.
•The role of heat shock protein, as a natural adjuvant, at eliciting innate and adaptive immune responses.
•Development of the T cell receptor repertoire in naïve, immunodeficient infants, given bone marrow or thymic transplantation.
•Thymic output, T cell diversity and T cell function in long-term human SCID chimeras.
•Telomere length in T cells from SCID chimeras.

Current Appointments & Affiliations

Research Professor of Integrative Immunobiology · 2013 - Present Integrative Immunobiology, Basic Science Departments
Associate Professor in Surgery · 2020 - Present Surgery, Clinical Science Departments
Member of the Duke Human Vaccine Institute · 2006 - Present Duke Human Vaccine Institute, Institutes and Centers

Education, Training & Certifications

University of Turin (Italy) · 1986 D.R.
University of Turin (Italy) · 1980 Ph.D.