T cell immunity in neonates.

Journal Article (Journal Article;Review)

Typically, neonates exhibit decreased or aberrant cellular immune responses when compared to adults, resulting in increased susceptibility to infection. However, it is clear that newborns are able to generate adult-like protective T cell responses under certain conditions. The focus of our research is to understand the deficiencies within the neonatal immune system that lead to improper cellular responses and how priming conditions can be altered to elicit the appropriate T cell response necessary to protect against development of pathogen-induced disease. With these goals in mind, we are exploring the attributes of neonatal T cells and their development, as well as the conditions during priming that influence the resulting response to immune challenge during the neonatal period.

Full Text

Duke Authors

Cited Authors

  • Garcia, AM; Fadel, SA; Cao, S; Sarzotti, M

Published Date

  • 2000

Published In

Volume / Issue

  • 22 / 2-3

Start / End Page

  • 177 - 190

PubMed ID

  • 11339354

International Standard Serial Number (ISSN)

  • 0257-277X

Digital Object Identifier (DOI)

  • 10.1385/IR:22:2-3:177


  • eng

Conference Location

  • United States