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Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior.

Publication ,  Journal Article
Murphy, SK; Wylie, AA; Jirtle, RL
Published in: Genomics
January 1, 2001

The paternally expressed Peg3 gene in mice encodes an unusual Krüppel-type zinc finger protein implicated in critical cellular and behavioral functions including growth, apoptosis, and maternal nurturing behavior. Methylation and expression analyses were used to determine whether PEG3 on chromosome 19q13.4 is imprinted in humans. The PEG3 promoter is encompassed within a large CpG-rich region that is differentially methylated in fetal tissues. Furthermore, expression studies demonstrate that PEG3 is ubiquitously imprinted throughout development and postnatally. Multiple isoforms of the PEG3 gene, including a novel transcript, are paternally expressed. These results are the first to show that human chromosome 19q13.4 contains an imprinted region. The imprinted status of PEG3 throughout life coupled with its neural expression and putative roles in regulating cell growth suggests that PEG3 may be a susceptibility locus for cancer as well as neurobehavioral deficits.

Duke Scholars

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

January 1, 2001

Volume

71

Issue

1

Start / End Page

110 / 117

Location

United States

Related Subject Headings

  • Transcription Factors
  • Tissue Distribution
  • Testis
  • Sequence Analysis, DNA
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Proteins
  • Protein Kinases
  • Protein Isoforms
  • Promoter Regions, Genetic
 

Citation

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Murphy, S. K., Wylie, A. A., & Jirtle, R. L. (2001). Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior. Genomics, 71(1), 110–117. https://doi.org/10.1006/geno.2000.6419
Murphy, S. K., A. A. Wylie, and R. L. Jirtle. “Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior.Genomics 71, no. 1 (January 1, 2001): 110–17. https://doi.org/10.1006/geno.2000.6419.
Murphy SK, Wylie AA, Jirtle RL. Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior. Genomics. 2001 Jan 1;71(1):110–7.
Murphy, S. K., et al. “Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior.Genomics, vol. 71, no. 1, Jan. 2001, pp. 110–17. Pubmed, doi:10.1006/geno.2000.6419.
Murphy SK, Wylie AA, Jirtle RL. Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior. Genomics. 2001 Jan 1;71(1):110–117.
Journal cover image

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

January 1, 2001

Volume

71

Issue

1

Start / End Page

110 / 117

Location

United States

Related Subject Headings

  • Transcription Factors
  • Tissue Distribution
  • Testis
  • Sequence Analysis, DNA
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Proteins
  • Protein Kinases
  • Protein Isoforms
  • Promoter Regions, Genetic