Gene-environment interplay and psychopathology: multiple varieties but real effects.

Journal Article (Review;Journal Article)

Gene-environment interplay is a general term that covers several divergent concepts with different meanings and different implications. In this review, we evaluate research evidence on four varieties of gene-environment interplay. First, we consider epigenetic mechanisms by which environmental influences alter the effects of genes. Second, we focus on variations in heritability according to environmental circumstances. Third, we discuss what is known about gene-environment correlations. Finally, we assess concepts and findings on the interaction between specific identified genes and specific measured environmental risks. In order to provide an understanding of what may be involved in gene-environment interplay, we begin our presentation with a brief historical review of prevailing views about the role of genetic and environmental factors in the causation of mental disorders, and we provide a simplified account of some of the key features of how genes 'work'.

Full Text

Duke Authors

Cited Authors

  • Rutter, M; Moffitt, TE; Caspi, A

Published Date

  • March 2006

Published In

Volume / Issue

  • 47 / 3-4

Start / End Page

  • 226 - 261

PubMed ID

  • 16492258

Electronic International Standard Serial Number (EISSN)

  • 1469-7610

International Standard Serial Number (ISSN)

  • 0021-9630

Digital Object Identifier (DOI)

  • 10.1111/j.1469-7610.2005.01557.x


  • eng