On the relation between seizures and brain lesions after intracerebroventricular kainic acid.

Journal Article

To analyze the relation between kainic acid-induced limbic seizures and the associated brain lesions, various doses of kainic acid (117-940 pmol) were administered intracerebroventricularly to unanesthetized rats. Rats which experienced status epilepticus developed lesions in several limbic, neocortical and thalamic regions. However, rats which experienced only temporally discrete seizures (less than 30 min each) suffered neuronal degeneration exclusively in the CA3-CA4 area ipsilateral to the kainic acid infusion, even when other regions exhibited the same total electrographic seizure duration. These results can best be explained by postulating that, in addition to evoking seizures, kainic acid also enhances the toxic effects of seizures on CA3-CA4 neurons.

Full Text

Duke Authors

Cited Authors

  • Sater, RA; Nadler, JV

Published Date

  • January 11, 1988

Published In

Volume / Issue

  • 84 / 1

Start / End Page

  • 73 - 78

PubMed ID

  • 3347375

International Standard Serial Number (ISSN)

  • 0304-3940

Language

  • eng

Conference Location

  • Ireland