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On the relation between seizures and brain lesions after intracerebroventricular kainic acid.

Publication ,  Journal Article
Sater, RA; Nadler, JV
Published in: Neurosci Lett
January 11, 1988

To analyze the relation between kainic acid-induced limbic seizures and the associated brain lesions, various doses of kainic acid (117-940 pmol) were administered intracerebroventricularly to unanesthetized rats. Rats which experienced status epilepticus developed lesions in several limbic, neocortical and thalamic regions. However, rats which experienced only temporally discrete seizures (less than 30 min each) suffered neuronal degeneration exclusively in the CA3-CA4 area ipsilateral to the kainic acid infusion, even when other regions exhibited the same total electrographic seizure duration. These results can best be explained by postulating that, in addition to evoking seizures, kainic acid also enhances the toxic effects of seizures on CA3-CA4 neurons.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

January 11, 1988

Volume

84

Issue

1

Start / End Page

73 / 78

Location

Ireland

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Neurons
  • Nerve Degeneration
  • Male
  • Limbic System
  • Kainic Acid
  • Injections, Intraventricular
  • Electroencephalography
 

Citation

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MLA
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Sater, R. A., & Nadler, J. V. (1988). On the relation between seizures and brain lesions after intracerebroventricular kainic acid. Neurosci Lett, 84(1), 73–78. https://doi.org/10.1016/0304-3940(88)90340-0
Sater, R. A., and J. V. Nadler. “On the relation between seizures and brain lesions after intracerebroventricular kainic acid.Neurosci Lett 84, no. 1 (January 11, 1988): 73–78. https://doi.org/10.1016/0304-3940(88)90340-0.
Sater RA, Nadler JV. On the relation between seizures and brain lesions after intracerebroventricular kainic acid. Neurosci Lett. 1988 Jan 11;84(1):73–8.
Sater, R. A., and J. V. Nadler. “On the relation between seizures and brain lesions after intracerebroventricular kainic acid.Neurosci Lett, vol. 84, no. 1, Jan. 1988, pp. 73–78. Pubmed, doi:10.1016/0304-3940(88)90340-0.
Sater RA, Nadler JV. On the relation between seizures and brain lesions after intracerebroventricular kainic acid. Neurosci Lett. 1988 Jan 11;84(1):73–78.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

January 11, 1988

Volume

84

Issue

1

Start / End Page

73 / 78

Location

Ireland

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Neurons
  • Nerve Degeneration
  • Male
  • Limbic System
  • Kainic Acid
  • Injections, Intraventricular
  • Electroencephalography