Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Yale University 1972
• 

  Duke Appointment History

  • Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1990 - 2014
  • Professor of Neurobiology, Neurobiology, Basic Science Departments 1994 - 2014
  • Associate Professor in Neurobiology, Neurobiology, Basic Science Departments 1994
  • Associate Professor in the Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1983 - 1990
  • Assistant Professor in the Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1978 - 1983
• Recognition
• 

  Awards & Honors

  • Epilepsy Research Award for Outstanding Contributions to the Pharmacology of Antiepileptic Drugs. American Society for Pharmacology and Experimental Therapeutics. 2005
• Research
• 

  Selected Grants

  • Gender Differences in Stimulant Action awarded by National Institutes of Health 1998 - 2013
  • Ectopic Granule Cells in Epilepsy awarded by National Institutes of Health 2009 - 2011
  • Dentate Granule Cell Network in Epilepsy awarded by National Institutes of Health 1999 - 2009
  • ASPARTATE TRANSMISSION awarded by National Institutes of Health 2004 - 2006
  • Transient Cerebral Ischemia & GABA Neurotransmission awarded by National Institutes of Health 2000 - 2006
  • Limbic epilepsy: A neurobiologic approach awarded by National Institutes of Health 1995 - 2000
  • Excitatory Amino Acid Transmitters In Cns awarded by National Institutes of Health 1995 - 2000
  • Investigation of a CNS L-Proline Transporter awarded by National Institutes of Health 1993 - 1999
  • Limbic Epilepsy: A Neurobiologic Approach awarded by National Institutes of Health 1995 - 1999
  • Shared Instrumentation For Confocal Ion Imaging In Living awarded by  National Science Foundation 1994 - 1996
  • Limbic Epilepsy: A Neurobiologic Approach awarded by National Institutes of Health 1990 - 1995
  • Duke-Va Center For Cerebrovascular Research/Catecholamine awarded by National Institutes of Health 1990 - 1992
  • Shared Instrumentation For Anatomical Studies awarded by  National Science Foundation 1987 - 1988
• Publications & Artistic Works
• 

  Selected Publications

  • Books

    • Nadler, J. V., and D. D. Spencer. What is a seizure focus? Vol. 813, 2014. https://doi.org/10.1007/978-94-017-8914-1-4.
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    • Nadler, J. V., and D. D. Spencer. What is a seizure focus? Vol. 813, 2014. https://doi.org/10.1007/978-94-17-8914-1_4.
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  • Academic Articles

    • Hunanyan, Arsen S., Ashley R. Helseth, Elie Abdelnour, Bassil Kherallah, Monisha Sachdev, Leeyup Chung, Melanie Masoud, et al. “Mechanisms of increased hippocampal excitability in the Mashl+/- mouse model of Na+ /K+ -ATPase dysfunction.” Epilepsia 59, no. 7 (July 2018): 1455–68. https://doi.org/10.1111/epi.14441.
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    • Dingledine, Raymond, Douglas A. Coulter, Brita Fritsch, Jan A. Gorter, Nadia Lelutiu, James McNamara, J Victor Nadler, et al. “Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models.” Sci Data 4 (May 9, 2017): 170061. https://doi.org/10.1038/sdata.2017.61.
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    • Wang, Xiaochen, Xinyu Song, Lin Wu, J Victor Nadler, and Ren-Zhi Zhan. “Persistent Hyperactivity of Hippocampal Dentate Interneurons After a Silent Period in the Rat Pilocarpine Model of Epilepsy.” Front Cell Neurosci 10 (2016): 94. https://doi.org/10.3389/fncel.2016.00094.
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    • Nadler, J Victor, and Dennis D. Spencer. “What is a seizure focus?” Adv Exp Med Biol 813 (2014): 55–62. https://doi.org/10.1007/978-94-017-8914-1_4.
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    • Cameron, Michael C., Ren-Zhi Zhan, and J Victor Nadler. “Morphologic integration of hilar ectopic granule cells into dentate gyrus circuitry in the pilocarpine model of temporal lobe epilepsy.” J Comp Neurol 519, no. 11 (August 1, 2011): 2175–92. https://doi.org/10.1002/cne.22623.
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    • Nadler, J Victor. “Aspartate release and signalling in the hippocampus.” Neurochem Res 36, no. 4 (April 2011): 668–76. https://doi.org/10.1007/s11064-010-0291-3.
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    • Ribak, C. E., L. A. Shapiro, X. X. Yan, K. Dashtipour, J. V. Nadler, A. Obenaus, I. Spigelman, and P. S. Buckmaster. “Seizure-induced basal dendrites on granule cells.” Epilepsia 51, no. SUPPL. 5 (December 1, 2010): 43. https://doi.org/10.1111/j.1528-1167.2010.02829.x.
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    • Victor Nadler, J. “Plasticity of glutamate synaptic mechanisms.” Epilepsia 51, no. SUPPL. 5 (December 1, 2010): 17. https://doi.org/10.1111/j.1528-1167.2010.02803.x.
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    • Zhan, Ren-Zhi, Olga Timofeeva, and J Victor Nadler. “High ratio of synaptic excitation to synaptic inhibition in hilar ectopic granule cells of pilocarpine-treated rats.” J Neurophysiol 104, no. 6 (December 2010): 3293–3304. https://doi.org/10.1152/jn.00663.2010.
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    • Zhang, Xuying, and J Victor Nadler. “Postsynaptic response to stimulation of the Schaffer collaterals with properties similar to those of synaptosomal aspartate release.” Brain Res 1295 (October 27, 2009): 13–20. https://doi.org/10.1016/j.brainres.2009.07.104.
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    • Zhan, Ren-Zhi, and J Victor Nadler. “Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus.” J Neurophysiol 102, no. 2 (August 2009): 670–81. https://doi.org/10.1152/jn.00147.2009.
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    • Zhan, Ren-Zhi, J Victor Nadler, and Rochelle D. Schwartz-Bloom. “Impaired firing and sodium channel function in CA1 hippocampal interneurons after transient cerebral ischemia.” Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 27, no. 8 (August 2007): 1444–52. https://doi.org/10.1038/sj.jcbfm.9600448.
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    • Jiao, Yiqun, and J Victor Nadler. “Stereological analysis of GluR2-immunoreactive hilar neurons in the pilocarpine model of temporal lobe epilepsy: correlation of cell loss with mossy fiber sprouting.” Exp Neurol 205, no. 2 (June 2007): 569–82. https://doi.org/10.1016/j.expneurol.2007.03.025.
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    • Wang, Lulu, and J Victor Nadler. “Reduced aspartate release from rat hippocampal synaptosomes loaded with Clostridial toxin light chain by electroporation: evidence for an exocytotic mechanism.” Neurosci Lett 412, no. 3 (February 2, 2007): 239–42. https://doi.org/10.1016/j.neulet.2006.11.006.
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    • Nadler, J Victor, Bin Tu, Olga Timofeeva, Yiqun Jiao, and Herbert Herzog. “Neuropeptide Y in the recurrent mossy fiber pathway.” Peptides 28, no. 2 (February 2007): 357–64. https://doi.org/10.1016/j.peptides.2006.07.026.
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    • Nadler, J. V. “Excitatory Amino Acids,” January 1, 2007, 970–75. https://doi.org/10.1016/B978-012373947-6.00151-3.
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    • Tu, B., Y. Jiao, H. Herzog, and J. V. Nadler. “Neuropeptide Y regulates recurrent mossy fiber synaptic transmission less effectively in mice than in rats: Correlation with Y2 receptor plasticity.” Neuroscience 143, no. 4 (December 2006): 1085–94. https://doi.org/10.1016/j.neuroscience.2006.08.036.
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    • Timofeeva, Olga, and J Victor Nadler. “Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy.” Brain Res 1078, no. 1 (March 17, 2006): 227–34. https://doi.org/10.1016/j.brainres.2006.01.051.
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    • Zhan, Ren-Zhi, J Victor Nadler, and Rochelle D. Schwartz-Bloom. “Depressed responses to applied and synaptically-released GABA in CA1 pyramidal cells, but not in CA1 interneurons, after transient forebrain ischemia.” Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 26, no. 1 (January 2006): 112–24. https://doi.org/10.1038/sj.jcbfm.9600171.
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    • Tu, Bin, Olga Timofeeva, Yiqun Jiao, and J Victor Nadler. “Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain.” J Neurosci 25, no. 7 (February 16, 2005): 1718–29. https://doi.org/10.1523/JNEUROSCI.4835-04.2005.
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    • Bradford, S. E., and J. V. Nadler. “Aspartate release from rat hippocampal synaptosomes.” Neuroscience 128, no. 4 (January 2004): 751–65. https://doi.org/10.1016/j.neuroscience.2004.06.065.
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    • Nadler, J Victor. “The recurrent mossy fiber pathway of the epileptic brain.” Neurochem Res 28, no. 11 (November 2003): 1649–58. https://doi.org/10.1023/a:1026004904199.
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    • Feng, Li, Peter Molnár, and J Victor Nadler. “Short-term frequency-dependent plasticity at recurrent mossy fiber synapses of the epileptic brain.” J Neurosci 23, no. 12 (June 15, 2003): 5381–90.
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    • Dashtipour, Khashayar, Xiao-Xin Yan, Trinh T. Dinh, Maxine M. Okazaki, J Victor Nadler, and Charles E. Ribak. “Quantitative and morphological analysis of dentate granule cells with recurrent basal dendrites from normal and epileptic rats.” Hippocampus 12, no. 2 (2002): 235–44. https://doi.org/10.1002/hipo.1114.
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    • Okazaki, M. M., and J. V. Nadler. “Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation.” Brain Research 915, no. 1 (October 2001): 58–69. https://doi.org/10.1016/s0006-8993(01)02824-4.
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    • Molnár, P., and J. V. Nadler. “Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses.” Brain Research 910, no. 1–2 (August 2001): 205–7. https://doi.org/10.1016/s0006-8993(01)02720-2.
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    • Molnár, P., and J. V. Nadler. “Lack of effect of mossy fiber-released zinc on granule cell GABA(A) receptors in the pilocarpine model of epilepsy.” J Neurophysiol 85, no. 5 (May 2001): 1932–40. https://doi.org/10.1152/jn.2001.85.5.1932.
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    • Dashtipour, K., P. H. Tran, M. M. Okazaki, J. V. Nadler, and C. E. Ribak. “Ultrastructural features and synaptic connections of hilar ectopic granule cells in the rat dentate gyrus are different from those of granule cells in the granule cell layer.” Brain Research 890, no. 2 (February 2001): 261–71. https://doi.org/10.1016/s0006-8993(00)03119-x.
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    • Ribak, C. E., P. H. Tran, I. Spigelman, M. M. Okazaki, and J. V. Nadler. “Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry.” J Comp Neurol 428, no. 2 (December 11, 2000): 240–53. https://doi.org/10.1002/1096-9861(20001211)428:2<240::aid-cne4>3.0.co;2-q.
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    • Hardison, J. L., M. M. Okazaki, and J. V. Nadler. “Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth.” J Neurophysiol 84, no. 5 (November 2000): 2380–89. https://doi.org/10.1152/jn.2000.84.5.2380.
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    • Molnár, P., and J. V. Nadler. “gamma-Aminobutyrate, alpha-carboxy-2-nitrobenzyl ester selectively blocks inhibitory synaptic transmission in rat dentate gyrus.” European Journal of Pharmacology 391, no. 3 (March 2000): 255–62. https://doi.org/10.1016/s0014-2999(00)00106-0.
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    • Schwartz-Bloom, R. D., K. A. Miller, D. A. Evenson, B. J. Crain, and J. V. Nadler. “Benzodiazepines protect hippocampal neurons from degeneration after transient cerebral ischemia: an ultrastructural study.” Neuroscience 98, no. 3 (January 2000): 471–84. https://doi.org/10.1016/s0306-4522(00)00144-5.
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    • Molnár, P., and J. V. Nadler. “Mossy fiber-granule cell synapses in the normal and epileptic rat dentate gyrus studied with minimal laser photostimulation.” J Neurophysiol 82, no. 4 (October 1999): 1883–94. https://doi.org/10.1152/jn.1999.82.4.1883.
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    • Gogos, J. A., M. Santha, Z. Takacs, K. D. Beck, V. Luine, L. R. Lucas, J. V. Nadler, and M. Karayiorgou. “The gene encoding proline dehydrogenase modulates sensorimotor gating in mice.” Nat Genet 21, no. 4 (April 1999): 434–39. https://doi.org/10.1038/7777.
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    • Okazaki, M. M., P. Molnár, and J. V. Nadler. “Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth.” J Neurophysiol 81, no. 4 (April 1999): 1645–60. https://doi.org/10.1152/jn.1999.81.4.1645.
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    • Cohen, S. M., and J. V. Nadler. “Proline-induced inhibition of glutamate release in hippocampal area CA1.” Brain Research 769, no. 2 (September 1997): 333–39. https://doi.org/10.1016/s0006-8993(97)00721-x.
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    • Cohen, S. M., and J. V. Nadler. “Proline-induced potentiation of glutamate transmission.” Brain Research 761, no. 2 (July 1997): 271–82. https://doi.org/10.1016/s0006-8993(97)00352-1.
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    • Cohen, S. M., and J. V. Nadler. “Sodium-dependent proline and glutamate uptake by hippocampal synaptosomes during postnatal development.” Brain Research. Developmental Brain Research 100, no. 2 (June 1997): 230–33. https://doi.org/10.1016/s0165-3806(97)00045-x.
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    • Kraus, J. E., J. V. Nadler, and J. O. McNamara. “Regulation of alternative splicing of NMDAR1 in the kindling model.” Brain Res Mol Brain Res 41, no. 1–2 (September 5, 1996): 97–104. https://doi.org/10.1016/0169-328x(96)00072-1.
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    • Fremeau, R. T., M. Velaz-Faircloth, J. W. Miller, V. A. Henzi, S. M. Cohen, J. V. Nadler, S. Shafqat, R. D. Blakely, and B. Domin. “A novel nonopioid action of enkephalins: competitive inhibition of the mammalian brain high affinity L-proline transporter.” Mol Pharmacol 49, no. 6 (June 1996): 1033–41.
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    • Bowe, M. A., and J. V. Nadler. “Polyamines antagonize N-methyl-D-aspartate-evoked depolarizations, but reduce Mg2+ block.” Eur J Pharmacol 278, no. 1 (May 4, 1995): 55–65. https://doi.org/10.1016/0014-2999(95)00102-q.
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    • Zhou, M., C. L. Peterson, Y. B. Lu, and J. V. Nadler. “Release of glutamate and aspartate from CA1 synaptosomes: selective modulation of aspartate release by ionotropic glutamate receptor ligands.” Journal of Neurochemistry 64, no. 4 (April 1995): 1556–66. https://doi.org/10.1046/j.1471-4159.1995.64041556.x.
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    • Peterson, C. L., M. A. Thompson, D. Martin, and J. V. Nadler. “Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism.” Journal of Neurochemistry 64, no. 3 (March 1995): 1152–60. https://doi.org/10.1046/j.1471-4159.1995.64031152.x.
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    • Okazaki, M. M., D. A. Evenson, and J. V. Nadler. “Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: visualization after retrograde transport of biocytin.” J Comp Neurol 352, no. 4 (February 20, 1995): 515–34. https://doi.org/10.1002/cne.903520404.
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    • Kraus, J. E., G. C. Yeh, D. W. Bonhaus, J. V. Nadler, and J. O. McNamara. “Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3.” J Neurosci 14, no. 7 (July 1994): 4196–4205.
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    • Nadler, J. V., M. A. Thompson, and J. O. McNamara. “Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists.” Neuropharmacology 33, no. 2 (February 1994): 147–53. https://doi.org/10.1016/0028-3908(94)90001-9.
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    • Martin, D., M. A. Thompson, and J. V. Nadler. “The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1.” Eur J Pharmacol 250, no. 3 (December 21, 1993): 473–76. https://doi.org/10.1016/0014-2999(93)90037-i.
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    • Martin, D., B. Ault, and J. V. Nadler. “NMDA receptor-mediated depolarizing action of proline on CA1 pyramidal cells.” Eur J Pharmacol 219, no. 1 (August 14, 1992): 59–66. https://doi.org/10.1016/0014-2999(92)90580-w.
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    • Nadler, J. V., S. D. Bray, and D. A. Evenson. “Autoradiographic localization of proline uptake in excitatory hippocampal pathways.” Hippocampus 2, no. 3 (July 1992): 269–78. https://doi.org/10.1002/hipo.450020306.
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    • Martin, D., J. O. McNamara, and J. V. Nadler. “Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA.” J Neurosci 12, no. 5 (May 1992): 1928–35.
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    • McNamara, J. O., R. Morrisett, and J. V. Nadler. “Recent advances in understanding mechanisms of the kindling model.” Adv Neurol 57 (1992): 555–60.
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    • Warner, M. A., K. H. Neill, J. V. Nadler, and B. J. Crain. “Regionally selective effects of NMDA receptor antagonists against ischemic brain damage in the gerbil.” J Cereb Blood Flow Metab 11, no. 4 (July 1991): 600–610. https://doi.org/10.1038/jcbfm.1991.110.
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    • Martin, D., G. A. Bustos, M. A. Bowe, S. D. Bray, and J. V. Nadler. “Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area.” J Neurochem 56, no. 5 (May 1991): 1647–55. https://doi.org/10.1111/j.1471-4159.1991.tb02063.x.
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    • Hosford, D. A., B. J. Crain, Z. Cao, D. W. Bonhaus, A. H. Friedman, M. M. Okazaki, J. V. Nadler, and J. O. McNamara. “Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus.” J Neurosci 11, no. 2 (February 1991): 428–34.
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    • Aitken, P. G., D. B. Jaffe, and J. V. Nadler. “Cholecystokinin blocks some effects of kainic acid in CA3 region of hippocampal slices.” Peptides 12, no. 1 (January 1991): 127–29. https://doi.org/10.1016/0196-9781(91)90178-r.
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    • Martin, D., and J. V. Nadler. “Grease-Gap Methods for Studying Pharmacology of Excitatory Amino Acids on Central Nervous System Neurons” 4, no. C (January 1, 1991): 349–64. https://doi.org/10.1016/B978-0-12-185257-3.50026-4.
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    • Urban, L., K. H. Neill, B. J. Crain, J. V. Nadler, and G. G. Somjen. “Postischemic synaptic excitation and N-methyl-D-aspartate receptor activation in gerbils.” Stroke 21, no. 11 Suppl (November 1990): III23–27.
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    • Bowe, M. A., and J. V. Nadler. “Developmental increase in the sensitivity to magnesium of NMDA receptors on CA1 hippocampal pyramidal cells.” Brain Res Dev Brain Res 56, no. 1 (October 1, 1990): 55–61. https://doi.org/10.1016/0165-3806(90)90164-t.
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    • Neill, K. H., B. J. Crain, and J. V. Nadler. “A simple, inexpensive method of monitoring brain temperature in conscious rodents.” J Neurosci Methods 33, no. 2–3 (August 1990): 179–83. https://doi.org/10.1016/0165-0270(90)90022-8.
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    • Vicedomini, J. P., and J. V. Nadler. “Stimulation-induced status epilepticus: role of the hippocampal mossy fibers in the seizures and associated neuropathology.” Brain Res 512, no. 1 (March 26, 1990): 70–74. https://doi.org/10.1016/0006-8993(90)91171-c.
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    • Crain, B. J., D. A. Evenson, K. Polsky, and J. V. Nadler. “Electron microscopic study of the gerbil dentate gyrus after transient forebrain ischemia.” Acta Neuropathol 79, no. 4 (1990): 409–17. https://doi.org/10.1007/bf00308717.
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    • Lin, C. S., K. Polsky, J. V. Nadler, and B. J. Crain. “Selective neocortical and thalamic cell death in the gerbil after transient ischemia.” Neuroscience 35, no. 2 (1990): 289–99. https://doi.org/10.1016/0306-4522(90)90083-g.
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    • McNamara, J. O., G. Yeh, D. W. Bonhaus, M. Okazaki, and J. V. Nadler. “NMDA receptor plasticity in the kindling model.” Adv Exp Med Biol 268 (1990): 451–59. https://doi.org/10.1007/978-1-4684-5769-8_50.
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    • Nadler, J. V., D. Martin, G. A. Bustos, S. P. Burke, and M. A. Bowe. “Regulation of glutamate and aspartate release from the Schaffer collaterals and other projections of CA3 hippocampal pyramidal cells.” Prog Brain Res 83 (1990): 115–30. https://doi.org/10.1016/s0079-6123(08)61245-5.
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    • Nadler, J. V., D. Martin, M. A. Bowe, R. A. Morrisett, and J. O. McNamara. “Kindling, prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA.” Adv Exp Med Biol 268 (1990): 407–17. https://doi.org/10.1007/978-1-4684-5769-8_45.
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    • Okazaki, M. M., J. O. McNamara, and J. V. Nadler. “Kainate and quisqualate receptor autoradiography in rat brain after angular bundle kindling.” Neuroscience 37, no. 1 (1990): 135–42. https://doi.org/10.1016/0306-4522(90)90198-d.
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    • Urban, L., K. H. Neill, B. J. Crain, J. V. Nadler, and G. G. Somjen. “Effects of transient forebrain ischemia in area CA1 of the gerbil hippocampus: an in vitro study.” Adv Exp Med Biol 268 (1990): 491–500. https://doi.org/10.1007/978-1-4684-5769-8_54.
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    • Urban, L., K. H. Neill, B. J. Crain, J. V. Nadler, and G. G. Somjen. “Postischemic synaptic physiology of CA1 hippocampal pyramidal cells.” Prog Clin Biol Res 361 (1990): 415–20.
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    • Urban, L., K. H. Neill, B. J. Crain, J. V. Nadler, and G. G. Somjen. “Postischemic synaptic excitation and N-methyl-D-aspartate receptor activation in gerbils.” Stroke 21, no. 11 SUPPL. (1990).
    • Warner, M. A., J. V. Nadler, and B. J. Crain. “Effects of NMDA receptor antagonists and body temperature in the gerbil carotid occlusion model of transient forebrain ischemia.” Prog Clin Biol Res 361 (1990): 409–14.
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    • Urban, L., K. H. Neill, B. J. Crain, J. V. Nadler, and G. G. Somjen. “Postischemic synaptic physiology in area CA1 of the gerbil hippocampus studied in vitro.” J Neurosci 9, no. 11 (November 1989): 3966–75.
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    • Burke, S. P., and J. V. Nadler. “Effects of glucose deficiency on glutamate/aspartate release and excitatory synaptic responses in the hippocampal CA1 area in vitro.” Brain Res 500, no. 1–2 (October 23, 1989): 333–42. https://doi.org/10.1016/0006-8993(89)90329-6.
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    • Yeh, G. C., D. W. Bonhaus, J. V. Nadler, and J. O. McNamara. “N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex.” Proc Natl Acad Sci U S A 86, no. 20 (October 1989): 8157–60. https://doi.org/10.1073/pnas.86.20.8157.
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    • Morrisett, R. A., C. Chow, J. V. Nadler, and J. O. McNamara. “Biochemical evidence for enhanced sensitivity to N-methyl-D-aspartate in the hippocampal formation of kindled rats.” Brain Res 496, no. 1–2 (September 4, 1989): 25–28. https://doi.org/10.1016/0006-8993(89)91048-2.
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    • Martin, D., M. A. Bowe, and J. V. Nadler. “A grease-gap method for studying the excitatory amino acid pharmacology of CA1 hippocampal pyramidal cells.” J Neurosci Methods 29, no. 2 (August 1989): 107–14. https://doi.org/10.1016/0165-0270(89)90021-6.
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    • Bray, S., G. A. Bustos, P. H. Lee, J. S. Hong, P. G. Aitken, and J. V. Nadler. “Kainic acid inhibits cholecystokinin release from rat hippocampal slices.” Neurosci Lett 100, no. 1–3 (May 22, 1989): 313–18. https://doi.org/10.1016/0304-3940(89)90705-2.
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    • Okazaki, M. M., J. O. McNamara, and J. V. Nadler. “N-methyl-D-aspartate receptor autoradiography in rat brain after angular bundle kindling.” Brain Res 482, no. 2 (March 20, 1989): 359–64. https://doi.org/10.1016/0006-8993(89)91201-8.
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    • Armstrong, D. R., K. H. Neill, B. J. Crain, and J. V. Nadler. “Absence of electrographic seizures after transient forebrain ischemia in the Mongolian gerbil.” Brain Res 476, no. 1 (January 2, 1989): 174–78. https://doi.org/10.1016/0006-8993(89)91554-0.
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    • Kaplan, T. M., T. M. Lasner, J. V. Nadler, and B. J. Crain. “Lesions of excitatory pathways reduce hippocampal cell death after transient forebrain ischemia in the gerbil.” Acta Neuropathol 78, no. 3 (1989): 283–90. https://doi.org/10.1007/bf00687758.
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    • McNamara, J. O., D. W. Bonhaus, and J. V. Nadler. “Novel approach to studying N‐methyl‐D‐aspartate receptor function in the kindling model of epilepsy.” Drug Development Research 17, no. 4 (January 1, 1989): 321–30. https://doi.org/10.1002/ddr.430170407.
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    • Somjen, G. G., P. G. Aitken, M. Balestrino, B. J. Crain, G. Czéh, K. Kawasaki, J. V. Nadler, K. H. Neill, and L. Urbán. “Extracellular ions, hypoxic irreversible loss of function and delayed postischemic neuron degeneration studied in vitro.” Acta Physiol Scand Suppl 582 (1989): 58.
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    • Burke, S. P., and J. V. Nadler. “Regulation of glutamate and aspartate release from slices of the hippocampal CA1 area: effects of adenosine and baclofen.” J Neurochem 51, no. 5 (November 1988): 1541–51. https://doi.org/10.1111/j.1471-4159.1988.tb01123.x.
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    • Crain, B. J., W. D. Westerkam, A. H. Harrison, and J. V. Nadler. “Selective neuronal death after transient forebrain ischemia in the Mongolian gerbil: a silver impregnation study.” Neuroscience 27, no. 2 (November 1988): 387–402. https://doi.org/10.1016/0306-4522(88)90276-x.
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    • Schweitzer, L., J. V. Nadler, and T. A. Slotkin. “Ontogenetic changes in laminar distribution of ornithine decarboxylase during development of cerebellar cortex: autoradiographic localization with [3H]alpha-difluoromethylornithine.” Neuroscience 27, no. 2 (November 1988): 453–64. https://doi.org/10.1016/0306-4522(88)90280-1.
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    • Okazaki, M. M., and J. V. Nadler. “Protective effects of mossy fiber lesions against kainic acid-induced seizures and neuronal degeneration.” Neuroscience 26, no. 3 (September 1988): 763–81. https://doi.org/10.1016/0306-4522(88)90097-8.
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    • Nadler, J. V., A. Wang, and A. Hakim. “Toxicity of L-proline toward rat hippocampal neurons.” Brain Res 456, no. 1 (July 19, 1988): 168–72. https://doi.org/10.1016/0006-8993(88)90358-7.
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    • Okazaki, M. M., P. G. Aitken, and J. V. Nadler. “Mossy fiber lesion reduces the probability that kainic acid will provoke CA3 hippocampal pyramidal cell bursting.” Brain Res 440, no. 2 (February 9, 1988): 352–56. https://doi.org/10.1016/0006-8993(88)91006-2.
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    • Sater, R. A., and J. V. Nadler. “On the relation between seizures and brain lesions after intracerebroventricular kainic acid.” Neurosci Lett 84, no. 1 (January 11, 1988): 73–78. https://doi.org/10.1016/0304-3940(88)90340-0.
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    • Nadler, J. V. “Sodium-dependent proline uptake in the rat hippocampal formation: association with ipsilateral-commissural projections of CA3 pyramidal cells.” J Neurochem 49, no. 4 (October 1987): 1155–60. https://doi.org/10.1111/j.1471-4159.1987.tb10006.x.
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    • Jaffe, D. B., P. G. Aitken, and J. V. Nadler. “The effects of cholecystokinin and cholecystokinin antagonists on synaptic function in the CA1 region of the rat hippocampal slice.” Brain Res 415, no. 1 (July 7, 1987): 197–203. https://doi.org/10.1016/0006-8993(87)90288-5.
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    • Vicedomini, J. P., and J. V. Nadler. “A model of status epilepticus based on electrical stimulation of hippocampal afferent pathways.” Exp Neurol 96, no. 3 (June 1987): 681–91. https://doi.org/10.1016/0014-4886(87)90229-9.
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    • Greene, W. M., A. Wang, and J. V. Nadler. “Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes.” Eur J Pharmacol 130, no. 3 (November 4, 1986): 333–36. https://doi.org/10.1016/0014-2999(86)90288-8.
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    • Ault, B., M. Gruenthal, D. R. Armstrong, and J. V. Nadler. “Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome.” J Pharmacol Exp Ther 239, no. 2 (November 1986): 612–17.
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    • Gruenthal, M., D. R. Armstrong, B. Ault, and J. V. Nadler. “Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide.” Exp Neurol 93, no. 3 (September 1986): 621–30. https://doi.org/10.1016/0014-4886(86)90181-0.
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    • Ault, B., M. Gruenthal, D. R. Armstrong, J. V. Nadler, and C. M. Wang. “Baclofen suppresses bursting activity induced in hippocampal slices by differing convulsant treatments.” Eur J Pharmacol 126, no. 3 (July 31, 1986): 289–92. https://doi.org/10.1016/0014-2999(86)90059-2.
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    • Morris, G., J. V. Nadler, and T. A. Slotkin. “Autoradiographic localization of ornithine decarboxylase in cerebellar cortex of the developing rat with [3H]alpha-difluoromethylornithine.” Neuroscience 17, no. 1 (1986): 183–88. https://doi.org/10.1016/0306-4522(86)90235-6.
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    • Nadler, J. V., M. M. Okazaki, M. Gruenthal, B. Ault, and D. R. Armstrong. “Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs.” Adv Exp Med Biol 203 (1986): 673–86. https://doi.org/10.1007/978-1-4684-7971-3_51.
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    • Morris, G., J. V. Nadler, C. B. Nemeroff, and T. A. Slotkin. “Effects of neonatal treatment with 6-aminonicotinamide on basal and isoproterenol-stimulated ornithine decarboxylase activity in cerebellum of the development rat.” Biochem Pharmacol 34, no. 18 (September 15, 1985): 3281–84. https://doi.org/10.1016/0006-2952(85)90346-6.
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    • Nadler, J. V., A. Wang, and L. L. Werling. “Binding sites for L-[3H]glutamate on hippocampal synaptic membranes: three populations differentially affected by chloride and calcium ions.” J Neurochem 44, no. 6 (June 1985): 1791–98. https://doi.org/10.1111/j.1471-4159.1985.tb07170.x.
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    • Bartolome, J. V., L. Schweitzer, T. A. Slotkin, and J. V. Nadler. “Impaired development of cerebellar cortex in rats treated postnatally with alpha-difluoromethylornithine.” Neuroscience 15, no. 1 (May 1985): 203–13. https://doi.org/10.1016/0306-4522(85)90132-0.
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    • Tauck, D. L., and J. V. Nadler. “Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats.” J Neurosci 5, no. 4 (April 1985): 1016–22.
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    • Savage, D. D., J. V. Nadler, and J. O. McNamara. “Reduced kainic acid binding in rat hippocampal formation after limbic kindling.” Brain Res 323, no. 1 (December 3, 1984): 128–31. https://doi.org/10.1016/0006-8993(84)90274-9.
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    • Savage, D. D., L. L. Werling, J. V. Nadler, and J. O. McNamara. “Selective and reversible increase in the number of quisqualate-sensitive glutamate binding sites on hippocampal synaptic membranes after angular bundle kindling.” Brain Res 307, no. 1–2 (July 30, 1984): 332–35. https://doi.org/10.1016/0006-8993(84)90488-8.
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    • Werling, L. L., and J. V. Nadler. “Evidence for differential localization of two binding sites for L-[3H]glutamate in rat fascia dentata.” Brain Res 276, no. 2 (October 16, 1983): 344–47. https://doi.org/10.1016/0006-8993(83)90744-8.
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    • Ault, B., and J. V. Nadler. “Effects of baclofen on synaptically-induced cell firing in the rat hippocampal slice.” Br J Pharmacol 80, no. 1 (September 1983): 211–19. https://doi.org/10.1111/j.1476-5381.1983.tb11068.x.
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    • Werling, L. L., K. A. Doman, and J. V. Nadler. “L-[3H]Glutamate binding to hippocampal synaptic membranes: two binding sites discriminated by their differing affinities for quisqualate.” J Neurochem 41, no. 2 (August 1983): 586–93. https://doi.org/10.1111/j.1471-4159.1983.tb04779.x.
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    • Ault, B., and J. V. Nadler. “Anticonvulsant-like actions of baclofen in the rat hippocampal slice.” Br J Pharmacol 78, no. 4 (April 1983): 701–8. https://doi.org/10.1111/j.1476-5381.1983.tb09423.x.
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    • Nadler, J. V., and D. A. Evenson. “Use of excitatory amino acids to make axon-sparing lesions of hypothalamus.” Methods Enzymol 103 (1983): 393–400. https://doi.org/10.1016/s0076-6879(83)03027-x.
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    • Werling, L. L., K. A. Doman, and J. V. Nadler. “L-[³H]glutamate binding to hippocampal synaptic membranes: Two binding sites discriminated by their differing affinities for quisqualate.” Journal of Neurochemistry 41, no. 2 (1983): 586–93.
    • Savage, D. D., L. L. Werling, J. V. Nadler, and J. O. McNamara. “Selective increase in L-[3H]glutamate binding to a quisqualate-sensitive site on hippocampal synaptic membranes after angular bundle kindling.” Eur J Pharmacol 85, no. 2 (November 19, 1982): 255–56. https://doi.org/10.1016/0014-2999(82)90479-4.
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    • Ault, B., and J. V. Nadler. “Baclofen selectively inhibits transmission at synapses made by axons of CA3 pyramidal cells in the hippocampal slice.” J Pharmacol Exp Ther 223, no. 2 (November 1982): 291–97.
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    • Nadler, J. V., and D. A. Evenson. “Autoradiographic evidence that septohippocampal fibers reinnervate fascia dentata denervated by entorhinal lesion during development.” Anat Embryol (Berl) 165, no. 1 (September 1982): 113–23. https://doi.org/10.1007/bf00304587.
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    • Werling, L. L., and J. V. Nadler. “Complex binding of L-[3H]glutamate to hippocampal synaptic membranes in the absence of sodium.” J Neurochem 38, no. 4 (April 1982): 1050–62. https://doi.org/10.1111/j.1471-4159.1982.tb05347.x.
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    • Nadler, J. V. “Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy.” Life Sci 29, no. 20 (November 16, 1981): 2031–42. https://doi.org/10.1016/0024-3205(81)90659-7.
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    • Nadler, J. V. “Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion.” Neurosci Lett 26, no. 3 (November 4, 1981): 275–81. https://doi.org/10.1016/0304-3940(81)90145-2.
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    • Nadler, J. V., and E. M. Smith. “Perforant path lesion depletes glutamate content of fascia dentata synaptosomes.” Neurosci Lett 25, no. 3 (September 25, 1981): 275–80. https://doi.org/10.1016/0304-3940(81)90404-3.
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    • Nadler, J. V., B. W. Perry, C. Gentry, and C. W. Cotman. “Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid.” J Comp Neurol 196, no. 4 (March 10, 1981): 549–69. https://doi.org/10.1002/cne.901960404.
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    • Nadler, J. V., D. A. Evenson, and E. M. Smith. “Evidence from lesion studies for epileptogenic and non-epileptogenic neurotoxic interactions between kainic acid and excitatory innervation.” Brain Res 205, no. 2 (February 2, 1981): 405–10. https://doi.org/10.1016/0006-8993(81)90351-6.
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    • Coyle, J. T., S. J. Bird, R. H. Evans, R. L. Gulley, J. V. Nadler, W. J. Nicklas, and J. W. Olney. “Excitatory amino acid neurotoxins: selectivity, specificity, and mechanisms of action. Based on an NRP one-day conference held June 30, 1980.” Neurosci Res Program Bull 19, no. 4 (1981): 1–427.
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    • Nadler, J. V. “Role of excitatory pathways in the hippocampal damage produced by kainic acid.” Adv Biochem Psychopharmacol 27 (1981): 395–402.
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    • Nadler, J. V., D. A. Evenson, and G. J. Cuthbertson. “Comparative toxicity of kainic acid and other acidic amino acids toward rat hippocampal neurons.” Neuroscience 6, no. 12 (1981): 2505–17. https://doi.org/10.1016/0306-4522(81)90096-8.
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    • Nadler, J. V., and G. J. Cuthbertson. “Kainic acid neurotoxicity toward hippocampal formation: dependence on specific excitatory pathways.” Brain Res 195, no. 1 (August 11, 1980): 47–56. https://doi.org/10.1016/0006-8993(80)90865-3.
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    • Nadler, J. V., B. W. Perry, C. Gentry, and C. W. Cotman. “Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid.” J Comp Neurol 192, no. 2 (July 15, 1980): 333–59. https://doi.org/10.1002/cne.901920209.
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    • Nadler, J. V., B. W. Perry, C. Gentry, and C. W. Cotman. “Loss and reacquisition of hippocampal synapses after selective destruction of CA3-CA4 afferents with kainic acid.” Brain Res 191, no. 2 (June 9, 1980): 387–403. https://doi.org/10.1016/0006-8993(80)91289-5.
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    • Nadler, J. V., B. W. Perry, and C. W. Cotman. “Interaction with CA4-derived fibers accounts for distribution of septohippocampal fibers in rat fascia dentata after entorhinal lesion.” Exp Neurol 68, no. 1 (April 1980): 185–94. https://doi.org/10.1016/0014-4886(80)90076-x.
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    • Nadler, J. V., B. W. Perry, and C. W. Cotman. “Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid.” Brain Res 182, no. 1 (January 20, 1980): 1–9. https://doi.org/10.1016/0006-8993(80)90825-2.
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    • Nadler, J. V., D. L. Shelton, B. W. Perry, and C. W. Cotman. “Regional distribution of [3H]kainic acid after intraventricular injection.” Life Sci 26, no. 2 (January 14, 1980): 133–38. https://doi.org/10.1016/0024-3205(80)90057-0.
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    • White, W. F., J. V. Nadler, and C. W. Cotman. “Analysis of short-term plasticity at the perforant path-granule cell synapse.” Brain Res 178, no. 1 (December 7, 1979): 41–53. https://doi.org/10.1016/0006-8993(79)90086-6.
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    • Nadler, J. V., D. L. Shelton, and C. W. Cotman. “Lesion-induced plasticity of high affinity choline uptake in the developing rat fascia dentata.” Brain Res 164 (March 23, 1979): 207–16. https://doi.org/10.1016/0006-8993(79)90016-7.
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    • White, W. F., J. V. Nadler, and C. W. Cotman. “The effect of acidic amino acid antagonists on synaptic transmission in the hippocampal formation in vitro.” Brain Res 164 (March 23, 1979): 177–94. https://doi.org/10.1016/0006-8993(79)90014-3.
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    • Shelton, D. L., J. V. Nadler, and C. W. Cotman. “Development of high affinity choline uptake and associated acetylcholine synthesis in the rat fascia dentata.” Brain Res 163, no. 2 (March 16, 1979): 263–75. https://doi.org/10.1016/0006-8993(79)90354-8.
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    • Nadler, J. V. “Kainic acid: neurophysiological and neurotoxic actions.” Life Sci 24, no. 4 (January 22, 1979): 289–99. https://doi.org/10.1016/0024-3205(79)90325-4.
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    • White, W. F., J. V. Nadler, and C. W. Cotman. “A perfusion chamber for the study of CNS physiology and pharmacology in vitro.” Brain Res 152, no. 3 (September 8, 1978): 591–96. https://doi.org/10.1016/0006-8993(78)91115-0.
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    • Nadler, J. V., W. F. White, K. W. Vaca, B. W. Perry, and C. W. Cotman. “Biochemical correlates of transmission mediated by glutamate and aspartate.” J Neurochem 31, no. 1 (July 1978): 147–55. https://doi.org/10.1111/j.1471-4159.1978.tb12442.x.
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    • Nadler, J. V., and C. W. Cotman. “Interactions between afferents to the dentate gyrus after entorhinal lesion during development: long-term regulation of choline acetyl-transferase activity.” Brain Res 142, no. 1 (February 17, 1978): 174–81. https://doi.org/10.1016/0006-8993(78)90188-9.
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    • Nadler, J. V., B. W. Perry, and C. W. Cotman. “Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells.” Nature 271, no. 5646 (February 1978): 676–77. https://doi.org/10.1038/271676a0.
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    • White, W. F., J. V. Nadler, A. Hamberger, C. W. Cotman, and J. T. Cummins. “Glutamate as transmitter of hippocampal perforant path.” Nature 270, no. 5635 (November 1977): 356–57. https://doi.org/10.1038/270356a0.
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    • Nadler, J. V., W. F. White, K. W. Vaca, and C. W. Cotman. “Calcium-dependent gamma-aminobutyrate release by interneurons of rat hippocampal regions: lesion-induced plasticity.” Brain Res 131, no. 2 (August 12, 1977): 241–58. https://doi.org/10.1016/0006-8993(77)90518-2.
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    • Nadler, J. V., W. F. White, K. W. Vaca, D. A. Redburn, and C. W. Cotman. “Characterization of putative amino acid transmitter release from slices of rat dentate gyrus.” J Neurochem 29, no. 2 (August 1977): 279–90. https://doi.org/10.1111/j.1471-4159.1977.tb09620.x.
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    • Nadler, J. V., C. W. Cotman, C. Paoletti, and G. S. Lynch. “Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. II. Effects of partial entorhinal and simultaneous multiple lesions.” J Comp Neurol 171, no. 4 (February 15, 1977): 589–604. https://doi.org/10.1002/cne.901710410.
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    • Nadler, J. V., C. W. Cotman, and G. S. Lynch. “Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. I. Time course after complete unilateral entorhinal lesion at various ages.” J Comp Neurol 171, no. 4 (February 15, 1977): 561–87. https://doi.org/10.1002/cne.901710409.
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    • Nadler, J. V., K. W. Vaca, W. F. White, G. S. Lynch, and C. W. Cotman. “Aspartate and glutamate as possible transmitters of excitatory hippocampal afferents.” Nature 260, no. 5551 (April 1976): 538–40. https://doi.org/10.1038/260538a0.
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    • Nadler, J. V., C. W. Cotman, and G. S. Lynch. “Biochemical plasticity of short-axon interneurons: increased glutamate decarboxylase activity in the denervated area of rat dentate gyrus following entorhinal lesion.” Exp Neurol 45, no. 2 (November 1974): 403–13. https://doi.org/10.1016/0014-4886(74)90128-9.
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    • Nadler, J. V., C. W. Cotman, and G. S. Lynch. “Subcellular distribution of transmitter-related enzyme activities in discrete areas of the rat dentate gyrus.” Brain Res 79, no. 3 (October 25, 1974): 465–75. https://doi.org/10.1016/0006-8993(74)90444-2.
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    • Matthews, D. A., J. V. Nadler, G. S. Lynch, and C. W. Cotman. “Development of cholinergic innervation in the hippocampal formation of the rat. I. Histochemical demonstration of acetylcholinesterase activity.” Dev Biol 36, no. 1 (January 1974): 130–41. https://doi.org/10.1016/0012-1606(74)90196-1.
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    • Nadler, J. V., D. A. Matthews, C. W. Cotman, and G. S. Lynch. “Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities.” Dev Biol 36, no. 1 (January 1974): 142–54. https://doi.org/10.1016/0012-1606(74)90197-3.
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    • Nadler, J. V., C. W. Cotman, and G. S. Lynch. “Altered distribution of choline acetyltransferase and acetylcholinesterase activities in the developing rat dentate gyrus following entorhinal lesion.” Brain Res 63 (December 7, 1973): 215–20. https://doi.org/10.1016/0006-8993(73)90090-5.
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    • Nadler, J. V., P. Horwitch, and J. R. Cooper. “Effects of sodium fluoroacetate on the metabolism of N-acetylaspartate and aspartate in mouse brain.” J Neurochem 19, no. 9 (September 1972): 2107–18. https://doi.org/10.1111/j.1471-4159.1972.tb05120.x.
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    • Nadler, J. V., and J. R. Cooper. “Metabolism of the aspartyl moiety of N-acetyl-L-aspartic acid in the rat brain.” J Neurochem 19, no. 9 (September 1972): 2091–2105. https://doi.org/10.1111/j.1471-4159.1972.tb05119.x.
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    • Nadler, J. V., and J. R. Cooper. “N-acetyl-L-aspartic acid content of human neural tumours and bovine peripheral nervous tissues.” J Neurochem 19, no. 2 (February 1972): 313–19. https://doi.org/10.1111/j.1471-4159.1972.tb01341.x.
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  • Book Sections

    • Nadler, J. V. “Plasticity: Axon Sprouting in Epilepsy.” In Encyclopedia of Basic Epilepsy Research, 1143–48, 2009. https://doi.org/10.1016/B978-012373961-2.00134-X.
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    • Nadler, J. V., and R. Z. Zhan. “Granule Cells: Properties of Dentate Granule Cells and their Relevance to Seizures.” In Encyclopedia of Basic Epilepsy Research, 472–76, 2009. https://doi.org/10.1016/B978-012373961-2.00133-8.
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  • Conference Papers

    • Urban, L., K. H. Neill, B. J. Crain, J. V. Nadler, and G. G. Somjen. “Postischemic synaptic excitation and N-methyl-D-aspartate receptor activation in gerbils.” In Stroke, Vol. 21, 1990.
• Teaching & Mentoring
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  Recent Courses

  • MOLMED 305B: Research in MOLMED - Translational Pharmacology 2020
  • PATHASST 102: Body and Disease 2020
  • INTERDIS 102B: Body and Disease 2019

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