J. Victor Nadler | Scholars@Duke

J. Victor Nadler
Professor Emeritus of Pharmacology & Cancer Biology

Research in this laboratory focuses primarily on mechanisms of epileptogenesis, that is, the process by which normal brain tissue becomes prone to seizures. Additional studies concern the mechanisms of excitatory synaptic transmission in the mammalian brain. We use an interdisciplinary approach that involves diverse methodologies, including cellular electrophysiology, immunocytochemistry, electron microscopy, confocal microscopy and high speed imaging.

In persons with temporal lobe epilepsy, the most common form of epilepsy in adults, mossy fibers in the hippocampus form a reverberating excitatory circuit that probably contributes to seizure development. In addition, neurons generated as a result of seizures migrate to aberrant locations, become incorporated into the reverberating excitatory circuit and fire spontaneously. We are studying the physiology and pharmacology of this circuit and its role in epileptogenesis with use of brain tissue from animals that have been made epileptic. Properties of recurrent mossy fiber synapses and ectopically-located hyperexcitable neurons may be exploited to develop novel approaches toward the treatment of temporal lobe epilepsy.

In addition, we are investigating the mechanism and significance of aspartate release. Aspartate is co-released with glutamate from some excitatory terminals in the brain. Recent data indicate that aspartate and glutamate are released by distinct mechanisms. However, the role of aspartate in excitatory transmission is currently unknown. One possibility suggested by our findings is that aspartate serves a paracrine function, targeting extrasynaptic NMDA receptors. Extrasynaptic and synaptic NMDA receptors couple to different signalling mechanisms and have opposite effects on cell survival. Thus the aspartate release/extrasynaptic NMDA receptor pathway offers a new target for pharmacological intervention in neuropsychiatric disease.

Current Appointments & Affiliations

Professor Emeritus of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2015
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2011

Contact Information

308 Research Drive, Durham, NC 27710
Duke Box 3813, Durham, NC 27710
nadle002@acpub.duke.edu (919) 684-5317

Background
Education, Training, & Certifications
- Ph.D., Yale University 1972
Previous Appointments & Affiliations
- Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1990 - 2014
- Professor of Neurobiology, Neurobiology, Basic Science Departments 1994 - 2014
- Associate Professor in Neurobiology, Neurobiology, Basic Science Departments 1994
- Associate Professor in the Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1983 - 1990
- Assistant Professor in the Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1978 - 1983
Recognition
Awards & Honors
- Epilepsy Research Award for Outstanding Contributions to the Pharmacology of Antiepileptic Drugs. American Society for Pharmacology and Experimental Therapeutics. 2005
Research
Selected Grants
- Gender Differences in Stimulant Action awarded by National Institutes of Health 1998 - 2013
- Ectopic Granule Cells in Epilepsy awarded by National Institutes of Health 2009 - 2011
- Dentate Granule Cell Network in Epilepsy awarded by National Institutes of Health 1999 - 2009
- ASPARTATE TRANSMISSION awarded by National Institutes of Health 2004 - 2006
- Transient Cerebral Ischemia & Gaba Neurotransmission awarded by National Institutes of Health 2000 - 2006
- same awarded by National Institutes of Health 1995 - 2000
- Excitatory Amino Acid Transmitters In Cns awarded by National Institutes of Health 1995 - 2000
- Same awarded by National Institutes of Health 1993 - 1999
- Limbic Epilepsy: A Neurobiologic Approach awarded by National Institutes of Health 1995 - 1999
- Shared Instrumentation For Confocal Ion Imaging In Living awarded by National Science Foundation 1994 - 1996
- Limbic Epilepsy: A Neurobiologic Approach awarded by National Institutes of Health 1990 - 1995
- Duke-Va Center For Cerebrovascular Research/Catecholamine awarded by National Institutes of Health 1990 - 1992
- Shared Instrumentation For Anatomical Studies awarded by National Science Foundation 1987 - 1988
Publications & Artistic Works
Selected Publications
- Books
  - Nadler, J. V., and D. D. Spencer. What is a seizure focus? Vol. 813, 2014. https://doi.org/10.1007/978-94-017-8914-1-4.
    Full Text
  - Nadler, J. V., and D. D. Spencer. What is a seizure focus? Vol. 813, 2014. https://doi.org/10.1007/978-94-17-8914-1_4.
    Full Text
- Academic Articles
  - Hunanyan, Arsen S., Ashley R. Helseth, Elie Abdelnour, Bassil Kherallah, Monisha Sachdev, Leeyup Chung, Melanie Masoud, et al. “Mechanisms of increased hippocampal excitability in the Mashl+/- mouse model of Na+ /K+ -ATPase dysfunction.” Epilepsia 59, no. 7 (July 2018): 1455–68. https://doi.org/10.1111/epi.14441.
    Full Text Link to Item
  - Dingledine, Raymond, Douglas A. Coulter, Brita Fritsch, Jan A. Gorter, Nadia Lelutiu, James McNamara, J Victor Nadler, et al. “Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models.” Sci Data 4 (May 9, 2017): 170061. https://doi.org/10.1038/sdata.2017.61.
    Full Text Open Access Copy Link to Item
  - Wang, Xiaochen, Xinyu Song, Lin Wu, J Victor Nadler, and Ren-Zhi Zhan. “Persistent Hyperactivity of Hippocampal Dentate Interneurons After a Silent Period in the Rat Pilocarpine Model of Epilepsy.” Front Cell Neurosci 10 (2016): 94. https://doi.org/10.3389/fncel.2016.00094.
    Full Text Link to Item
  - Nadler, J Victor, and Dennis D. Spencer. “What is a seizure focus?” Adv Exp Med Biol 813 (2014): 55–62. https://doi.org/10.1007/978-94-017-8914-1_4.
    Full Text Link to Item
  - Cameron, Michael C., Ren-Zhi Zhan, and J Victor Nadler. “Morphologic integration of hilar ectopic granule cells into dentate gyrus circuitry in the pilocarpine model of temporal lobe epilepsy.” J Comp Neurol 519, no. 11 (August 1, 2011): 2175–92. https://doi.org/10.1002/cne.22623.
    Full Text Link to Item
  - Nadler, J Victor. “Aspartate release and signalling in the hippocampus.” Neurochem Res 36, no. 4 (April 2011): 668–76. https://doi.org/10.1007/s11064-010-0291-3.
    Full Text Link to Item
  - Ribak, C. E., L. A. Shapiro, X. X. Yan, K. Dashtipour, J. V. Nadler, A. Obenaus, I. Spigelman, and P. S. Buckmaster. “Seizure-induced basal dendrites on granule cells.” Epilepsia 51, no. SUPPL. 5 (December 1, 2010): 43. https://doi.org/10.1111/j.1528-1167.2010.02829.x.
    Full Text
  - Victor Nadler, J. “Plasticity of glutamate synaptic mechanisms.” Epilepsia 51, no. SUPPL. 5 (December 1, 2010): 17. https://doi.org/10.1111/j.1528-1167.2010.02803.x.
    Full Text
  - Zhan, Ren-Zhi, Olga Timofeeva, and J Victor Nadler. “High ratio of synaptic excitation to synaptic inhibition in hilar ectopic granule cells of pilocarpine-treated rats.” J Neurophysiol 104, no. 6 (December 2010): 3293–3304. https://doi.org/10.1152/jn.00663.2010.
    Full Text Link to Item
  - Zhang, Xuying, and J Victor Nadler. “Postsynaptic response to stimulation of the Schaffer collaterals with properties similar to those of synaptosomal aspartate release.” Brain Res 1295 (October 27, 2009): 13–20. https://doi.org/10.1016/j.brainres.2009.07.104.
    Full Text Link to Item
  - Zhan, Ren-Zhi, and J Victor Nadler. “Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus.” J Neurophysiol 102, no. 2 (August 2009): 670–81. https://doi.org/10.1152/jn.00147.2009.
    Full Text Link to Item
  - Zhan, Ren-Zhi, J Victor Nadler, and Rochelle D. Schwartz-Bloom. “Impaired firing and sodium channel function in CA1 hippocampal interneurons after transient cerebral ischemia.” J Cereb Blood Flow Metab 27, no. 8 (August 2007): 1444–52. https://doi.org/10.1038/sj.jcbfm.9600448.
    Full Text Link to Item
  - Jiao, Yiqun, and J Victor Nadler. “Stereological analysis of GluR2-immunoreactive hilar neurons in the pilocarpine model of temporal lobe epilepsy: correlation of cell loss with mossy fiber sprouting.” Exp Neurol 205, no. 2 (June 2007): 569–82. https://doi.org/10.1016/j.expneurol.2007.03.025.
    Full Text Link to Item
  - Wang, Lulu, and J Victor Nadler. “Reduced aspartate release from rat hippocampal synaptosomes loaded with Clostridial toxin light chain by electroporation: evidence for an exocytotic mechanism.” Neurosci Lett 412, no. 3 (February 2, 2007): 239–42. https://doi.org/10.1016/j.neulet.2006.11.006.
    Full Text Link to Item
  - Nadler, J Victor, Bin Tu, Olga Timofeeva, Yiqun Jiao, and Herbert Herzog. “Neuropeptide Y in the recurrent mossy fiber pathway.” Peptides 28, no. 2 (February 2007): 357–64. https://doi.org/10.1016/j.peptides.2006.07.026.
    Full Text Link to Item
  - Nadler, J. V. “Excitatory Amino Acids,” January 1, 2007, 970–75. https://doi.org/10.1016/B978-012373947-6.00151-3.
    Full Text
  - Tu, B., Y. Jiao, H. Herzog, and J. V. Nadler. “Neuropeptide Y regulates recurrent mossy fiber synaptic transmission less effectively in mice than in rats: Correlation with Y2 receptor plasticity.” Neuroscience 143, no. 4 (December 28, 2006): 1085–94. https://doi.org/10.1016/j.neuroscience.2006.08.036.
    Full Text Link to Item
  - Timofeeva, Olga, and J Victor Nadler. “Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy.” Brain Res 1078, no. 1 (March 17, 2006): 227–34. https://doi.org/10.1016/j.brainres.2006.01.051.
    Full Text Link to Item
  - Zhan, Ren-Zhi, J Victor Nadler, and Rochelle D. Schwartz-Bloom. “Depressed responses to applied and synaptically-released GABA in CA1 pyramidal cells, but not in CA1 interneurons, after transient forebrain ischemia.” J Cereb Blood Flow Metab 26, no. 1 (January 2006): 112–24. https://doi.org/10.1038/sj.jcbfm.9600171.
    Full Text Link to Item
  - Tu, Bin, Olga Timofeeva, Yiqun Jiao, and J Victor Nadler. “Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain.” J Neurosci 25, no. 7 (February 16, 2005): 1718–29. https://doi.org/10.1523/JNEUROSCI.4835-04.2005.
    Full Text Link to Item
  - Bradford, S. E., and J. V. Nadler. “Aspartate release from rat hippocampal synaptosomes.” Neuroscience 128, no. 4 (2004): 751–65. https://doi.org/10.1016/j.neuroscience.2004.06.065.
    Full Text Link to Item
  - Nadler, J Victor. “The recurrent mossy fiber pathway of the epileptic brain.” Neurochem Res 28, no. 11 (November 2003): 1649–58. https://doi.org/10.1023/a:1026004904199.
    Full Text Link to Item
  - Feng, Li, Peter Molnár, and J Victor Nadler. “Short-term frequency-dependent plasticity at recurrent mossy fiber synapses of the epileptic brain.” J Neurosci 23, no. 12 (June 15, 2003): 5381–90. https://doi.org/10.1523/JNEUROSCI.23-12-05381.2003.
    Full Text Link to Item
  - Dashtipour, Khashayar, Xiao-Xin Yan, Trinh T. Dinh, Maxine M. Okazaki, J Victor Nadler, and Charles E. Ribak. “Quantitative and morphological analysis of dentate granule cells with recurrent basal dendrites from normal and epileptic rats.” Hippocampus 12, no. 2 (2002): 235–44. https://doi.org/10.1002/hipo.1114.
    Full Text Link to Item
  - Okazaki, M. M., and J. V. Nadler. “Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation.” Brain Res 915, no. 1 (October 5, 2001): 58–69. https://doi.org/10.1016/s0006-8993(01)02824-4.
    Full Text Link to Item
  - Molnár, P., and J. V. Nadler. “Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses.” Brain Res 910, no. 1–2 (August 10, 2001): 205–7. https://doi.org/10.1016/s0006-8993(01)02720-2.
    Full Text Link to Item
  - Molnár, P., and J. V. Nadler. “Lack of effect of mossy fiber-released zinc on granule cell GABA(A) receptors in the pilocarpine model of epilepsy.” J Neurophysiol 85, no. 5 (May 2001): 1932–40. https://doi.org/10.1152/jn.2001.85.5.1932.
    Full Text Link to Item
  - Dashtipour, K., P. H. Tran, M. M. Okazaki, J. V. Nadler, and C. E. Ribak. “Ultrastructural features and synaptic connections of hilar ectopic granule cells in the rat dentate gyrus are different from those of granule cells in the granule cell layer.” Brain Res 890, no. 2 (February 2, 2001): 261–71. https://doi.org/10.1016/s0006-8993(00)03119-x.
    Full Text Link to Item
  - Ribak, C. E., P. H. Tran, I. Spigelman, M. M. Okazaki, and J. V. Nadler. “Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry.” J Comp Neurol 428, no. 2 (December 11, 2000): 240–53. https://doi.org/10.1002/1096-9861(20001211)428:2<240::aid-cne4>3.0.co;2-q.
    Full Text Link to Item
  - Hardison, J. L., M. M. Okazaki, and J. V. Nadler. “Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth.” J Neurophysiol 84, no. 5 (November 2000): 2380–89. https://doi.org/10.1152/jn.2000.84.5.2380.
    Full Text Link to Item
  - Molnár, P., and J. V. Nadler. “gamma-Aminobutyrate, alpha-carboxy-2-nitrobenzyl ester selectively blocks inhibitory synaptic transmission in rat dentate gyrus.” Eur J Pharmacol 391, no. 3 (March 17, 2000): 255–62. https://doi.org/10.1016/s0014-2999(00)00106-0.
    Full Text Link to Item
  - Schwartz-Bloom, R. D., K. A. Miller, D. A. Evenson, B. J. Crain, and J. V. Nadler. “Benzodiazepines protect hippocampal neurons from degeneration after transient cerebral ischemia: an ultrastructural study.” Neuroscience 98, no. 3 (2000): 471–84. https://doi.org/10.1016/s0306-4522(00)00144-5.
    Full Text Link to Item
  - Molnár, P., and J. V. Nadler. “Mossy fiber-granule cell synapses in the normal and epileptic rat dentate gyrus studied with minimal laser photostimulation.” J Neurophysiol 82, no. 4 (October 1999): 1883–94. https://doi.org/10.1152/jn.1999.82.4.1883.
    Full Text Link to Item
  - Okazaki, M. M., P. Molnár, and J. V. Nadler. “Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth.” J Neurophysiol 81, no. 4 (April 1999): 1645–60. https://doi.org/10.1152/jn.1999.81.4.1645.
    Full Text Link to Item
  - Gogos, J. A., M. Santha, Z. Takacs, K. D. Beck, V. Luine, L. R. Lucas, J. V. Nadler, and M. Karayiorgou. “The gene encoding proline dehydrogenase modulates sensorimotor gating in mice.” Nat Genet 21, no. 4 (April 1999): 434–39. https://doi.org/10.1038/7777.
    Full Text Link to Item
  - Cohen, S. M., and J. V. Nadler. “Proline-induced inhibition of glutamate release in hippocampal area CA1.” Brain Res 769, no. 2 (September 26, 1997): 333–39. https://doi.org/10.1016/s0006-8993(97)00721-x.
    Full Text Link to Item
  - Cohen, S. M., and J. V. Nadler. “Proline-induced potentiation of glutamate transmission.” Brain Res 761, no. 2 (July 4, 1997): 271–82. https://doi.org/10.1016/s0006-8993(97)00352-1.
    Full Text Link to Item
  - Cohen, S. M., and J. V. Nadler. “Sodium-dependent proline and glutamate uptake by hippocampal synaptosomes during postnatal development.” Brain Res Dev Brain Res 100, no. 2 (June 18, 1997): 230–33. https://doi.org/10.1016/s0165-3806(97)00045-x.
    Full Text Link to Item
  - Kraus, J. E., J. V. Nadler, and J. O. McNamara. “Regulation of alternative splicing of NMDAR1 in the kindling model.” Brain Res Mol Brain Res 41, no. 1–2 (September 5, 1996): 97–104. https://doi.org/10.1016/0169-328x(96)00072-1.
    Full Text Link to Item
  - Fremeau, R. T., M. Velaz-Faircloth, J. W. Miller, V. A. Henzi, S. M. Cohen, J. V. Nadler, S. Shafqat, R. D. Blakely, and B. Domin. “A novel nonopioid action of enkephalins: competitive inhibition of the mammalian brain high affinity L-proline transporter.” Mol Pharmacol 49, no. 6 (June 1996): 1033–41.
    Link to Item
  - Bowe, M. A., and J. V. Nadler. “Polyamines antagonize N-methyl-D-aspartate-evoked depolarizations, but reduce Mg2+ block.” Eur J Pharmacol 278, no. 1 (May 4, 1995): 55–65. https://doi.org/10.1016/0014-2999(95)00102-q.
    Full Text Link to Item
  - Zhou, M., C. L. Peterson, Y. B. Lu, and J. V. Nadler. “Release of glutamate and aspartate from CA1 synaptosomes: selective modulation of aspartate release by ionotropic glutamate receptor ligands.” J Neurochem 64, no. 4 (April 1995): 1556–66. https://doi.org/10.1046/j.1471-4159.1995.64041556.x.
    Full Text Link to Item
  - Peterson, C. L., M. A. Thompson, D. Martin, and J. V. Nadler. “Modulation of glutamate and aspartate release from slices of hippocampal area CA1 by inhibitors of arachidonic acid metabolism.” J Neurochem 64, no. 3 (March 1995): 1152–60. https://doi.org/10.1046/j.1471-4159.1995.64031152.x.
    Full Text Link to Item
  - Okazaki, M. M., D. A. Evenson, and J. V. Nadler. “Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: visualization after retrograde transport of biocytin.” J Comp Neurol 352, no. 4 (February 20, 1995): 515–34. https://doi.org/10.1002/cne.903520404.
    Full Text Link to Item
  - Kraus, J. E., G. C. Yeh, D. W. Bonhaus, J. V. Nadler, and J. O. McNamara. “Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3.” J Neurosci 14, no. 7 (July 1994): 4196–4205. https://doi.org/10.1523/JNEUROSCI.14-07-04196.1994.
    Full Text Link to Item
  - Nadler, J. V., M. A. Thompson, and J. O. McNamara. “Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists.” Neuropharmacology 33, no. 2 (February 1994): 147–53. https://doi.org/10.1016/0028-3908(94)90001-9.
    Full Text Link to Item
  - Martin, D., M. A. Thompson, and J. V. Nadler. “The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1.” Eur J Pharmacol 250, no. 3 (December 21, 1993): 473–76. https://doi.org/10.1016/0014-2999(93)90037-i.
    Full Text Link to Item
  - Martin, D., B. Ault, and J. V. Nadler. “NMDA receptor-mediated depolarizing action of proline on CA1 pyramidal cells.” Eur J Pharmacol 219, no. 1 (August 14, 1992): 59–66. https://doi.org/10.1016/0014-2999(92)90580-w.
    Full Text Link to Item
  - Nadler, J. V., S. D. Bray, and D. A. Evenson. “Autoradiographic localization of proline uptake in excitatory hippocampal pathways.” Hippocampus 2, no. 3 (July 1992): 269–78. https://doi.org/10.1002/hipo.450020306.
    Full Text Link to Item
  - Martin, D., J. O. McNamara, and J. V. Nadler. “Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA.” J Neurosci 12, no. 5 (May 1992): 1928–35. https://doi.org/10.1523/JNEUROSCI.12-05-01928.1992.
    Full Text Link to Item
  - McNamara, J. O., R. Morrisett, and J. V. Nadler. “Recent advances in understanding mechanisms of the kindling model.” Adv Neurol 57 (1992): 555–60.
    Link to Item
  - Warner, M. A., K. H. Neill, J. V. Nadler, and B. J. Crain. “Regionally selective effects of NMDA receptor antagonists against ischemic brain damage in the gerbil.” J Cereb Blood Flow Metab 11, no. 4 (July 1991): 600–610. https://doi.org/10.1038/jcbfm.1991.110.
    Full Text Link to Item
  - Martin, D., G. A. Bustos, M. A. Bowe, S. D. Bray, and J. V. Nadler. “Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area.” J Neurochem 56, no. 5 (May 1991): 1647–55. https://doi.org/10.1111/j.1471-4159.1991.tb02063.x.
    Full Text Link to Item
  - Hosford, D. A., B. J. Crain, Z. Cao, D. W. Bonhaus, A. H. Friedman, M. M. Okazaki, J. V. Nadler, and J. O. McNamara. “Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus.” J Neurosci 11, no. 2 (February 1991): 428–34. https://doi.org/10.1523/JNEUROSCI.11-02-00428.1991.
    Full Text Link to Item
  - Martin, D., and J. V. Nadler. “Grease-Gap Methods for Studying Pharmacology of Excitatory Amino Acids on Central Nervous System Neurons” 4, no. C (January 1, 1991): 349–64. https://doi.org/10.1016/B978-0-12-185257-3.50026-4.
    Full Text
  - Aitken, P. G., D. B. Jaffe, and J. V. Nadler. “Cholecystokinin blocks some effects of kainic acid in CA3 region of hippocampal slices.” Peptides 12, no. 1 (1991): 127–29. https://doi.org/10.1016/0196-9781(91)90178-r.
    Full Text Link to Item
  - Urban, L., K. H. Neill, B. J. Crain, J. V. Nadler, and G. G. Somjen. “Postischemic synaptic excitation and N-methyl-D-aspartate receptor activation in gerbils.” Stroke 21, no. 11 Suppl (November 1990): III23–27.
    Link to Item
  - Bowe, M. A., and J. V. Nadler. “Developmental increase in the sensitivity to magnesium of NMDA receptors on CA1 hippocampal pyramidal cells.” Brain Res Dev Brain Res 56, no. 1 (October 1, 1990): 55–61. https://doi.org/10.1016/0165-3806(90)90164-t.
    Full Text Link to Item
  - Neill, K. H., B. J. Crain, and J. V. Nadler. “A simple, inexpensive method of monitoring brain temperature in conscious rodents.” J Neurosci Methods 33, no. 2–3 (August 1990): 179–83. https://doi.org/10.1016/0165-0270(90)90022-8.
    Full Text Link to Item
  - Vicedomini, J. P., and J. V. Nadler. “Stimulation-induced status epilepticus: role of the hippocampal mossy fibers in the seizures and associated neuropathology.” Brain Res 512, no. 1 (March 26, 1990): 70–74. https://doi.org/10.1016/0006-8993(90)91171-c.
    Full Text Link to Item
  - Lin, C. S., K. Polsky, J. V. Nadler, and B. J. Crain. “Selective neocortical and thalamic cell death in the gerbil after transient ischemia.” Neuroscience 35, no. 2 (1990): 289–99. https://doi.org/10.1016/0306-4522(90)90083-g.
    Full Text Link to Item
  - Nadler, J. V., D. Martin, M. A. Bowe, R. A. Morrisett, and J. O. McNamara. “Kindling, prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA.” Adv Exp Med Biol 268 (1990): 407–17. https://doi.org/10.1007/978-1-4684-5769-8_45.
    Full Text Link to Item
  - Okazaki, M. M., J. O. McNamara, and J. V. Nadler. “Kainate and quisqualate receptor autoradiography in rat brain after angular bundle kindling.” Neuroscience 37, no. 1 (1990): 135–42. https://doi.org/10.1016/0306-4522(90)90198-d.
    Full Text Link to Item
  - Urban, L., K. H. Neill, B. J. Crain, J. V. Nadler, and G. G. Somjen. “Effects of transient forebrain ischemia in area CA1 of the gerbil hippocampus: an in vitro study.” Adv Exp Med Biol 268 (1990): 491–500. https://doi.org/10.1007/978-1-4684-5769-8_54.
    Full Text Link to Item
  - Urban, L., K. H. Neill, B. J. Crain, J. V. Nadler, and G. G. Somjen. “Postischemic synaptic physiology of CA1 hippocampal pyramidal cells.” Prog Clin Biol Res 361 (1990): 415–20.
    Link to Item
  - Urban, L., K. H. Neill, B. J. Crain, J. V. Nadler, and G. G. Somjen. “Postischemic synaptic excitation and N-methyl-D-aspartate receptor activation in gerbils.” Stroke 21, no. 11 SUPPL. (1990): III-23-III–27.
  - Warner, M. A., J. V. Nadler, and B. J. Crain. “Effects of NMDA receptor antagonists and body temperature in the gerbil carotid occlusion model of transient forebrain ischemia.” Prog Clin Biol Res 361 (1990): 409–14.
    Link to Item
  - Crain, B. J., D. A. Evenson, K. Polsky, and J. V. Nadler. “Electron microscopic study of the gerbil dentate gyrus after transient forebrain ischemia.” Acta Neuropathol 79, no. 4 (1990): 409–17. https://doi.org/10.1007/BF00308717.
    Full Text Link to Item
  - McNamara, J. O., G. Yeh, D. W. Bonhaus, M. Okazaki, and J. V. Nadler. “NMDA receptor plasticity in the kindling model.” Adv Exp Med Biol 268 (1990): 451–59. https://doi.org/10.1007/978-1-4684-5769-8_50.
    Full Text Link to Item
  - Nadler, J. V., D. Martin, G. A. Bustos, S. P. Burke, and M. A. Bowe. “Regulation of glutamate and aspartate release from the Schaffer collaterals and other projections of CA3 hippocampal pyramidal cells.” Prog Brain Res 83 (1990): 115–30. https://doi.org/10.1016/s0079-6123(08)61245-5.
    Full Text Link to Item
  - Urban, L., K. H. Neill, B. J. Crain, J. V. Nadler, and G. G. Somjen. “Postischemic synaptic physiology in area CA1 of the gerbil hippocampus studied in vitro.” J Neurosci 9, no. 11 (November 1989): 3966–75. https://doi.org/10.1523/JNEUROSCI.09-11-03966.1989.
    Full Text Link to Item
  - Burke, S. P., and J. V. Nadler. “Effects of glucose deficiency on glutamate/aspartate release and excitatory synaptic responses in the hippocampal CA1 area in vitro.” Brain Res 500, no. 1–2 (October 23, 1989): 333–42. https://doi.org/10.1016/0006-8993(89)90329-6.
    Full Text Link to Item
  - Yeh, G. C., D. W. Bonhaus, J. V. Nadler, and J. O. McNamara. “N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex.” Proc Natl Acad Sci U S A 86, no. 20 (October 1989): 8157–60. https://doi.org/10.1073/pnas.86.20.8157.
    Full Text Link to Item
  - Morrisett, R. A., C. Chow, J. V. Nadler, and J. O. McNamara. “Biochemical evidence for enhanced sensitivity to N-methyl-D-aspartate in the hippocampal formation of kindled rats.” Brain Res 496, no. 1–2 (September 4, 1989): 25–28. https://doi.org/10.1016/0006-8993(89)91048-2.
    Full Text Link to Item
  - Martin, D., M. A. Bowe, and J. V. Nadler. “A grease-gap method for studying the excitatory amino acid pharmacology of CA1 hippocampal pyramidal cells.” J Neurosci Methods 29, no. 2 (August 1989): 107–14. https://doi.org/10.1016/0165-0270(89)90021-6.
    Full Text Link to Item
  - Bray, S., G. A. Bustos, P. H. Lee, J. S. Hong, P. G. Aitken, and J. V. Nadler. “Kainic acid inhibits cholecystokinin release from rat hippocampal slices.” Neurosci Lett 100, no. 1–3 (May 22, 1989): 313–18. https://doi.org/10.1016/0304-3940(89)90705-2.
    Full Text Link to Item
  - Okazaki, M. M., J. O. McNamara, and J. V. Nadler. “N-methyl-D-aspartate receptor autoradiography in rat brain after angular bundle kindling.” Brain Res 482, no. 2 (March 20, 1989): 359–64. https://doi.org/10.1016/0006-8993(89)91201-8.
    Full Text Link to Item
  - Armstrong, D. R., K. H. Neill, B. J. Crain, and J. V. Nadler. “Absence of electrographic seizures after transient forebrain ischemia in the Mongolian gerbil.” Brain Res 476, no. 1 (January 2, 1989): 174–78. https://doi.org/10.1016/0006-8993(89)91554-0.
    Full Text Link to Item
  - Kaplan, T. M., T. M. Lasner, J. V. Nadler, and B. J. Crain. “Lesions of excitatory pathways reduce hippocampal cell death after transient forebrain ischemia in the gerbil.” Acta Neuropathol 78, no. 3 (1989): 283–90. https://doi.org/10.1007/BF00687758.
    Full Text Link to Item
  - McNamara, J. O., D. W. Bonhaus, and J. V. Nadler. “Novel approach to studying N‐methyl‐D‐aspartate receptor function in the kindling model of epilepsy.” Drug Development Research 17, no. 4 (January 1, 1989): 321–30. https://doi.org/10.1002/ddr.430170407.
    Full Text
  - Somjen, G. G., P. G. Aitken, M. Balestrino, B. J. Crain, G. Czéh, K. Kawasaki, J. V. Nadler, K. H. Neill, and L. Urbán. “Extracellular ions, hypoxic irreversible loss of function and delayed postischemic neuron degeneration studied in vitro.” Acta Physiol Scand Suppl 582 (1989): 58.
    Link to Item
  - Burke, S. P., and J. V. Nadler. “Regulation of glutamate and aspartate release from slices of the hippocampal CA1 area: effects of adenosine and baclofen.” J Neurochem 51, no. 5 (November 1988): 1541–51. https://doi.org/10.1111/j.1471-4159.1988.tb01123.x.
    Full Text Link to Item
  - Schweitzer, L., J. V. Nadler, and T. A. Slotkin. “Ontogenetic changes in laminar distribution of ornithine decarboxylase during development of cerebellar cortex: autoradiographic localization with [3H]alpha-difluoromethylornithine.” Neuroscience 27, no. 2 (November 1988): 453–64. https://doi.org/10.1016/0306-4522(88)90280-1.
    Full Text Link to Item
  - Crain, B. J., W. D. Westerkam, A. H. Harrison, and J. V. Nadler. “Selective neuronal death after transient forebrain ischemia in the Mongolian gerbil: a silver impregnation study.” Neuroscience 27, no. 2 (November 1988): 387–402. https://doi.org/10.1016/0306-4522(88)90276-x.
    Full Text Link to Item
  - Okazaki, M. M., and J. V. Nadler. “Protective effects of mossy fiber lesions against kainic acid-induced seizures and neuronal degeneration.” Neuroscience 26, no. 3 (September 1988): 763–81. https://doi.org/10.1016/0306-4522(88)90097-8.
    Full Text Link to Item
  - Nadler, J. V., A. Wang, and A. Hakim. “Toxicity of L-proline toward rat hippocampal neurons.” Brain Res 456, no. 1 (July 19, 1988): 168–72. https://doi.org/10.1016/0006-8993(88)90358-7.
    Full Text Link to Item
  - Okazaki, M. M., P. G. Aitken, and J. V. Nadler. “Mossy fiber lesion reduces the probability that kainic acid will provoke CA3 hippocampal pyramidal cell bursting.” Brain Res 440, no. 2 (February 9, 1988): 352–56. https://doi.org/10.1016/0006-8993(88)91006-2.
    Full Text Link to Item
  - Sater, R. A., and J. V. Nadler. “On the relation between seizures and brain lesions after intracerebroventricular kainic acid.” Neurosci Lett 84, no. 1 (January 11, 1988): 73–78. https://doi.org/10.1016/0304-3940(88)90340-0.
    Full Text Link to Item
  - Nadler, J. V. “Sodium-dependent proline uptake in the rat hippocampal formation: association with ipsilateral-commissural projections of CA3 pyramidal cells.” J Neurochem 49, no. 4 (October 1987): 1155–60. https://doi.org/10.1111/j.1471-4159.1987.tb10006.x.
    Full Text Link to Item
  - Jaffe, D. B., P. G. Aitken, and J. V. Nadler. “The effects of cholecystokinin and cholecystokinin antagonists on synaptic function in the CA1 region of the rat hippocampal slice.” Brain Res 415, no. 1 (July 7, 1987): 197–203. https://doi.org/10.1016/0006-8993(87)90288-5.
    Full Text Link to Item
  - Vicedomini, J. P., and J. V. Nadler. “A model of status epilepticus based on electrical stimulation of hippocampal afferent pathways.” Exp Neurol 96, no. 3 (June 1987): 681–91. https://doi.org/10.1016/0014-4886(87)90229-9.
    Full Text Link to Item
  - Greene, W. M., A. Wang, and J. V. Nadler. “Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes.” Eur J Pharmacol 130, no. 3 (November 4, 1986): 333–36. https://doi.org/10.1016/0014-2999(86)90288-8.
    Full Text Link to Item
  - Ault, B., M. Gruenthal, D. R. Armstrong, and J. V. Nadler. “Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome.” J Pharmacol Exp Ther 239, no. 2 (November 1986): 612–17.
    Link to Item
  - Gruenthal, M., D. R. Armstrong, B. Ault, and J. V. Nadler. “Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide.” Exp Neurol 93, no. 3 (September 1986): 621–30. https://doi.org/10.1016/0014-4886(86)90181-0.
    Full Text Link to Item
  - Ault, B., M. Gruenthal, D. R. Armstrong, J. V. Nadler, and C. M. Wang. “Baclofen suppresses bursting activity induced in hippocampal slices by differing convulsant treatments.” Eur J Pharmacol 126, no. 3 (July 31, 1986): 289–92. https://doi.org/10.1016/0014-2999(86)90059-2.
    Full Text Link to Item
  - Morris, G., J. V. Nadler, and T. A. Slotkin. “Autoradiographic localization of ornithine decarboxylase in cerebellar cortex of the developing rat with [3H]alpha-difluoromethylornithine.” Neuroscience 17, no. 1 (1986): 183–88. https://doi.org/10.1016/0306-4522(86)90235-6.
    Full Text Link to Item
  - Nadler, J. V., M. M. Okazaki, M. Gruenthal, B. Ault, and D. R. Armstrong. “Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs.” Adv Exp Med Biol 203 (1986): 673–86. https://doi.org/10.1007/978-1-4684-7971-3_51.
    Full Text Link to Item
  - Morris, G., J. V. Nadler, C. B. Nemeroff, and T. A. Slotkin. “Effects of neonatal treatment with 6-aminonicotinamide on basal and isoproterenol-stimulated ornithine decarboxylase activity in cerebellum of the development rat.” Biochem Pharmacol 34, no. 18 (September 15, 1985): 3281–84. https://doi.org/10.1016/0006-2952(85)90346-6.
    Full Text Link to Item
  - Nadler, J. V., A. Wang, and L. L. Werling. “Binding sites for L-[3H]glutamate on hippocampal synaptic membranes: three populations differentially affected by chloride and calcium ions.” J Neurochem 44, no. 6 (June 1985): 1791–98. https://doi.org/10.1111/j.1471-4159.1985.tb07170.x.
    Full Text Link to Item
  - Bartolome, J. V., L. Schweitzer, T. A. Slotkin, and J. V. Nadler. “Impaired development of cerebellar cortex in rats treated postnatally with alpha-difluoromethylornithine.” Neuroscience 15, no. 1 (May 1985): 203–13. https://doi.org/10.1016/0306-4522(85)90132-0.
    Full Text Link to Item
  - Tauck, D. L., and J. V. Nadler. “Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats.” J Neurosci 5, no. 4 (April 1985): 1016–22. https://doi.org/10.1523/JNEUROSCI.05-04-01016.1985.
    Full Text Link to Item
  - Savage, D. D., J. V. Nadler, and J. O. McNamara. “Reduced kainic acid binding in rat hippocampal formation after limbic kindling.” Brain Res 323, no. 1 (December 3, 1984): 128–31. https://doi.org/10.1016/0006-8993(84)90274-9.
    Full Text Link to Item
  - Savage, D. D., L. L. Werling, J. V. Nadler, and J. O. McNamara. “Selective and reversible increase in the number of quisqualate-sensitive glutamate binding sites on hippocampal synaptic membranes after angular bundle kindling.” Brain Res 307, no. 1–2 (July 30, 1984): 332–35. https://doi.org/10.1016/0006-8993(84)90488-8.
    Full Text Link to Item
  - Werling, L. L., and J. V. Nadler. “Evidence for differential localization of two binding sites for L-[3H]glutamate in rat fascia dentata.” Brain Res 276, no. 2 (October 16, 1983): 344–47. https://doi.org/10.1016/0006-8993(83)90744-8.
    Full Text Link to Item
  - Ault, B., and J. V. Nadler. “Effects of baclofen on synaptically-induced cell firing in the rat hippocampal slice.” Br J Pharmacol 80, no. 1 (September 1983): 211–19. https://doi.org/10.1111/j.1476-5381.1983.tb11068.x.
    Full Text Link to Item
  - Werling, L. L., K. A. Doman, and J. V. Nadler. “L-[3H]Glutamate binding to hippocampal synaptic membranes: two binding sites discriminated by their differing affinities for quisqualate.” J Neurochem 41, no. 2 (August 1983): 586–93. https://doi.org/10.1111/j.1471-4159.1983.tb04779.x.
    Full Text Link to Item
  - Ault, B., and J. V. Nadler. “Anticonvulsant-like actions of baclofen in the rat hippocampal slice.” Br J Pharmacol 78, no. 4 (April 1983): 701–8. https://doi.org/10.1111/j.1476-5381.1983.tb09423.x.
    Full Text Link to Item
  - Werling, L. L., K. A. Doman, and J. V. Nadler. “L-[³H]glutamate binding to hippocampal synaptic membranes: Two binding sites discriminated by their differing affinities for quisqualate.” Journal of Neurochemistry 41, no. 2 (1983): 586–93.
  - Nadler, J. V., and D. A. Evenson. “Use of excitatory amino acids to make axon-sparing lesions of hypothalamus.” Methods Enzymol 103 (1983): 393–400. https://doi.org/10.1016/s0076-6879(83)03027-x.
    Full Text Link to Item
  - Savage, D. D., L. L. Werling, J. V. Nadler, and J. O. McNamara. “Selective increase in L-[3H]glutamate binding to a quisqualate-sensitive site on hippocampal synaptic membranes after angular bundle kindling.” Eur J Pharmacol 85, no. 2 (November 19, 1982): 255–56. https://doi.org/10.1016/0014-2999(82)90479-4.
    Full Text Link to Item
  - Ault, B., and J. V. Nadler. “Baclofen selectively inhibits transmission at synapses made by axons of CA3 pyramidal cells in the hippocampal slice.” J Pharmacol Exp Ther 223, no. 2 (November 1982): 291–97.
    Link to Item
  - Nadler, J. V., and D. A. Evenson. “Autoradiographic evidence that septohippocampal fibers reinnervate fascia dentata denervated by entorhinal lesion during development.” Anat Embryol (Berl) 165, no. 1 (September 1982): 113–23. https://doi.org/10.1007/BF00304587.
    Full Text Link to Item
  - Werling, L. L., and J. V. Nadler. “Complex binding of L-[3H]glutamate to hippocampal synaptic membranes in the absence of sodium.” J Neurochem 38, no. 4 (April 1982): 1050–62. https://doi.org/10.1111/j.1471-4159.1982.tb05347.x.
    Full Text Link to Item
  - Nadler, J. V. “Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion.” Neurosci Lett 26, no. 3 (November 4, 1981): 275–81. https://doi.org/10.1016/0304-3940(81)90145-2.
    Full Text Link to Item
  - Nadler, J. V. “Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy.” Life Sciences 29, no. 20 (November 1981): 2031–42. https://doi.org/10.1016/0024-3205(81)90659-7.
    Full Text
  - Nadler, J. V., and E. M. Smith. “Perforant path lesion depletes glutamate content of fascia dentata synaptosomes.” Neurosci Lett 25, no. 3 (September 25, 1981): 275–80. https://doi.org/10.1016/0304-3940(81)90404-3.
    Full Text Link to Item
  - Nadler, J. V., B. W. Perry, C. Gentry, and C. W. Cotman. “Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid.” J Comp Neurol 196, no. 4 (March 10, 1981): 549–69. https://doi.org/10.1002/cne.901960404.
    Full Text Link to Item
  - Nadler, J. V., D. A. Evenson, and E. M. Smith. “Evidence from lesion studies for epileptogenic and non-epileptogenic neurotoxic interactions between kainic acid and excitatory innervation.” Brain Res 205, no. 2 (February 2, 1981): 405–10. https://doi.org/10.1016/0006-8993(81)90351-6.
    Full Text Link to Item
  - Coyle, J. T., S. J. Bird, R. H. Evans, R. L. Gulley, J. V. Nadler, W. J. Nicklas, and J. W. Olney. “Excitatory amino acid neurotoxins: selectivity, specificity, and mechanisms of action. Based on an NRP one-day conference held June 30, 1980.” Neurosci Res Program Bull 19, no. 4 (1981): 1–427.
    Link to Item
  - Nadler, J. V. “Role of excitatory pathways in the hippocampal damage produced by kainic acid.” Adv Biochem Psychopharmacol 27 (1981): 395–402.
    Link to Item
  - Nadler, J. V., D. A. Evenson, and G. J. Cuthbertson. “Comparative toxicity of kainic acid and other acidic amino acids toward rat hippocampal neurons.” Neuroscience 6, no. 12 (1981): 2505–17. https://doi.org/10.1016/0306-4522(81)90096-8.
    Full Text Link to Item
  - Nadler, J. V., and G. J. Cuthbertson. “Kainic acid neurotoxicity toward hippocampal formation: dependence on specific excitatory pathways.” Brain Res 195, no. 1 (August 11, 1980): 47–56. https://doi.org/10.1016/0006-8993(80)90865-3.
    Full Text Link to Item
  - Nadler, J. V., B. W. Perry, C. Gentry, and C. W. Cotman. “Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid.” J Comp Neurol 192, no. 2 (July 15, 1980): 333–59. https://doi.org/10.1002/cne.901920209.
    Full Text Link to Item
  - Nadler, J. V., B. W. Perry, C. Gentry, and C. W. Cotman. “Loss and reacquisition of hippocampal synapses after selective destruction of CA3-CA4 afferents with kainic acid.” Brain Res 191, no. 2 (June 9, 1980): 387–403. https://doi.org/10.1016/0006-8993(80)91289-5.
    Full Text Link to Item
  - Nadler, J. V., B. W. Perry, and C. W. Cotman. “Interaction with CA4-derived fibers accounts for distribution of septohippocampal fibers in rat fascia dentata after entorhinal lesion.” Exp Neurol 68, no. 1 (April 1980): 185–94. https://doi.org/10.1016/0014-4886(80)90076-x.
    Full Text Link to Item
  - Nadler, J. V., B. W. Perry, and C. W. Cotman. “Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid.” Brain Res 182, no. 1 (January 20, 1980): 1–9. https://doi.org/10.1016/0006-8993(80)90825-2.
    Full Text Link to Item
  - Nadler, J. V., D. L. Shelton, B. W. Perry, and C. W. Cotman. “Regional distribution of [3H]kainic acid after intraventricular injection.” Life Sci 26, no. 2 (January 14, 1980): 133–38. https://doi.org/10.1016/0024-3205(80)90057-0.
    Full Text Link to Item
  - White, W. F., J. V. Nadler, and C. W. Cotman. “Analysis of short-term plasticity at the perforant path-granule cell synapse.” Brain Res 178, no. 1 (December 7, 1979): 41–53. https://doi.org/10.1016/0006-8993(79)90086-6.
    Full Text Link to Item
  - Nadler, J. V., D. L. Shelton, and C. W. Cotman. “Lesion-induced plasticity of high affinity choline uptake in the developing rat fascia dentata.” Brain Res 164 (March 23, 1979): 207–16. https://doi.org/10.1016/0006-8993(79)90016-7.
    Full Text Link to Item
  - White, W. F., J. V. Nadler, and C. W. Cotman. “The effect of acidic amino acid antagonists on synaptic transmission in the hippocampal formation in vitro.” Brain Res 164 (March 23, 1979): 177–94. https://doi.org/10.1016/0006-8993(79)90014-3.
    Full Text Link to Item
  - Shelton, D. L., J. V. Nadler, and C. W. Cotman. “Development of high affinity choline uptake and associated acetylcholine synthesis in the rat fascia dentata.” Brain Res 163, no. 2 (March 16, 1979): 263–75. https://doi.org/10.1016/0006-8993(79)90354-8.
    Full Text Link to Item
  - Nadler, J. V. “Kainic acid: neurophysiological and neurotoxic actions.” Life Sci 24, no. 4 (January 22, 1979): 289–99. https://doi.org/10.1016/0024-3205(79)90325-4.
    Full Text Link to Item
  - White, W. F., J. V. Nadler, and C. W. Cotman. “A perfusion chamber for the study of CNS physiology and pharmacology in vitro.” Brain Res 152, no. 3 (September 8, 1978): 591–96. https://doi.org/10.1016/0006-8993(78)91115-0.
    Full Text Link to Item
  - Nadler, J. V., W. F. White, K. W. Vaca, B. W. Perry, and C. W. Cotman. “Biochemical correlates of transmission mediated by glutamate and aspartate.” J Neurochem 31, no. 1 (July 1978): 147–55. https://doi.org/10.1111/j.1471-4159.1978.tb12442.x.
    Full Text Link to Item
  - Nadler, J. V., and C. W. Cotman. “Interactions between afferents to the dentate gyrus after entorhinal lesion during development: long-term regulation of choline acetyl-transferase activity.” Brain Res 142, no. 1 (February 17, 1978): 174–81. https://doi.org/10.1016/0006-8993(78)90188-9.
    Full Text Link to Item
  - Nadler, J. V., B. W. Perry, and C. W. Cotman. “Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells.” Nature 271, no. 5646 (February 16, 1978): 676–77. https://doi.org/10.1038/271676a0.
    Full Text Link to Item
  - White, W. F., J. V. Nadler, A. Hamberger, C. W. Cotman, and J. T. Cummins. “Glutamate as transmitter of hippocampal perforant path.” Nature 270, no. 5635 (November 24, 1977): 356–57. https://doi.org/10.1038/270356a0.
    Full Text Link to Item
  - Nadler, J. V., W. F. White, K. W. Vaca, and C. W. Cotman. “Calcium-dependent gamma-aminobutyrate release by interneurons of rat hippocampal regions: lesion-induced plasticity.” Brain Res 131, no. 2 (August 12, 1977): 241–58. https://doi.org/10.1016/0006-8993(77)90518-2.
    Full Text Link to Item
  - Nadler, J. V., W. F. White, K. W. Vaca, D. A. Redburn, and C. W. Cotman. “Characterization of putative amino acid transmitter release from slices of rat dentate gyrus.” J Neurochem 29, no. 2 (August 1977): 279–90. https://doi.org/10.1111/j.1471-4159.1977.tb09620.x.
    Full Text Link to Item
  - Nadler, J. V., C. W. Cotman, C. Paoletti, and G. S. Lynch. “Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. II. Effects of partial entorhinal and simultaneous multiple lesions.” J Comp Neurol 171, no. 4 (February 15, 1977): 589–604. https://doi.org/10.1002/cne.901710410.
    Full Text Link to Item
  - Nadler, J. V., C. W. Cotman, and G. S. Lynch. “Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. I. Time course after complete unilateral entorhinal lesion at various ages.” J Comp Neurol 171, no. 4 (February 15, 1977): 561–87. https://doi.org/10.1002/cne.901710409.
    Full Text Link to Item
  - Nadler, J. V., K. W. Vaca, W. F. White, G. S. Lynch, and C. W. Cotman. “Aspartate and glutamate as possible transmitters of excitatory hippocampal afferents.” Nature 260, no. 5551 (April 8, 1976): 538–40. https://doi.org/10.1038/260538a0.
    Full Text Link to Item
  - Nadler, J. V., C. W. Cotman, and G. S. Lynch. “Biochemical plasticity of short-axon interneurons: increased glutamate decarboxylase activity in the denervated area of rat dentate gyrus following entorhinal lesion.” Exp Neurol 45, no. 2 (November 1974): 403–13. https://doi.org/10.1016/0014-4886(74)90128-9.
    Full Text Link to Item
  - Nadler, J. V., C. W. Cotman, and G. S. Lynch. “Subcellular distribution of transmitter-related enzyme activities in discrete areas of the rat dentate gyrus.” Brain Res 79, no. 3 (October 25, 1974): 465–75. https://doi.org/10.1016/0006-8993(74)90444-2.
    Full Text Link to Item
  - Matthews, D. A., J. V. Nadler, G. S. Lynch, and C. W. Cotman. “Development of cholinergic innervation in the hippocampal formation of the rat. I. Histochemical demonstration of acetylcholinesterase activity.” Dev Biol 36, no. 1 (January 1974): 130–41. https://doi.org/10.1016/0012-1606(74)90196-1.
    Full Text Link to Item
  - Nadler, J. V., D. A. Matthews, C. W. Cotman, and G. S. Lynch. “Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities.” Dev Biol 36, no. 1 (January 1974): 142–54. https://doi.org/10.1016/0012-1606(74)90197-3.
    Full Text Link to Item
  - Nadler, J. V., C. W. Cotman, and G. S. Lynch. “Altered distribution of choline acetyltransferase and acetylcholinesterase activities in the developing rat dentate gyrus following entorhinal lesion.” Brain Res 63 (December 7, 1973): 215–20. https://doi.org/10.1016/0006-8993(73)90090-5.
    Full Text Link to Item
  - Nadler, J. V., P. Horwitch, and J. R. Cooper. “Effects of sodium fluoroacetate on the metabolism of N-acetylaspartate and aspartate in mouse brain.” J Neurochem 19, no. 9 (September 1972): 2107–18. https://doi.org/10.1111/j.1471-4159.1972.tb05120.x.
    Full Text Link to Item
  - Nadler, J. V., and J. R. Cooper. “Metabolism of the aspartyl moiety of N-acetyl-L-aspartic acid in the rat brain.” J Neurochem 19, no. 9 (September 1972): 2091–2105. https://doi.org/10.1111/j.1471-4159.1972.tb05119.x.
    Full Text Link to Item
  - Nadler, J. V., and J. R. Cooper. “N-acetyl-L-aspartic acid content of human neural tumours and bovine peripheral nervous tissues.” J Neurochem 19, no. 2 (February 1972): 313–19. https://doi.org/10.1111/j.1471-4159.1972.tb01341.x.
    Full Text Link to Item
- Book Sections
  - Nadler, J. V., and R. Z. Zhan. “Properties of dentate granule cells and their relevance to seizures.” In The Curated Reference Collection in Neuroscience and Biobehavioral Psychology, 472–76, 2016. https://doi.org/10.1016/B978-0-12-809324-5.00080-8.
    Full Text
  - Nadler, J. V. “Plasticity: Axon Sprouting in Epilepsy.” In Encyclopedia of Basic Epilepsy Research, 1143–48, 2009. https://doi.org/10.1016/B978-012373961-2.00134-X.
    Full Text
  - Nadler, J. V., and R. Z. Zhan. “Granule Cells: Properties of Dentate Granule Cells and their Relevance to Seizures.” In Encyclopedia of Basic Epilepsy Research, 472–76, 2009. https://doi.org/10.1016/B978-012373961-2.00133-8.
    Full Text
- Conference Papers
  - Urban, L., K. H. Neill, B. J. Crain, J. V. Nadler, and G. G. Somjen. “Postischemic synaptic excitation and N-methyl-D-aspartate receptor activation in gerbils.” In Stroke, Vol. 21, 1990.

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Previous Appointments & Affiliations

Awards & Honors

Selected Grants

Selected Publications

Books

Academic Articles

Book Sections

Conference Papers