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Combination chemotherapy and adriamycin in patients with advanced breast cancer. A Southwest Oncology Group study.

Publication ,  Journal Article
Hoogstraten, B; George, SL; Samal, B; Rivkin, SE; Costanzi, JJ; Bonnet, JD; Thigpen, T; Braine, H
Published in: Cancer
July 1976

In January, 1972, the Southwest Oncology Group initiated two randomized studies for patients with advanced breast cancer. The study for patients with prior chemotherapy showed a 33% response rate with adriamycin. The study for patients without previous chemotherapy consisted of three treatment regimens; a weekly repeated combination of cyclophosphamide, methotrexate, 5-fluorouracil, vincristine, and prednisone; these same five drugs given in courses of 5 days repeated every 4 weeks; and adriamycin as a single agent every 3 weeks. For the 283 evaluable patients, the response rates were: weekly combination 63/106 (59%); intermittent combination 39/98 (40%); and adriamycin 31/79 (39%). The median duration of response was 8 months for weekly combination, 10 months for intermittent therapy and only 4 months for adriamycin. Leukopenia was the dose-limiting toxicity with all three regimens. The weekly combination is the most effective therapy for patients with advanced disease. Extensive trails of combinations that include adriamycin are underway.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

July 1976

Volume

38

Issue

1

Start / End Page

13 / 20

Location

United States

Related Subject Headings

  • Vomiting
  • Vincristine
  • Prednisone
  • Oncology & Carcinogenesis
  • Methotrexate
  • Leukopenia
  • Humans
  • Heart
  • Fluorouracil
  • Female
 

Citation

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Hoogstraten, B., George, S. L., Samal, B., Rivkin, S. E., Costanzi, J. J., Bonnet, J. D., … Braine, H. (1976). Combination chemotherapy and adriamycin in patients with advanced breast cancer. A Southwest Oncology Group study. Cancer, 38(1), 13–20. https://doi.org/10.1002/1097-0142(197607)38:1<13::aid-cncr2820380104>3.0.co;2-5
Hoogstraten, B., S. L. George, B. Samal, S. E. Rivkin, J. J. Costanzi, J. D. Bonnet, T. Thigpen, and H. Braine. “Combination chemotherapy and adriamycin in patients with advanced breast cancer. A Southwest Oncology Group study.Cancer 38, no. 1 (July 1976): 13–20. https://doi.org/10.1002/1097-0142(197607)38:1<13::aid-cncr2820380104>3.0.co;2-5.
Hoogstraten B, George SL, Samal B, Rivkin SE, Costanzi JJ, Bonnet JD, et al. Combination chemotherapy and adriamycin in patients with advanced breast cancer. A Southwest Oncology Group study. Cancer. 1976 Jul;38(1):13–20.
Hoogstraten, B., et al. “Combination chemotherapy and adriamycin in patients with advanced breast cancer. A Southwest Oncology Group study.Cancer, vol. 38, no. 1, July 1976, pp. 13–20. Pubmed, doi:10.1002/1097-0142(197607)38:1<13::aid-cncr2820380104>3.0.co;2-5.
Hoogstraten B, George SL, Samal B, Rivkin SE, Costanzi JJ, Bonnet JD, Thigpen T, Braine H. Combination chemotherapy and adriamycin in patients with advanced breast cancer. A Southwest Oncology Group study. Cancer. 1976 Jul;38(1):13–20.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

July 1976

Volume

38

Issue

1

Start / End Page

13 / 20

Location

United States

Related Subject Headings

  • Vomiting
  • Vincristine
  • Prednisone
  • Oncology & Carcinogenesis
  • Methotrexate
  • Leukopenia
  • Humans
  • Heart
  • Fluorouracil
  • Female