Overview
Current Appointments & Affiliations
Professor Emeritus of Biostatistics & Bioinformatics
·
2015 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Recent Publications
Biomarker analyses from the phase III randomized CLEAR trial: lenvatinib plus pembrolizumab versus sunitinib in advanced renal cell carcinoma.
Journal Article Ann Oncol · April 2025 BACKGROUND: In CLEAR, lenvatinib + pembrolizumab (L + P) significantly improved efficacy versus sunitinib in first-line treatment of patients with advanced renal cell carcinoma (aRCC). We report results from CLEAR biomarker analyses. PATIENTS AND METHODS: ... Full text Link to item CiteRandomized phase II dose comparison LITESPARK-013 study of belzutifan in patients with advanced clear cell renal cell carcinoma.
Journal Article Ann Oncol · December 2024 BACKGROUND: Belzutifan is a first-in-class hypoxia-inducible factor subunit 2α (HIF-2α) inhibitor approved at a dose of 120 mg once daily for certain adults with VHL disease and adults with advanced renal cell carcinoma (RCC) following therapy with a progr ... Full text Link to item CiteAssessment of Treatment Effect Heterogeneity for Multiregional Randomized Clinical Trials
Journal Article Statistics in Biopharmaceutical Research · January 1, 2024 Multiregional clinical trials (MRCTs) have become increasingly common in recent years. Detecting underlying regional heterogeneity is a critical issue for these trials. Existing methods for assessing treatment effect heterogeneity across regions have ignor ... Full text CiteRecent Grants
Duke CTSA (TL1) Year 5
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024Translational meta-analysis for elderly lung cancer patients
ResearchCollaborator · Awarded by National Institutes of Health · 2013 - 2016CTSA UL
ResearchDirector · Awarded by National Institutes of Health · 2006 - 2012View All Grants
Education, Training & Certifications
Southern Methodist University ·
1969
Ph.D.