Skip to main content

Stephen L. George

Professor Emeritus of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
Duke Box 2721, Durham, NC 27710
2424 Erwin Road Ste 1102, 11082 Hock Plaza, Durham, NC 27705

Overview


Statistical issues related to the design, conduct, and analysis of clinical trials and related biomedical studies including sample size and study length determinations, sequential procedures, and the analysis of prognostic or predictive factors in clinical trials.

Current Appointments & Affiliations


Professor Emeritus of Biostatistics & Bioinformatics · 2015 - Present Biostatistics & Bioinformatics, Division of Biostatistics, Biostatistics & Bioinformatics

Recent Publications


Biomarker analyses from the phase III randomized CLEAR trial: lenvatinib plus pembrolizumab versus sunitinib in advanced renal cell carcinoma.

Journal Article Ann Oncol · April 2025 BACKGROUND: In CLEAR, lenvatinib + pembrolizumab (L + P) significantly improved efficacy versus sunitinib in first-line treatment of patients with advanced renal cell carcinoma (aRCC). We report results from CLEAR biomarker analyses. PATIENTS AND METHODS: ... Full text Link to item Cite

Randomized phase II dose comparison LITESPARK-013 study of belzutifan in patients with advanced clear cell renal cell carcinoma.

Journal Article Ann Oncol · December 2024 BACKGROUND: Belzutifan is a first-in-class hypoxia-inducible factor subunit 2α (HIF-2α) inhibitor approved at a dose of 120 mg once daily for certain adults with VHL disease and adults with advanced renal cell carcinoma (RCC) following therapy with a progr ... Full text Link to item Cite

Assessment of Treatment Effect Heterogeneity for Multiregional Randomized Clinical Trials

Journal Article Statistics in Biopharmaceutical Research · January 1, 2024 Multiregional clinical trials (MRCTs) have become increasingly common in recent years. Detecting underlying regional heterogeneity is a critical issue for these trials. Existing methods for assessing treatment effect heterogeneity across regions have ignor ... Full text Cite
View All Publications

Recent Grants


Duke CTSA (TL1) Year 5

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024

Translational meta-analysis for elderly lung cancer patients

ResearchCollaborator · Awarded by National Institutes of Health · 2013 - 2016

CTSA UL

ResearchDirector · Awarded by National Institutes of Health · 2006 - 2012

View All Grants

Education, Training & Certifications


Southern Methodist University · 1969 Ph.D.