Scholars@Duke
Stephen L. George

Stephen L. George

Professor Emeritus of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
stephen.george@duke.edu
Duke Box 2721, Durham, NC 27710
2424 Erwin Road Ste 1102, 11082 Hock Plaza, Durham, NC 27705

Selected Publications

Biomarker analyses from the phase III randomized CLEAR trial: lenvatinib plus pembrolizumab versus sunitinib in advanced renal cell carcinoma.

Journal Article Ann Oncol · December 11, 2024 BACKGROUND: In CLEAR, lenvatinibĀ + pembrolizumab (LĀ + P) significantly improved efficacy versus sunitinib in first-line treatment of patients with advanced renal cell carcinoma (aRCC). We report results from CLEAR biomarker analyses. PATIENTS AND METHODS: ... Full text Link to item Cite

Randomized phase II dose comparison LITESPARK-013 study of belzutifan in patients with advanced clear cell renal cell carcinoma.

Journal Article Ann Oncol · December 2024 BACKGROUND: Belzutifan is a first-in-class hypoxia-inducible factor subunit 2Ī± (HIF-2Ī±) inhibitor approved at a dose of 120 mg once daily for certain adults with VHL disease and adults with advanced renal cell carcinoma (RCC) following therapy with a progr ... Full text Link to item Cite

Assessment of Treatment Effect Heterogeneity for Multiregional Randomized Clinical Trials

Journal Article Statistics in Biopharmaceutical Research · January 1, 2024 Multiregional clinical trials (MRCTs) have become increasingly common in recent years. Detecting underlying regional heterogeneity is a critical issue for these trials. Existing methods for assessing treatment effect heterogeneity across regions have ignor ... Full text Cite

Futility monitoring for randomized clinical trials with non-proportional hazards: An optimal conditional power approach.

Journal Article Clin Trials · December 2023 BACKGROUND: Standard futility analyses designed for a proportional hazards setting may have serious drawbacks when non-proportional hazards are present. One important type of non-proportional hazards occurs when the treatment effect is delayed. That is, th ... Full text Link to item Cite

Fraud in Clinical Trials

Chapter · January 1, 2022 Several high-profile cases of fabrication or falsification of data have occurred in clinical trials in recent years. The number of such reported cases is quite low, given the large number of clinical trials conducted worldwide. Although this suggests that ... Full text Cite

A Signature Enrichment Design with Bayesian Adaptive Randomization.

Journal Article J Appl Stat · 2021 Clinical trials in the era of precision cancer medicine aim to identify and validate biomarker signatures which can guide the assignment of individually optimal treatments to patients. In this article, we propose a group sequential randomized phase II desi ... Full text Link to item Cite

Design and analysis of biomarker-integrated clinical trials with adaptive threshold detection and flexible patient enrichment.

Journal Article J Biopharm Stat · November 1, 2020 We propose a new adaptive threshold detection and enrichment design in which the biomarker threshold is adaptively estimated and updated by optimizing a trade-off between the size of the biomarker positive population and the magnitude of the treatment effe ... Full text Link to item Cite

Bias-adjusted Kaplan-Meier survival curves for marginal treatment effect in observational studies.

Journal Article J Biopharm Stat · 2019 For time-to-event outcomes, the Kaplan-Meier estimator is commonly used to estimate survival functions of treatment groups and to compute marginal treatment effects, such as the difference in survival rates between treatments at a landmark time. The derive ... Full text Link to item Cite

Auxiliary variable-enriched biomarker-stratified design.

Journal Article Stat Med · December 30, 2018 Clinical trials in the era of precision medicine require assessment of biomarkers to identify appropriate subgroups of patients for targeted therapy. In a biomarker-stratified design (BSD), biomarkers are measured on all patients and used as stratification ... Full text Link to item Cite

On Enrichment Strategies for Biomarker Stratified Clinical Trials.

Journal Article J Biopharm Stat · 2018 Featured Publication In the era of precision medicine, drugs are increasingly developed to target subgroups of patients with certain biomarkers. In large all-comer trials using a biomarker stratified design, the cost of treating and following patients for clinical outcomes may ... Full text Open Access Link to item Cite

Validation of Progression-Free Survival as a Surrogate Endpoint for Overall Survival in Malignant Mesothelioma: Analysis of Cancer and Leukemia Group B and North Central Cancer Treatment Group (Alliance) Trials.

Journal Article Oncologist · February 2017 Featured Publication PURPOSE: The aim of this study was to investigate whether progression-free survival (PFS) can be considered a surrogate endpoint for overall survival (OS) in malignant mesothelioma. MATERIALS AND METHODS: Individual data were collected from 15 Cancer and L ... Full text Link to item Cite

Prevalence of data fraud.

Journal Article Int J Clin Oncol · December 2016 Featured Publication Full text Link to item Cite

Design and analysis of phase II cancer clinical trials

Book · August 19, 2016 Featured Publication Full text Cite

Time-dependent classification accuracy curve under marker-dependent sampling.

Journal Article Biom J · July 2016 Featured Publication Evaluating the classification accuracy of a candidate biomarker signaling the onset of disease or disease status is essential for medical decision making. A good biomarker would accurately identify the patients who are likely to progress or die at a partic ... Full text Link to item Cite

Research misconduct and data fraud in clinical trials: prevalence and causal factors.

Journal Article Int J Clin Oncol · February 2016 Featured Publication The disclosure of cases of research misconduct in clinical trials, conventionally defined as fabrication, falsification or plagiarism, has been a disturbingly common phenomenon in recent years. Such cases can potentially harm patients enrolled on the trial ... Full text Link to item Cite

Relationship between obesity and clinical outcome in adults with acute myeloid leukemia: A pooled analysis from four CALGB (alliance) clinical trials.

Journal Article Am J Hematol · February 2016 Obesity has been previously suggested as an adverse prognostic marker in patients with acute leukemia. To evaluate the relationship between obesity and clinical outcome, disease-free survival (DFS) and overall survival (OS), in patients with acute myelogen ... Full text Link to item Cite

A Multi-state Model for Designing Clinical Trials for Testing Overall Survival Allowing for Crossover after Progression.

Journal Article Stat Biopharm Res · 2016 Featured Publication In designing a clinical trial for comparing two or more treatments with respect to overall survival (OS), a proportional hazards assumption is commonly made. However, in many cancer clinical trials, patients pass through various disease states prior to dea ... Full text Link to item Cite

Data fraud in clinical trials.

Journal Article Clin Investig (Lond) · 2015 Highly publicized cases of fabrication or falsification of data in clinical trials have occurred in recent years and it is likely that there are additional undetected or unreported cases. We review the available evidence on the incidence of data fraud in c ... Full text Link to item Cite

Recombinant interleukin-2 in patients aged younger than 60 years with acute myeloid leukemia in first complete remission: results from Cancer and Leukemia Group B 19808.

Journal Article Cancer · April 1, 2014 BACKGROUND: Recombinant interleukin-2 (rIL-2) induces cellular cytotoxicity against leukemia blasts. Patients with acute myeloid leukemia (AML) in first complete remission (CR) may harbor minimal residual disease that is susceptible to rIL-2-activated effe ... Full text Link to item Cite

ROC curve estimation under test-result-dependent sampling.

Journal Article Biostatistics · January 2013 Featured Publication The receiver operating characteristic (ROC) curve is often used to evaluate the performance of a biomarker measured on continuous scale to predict the disease status or a clinical condition. Motivated by the need for novel study designs with better estimat ... Full text Link to item Cite

Panel discussion 1.

Journal Article Clin Trials · December 2012 Full text Link to item Cite

Gene selection using iterative feature elimination random forests for survival outcomes.

Journal Article IEEE/ACM Trans Comput Biol Bioinform · 2012 Although many feature selection methods for classification have been developed, there is a need to identify genes in high-dimensional data with censored survival outcomes. Traditional methods for gene selection in classification problems have several drawb ... Full text Open Access Link to item Cite

Estimation of AUC or Partial AUC under Test-Result-Dependent Sampling.

Journal Article Stat Biopharm Res · January 1, 2012 The area under the ROC curve (AUC) and partial area under the ROC curve (pAUC) are summary measures used to assess the accuracy of a biomarker in discriminating true disease status. The standard sampling approach used in biomarker validation studies is oft ... Full text Link to item Cite

Update on the FAA UAS Program to the AUVSI Conference August 16, 2011

Conference AUVSI Unmanned Systems North America Conference 2011 · December 1, 2011 Cite

Comparison of reduced-intensity hematopoietic cell transplantation with chemotherapy in patients age 60-70 years with acute myelogenous leukemia in first remission.

Journal Article Biol Blood Marrow Transplant · December 2011 We compared the outcomes of patients age 60-70 years with acute myelogenous leukemia receiving reduced-intensity allogeneic hematopoietic cell transplantation (HCT) in first remission (CR1) reported to the Center for International Blood and Marrow Research ... Full text Link to item Cite

Individual patient data meta-analysis of randomized trials evaluating IL-2 monotherapy as remission maintenance therapy in acute myeloid leukemia.

Journal Article Blood · June 30, 2011 Featured Publication IL-2 is a natural, T cell-derived cytokine that stimulates the cytotoxic functions of T and natural killer cells. IL-2 monotherapy has been evaluated in several randomized clinical trials (RCTs) for remission maintenance in patients with acute myeloid leuk ... Full text Link to item Cite

Multiple testing of treatment-effect-modifying biomarkers in a randomized clinical trial with a survival endpoint.

Journal Article Stat Med · June 15, 2011 Featured Publication The recent revolution in genomics and the advent of targeted therapies have increased interest in biomarker-defined subgroups of patients who respond to therapy or exhibit specific toxicities. Such biomarker-defined subgroups are also being investigated fo ... Full text Link to item Cite

Multiple testing for gene sets from microarray experiments.

Journal Article BMC Bioinformatics · May 26, 2011 Featured Publication BACKGROUND: A key objective in many microarray association studies is the identification of individual genes associated with clinical outcome. It is often of additional interest to identify sets of genes, known a priori to have similar biologic function, a ... Full text Open Access Link to item Cite

Escalation of daunorubicin and addition of etoposide in the ADE regimen in acute myeloid leukemia patients aged 60 years and older: Cancer and Leukemia Group B Study 9720.

Journal Article Leukemia · May 2011 Untreated de novo (n=421) and secondary (n=189) acute myeloid leukemia (AML) patients ā‰„60 years received intensified chemotherapy, including daunorubicin 60ā€‰mg/m(2) and etoposide 100ā€‰mg/m(2) during days 1, 2, 3 with cytarabine 100ā€‰mg/m(2) during days 1-7, ... Full text Link to item Cite

FAA UAS sense and avoid workshops

Conference AUVSI Unmanned Systems North America Conference 2010 · December 1, 2010 Cite

Clinical trials data collection: when less is more.

Journal Article J Clin Oncol · December 1, 2010 Featured Publication Full text Link to item Cite

P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808.

Journal Article Blood · September 2, 2010 Cancer and Leukemia Group B 19808 (CALGB 19808) is the only randomized trial of a second-generation P-glycoprotein (Pgp) modulator in untreated patients with acute myeloid leukemia (AML) younger than age 60 years. We randomly assigned 302 patients to recei ... Full text Link to item Cite

Robust test method for time-course microarray experiments.

Journal Article BMC Bioinformatics · July 22, 2010 Featured Publication BACKGROUND: In a time-course microarray experiment, the expression level for each gene is observed across a number of time-points in order to characterize the temporal trajectories of the gene-expression profiles. For many of these experiments, the scienti ... Full text Open Access Link to item Cite

permGPU: Using graphics processing units in RNA microarray association studies.

Journal Article BMC Bioinformatics · June 16, 2010 Featured Publication BACKGROUND: Many analyses of microarray association studies involve permutation, bootstrap resampling and cross-validation, that are ideally formulated as embarrassingly parallel computing problems. Given that these analyses are computationally intensive, ... Full text Open Access Link to item Cite

How the doughnut hole affects prescription fulfillment decisions involving cardiovascular medications for medicare Part D enrollees

Journal Article Managed Care · January 1, 2010 Purpose: The unsupplemented Medicare Part D prescription drug benefit does not provide coverage for stand-alone prescription drug plan (PDP) beneficiaries within the coverage gap (often called a doughnut hole) in Medicare Part D. Design: We evaluated wheth ... Cite

A permutation-based multiple testing method for time-course microarray experiments.

Journal Article BMC Bioinformatics · October 15, 2009 Featured Publication BACKGROUND: Time-course microarray experiments are widely used to study the temporal profiles of gene expression. Storey et al. (2005) developed a method for analyzing time-course microarray studies that can be applied to discovering genes whose expression ... Full text Link to item Cite

Flexible Phase I Clinical Trials: Allowing for Nonbinary Toxicity Response and Removal of Other Common Limitations.

Journal Article Stat Biopharm Res · August 1, 2009 Featured Publication Phase I clinical trials are often subject to severe limitations. The most important one is that they typically allow only for binary response-toxic (1) or nontoxic (0)-rather than a range of responses from 0 to 1. They also may not allow a new patient to b ... Full text Link to item Cite

Sample size calculation for microarray experiments with blocked one-way design.

Journal Article BMC Bioinformatics · May 28, 2009 Featured Publication BACKGROUND: One of the main objectives of microarray analysis is to identify differentially expressed genes for different types of cells or treatments. Many statistical methods have been proposed to assess the treatment effects in microarray experiments. R ... Full text Link to item Cite

Between-arm comparisons in randomized Phase II trials.

Journal Article J Biopharm Stat · 2009 Featured Publication In a Phase II trial, we may randomize patients to multiple arms of experimental therapies and evaluate their efficacy to determine if any of them is worthy of a large scale Phase III trial. Usually the primary objective of such a study is to identify exper ... Full text Link to item Cite

Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2008 BACKGROUND: Prostate cancer affects one of six men during their lifetime. Dietary factors are postulated to influence the development and progression of prostate cancer. Low-fat diets and flaxseed supplementation may offer potentially protective strategies ... Full text Link to item Cite

Low-dose interleukin-2 immunotherapy does not improve outcome of patients age 60 years and older with acute myeloid leukemia in first complete remission: Cancer and Leukemia Group B Study 9720.

Journal Article J Clin Oncol · October 20, 2008 Featured Publication PURPOSE: Cancer and Leukemia Group B (CALGB) 9720 evaluated subcutaneous low-dose recombinant interleukin-2 (rIL-2) maintenance immunotherapy as a strategy for prolonging remission in older patients with acute myeloid leukemia (AML). PATIENTS AND METHODS: ... Full text Link to item Cite

Tomorrow's cancer treatments today: the first 50 years of the Cancer and Leukemia Group B.

Journal Article Semin Oncol · October 2008 Featured Publication Members of the Cancer and Leukemia Group B (CALGB) have been striving to improve cancer therapies for more than 50 years. The organization began in the mid 1950s as a multi-institutional collaboration between investigators at the National Cancer Institute, ... Full text Link to item Cite

Statistical issues in translational cancer research.

Journal Article Clin Cancer Res · October 1, 2008 Featured Publication The explosion of knowledge about the basic biological processes and the genetics of cancer has led to increasing optimism that this knowledge can be put to practical clinical use in the near future. Indeed, important examples of translational approaches ca ... Full text Link to item Cite

Statistical challenges in preprocessing in microarray experiments in cancer.

Journal Article Clin Cancer Res · October 1, 2008 Featured Publication Many clinical studies incorporate genomic experiments to investigate the potential associations between high-dimensional molecular data and clinical outcome. A critical first step in the statistical analyses of these experiments is that the molecular data ... Full text Link to item Cite

Overcoming challenges in designing and implementing a phase II randomized controlled trial using a presurgical model to test a dietary intervention in prostate cancer.

Journal Article Clin Trials · 2008 Featured Publication BACKGROUND: The time between the diagnosis of cancer and a planned definitive surgical procedure offers a strong and direct approach for assessing the impact of interventions (including lifestyle interventions) on the biology of the target tissue and the t ... Full text Link to item Cite

Randomized clinical trial design for assessing noninferiority when superiority is expected.

Journal Article J Clin Oncol · November 1, 2007 Featured Publication The randomized clinical trial (RCT) is the gold standard for definitive evaluation of new therapies. RCTs designed to show that the therapeutic efficacy of a new therapy is not unacceptably inferior to that of standard therapy are called noninferiority tri ... Full text Link to item Cite

Response rate as an endpoint in clinical trials.

Journal Article J Natl Cancer Inst · January 17, 2007 Featured Publication Full text Link to item Cite

Controversies in the early reporting of a clinical trial in early breast cancer

Journal Article · December 1, 2006 Featured Publication The role of adjuvant chemotherapy in the treatment of breast cancer has been the subject of intense research activity in recent years. It is now generally accepted that some types of adjuvant therapy have a positive effect on disease-free and overall survi ... Full text Cite

Rejoinder

Journal Article Journal of Biopharmaceutical Statistics · December 1, 2006 Full text Cite

Processes to activate phase III clinical trials in a Cooperative Oncology Group: the Case of Cancer and Leukemia Group B.

Journal Article J Clin Oncol · October 1, 2006 Featured Publication PURPOSE: National Cancer Institute-sponsored cooperative oncology groups are major sponsors of phase III clinical trials, yet the time and steps required to design and activate such studies has not been well studied. We examine the processes and document t ... Full text Link to item Cite

Self reported morbidity and awareness regarding common cancers in elderly women.

Journal Article J Commun Dis · March 2006 A study based on 198 women above 45 years of age was undertaken using interview methods in a house to house survey, to find the self reported morbidity and awareness regarding common cancers and screening tests. In this study the most commonly reported mor ... Link to item Cite

P-value calculation for multistage phase II cancer clinical trials.

Journal Article J Biopharm Stat · 2006 Featured Publication Due to ethical and practical issues, clinical trials are conducted in multiple stages, but the reported p-values often fail to reflect the design aspect of the trials. We investigate some approaches to p-value calculation in analyzing multi-stage Phase II ... Full text Link to item Cite

A multiple testing procedure to associate gene expression levels with survival.

Journal Article Stat Med · October 30, 2005 Featured Publication In many microarray studies the primary objective is to identify, from a large panel of genes, those which are prognostic markers of a censored survival endpoint such as time to disease recurrence or death. Often, these genes are considered prognostic in th ... Full text Link to item Cite

Criterion validity of Medicare chemotherapy claims in Cancer and Leukemia Group B breast and lung cancer trial participants.

Journal Article J Natl Cancer Inst · July 20, 2005 To determine the accuracy with which Medicare claims data measure chemotherapy use in elderly Medicare beneficiaries with cancer, we performed a criterion validation study. We compared gold-standard clinical trial data for 175 elderly cancer patients treat ... Full text Link to item Cite

Sequential multiagent chemotherapy is not superior to high-dose cytarabine alone as postremission intensification therapy for acute myeloid leukemia in adults under 60 years of age: Cancer and Leukemia Group B Study 9222.

Journal Article Blood · May 1, 2005 The Cancer and Leukemia Group B (CALGB) study 9222 tested the hypothesis that treatment intensification of acute myeloid leukemia (AML) in first remission with multiple chemotherapy agents is superior to high-dose cytarabine (HiDAC) alone. We enrolled 474 ... Full text Link to item Cite

Sample size calculation for simulation-based multiple-testing procedures.

Journal Article J Biopharm Stat · 2005 Featured Publication In this article, we present a simple method to calculate sample size and power for a simulation-based multiple testing procedure which gives a sharper critical value than the standard Bonferroni method. The method is especially useful when several highly c ... Full text Link to item Cite

A general formulation for a one-sided group sequential design.

Journal Article Clin Trials · 2005 Featured Publication BACKGROUND: A major contribution to the statistical literature on group sequential designs was provided by Pampallona and Tsiatis who developed closed form functions that can be used to iteratively calculate the boundary points of a family of popular group ... Full text Link to item Cite

Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: final induction results of Cancer and Leukemia Group B Study 9621.

Journal Article J Clin Oncol · November 1, 2004 PURPOSE: P-glycoprotein (Pgp) is strongly inhibited by PSC-833. A chemotherapy dose-escalation study was performed with PSC-833 in patients younger than 60 years with untreated acute myeloid leukemia. Clinical rather than pharmacokinetic end points were us ... Full text Link to item Cite

Strength of accumulating evidence and data monitoring committee decision making.

Journal Article Stat Med · September 15, 2004 Featured Publication The data monitoring committee (DMC) is a vital component of a randomized clinical trial. Its responsibilities include stopping the trial early for extreme results. The decision to stop the trial must be based on a careful synthesis of statistical methodolo ... Full text Link to item Cite

Managing accrual in cooperative group clinical trials.

Journal Article J Clin Oncol · August 1, 2004 Featured Publication Full text Link to item Cite

Impact of race on survival in men with metastatic hormone-refractory prostate cancer.

Journal Article Urology · August 2004 OBJECTIVES: To determine whether blacks with hormone-refractory prostate cancer have shorter survival compared with whites with the same disease. METHODS: Data from eight multicenter trials (four Phase II and four randomized Phase III studies) conducted by ... Full text Link to item Cite

Fulfillment of the uncertainty principle in cancer clinical trials.

Journal Article J Clin Oncol · July 15, 2004 Featured Publication 6003 Background: For randomized controlled trials to be ethical, the relative benefits of the study treatments must be uncertain. Therefore, the prior probability that either treatment is actually better should not be too high. Concerns about violation of ... Link to item Cite

Satisfaction of the uncertainty principle in cancer clinical trials: retrospective cohort analysis.

Journal Article BMJ · June 19, 2004 Featured Publication OBJECTIVE: To assess whether publicly funded adult cancer trials satisfy the uncertainty principle, which states that physicians should enroll a patient in a trial only if they are substantially uncertain which of the treatments in the trial is most approp ... Full text Link to item Cite

Should statisticians reporting to data monitoring committees be independent of the trial sponsor and leadership?

Journal Article Stat Med · May 30, 2004 Featured Publication It has long been a fundamental principle of clinical trials that interim comparative data should be kept confidential, with such data accessible only to a small number of individuals responsible for its analysis and monitoring. The rationale for keeping in ... Full text Link to item Cite

Renovascular disease is associated with low producer genotypes of the anti-inflammatory cytokine interleukin-10.

Journal Article Tissue Antigens · May 2004 Cytokines are important mediators of inflammatory and proliferative responses in disease states including atherosclerosis. Genetic variations in cytokine production could potentially influence the outcome of these responses. The aim of this study was to de ... Full text Link to item Cite

Admissible two-stage designs for phase II cancer clinical trials.

Journal Article Stat Med · February 28, 2004 Featured Publication In a typical two-stage design for a phase II cancer clinical trial for efficacy screening of cytotoxic agents, a fixed number of patients are initially enrolled and treated. The trial may be terminated for lack of efficacy if the observed number of tumour ... Full text Link to item Cite

Data monitoring and large apparent treatment effects.

Journal Article Control Clin Trials · February 2004 Featured Publication Full text Link to item Cite

Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia.

Journal Article Ann Hematol · 2004 The current cure rate of 80% in childhood acute lymphoblastic leukemia (ALL) attests to the effectiveness of risk-directed therapy developed through well-designed clinical trials. The ongoing Total Therapy Study XV at St. Jude Children's Research Hospital ... Full text Link to item Cite

The Society for Clinical Trials supports United States legislation mandating trials registration. Position paper.

Journal Article Clin Trials · 2004 Featured Publication The official position of the Society for Clinical Trials is to support legislation in the United States and internationally that mandates registration of all controlled clinicals trials at or before enrollment of the first participant. The major trial spon ... Full text Link to item Cite

Medulloblastoma and birth date: evaluation of 3 U.S. datasets.

Journal Article Arch Environ Health · January 2004 Studies from Norway and Japan have found a higher incidence of medulloblastoma related to births that occur in the fall. The authors sought further evidence concerning this association. For 122 patients in a Duke University database and 90 patients from th ... Full text Link to item Cite

Fulfillment of the uncertainty principle in cancer clinical trials.

Conference JOURNAL OF CLINICAL ONCOLOGY · 2004 Featured Publication Cite

Fixed-dose pegfilgrastim is safe and allows neutrophil recovery in patients with non-Hodgkin's lymphoma.

Journal Article Leuk Lymphoma · October 2003 Twenty-nine patients with non-Hodgkin's lymphoma received a single subcutaneous injection of 6 mg pegfilgrastim approximately 24 h after the start of CHOP chemotherapy. The safety of pegfilgrastim in this patient population was determined by reports of adv ... Full text Link to item Cite

Selection bias, phase II trials, and the FDA accelerated approval process.

Journal Article J Natl Cancer Inst · September 17, 2003 Featured Publication Full text Link to item Cite

Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject.

Journal Article Endocrinology · February 2003 An infant with Donohue's syndrome (leprechaunism) was found to be homozygous for an in-frame trinucleotide deletion within the insulin receptor gene resulting in the deletion of valine 335. When transiently transfected into Chinese hamster ovary cells, mut ... Full text Link to item Cite

Admissible two-stage designs for phase II cancer clinical trials

Conference CONTROLLED CLINICAL TRIALS · 2003 Featured Publication Cite

Use of on-site testing for drugs of abuse.

Journal Article Clin Chem · October 2002 BACKGROUND: There is currently a profusion of near-patient testing devices that have been specifically targeted at drug dependency units and clinics. Some of these devices have been shown to produce accurate results. However, some devices suffer from inapp ... Link to item Cite

The long-term clinical course of patients with cutaneous melanoma.

Journal Article Cancer · September 15, 2002 Featured Publication BACKGROUND: The clinical course of cutaneous melanoma is associated with pathologic and clinical factors, such as thickness, ulceration, and location of tumor and gender of the patient. The authors used a parametric survival model that incorporated a cured ... Full text Link to item Cite

Differences in understanding of specialist palliative care amongst service providers and commissioners in South London.

Journal Article Palliat Med · September 2002 This paper describes a study that sought to identify service providers' and commissioners' understanding of specialist palliative care within the context of changing service provision in one area of South London. Using a formative evaluation framework, we ... Full text Link to item Cite

Postremission therapy with low-dose interleukin 2 with or without intermediate pulse dose interleukin 2 therapy is well tolerated in elderly patients with acute myeloid leukemia: Cancer and Leukemia Group B study 9420.

Journal Article Clin Cancer Res · September 2002 PURPOSE: The purpose of the study is to investigate the tolerability of interleukin 2 (IL-2) after intensive chemotherapy in elderly acute myeloid leukemia (AML) patients in first complete remission (CR). EXPERIMENTAL DESIGN: AML patients > or =60 years in ... Link to item Cite

Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720.

Journal Article Blood · August 15, 2002 The Cancer and Leukemia Group B conducted a phase 3 trial of the P-glycoprotein modulator PSC-833 in untreated acute myeloid leukemia patients aged 60 years and older. Patients were randomized to 1 of 2 regimens, with doses determined in a prior phase 1 st ... Link to item Cite

Effect of filgrastim priming dose on peripheral blood progenitor cell yield, engraftment, and survival in women undergoing high dose chemotherapy for breast cancer

Journal Article Breast Cancer Research and Treatment · December 1, 2001 To investigate the effect of priming dose of filgrastim (G-CSF) on clinical parameters in women undergoing stem cell transplant for breast cancer, patients were randomized to receive 5 or 10Ī¼g/kg G-CSF on days 1-7 with 10 liter stem cell collections on day ... Cite

Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.

Journal Article Cancer Res · October 1, 2001 The FLT3 gene is mutated by an internal tandem duplication (ITD) in 20-25% of adults with acute myeloid leukemia (AML). We studied 82 adults <60 years of age with primary AML and normal cytogenetics, who received uniform high-dose therapy and found FLT3 IT ... Link to item Cite

Postremission therapy in older patients with de novo acute myeloid leukemia: a randomized trial comparing mitoxantrone and intermediate-dose cytarabine with standard-dose cytarabine.

Journal Article Blood · August 1, 2001 The treatment of older patients with acute myeloid leukemia (AML) remains unsatisfactory, with complete remission (CR) achieved in only approximately 50% and long-term disease-free survival in 10% to 20%. Three hundred eighty-eight patients (60 years of ag ... Full text Link to item Cite

Knowledge of fraud among biostatisticians.

Journal Article Control Clin Trials · June 2001 Full text Link to item Cite

A screening questionnaire for mother-infant bonding disorders

Journal Article Archives of Women's Mental Health · April 17, 2001 Background: There is a need in primary care for an easily administered instrument to give early indications of disorders in mother-infant relationships. Methods: An 84 item questionnaire was administered to 104 subjects, including normal mothers, depressed ... Full text Cite

Duration of symptoms prior to diagnosis is related inversely to presenting disease stage in children with medulloblastoma.

Journal Article Cancer · April 15, 2001 BACKGROUND: The authors tested the hypothesis that children with a longer duration of symptoms prior to diagnosis of medulloblastoma have more advanced disease. In addition, they evaluated whether there are correlations between gender, duration of presenti ... Full text Link to item Cite

Detecting treatment-by-centre interaction in multi-centre clinical trials.

Journal Article Stat Med · January 30, 2001 Featured Publication This paper considers several permutation tests for treatment-by-centre interaction in multi-centre clinical trials in which the endpoint is survival time subject to censoring. Some of the tests are based on existing tests and some are new. To evaluate and ... Full text Link to item Cite

Detection of micrometastatic clonogenic growth in bone marrow of early stage breast cancer patients presenting with or without lymph node involvement

Journal Article Breast Cancer Research and Treatment · January 1, 2001 Micrometastases found in the bone marrow (BM) of early stage patients has been associated with a poor clinical outcome for breast cancer (BrCa). We have previously demonstrated that the presence of clonogenic breast cancer cells in the BM or peripheral blo ... Cite

Fraud in medical research: an international survey of biostatisticians. ISCB Subcommittee on Fraud.

Journal Article Control Clin Trials · October 2000 Featured Publication The characteristics of scientific fraud and its impact on medical research are in general not well known. However, the interest in the phenomenon has increased steadily during the last decade. Biostatisticians routinely work closely with physicians and sci ... Full text Link to item Cite

Surgery for colorectal cancer in elderly patients: a systematic review. Colorectal Cancer Collaborative Group.

Journal Article Lancet · September 16, 2000 BACKGROUND: The effectiveness of surgery for colorectal cancer depends on it being carried out safely, which allows most patients to return to productive lives, with an improved postoperative life expectancy, or at least one that is not diminished by the s ... Link to item Cite

Simple high-performance liquid chromatographic method to monitor vigabatrin, and preliminary review of concentrations determined in epileptic patients.

Journal Article Ann Clin Biochem · May 2000 A simple and rapid high-performance liquid chromatographic method has been developed for the determination of vigabatrin concentrations in plasma or serum. The assay uses only 100 microL of specimen and has been found to be linear over a concentration rang ... Full text Link to item Cite

Ovarian dysmetabolic syndrome.

Journal Article Endocr Pract · 2000 Full text Link to item Cite

The role of biostatistics in the prevention, detection and treatment of fraud in clinical trials.

Journal Article Stat Med · December 30, 1999 Featured Publication Recent cases of fraud in clinical trials have attracted considerable media attention, but relatively little reaction from the biostatistical community. In this paper we argue that biostatisticians should be involved in preventing fraud (as well as unintent ... Full text Link to item Cite

Data monitoring committees and interim monitoring guidelines.

Journal Article Control Clin Trials · October 1999 Featured Publication Most large randomized clinical trials have a data monitoring committee that periodically examines efficacy and safety results. A typical data monitoring committee meets every 6 months, but the interim monitoring guidelines for many trials specify formal an ... Full text Link to item Cite

Parallel phase I studies of daunorubicin given with cytarabine and etoposide with or without the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age or older with acute myeloid leukemia: results of cancer and leukemia group B study 9420.

Journal Article J Clin Oncol · September 1999 PURPOSE: The Cancer and Leukemia Group B conducted parallel phase I trials of cytarabine, daunorubicin, and etoposide (ADE) with or without PSC-833 (P), a modulator of p-glycoprotein-mediated multidrug resistance. PATIENTS AND METHODS: One hundred ten newl ... Full text Link to item Cite

Use of whole body hyperthermia as a method to heat inaccessible tumours uniformly: a phase III trial in canine brain masses.

Journal Article Int J Hyperthermia · 1999 In this study, whole body hyperthermia (WBH) was assessed as a means of heating intracranial tumours uniformly. Twenty-five dogs received radiation therapy and 20 the combination of radiation and WBH. Total radiation dose was randomly assigned and was eith ... Full text Link to item Cite

Statistical reviewing policies of medical journals: caveat lector?

Journal Article J Gen Intern Med · November 1998 Featured Publication OBJECTIVE: To describe the current policies regarding statistical review of clinical research in biomedical journals. DESIGN: Cross-sectional survey. PARTICIPANTS: Editors of biomedical journals that publish original clinical research. MEASUREMENTS: Genera ... Full text Link to item Cite

Guidelines for quality assurance in multicenter trials: a position paper.

Journal Article Control Clin Trials · October 1998 Featured Publication In the wake of reports of falsified data in one of the trials of the National Surgical Adjuvant Project for Breast and Bowel Cancer supported by the National Cancer Institute, clinical trials came under close scrutiny by the public, the press, and Congress ... Full text Link to item Cite

A randomized controlled trial of filgrastim during remission induction and consolidation chemotherapy for adults with acute lymphoblastic leukemia: CALGB study 9111.

Journal Article Blood · September 1, 1998 Recombinant human granulocyte colony-stimulating factor (G-CSF; filgrastim) shortens the time to neutrophil recovery after intensive chemotherapy, but its role in the treatment of adults with acute lymphoblastic leukemia (ALL) is uncertain. We randomly ass ... Link to item Cite

Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer.

Journal Article N Engl J Med · June 18, 1998 BACKGROUND: Radiotherapy is often the primary treatment for advanced head and neck cancer, but the rates of locoregional recurrence are high and survival is poor. We investigated whether hyperfractionated irradiation plus concurrent chemotherapy (combined ... Full text Link to item Cite

An evaluation of combinations of diaziquone, etoposide and mitoxantrone in the treatment of adults with relapsed or refractory acute myeloid leukemia: results of 8722, a randomized phase II study conducted by Cancer and Leukemia Group B.

Journal Article Leukemia · February 1998 A phase II trial was conducted to determine which of the three possible two-drug combinations of diaziquone, etoposide and mitoxantrone was associated with the highest response rate in patients with relapsed or refractory acute myeloid leukemia (AML). Of t ... Full text Link to item Cite

The measurement of morphine in the hair of heroin abusers.

Journal Article Ann Clin Biochem · July 1997 Several techniques have been described for the determination of morphine in hair as a method of monitoring past heroin use. However, although some of the techniques [notably radioimmunoassay (RIA)] may appear relatively simple to perform, any results obtai ... Full text Link to item Cite

Specificity of human bactericidal antibodies against PorA P1.7,16 induced with a hexavalent meningococcal outer membrane vesicle vaccine.

Journal Article Infect Immun · July 1996 A set of isogenic strains was constructed from the meningococcal reference strain H44/76 (B:15:P1.7,16) which differed only in their outer membrane protein (OMP) compositions. First, three isogenic strains lacking the expression of either class 3 (PorB) or ... Full text Link to item Cite

Reducing patient eligibility criteria in cancer clinical trials.

Journal Article J Clin Oncol · April 1996 Featured Publication PURPOSE: To discuss patient eligibility criteria in phase III cancer clinical trials in the larger setting of the complexity of these trials, to review the various reasons for imposing restrictive eligibility requirements, to discuss the problems caused by ... Full text Link to item Cite

The approach of the british government to the 1996 intergovernmental conference of the european union

Journal Article Journal of European Public Policy · January 1, 1996 The British government's position in the 1996 IGC will reflect long-standing policy positions that have been shared by both main parties. This consistency in policy was partly masked by the tone of British statements on Europe during the Thatcher premiersh ... Full text Cite

Design of marker studies

Conference AMERICAN STATISTICAL ASSOCIATION 1996 PROCEEDINGS OF THE BIOMETRICS SECTION · 1996 Featured Publication Cite

Routine therapeutic monitoring of lamotrigine in epileptic patients using a simple and rapid high performance liquid chromatographic technique.

Journal Article Ann Clin Biochem · November 1995 We have developed a simple and rapid high performance liquid chromatographic technique to determine lamotrigine concentrations in epileptic patients and validated it using external quality control material. The method has been used to monitor the lamotrigi ... Full text Link to item Cite

Free-riding and the prisoner's dilemma: problems in funding economic analyses of phase III cancer clinical trials.

Journal Article J Clin Oncol · September 1995 Featured Publication PURPOSE: Both economic and clinical data on new agents are important to policy-makers who approve pharmaceuticals for widespread use. Randomized clinical trials have been used to evaluate both clinical results and total medical costs associated with new ag ... Full text Link to item Cite

Special events: are they worth the trouble?

Journal Article Fund Raising Manage · July 1995 Link to item Cite

Granulocyte-macrophage colony-stimulating factor as adjunct therapy in relapsed lymphoid malignancy: implications for economic analyses of phase III clinical trials.

Journal Article Stem Cells · July 1995 With the increasing concern over the high cost of health care, policy makers have incorporated economic analyses into phase III clinical trials as the randomized clinical trials can provide important information on the efficacy and potential cost-effective ... Full text Link to item Cite

Granulocyte-macrophage colony-stimulating factor after initial chemotherapy for elderly patients with primary acute myelogenous leukemia. Cancer and Leukemia Group B.

Journal Article N Engl J Med · June 22, 1995 BACKGROUND: Elderly patients with primary acute myelogenous leukemia (AML) are less likely to enter remission than younger adults, in part because of a higher mortality rate related to severe myelosuppression. Granulocyte-macrophage colony-stimulating fact ... Full text Link to item Cite

A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: Cancer and leukemia group B study 8811

Journal Article Blood · April 15, 1995 The goal of this phase II multicenter clinical trial was to evaluate a new intensive chemotherapy program for adults with untreated acute lymphoblastic leukemia (ALL) and to examine prospectively the impact of clinical and biologic characteristics on the o ... Full text Cite

A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.

Journal Article Blood · April 15, 1995 The goal of this phase II multicenter clinical trial was to evaluate a new intensive chemotherapy program for adults with untreated acute lymphoblastic leukemia (ALL) and to examine prospectively the impact of clinical and biologic characteristics on the o ... Link to item Cite

Drugs of abuse screening in the West Midlands: a 6 year retrospective survey of results.

Journal Article Ann Clin Biochem · September 1994 We describe the results of urinary drugs of abuse screening performed by the West Midlands Regional Laboratory for Toxicology, Birmingham, UK, on more than 27,800 urine specimens received between January 1988 and December 1993. The number of specimens posi ... Full text Link to item Cite

Stopping a clinical trial early: frequentist and Bayesian approaches applied to a CALGB trial in non-small-cell lung cancer.

Journal Article Stat Med · July 15, 1994 In May 1984, the Cancer and Leukemia Group B (CALGB) opened a phase III clinical trial for patients with stage III non-small-cell lung cancer (NSCLC). The experimental design entailed randomization of 240 patients equally to one of two treatments: radiothe ... Full text Link to item Cite

Statistical considerations and modeling of clinical utility of tumor markers.

Journal Article Hematol Oncol Clin North Am · June 1994 The proper assessment of potential tumor markers in the screening, diagnosis, prognosis, and monitoring of neoplastic diseases depends on careful attention to general principles of good design and analysis of scientific studies, as well as to some specific ... Link to item Cite

Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.

Journal Article Blood · March 15, 1994 Mutations of the N- and K-ras genes are the most frequent genetic aberrations in acute myeloid leukemia (AML) and their detection in preleukemic conditions such as the myelodysplastic syndrome (MDS) suggests a role in the earliest phases of leukemogenesis. ... Link to item Cite

An outbreak of anthrax meningoencephalitis.

Journal Article Trans R Soc Trop Med Hyg · 1994 We report a common-source outbreak of anthrax meningoencephalitis in Chittoor district in Andhra Pradesh, southern India, in October 1990. The source of infection was the carcass of a sheep. Of 5 persons who skinned and cut up its meat for human consumptio ... Full text Link to item Cite

Effect of whole body hyperthermia on carboplatin disposition and toxicity in dogs.

Journal Article Int J Hyperthermia · 1994 Fifty dogs with refractory or disseminated spontaneous tumours were evaluated in two independent phase I studies using either carboplatin (CBDCA) alone or CBDCA plus whole body hyperthermia (WBH). CBDCA was administered as a 30 min infusion at the onset of ... Full text Link to item Cite

Statistical assessment of the utility of tumor markers

Conference AMERICAN STATISTICAL ASSOCIATION 1994 PROCEEDINGS OF THE SECTION ON EPIDEMIOLOGY · January 1, 1994 Link to item Cite

BAYESIAN APPROACHES TO RANDOMIZED TRIALS - DISCUSSION

Journal Article JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY · January 1, 1994 Link to item Cite

Sample size requirements and length of study for testing interaction in a 2 x k factorial design when time-to-failure is the outcome [corrected].

Journal Article Control Clin Trials · December 1993 This paper provides equations for calculating the sample size necessary to test an interaction effect in an 2 x k factorial design when time-to-failure is the outcome of interest. The results are a direct extension of those used by George and Desu and Maku ... Full text Link to item Cite

Prolonged subcutaneous administration of recombinant alpha 2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: effect on remission duration and survival: Cancer and Leukemia Group B study 8583.

Journal Article Blood · November 15, 1993 We investigated whether recombinant alpha 2b interferon (r alpha 2bIFN) would reduce the proportion of bone marrow Philadelphia chromosome (Ph) cells in chronic-phase chronic myelogenous leukemia (CML) by treating 107 previously untreated patients daily wi ... Link to item Cite

Skin melanoma. Cured fraction and survival time as functions of thickness, site, histologic type, age, and sex.

Journal Article Cancer · August 15, 1993 BACKGROUND: Previously, nonparametric or semiparametric methods have been used to determine the relationship of various prognostic covariates with survival of skin cancer. Unfortunately, these methods do not readily distinguish between factors that modulat ... Full text Link to item Cite

A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. CNS Cancer Consortium.

Journal Article Int J Radiat Oncol Biol Phys · June 15, 1993 PURPOSE: The object of this study was to ascertain the value of topical ascorbic acid in the prevention of radiation dermatitis. METHODS AND MATERIALS: Patients with primary or metastatic brain tumors were eligible. Patients applied a topical solution, twi ... Full text Link to item Cite

Intra-arterial cisplatin with or without radiation in limb-sparing for canine osteosarcoma.

Journal Article Cancer · April 15, 1993 METHODS: Forty-nine dogs with spontaneously occurring osteosarcoma underwent limb-sparing surgery after preoperative therapy consisting of intra-arterial cisplatin alone or intra-arterial cisplatin in combination with doses of radiation from 20-40 Gy in 10 ... Full text Link to item Cite

Cumulative minutes with T90 greater than Tempindex is predictive of response of superficial malignancies to hyperthermia and radiation.

Journal Article Int J Radiat Oncol Biol Phys · April 2, 1993 PURPOSE: To better define thermal parameters related to tumor response in superficial malignancies treated with combined hyperthermia and radiation therapy. METHODS AND MATERIALS: Patients were randomized to receive one or two hyperthermia treatments per w ... Full text Link to item Cite

Toxic strep syndrome.

Journal Article J Assoc Physicians India · March 1993 Group A beta-hemolytic streptococci are known to produce infections with protean manifestations. We report here a case of toxic streptococcal syndrome in a patient who presented with a multisystemic disease. Serological and bacteriological evidence strongl ... Link to item Cite

A survey of monitoring practices in cancer clinical trials.

Journal Article Stat Med · March 1993 This paper reports the results of a survey of data monitoring practices of the 12 clinical co-operative groups in cancer sponsored by the National Cancer Institute in the United States. Most of these co-operative groups conduct a large number of active cli ... Full text Link to item Cite

Sensitivity of hyperthermia trial outcomes to temperature and time: implications for thermal goals of treatment.

Journal Article Int J Radiat Oncol Biol Phys · January 15, 1993 PURPOSE: In previous work we have found that the cumulative minutes of treatment for which 90% of measured intratumoral temperatures (T90) exceeded 39.5 degrees C was highly associated with complete response of superficial tumors. Similarly, the cumulative ... Full text Link to item Cite

Pharmacokinetic and phase I evaluation of carboplatin in dogs.

Journal Article J Vet Intern Med · 1993 Thirty dogs with spontaneously occurring malignant neoplasms were treated monthly with carboplatin (CBDCA) given as a 30-minute intravenous infusion in a dose escalation study. Twenty-eight dogs were considered evaluable for toxicity. The maximally tolerat ... Full text Link to item Cite

Multiple authorship in two English-language journals in radiation oncology.

Journal Article Acad Med · December 1992 Multiple authorship is the listing of more than one person as author of an article in the scholarly literature. Editors, researchers, and others in science publishing have raised concerns about the increasing number of authors being listed per article, the ... Full text Link to item Cite

A combination of two immunotoxins exerts synergistic cytotoxic activity against human breast-cancer cell lines.

Journal Article Int J Cancer · July 9, 1992 In previous studies, combinations of immunotoxins reactive with different cell-surface antigens have exerted additive cytotoxicity against tumor cells in culture. In this report we describe a combination of 2 immunotoxins that produce synergistic cytotoxic ... Full text Link to item Cite

Comparison of a novel assay for breast cancer mucin to CA15-3 and carcinoembryonic antigen.

Journal Article J Clin Oncol · July 1992 PURPOSE: To compare the sensitivity and specificity of an automated microparticle enzyme immunoassay (MEIA) for breast cancer mucin (IMx BCM; Abbott Laboratories, North Chicago, IL) to that of CA15-3 and carcinoembryonic antigen (CEA) for detecting and mon ... Full text Link to item Cite

Ha-ras polymorphisms in epithelial ovarian cancer.

Journal Article Gynecol Oncol · June 1992 Unusual restriction fragment length polymorphisms (RFLPs) of the Ha-ras locus have been found in DNA from leukocytes and tumor tissue of cancer patients. To determine whether rare alleles would be observed frequently in patients with ovarian cancer, Ha-ras ... Full text Link to item Cite

Endobronchial interstitial Au-198 implantation in the treatment of recurrent bronchogenic carcinoma.

Journal Article J Surg Oncol · April 1992 Nineteen patients with non-small-cell bronchogenic carcinoma, recurrent following initial conventional external beam radiotherapy, were treated with endobronchial implantation of Au-198 seeds. Seventeen patients were symptomatic with primary symptoms of pe ... Full text Link to item Cite

Analysis of 945 cases of pulmonary metastatic melanoma.

Journal Article J Thorac Cardiovasc Surg · April 1992 From 1970 to 1990, 7564 patients with melanoma were seen at Duke University Cancer Center. Complete follow-up data were available in all patients. The estimated probability of a pulmonary metastasis developing 5, 10, or 20 years after initial diagnosis was ... Link to item Cite

Therapeutic and prognostic considerations of head and neck melanoma.

Journal Article Ann Plast Surg · January 1992 Therapeutic considerations are discussed based on recurrence and survival statistics of 900 patients treated at Duke University Medical Center (Durham, NC). Approximately one-third of all patients developed recurrence. Factors affecting recurrence include ... Full text Link to item Cite

Relationships among tumor temperature, treatment time, and histopathological outcome using preoperative hyperthermia with radiation in soft tissue sarcomas.

Journal Article Int J Radiat Oncol Biol Phys · 1992 The lack of an unambiguous thermal dosimetry continues to impede progress in clinical hyperthermia. In an attempt to define better this dosimetry, a model based on the cumulative minutes during which arbitrary percentages of measured tumor temperature poin ... Full text Link to item Cite

Quantitative estimation of the thermal dose-modifying factor for cis-diamminedichloroplatinum (CDDP) in tumour-bearing dogs.

Journal Article Int J Hyperthermia · 1992 A statistical method for estimating clinical toxicity was used to determine a theoretical isoeffect dose-modifying factor for dogs with disseminated or refractory neoplasia treated with cis-diammine dichloroplatinum (II) plus whole-body hyperthermia or CDD ... Full text Link to item Cite

Candidal oesophagitis in Cushing's syndrome.

Journal Article J Assoc Physicians India · September 1991 Opportunistic infections are known to occur with increased frequency in patients with Cushing's syndrome, particularly those due to ectopic ACTH production. This report highlights the rare situation of a patient with Cushing's disease having candidal oesop ... Link to item Cite

Risk of adverse events in children completing treatment for acute lymphoblastic leukemia: St. Jude Total Therapy studies VIII, IX, and X.

Journal Article J Clin Oncol · August 1991 We studied the frequency, causes, and predictors of adverse events in 624 patients who had completed treatment for acute lymphoblastic leukemia (ALL) in three consecutive total therapy studies (VII, IX, and X, 1972 to 1983). Event-free survival in study X ... Full text Link to item Cite

An exploratory study of environmental and medical factors potentially related to childhood cancer.

Journal Article Med Pediatr Oncol · 1991 To determine whether a general-purpose epidemiologic questionnaire can be used in childhood cancer hospitals to identify associations between environmental factors and the major types of childhood cancer, we report the results of the analysis of the data o ... Full text Link to item Cite

Phase I study of melphalan alone and melphalan plus whole body hyperthermia in dogs with malignant melanoma.

Journal Article Int J Hyperthermia · 1991 The maximum tolerated dose of melphalan combined with whole body hyperthermia (WBH) in dogs with spontaneous malignant melanoma was lower than in dogs not receiving WBH by a factor of 1.9 +/- 0.71. Thirty-three dogs were treated monthly with escalating dos ... Full text Link to item Cite

Use of immunotoxins in combination to inhibit clonogenic growth of human breast carcinoma cells.

Journal Article Cancer Res · June 1, 1990 Substantial heterogeneity has been observed in the expression of individual antigens within tumor cell populations. Immunotoxins which bind to different cell surface antigens might exert additive or synergistic cytotoxicity when used in combination to elim ... Link to item Cite

Adjuvant chemotherapy for osteosarcoma of the extremity. Long-term results of two consecutive prospective protocol studies.

Journal Article Cancer · February 1, 1990 Seventy-six patients with classic high-grade osteosarcoma of an extremity received adjuvant chemotherapy by two protocols, initiated in 1972 and 1977, respectively, after appropriate amputations. Chemotherapy consisted of high-dose methotrexate, doxorubici ... Full text Link to item Cite

Possible protein binding displacement interaction between glibenclamide and metolazone.

Journal Article Eur J Clin Pharmacol · 1990 The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone ... Full text Link to item Cite

Complications of therapy for testicular cancer.

Journal Article J Urol · December 1989 Of 244 patients with testis cancer seen between January 1970 and December 1987 (mean followup 70 months) 88 (36.1%) experienced 1 or more early complications (within 1 year), while 16 (6.6%) had a late (greater than 1 year) complication. Chemotherapy-relat ... Full text Link to item Cite

Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia.

Journal Article N Engl J Med · July 20, 1989 We studied the risk of the development of acute myeloid leukemia (AML) during initial remission in 733 consecutive children with acute lymphoid leukemia (ALL) who were treated with intensive chemotherapy. This complication was identified according to stand ... Full text Link to item Cite

Identification and assessment of prognostic factors.

Journal Article Semin Oncol · October 1988 Link to item Cite

Efficacy of oral sucralfate suspension in prevention and treatment of chemotherapy-induced mucositis.

Journal Article J Pediatr · October 1988 The efficacy of orally administered sucralfate suspension in preventing and treating chemotherapy-induced mucositis was evaluated in a double-blind trial. Forty-eight children and adolescents with newly diagnosed acute nonlymphocytic leukemia were randomiz ... Full text Link to item Cite

Carcinomas in children. Clinical and demographic characteristics.

Journal Article Cancer · March 1, 1988 Carcinomas occur rarely in children and adolescents. Despite their rarity, these tumors present a unique opportunity to assess theories of origin because the interval from birth to tumor onset is relatively short compared with that seen in adults. We descr ... Full text Link to item Cite

Phase II testing of melphalan in children with newly diagnosed rhabdomyosarcoma: a model for anticancer drug development.

Journal Article J Clin Oncol · February 1988 We describe events that led to successful testing of melphalan, one of the nitrogen mustard compounds, in children with newly diagnosed, poor-risk rhabdomyosarcoma (RMS). Preclinical studies with xenografts of human RMS, growing in the flanks of immune-dep ... Full text Link to item Cite

Transcutaneous electrical nerve stimulation treatment of sickle cell pain crises.

Journal Article Acta Haematol · 1988 Transcutaneous electrical nerve stimulation (TENS) has been used in a variety of acute and chronic painful conditions, but has not been studied in sickle cell pain crises. We compared TENS versus placebo in a randomized, double-blind, cross-over study invo ... Full text Link to item Cite

Hypodiploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia.

Journal Article Blood · July 1987 Leukemic cells from 31 (7.6%) of 409 children with newly diagnosed acute lymphoblastic leukemia (ALL) had a hypodiploid karyotype. The patients' ages ranged from 0.8 to 17 years (median, 5 years) and their initial leukocyte counts from 1.0 to 132 X 10(9)/L ... Link to item Cite

Height at diagnosis of malignancies.

Journal Article Arch Dis Child · May 1987 Studies of the presenting height of children with malignancies have produced conflicting results, from an excess of taller patients to an excess of shorter patients. The problems of measurement bias, inadequate comparison populations, small numbers of pati ... Full text Link to item Cite

Impact of cuts in acute beds on services for patients.

Journal Article Br Med J (Clin Res Ed) · April 11, 1987 Full text Link to item Cite

Relationship between binding affinity, retention and sensitivity of human rhabdomyosarcoma xenografts to Vinca alkaloids.

Journal Article Biochem Pharmacol · January 1, 1987 Xenografts of human rhabdomyosarcoma (RMS) have been derived that differ in their degree of sensitivity to Vinca alkaloids. Lines Rh12 and Rh18 demonstrated, respectively, high and moderate sensitivity to vincristine (VCR), but showed little responsiveness ... Full text Link to item Cite

Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect.

Journal Article N Engl J Med · February 20, 1986 High-dose methotrexate (500 to 33,600 mg per square meter of body-surface area) with leucovorin rescue is a common component of therapy for acute lymphocytic leukemia. To increase understanding of the relation between the serum concentration and the effect ... Full text Link to item Cite

The pharmacokinetics of timegadine and two of its metabolites after multiple oral dosing, and the effects of concomitant administration of ibuprofen.

Journal Article Eur J Clin Pharmacol · 1986 A 250 mg tablet of timegadine was given twice daily for 15 days to 13 healthy volunteers. On Day 16 a single morning dose of timegadine was supplemented by two 200 mg tablets of a proprietary brand of ibuprofen. Serum concentrations of timegadine were meas ... Full text Link to item Cite

The importance of an isolated central nervous system relapse in children with acute lymphoblastic leukemia.

Journal Article J Clin Oncol · June 1985 We assessed the influence of an initial isolated meningeal relapse on treatment outcome in 839 children with acute lymphoblastic leukemia (ALL) who were admitted to St Jude Children's Research Hospital (Memphis) from mid-1967 through mid-1979. The patients ... Full text Link to item Cite

Nail patella syndrome.

Journal Article J Assoc Physicians India · April 1985 Link to item Cite

The bootstrap and identification of prognostic factors via Cox's proportional hazards regression model.

Journal Article Stat Med · 1985 This paper describes the use of the bootstrap, a new computer-based statistical methodology, to help validate a regression model resulting from the fitting of Cox's proportional hazards model to a set of censored survival data. As an example, we define a p ... Full text Link to item Cite

The protein binding of timegadine determined by equilibrium dialysis.

Journal Article Br J Clin Pharmacol · November 1984 The protein binding of timegadine to albumin, serum, plasma and plasma enriched with the acute phase reactants alpha 1-acid glycoprotein, alpha 1-anti-trypsin and C-reactive protein was determined by equilibrium dialysis. The effects of other analgesic and ... Full text Link to item Cite

Cloning efficiency of cultured human tumor cell lines measured with the use of a Coulter particle counter.

Journal Article J Natl Cancer Inst · September 1984 A technique is described by which colony formation in agarose may be rapidly and reproducibly determined with the use of a modified Coulter particle counter (CPC). The cloning efficiency of RD human rhabdomyosarcoma cells after exposure to vincristine sulf ... Link to item Cite

Failure of late intensification therapy to improve a poor result in childhood lymphoblastic leukemia.

Journal Article Cancer Res · August 1984 This clinical study, begun in 1975, tested the efficacy of early and delayed intensification treatments in children with acute lymphoblastic leukemia. Regardless of presenting features, all patients received 4 weeks of conventional induction therapy with d ... Link to item Cite

Poland's syndrome associated with childhood non-Hodgkin's lymphoma.

Journal Article Am J Dis Child · June 1984 Poland's syndrome is a congenital absence of the sternal portion of the pectoralis major muscle, often associated with ipsilateral upper-limb anomalies. We describe two children with non-Hodgkin's lymphoma associated with Poland's syndrome, ie, an associat ... Link to item Cite

T cell subpopulations in CLL: methods of T cell enrichment artificially alter proportions of OKT4 and OKT8 positive cells.

Journal Article Clin Exp Immunol · November 1983 There is growing speculation about the meaning of reported imbalances in subpopulations of T lymphocytes in patients with chronic lymphocytic leukaemia (CLL). This study compared two techniques for producing T cell enriched subpopulations from both patient ... Link to item Cite

Second central nervous system prophylaxis in children with acute lymphoblastic leukemia who relapse after elective cessation of therapy.

Journal Article J Clin Oncol · August 1983 A treatment plan to achieve better disease control in patients with acute lymphoblastic leukemia (ALL) who relapse after elective cessation of therapy was assessed. The principal modifications were (1) a second preventive treatment of the central nervous s ... Full text Link to item Cite

Hair regrowth after cancer therapy.

Journal Article Hum Toxicol · July 1983 Florid scalp hair regrowth following the depilatory effects of both whole cranial radiotherapy and cytotoxic chemotherapy is described in a patient who simultaneously exhibited acquired hypertrichosis lanuginosa in the head and neck region. The regrowth of ... Full text Link to item Cite

The influence of food intake on the bioavailability of timegadine, a novel non-steroidal anti-inflammatory drug.

Journal Article Br J Clin Pharmacol · April 1983 The effects of food ingestion on the absorption of timegadine, a recently synthesised non-steroidal anti-inflammatory drug, was studied in ten healthy volunteers. It was found that food enhanced the absorption of timegadine as shown by increased peak plasm ... Full text Link to item Cite

Systolic time interval characteristics in children with Duchenne's progressive muscular dystrophy.

Journal Article Pediatrics · December 1982 Systolic time interval (STI) characteristics of 17 boys with Duchenne's muscular dystrophy (DMD) were compared with those of 80 normal boys who served as control subjects. The heart rate decreased linearly with age in normal control subjects (r = -.47, P l ... Link to item Cite

Cytokinetically based induction chemotherapy and splenectomy for childhood acute nonlymphocytic leukemia.

Journal Article Blood · October 1982 A four-drug regimen, based on cell kinetic principles, induced complete remissions in 68 of 95 children (72%) with acute nonlymphocytic leukemia (ANLL). Patients entered remission after 2-5 weekly cycles of vincristine-daunorubicin (day 1) followed by sequ ... Link to item Cite

The natural history of colorectal carcinoma in adolescents.

Journal Article Cancer · April 15, 1982 The symptoms, histology, extent, and course of disease of 24 adolescents with colorectal carcinoma who were admitted to St. Jude Children's Hospital between 1964 and 1980 are presented. Twenty of the patients were referred between October 1974 and June 198 ... Full text Link to item Cite

Some historical perspectives on clinical therapeutic trials

Journal Article Cancer Bulletin · January 1, 1982 Cite

Treatment of childhood rhabdomyosarcoma at St. Jude Children's Research Hospital, 1962--78.

Journal Article Natl Cancer Inst Monogr · April 1981 Between March 1962 and December 1978, 153 children with rhabdomyosarcoma (RMS) received treatment at St. Jude Children's Research Hospital. As of January 1979, 62 of these patients were still alive. Between 1962 and 1968, 20 patients were not treated by pr ... Link to item Cite

Sequential clinical trials in cancer research.

Journal Article Cancer Treat Rep · 1980 Decisions to terminate clinical trials have been the subject of intense debate, both before and after the actual decisions are made. This situation reflects the unique character of studies involving human subjects in that the decision to stop is largely an ... Link to item Cite

Quality of survival in histiocytosis X: a Southwest Oncology Group study.

Journal Article Med Pediatr Oncol · 1980 Sixty children survived for five years after the diagnosis of histiocytosis X. Serious disabilities were seen in 50% of children whose disease involved soft tissue and bone. Late deaths from pulmonary failure were associated with opportunistic infections i ... Full text Link to item Cite

Phase II study demonstrating failure of both a five-drug continuous-therapy regimen and a two-drug pulse-therapy regimen in the treatment of metastatic neuroblastoma: Southwest Oncology Group Study 822.

Journal Article Cancer Treat Rep · August 1979 Twenty-six children greater than 1 year of age with previously untreated stage IV neuroblastoma were randomized to receive either a five-drug regimen (prednisone, cyclophosphamide, actinomycin D, vincristine, and daunorubicin) or a two-drug regimen (cyclop ... Link to item Cite

Topography of a flexible ribonucleoprotein helix: protein-protein contacts in Sendai virus nucleocapsids.

Journal Article J Virol · June 1979 Contacts among the three polypeptide species in the flexible helical nucleocapsids of a paramyxovirus were examined with bifunctional protein cross-linking reagents. Polypeptides L and P, minor components of Sendai virus nucleocapsids implicated in viral R ... Full text Link to item Cite

A reappraisal of the results of stopping therapy in childhood leukemia.

Journal Article N Engl J Med · February 8, 1979 We examined the results of stopping therapy in children with acute lymphocytic leukemia. Of 639 patients in eight consecutive "total therapy" studies, 278 (44 per cent) had all treatment stopped, usually after 2 1/2 years of complete remission. About one f ... Full text Link to item Cite

Early deaths in newly diagnosed cases of pediatric acute leukemia: a Southwest Oncology Group Study.

Journal Article Cancer · August 1978 A reanalysis of all ten clinical trials conducted by the Southwest Oncology Group from 1958 thorugh 1976 in newly diagnosed pediatric acute leukemia was carried out to quantify the "early death" rate (i.e., rate of deaths during the first four weeks of rem ... Full text Link to item Cite

Design and evaluation of leukaemia trials.

Journal Article Clin Haematol · June 1978 A satisfactory clinical trial in acute leukaemia has always required a substantial investment in terms of both time and resources. Today, the therapeutic success in the disease is increasing further the difficulty in carrying such trials through to complet ... Full text Link to item Cite

Prognostic factors in the initial response to therapy by patients with advanced breast cancer.

Journal Article J Natl Cancer Inst · April 1978 Identification of important prognostic factors with respect to the patient's initial response to therapy was made from a set of 25 covariates available on 281 patients with advanced breast cancer. Since the patients studied were all participants in a rando ... Full text Link to item Cite

Combination chemotherapy for osteosarcoma.

Journal Article Cancer Treat Rep · February 1978 Because of the great risk for development of pulmonary metastases following amputation for osteosarcoma, 24 consecutive patients with "clinically localized" osteosarcoma of an extremity were given adjuvant combination chemotherapy with adriamycin-cyclophos ... Link to item Cite

Successful chemoprophylaxis for Pneumocystis carinii pneumonitis.

Journal Article N Engl J Med · December 29, 1977 In a randomized, double-blind, placebocontrolled study to evaluate the efficacy of trimethoprim-sulfamethoxazole for the prevention of Pneumocystis carinii pneumonia, we studied 160 patients with cancer who were at high risk for this pneumonia over a two-y ... Full text Link to item Cite

Effects of continuous or discontinuous maintenance therapy on subsequent remission maintenance in childhood leukemia.

Journal Article Cancer · November 1977 This study was designed to determine if resistance to a standard drug during the second remission of children with acute leukemia was reduced by discontinuation of therapy during the initial remission. The initial maintenance therapy was either 6-mercaptop ... Full text Link to item Cite

Initial prognostic factors and lymphoblast-erythrocyte rosette formation in 109 children with acute lymphoblastic leukemia.

Journal Article Blood · October 1977 Bone marrow lymphoblasts from 109 children admitted with untreated acute lymphoblastic leukemia (ALL) were tested for spontaneous rosette formation with sheep erythrocytes. Twenty-six children (24%) had lymphoblasts that formed rosettes (E+). Of 13 initial ... Link to item Cite

Pretreatment cytokinetic studies in 94 children with acute leukemia. Relationship to other variables at diagnosis and to outcome of standard treatment.

Journal Article Blood · May 1977 The relationship of the pretreatment bone marrow mitotic index (MI) and in vitro 3H-thymidine labeling index (LI) to other variables present at diagnosis and to the outcome of standard therapy was examined in a series of 94 children with acute leukemia (71 ... Link to item Cite

Prognotic significance of pretreatment proliferative activity in adult acute leukemia.

Journal Article Cancer · April 1977 A statistical analysis of the prognostic significance of eight pretreatment variables was undertaken for 71 previously untreated adult patients with acute leukemia seen at M.D. Anderson Hospital over a 5 1/2-year period. None of the patients had received a ... Full text Link to item Cite

Combination chemotherapy in histiocytosis X.

Journal Article Med Pediatr Oncol · 1977 Twenty-five children with generalized histiocytosis X were treated with a combination of cyclophosphamide, vinblastine, and prednisone: 8 patients experienced complete response, 8 partial response, 2 imporvement, and 7 no response. Response rates for child ... Full text Link to item Cite

Combination chemotherapy and adriamycin in patients with advanced breast cancer. A Southwest Oncology Group study.

Journal Article Cancer · July 1976 In January, 1972, the Southwest Oncology Group initiated two randomized studies for patients with advanced breast cancer. The study for patients with prior chemotherapy showed a 33% response rate with adriamycin. The study for patients without previous che ... Full text Link to item Cite

Cyclophosphamide-asparaginase- vincristine-prednisone induction therapy in childhood acute lymphocytic and nonlymphocytic leukemia.

Journal Article Cancer · March 1976 A remission-induction regimen for childhood leukemia using cyclophosphamide, asparaginase, vincristine, and prednisone (CAVP) was compared to standard vincristine-prednisone (VP) induction. The more intensive regimen was associated with a lower complete re ... Full text Link to item Cite

Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia.

Journal Article Med Pediatr Oncol · 1976 Six regimens utilizing L-asparaginase in doses of 6,000 IU/M2, 2,000 IU/M2, and 500 IU/M2 in two separate schedules (consecutive and intermittent) along with vincristine and prednisone yielded remarkably similar response rates, approximating 70%, in 306 pr ... Full text Link to item Cite

Unfavorable prognosis of acute leukemia in infancy.

Journal Article Cancer · December 1975 Pretreatment characteristics of 48 infants (under 2 years of age) with leukemia treated over a period of 18 years at a single institution were studied in relation to response to therapy, extramedullary involvement, and survival. In order to provide a basis ... Full text Link to item Cite

Cancer chemotherapeutic response and intravenous hyperalimentation

Journal Article CANCER CHEMOTHER.REP. · December 1, 1975 The data given suggest that chemotherapeutic response is most probable in patients with stable body weight and that increased responsiveness might be realized by concomitant IVH of patients who are losing weight. Law et al. have provided evidence that nutr ... Cite

Adriamycin in the treatment of childhood solid tumors. A Southwest Oncology Group study.

Journal Article Cancer · November 1975 Ninety-eight children with solid tumors resistant to conventional chemotherapy received adriamycin 90 mg/m2, either as a single intravenous injection or in 6 divided doses administered every 6 hours. Of the 88 evaluable children, 6 (7%) achieved a complete ... Full text Link to item Cite

Long-term results of reinforcement therapy in children with acute leukemia.

Journal Article Cancer · November 1975 A total of 180 children with acute leukemia was randomized to one of two induction regimens: vincristine plus prednisone, or 6-mercaptopurine plus prednisone. Of 170 patients evaluable for induction therapy, a hematologic remission was achieved in 83% (72/ ... Full text Link to item Cite

Adjuvant chemotherapy in primary treatment of osteogenic sarcoma. A Southwest Oncology Group study.

Journal Article Cancer · November 1975 A four-drug adjuvant chemotherapy regimen (CONPADRI-I) was utilized in the primary treatment of 18 children with osteogenic sarcoma. All patients had surgical amputation for the primary lesion. The children then received cyclophosphamide, vincristine, melp ... Full text Link to item Cite

Adriamycin in the treatment of childhood acute leukemia. A Southwest Oncology Group study.

Journal Article Cancer · October 1975 Sixty-six children with acute leukemia, in advanced stages of their disease and resistant to conventional chemotherapy, received adriamycin for remssion induction. Seventeen of 46 (37%) evaluable children with acute lymphocytic leukemia achieved a complete ... Full text Link to item Cite

Comparison of prednisolone, vincristine, methotrexate, and 6-mercaptopurine vs. vincristine and prednisone induction therapy in childhood acute leukemia.

Journal Article Cancer · July 1975 This was designed to compare vincristine-prednisone (VP) vs. prednisolone, vincristine, methotrexate, and 6-mercaptopurine (POMP) with respect to response rates and toxicity for induction therapy in acute leukemia. Children with acute lymphoblastic, acute ... Full text Link to item Cite

Serial labeling index determination as a predictor of response in human solid tumors.

Journal Article Cancer Res · June 1975 A rapid method for determining labeling indices in solid tumor specimens, tumor-induced effusions, and tumor-bearing bone marrows was utilized in 116 patients. Of these, 48 patients were studied pre- and postchemotherapy. The magnitude of a significant cha ... Link to item Cite

Childhood rhabdomyosarcoma. Analysis of coordinated therapy and results.

Journal Article Am J Roentgenol Radium Ther Nucl Med · March 1975 Full text Link to item Cite

Evaluation of daunorubicin (NSC-82151) and methotrexate (NSC-740) in combination as a remission maintenance regimen in the treatment of acute leukemia.

Journal Article Cancer Chemother Rep · 1975 The addition of a single monthy dose of daunorubicin (25 mg/m given intravenously) to the maximum tolerated dose of methotrexate (25 mg/m/dose given orally twice weekly) was evaluated as a maintenance regimen in 0 children with acute lymphoblastic leukemia ... Link to item Cite

Concentration of various chemical constituents in the blood of normal cats

Journal Article Journal of the American Animal Hospital Association · January 1, 1975 The levels of several chemical constituents were measured in the serum of 35 apparently normal, mature cats by one to 3 contemporary assay methods. The mean and an estimated normal range of values were calculated from the results of this study. ... Cite

Replicated paired comparisons between two objects: The (k, r)-series

Journal Article Journal of the American Statistical Association · January 1, 1974 The problem considered here is selecting the better of two objects based on a series of replicated paired comparisons between the objects. A (k, r)-series, a generalization of the ordinary k-series, is defined as a sequential selection procedure such that ... Full text Cite

Adriamycin and combination chemotherapy in breast cancer: A Southwest oncology group study

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1974 Cite

Continuous maintenance therapy following either continuous or discontinuous maintenance therapy in childhood leukemia

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1974 Cite

Response and toxicity in childhood leukemia when cyclophosphamide and L asparaginase are added to vincristine prednisone induction

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1974 Cite

Planning the size and duration of a clinical trial studying the time to some critical event

Journal Article Journal of Chronic Diseases · 1974 This paper considers the dual problem of planning the size (i.e. the required number of patients) and the required duration of trial for a fixed sample size clinical trial comparing the length of time to some critical event (such as death or relapse) in tw ... Cite

Reduced mse estimation: Negative binomial distribution

Journal Article American Statistician · January 1, 1972 Full text Cite

A developmental investigation of intellectual functioning in the community aged.

Journal Article The Journal of genetic psychology ; child behavior, animal behavior, and comparative psychology · 1972 Cite

Mortality reporting for childhood leukemia.

Journal Article Pediatrics · November 1971 Link to item Cite

Evaluation of empirical Bayes estimators for small numbers of past samples

Journal Article Biometrika · April 1, 1971 SUMMARY: The usual technique for evaluating the performance of empirical Bayes estimators for small numbers, N, of past observations is to compare by Monte Carlo techniques the global risk for the empirical Bayes estimator to the risk obtained for some opt ... Full text Cite

Estimation of human body surface area from height and weight.

Journal Article Cancer Chemother Rep · August 1970 Link to item Cite

Targeted Clinical Trials

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Endpoints for cancer clinical trials

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