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Impact of race on survival in men with metastatic hormone-refractory prostate cancer.

Publication ,  Journal Article
Halabi, S; Small, EJ; Vogelzang, NJ; Barrier, RC; George, SL; Gilligan, TD
Published in: Urology
August 2004

OBJECTIVES: To determine whether blacks with hormone-refractory prostate cancer have shorter survival compared with whites with the same disease. METHODS: Data from eight multicenter trials (four Phase II and four randomized Phase III studies) conducted by the Cancer and Leukemia Group B were combined. Eligible patients had progressive prostate cancer after androgen deprivation therapy (with documented castration levels of testosterone), an Eastern Cooperative Oncology Group performance status of 0 to 2, and adequate hematologic, renal, and hepatic function. The proportional hazards model was used to assess the prognostic importance of race, adjusting for important factors. All statistical tests were two-sided. RESULTS: Of the 1183 patients, 15% were blacks, 45% of patients had a Gleason sum of 8 or greater, and the median age was 71 years. Of the 1183 patients, 35% had measurable disease and 89% had an Eastern Cooperative Oncology Group performance status of 0 to 1. Blacks were younger, had a shorter interval between diagnosis and study entry, and had greater prostate-specific antigen levels, lower hemoglobin levels, and a lower likelihood of prior prostatectomy than whites. The median survival was 15 months (95% confidence interval 12 to 18) for blacks compared with 14 months (95% confidence interval 13 to 15) for whites. In a multivariate analysis, adjusting for age, performance status, presence of visceral disease, hemoglobin, Gleason sum, prostate-specific antigen level, alkaline phosphatase, lactate dehydrogenase, and years since diagnosis, the hazard ratio was 0.85 (95% confidence interval 0.71 to 1.02, P = 0.08) for blacks compared with whites. CONCLUSIONS: No statistically significant difference was found in overall survival between blacks and whites with metastatic hormone-refractory prostate cancer.

Duke Scholars

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

August 2004

Volume

64

Issue

2

Start / End Page

212 / 217

Location

United States

Related Subject Headings

  • White People
  • Urology & Nephrology
  • United States
  • Survival Analysis
  • Socioeconomic Factors
  • Salvage Therapy
  • Randomized Controlled Trials as Topic
  • Racial Groups
  • Prostatic Neoplasms
  • Prostatectomy
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Halabi, S., Small, E. J., Vogelzang, N. J., Barrier, R. C., George, S. L., & Gilligan, T. D. (2004). Impact of race on survival in men with metastatic hormone-refractory prostate cancer. Urology, 64(2), 212–217. https://doi.org/10.1016/j.urology.2004.04.014
Halabi, Susan, Eric J. Small, Nicholas J. Vogelzang, Robert C. Barrier, Stephen L. George, and Timothy D. Gilligan. “Impact of race on survival in men with metastatic hormone-refractory prostate cancer.Urology 64, no. 2 (August 2004): 212–17. https://doi.org/10.1016/j.urology.2004.04.014.
Halabi S, Small EJ, Vogelzang NJ, Barrier RC, George SL, Gilligan TD. Impact of race on survival in men with metastatic hormone-refractory prostate cancer. Urology. 2004 Aug;64(2):212–7.
Halabi, Susan, et al. “Impact of race on survival in men with metastatic hormone-refractory prostate cancer.Urology, vol. 64, no. 2, Aug. 2004, pp. 212–17. Pubmed, doi:10.1016/j.urology.2004.04.014.
Halabi S, Small EJ, Vogelzang NJ, Barrier RC, George SL, Gilligan TD. Impact of race on survival in men with metastatic hormone-refractory prostate cancer. Urology. 2004 Aug;64(2):212–217.
Journal cover image

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

August 2004

Volume

64

Issue

2

Start / End Page

212 / 217

Location

United States

Related Subject Headings

  • White People
  • Urology & Nephrology
  • United States
  • Survival Analysis
  • Socioeconomic Factors
  • Salvage Therapy
  • Randomized Controlled Trials as Topic
  • Racial Groups
  • Prostatic Neoplasms
  • Prostatectomy