Adriamycin in the treatment of childhood solid tumors. A Southwest Oncology Group study.
Publication
, Journal Article
Ragab, AH; Sutow, WW; Komp, DM; Starling, KA; Lyon, GM; George, S
Published in: Cancer
November 1975
Ninety-eight children with solid tumors resistant to conventional chemotherapy received adriamycin 90 mg/m2, either as a single intravenous injection or in 6 divided doses administered every 6 hours. Of the 88 evaluable children, 6 (7%) achieved a complete response and 26 (29%) achieved a partial response. Tumors which demonstrated significant response rates were: neuroblastoma (9/18), Wilms' tumor (7/13), rhabdomyosarcoma (4/11), and lymphoma (4/8). The toxicities observed with this regimen included: alopecia, leukopenia, thrombocytopenia, nausea, vomiting, stomatitis, febrile episodes, and ST-segment changes.
Duke Scholars
Published In
Cancer
DOI
ISSN
0008-543X
Publication Date
November 1975
Volume
36
Issue
5
Start / End Page
1567 / 1576
Location
United States
Related Subject Headings
- Vomiting
- Thrombocytopenia
- Oncology & Carcinogenesis
- Neoplasms
- Nausea
- Male
- Leukopenia
- Infant
- Humans
- Fever
Citation
APA
Chicago
ICMJE
MLA
NLM
Ragab, A. H., Sutow, W. W., Komp, D. M., Starling, K. A., Lyon, G. M., & George, S. (1975). Adriamycin in the treatment of childhood solid tumors. A Southwest Oncology Group study. Cancer, 36(5), 1567–1576. https://doi.org/10.1002/1097-0142(197511)36:5<1567::aid-cncr2820360505>3.0.co;2-i
Ragab, A. H., W. W. Sutow, D. M. Komp, K. A. Starling, G. M. Lyon, and S. George. “Adriamycin in the treatment of childhood solid tumors. A Southwest Oncology Group study.” Cancer 36, no. 5 (November 1975): 1567–76. https://doi.org/10.1002/1097-0142(197511)36:5<1567::aid-cncr2820360505>3.0.co;2-i.
Ragab AH, Sutow WW, Komp DM, Starling KA, Lyon GM, George S. Adriamycin in the treatment of childhood solid tumors. A Southwest Oncology Group study. Cancer. 1975 Nov;36(5):1567–76.
Ragab, A. H., et al. “Adriamycin in the treatment of childhood solid tumors. A Southwest Oncology Group study.” Cancer, vol. 36, no. 5, Nov. 1975, pp. 1567–76. Pubmed, doi:10.1002/1097-0142(197511)36:5<1567::aid-cncr2820360505>3.0.co;2-i.
Ragab AH, Sutow WW, Komp DM, Starling KA, Lyon GM, George S. Adriamycin in the treatment of childhood solid tumors. A Southwest Oncology Group study. Cancer. 1975 Nov;36(5):1567–1576.
Published In
Cancer
DOI
ISSN
0008-543X
Publication Date
November 1975
Volume
36
Issue
5
Start / End Page
1567 / 1576
Location
United States
Related Subject Headings
- Vomiting
- Thrombocytopenia
- Oncology & Carcinogenesis
- Neoplasms
- Nausea
- Male
- Leukopenia
- Infant
- Humans
- Fever