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Endobronchial interstitial Au-198 implantation in the treatment of recurrent bronchogenic carcinoma.

Publication ,  Journal Article
Tomberlin, JK; Halperin, EC; Kusin, P; Leopold, K; Bentel, G; George, S; Powers, M; Wolfe, W
Published in: J Surg Oncol
April 1992

Nineteen patients with non-small-cell bronchogenic carcinoma, recurrent following initial conventional external beam radiotherapy, were treated with endobronchial implantation of Au-198 seeds. Seventeen patients were symptomatic with primary symptoms of persistent hemoptysis (9), bronchial obstruction (2), or worsening dyspnea (6). Two patients were asymptomatic and implanted for bronchoscopic evidence of tumor recurrence. The dose delivered was described by three dosimetric parameters: 1) the total activity implanted (m Ci); 2) the midbronchial dose point; and 3) the volume of tissue that received greater than 20 Gy. Response was determined based on a system reflecting the primary indication for the implant. Seven of nine (78%) presenting with hemoptysis, four of six (67%) with increasing dyspnea, and one of two with bronchial obstruction responded. The overall median survival was 5.25 months (2.5-10 months 95% confidence interval). There was no clear correlation between any of the dosimetric parameters evaluated and a clinical response to therapy. Technical complications related to the inability to penetrate the scirrhous tumor surface adequately often led to less than optimal dose distribution. Endobronchial Au-198 implantation is associated with a poor calculated dose distribution but is, nonetheless, a relatively simple and comparatively inexpensive technique that often produces a clinical response and can be a useful option in the management of patients with recurrent bronchogenic carcinoma.

Duke Scholars

Published In

J Surg Oncol

DOI

ISSN

0022-4790

Publication Date

April 1992

Volume

49

Issue

4

Start / End Page

213 / 219

Location

United States

Related Subject Headings

  • Survival Analysis
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Lung Neoplasms
  • Humans
  • Gold Radioisotopes
  • Fiber Optic Technology
  • Carcinoma, Bronchogenic
 

Citation

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Chicago
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Tomberlin, J. K., Halperin, E. C., Kusin, P., Leopold, K., Bentel, G., George, S., … Wolfe, W. (1992). Endobronchial interstitial Au-198 implantation in the treatment of recurrent bronchogenic carcinoma. J Surg Oncol, 49(4), 213–219. https://doi.org/10.1002/jso.2930490403
Tomberlin, J. K., E. C. Halperin, P. Kusin, K. Leopold, G. Bentel, S. George, M. Powers, and W. Wolfe. “Endobronchial interstitial Au-198 implantation in the treatment of recurrent bronchogenic carcinoma.J Surg Oncol 49, no. 4 (April 1992): 213–19. https://doi.org/10.1002/jso.2930490403.
Tomberlin JK, Halperin EC, Kusin P, Leopold K, Bentel G, George S, et al. Endobronchial interstitial Au-198 implantation in the treatment of recurrent bronchogenic carcinoma. J Surg Oncol. 1992 Apr;49(4):213–9.
Tomberlin, J. K., et al. “Endobronchial interstitial Au-198 implantation in the treatment of recurrent bronchogenic carcinoma.J Surg Oncol, vol. 49, no. 4, Apr. 1992, pp. 213–19. Pubmed, doi:10.1002/jso.2930490403.
Tomberlin JK, Halperin EC, Kusin P, Leopold K, Bentel G, George S, Powers M, Wolfe W. Endobronchial interstitial Au-198 implantation in the treatment of recurrent bronchogenic carcinoma. J Surg Oncol. 1992 Apr;49(4):213–219.
Journal cover image

Published In

J Surg Oncol

DOI

ISSN

0022-4790

Publication Date

April 1992

Volume

49

Issue

4

Start / End Page

213 / 219

Location

United States

Related Subject Headings

  • Survival Analysis
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Lung Neoplasms
  • Humans
  • Gold Radioisotopes
  • Fiber Optic Technology
  • Carcinoma, Bronchogenic