Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Yale University 1979
• 

  Previous Appointments & Affiliations

  • Professor of Radiation Oncology with Tenure, Radiation Oncology, Clinical Science Departments 1993 - 2006
  • Professor in Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 1997 - 2006
  • Vice Dean for Education and Clinical Affairs in the School of Medicine, and Associate Vice Chancellor for Academic Affairs, School of Medicine, Duke University 2002 - 2006
  • R. J. Reynolds Distinguished Professor of Medical Education, in the School of Medicine, Radiation Oncology, Clinical Science Departments 2003 - 2006
  • Leonard Prosnitz Distinguished Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 1999 - 2003
  • Chair, Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 1996 - 2003
  • Associate Professor in Pediatrics, Pediatrics, Clinical Science Departments 1994 - 1997
  • Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 1987 - 1993
  • Assistant Professor of Radiology, Radiology, Clinical Science Departments 1983 - 1987
• Research
• 

  Selected Grants

  • Race, Religion, and Desegregation in Southern Medical Education awarded by Josiah Charles Trent Memorial Foundation 2006 - 2007
  • Is it a gift or a bribe? awarded by Josiah Charles Trent Memorial Foundation 2001 - 2002
  • History of Jewish Quota for Medical Internships awarded by Josiah Charles Trent Memorial Foundation 1999 - 2000
  • Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
  • Src On Malignant Human Gliomas And Medulloblastomas awarded by National Institutes of Health 1993 - 1994
  • Incidence Of Religious Discrimination At Unc In 1933 awarded by Josiah Charles Trent Memorial Foundation 1989
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Halperin, Edward C. “Particle therapy and treatment of cancer.” Lancet Oncol 7, no. 8 (August 2006): 676–85. https://doi.org/10.1016/S1470-2045(06)70795-1.
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    • Halperin, Edward C. “What or who killed Alexander the Great?” Pharos Alpha Omega Alpha Honor Med Soc 69, no. 3 (2006): 19–25.
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    • Halperin, Edward C., William J. Fulkerson, Russel Kaufman, Paul Newman, and Gary L. Stiles. “Should an academic radiation oncologist be allowed to "opt out" of medicare?” J Am Coll Radiol 2, no. 10 (October 2005): 841–45. https://doi.org/10.1016/j.jacr.2005.03.009.
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    • Halperin, Edward C., Paul Hutchison, and Robert C. Barrier. “A population-based study of the prevalence and influence of gifts to radiation oncologists from pharmaceutical companies and medical equipment manufacturers.” Int J Radiat Oncol Biol Phys 59, no. 5 (August 1, 2004): 1477–83. https://doi.org/10.1016/j.ijrobp.2004.01.052.
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    • Halperin, Edward C. “Paleo-oncology: the role of ancient remains in the study of cancer.” Perspect Biol Med 47, no. 1 (2004): 1–14. https://doi.org/10.1353/pbm.2004.0010.
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    • Long, Gwynn D., Mary Laughlin, Bella Madan, Joanne Kurtzberg, Cristina Gasparetto, Ashley Morris, David Rizzieri, et al. “Unrelated umbilical cord blood transplantation in adult patients.” Biol Blood Marrow Transplant 9, no. 12 (December 2003): 772–80. https://doi.org/10.1016/j.bbmt.2003.08.007.
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    • Halperin, Edward C. “Free speech and snake oil.” Int J Radiat Oncol Biol Phys 57, no. 4 (November 15, 2003): 910–11. https://doi.org/10.1016/s0360-3016(03)00645-x.
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    • McLendon, Roger E., and Edward C. Halperin. “Is the long-term survival of patients with intracranial glioblastoma multiforme overstated?” Cancer 98, no. 8 (October 15, 2003): 1745–48. https://doi.org/10.1002/cncr.11666.
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    • Harrison, Bobby E., Jeffrey L. Johnson, Robert W. Clough, and Edward C. Halperin. “Selection of patients with melanoma brain metastases for aggressive treatment.” Am J Clin Oncol 26, no. 4 (August 2003): 354–57. https://doi.org/10.1097/01.COC.0000020963.71379.FE.
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    • Gururangan, Sridharan, Colleen McLaughlin, Jennifer Quinn, Jeremy Rich, David Reardon, Edward C. Halperin, James Herndon, et al. “High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas.” J Clin Oncol 21, no. 11 (June 1, 2003): 2187–91. https://doi.org/10.1200/JCO.2003.10.096.
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    • Kang, Song K., John P. Kirkpatrick, and Edward C. Halperin. “Low-dose radiation for posttransplant lymphoproliferative disorder.” Am J Clin Oncol 26, no. 2 (April 2003): 210–14. https://doi.org/10.1097/00000421-200304000-00023.
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    • Hahn, C. A., R. H. Dunn, P. E. Logue, J. H. King, C. L. Edwards, and E. C. Halperin. “Prospective study of neuropsychologic testing and quality-of-life assessment of adults with primary malignant brain tumors.” Int J Radiat Oncol Biol Phys 55, no. 4 (March 15, 2003): 992–99. https://doi.org/10.1016/s0360-3016(02)04205-0.
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    • Hutchison, Paul, and Edward C. Halperin. “The hidden persuaders: subtle advertising in radiation oncology.” Int J Radiat Oncol Biol Phys 54, no. 4 (November 15, 2002): 989–91. https://doi.org/10.1016/s0360-3016(02)03789-6.
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    • Halperin, Edward C. “The corporate presence at oncology meetings.” Am J Clin Oncol 25, no. 5 (October 2002): 535–36. https://doi.org/10.1097/00000421-200210000-00023.
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    • Halperin, Edward C., Fran Laurie, and T. J. Fitzgerald. “An evaluation of the relationship between the quality of prophylactic cranial radiotherapy in childhood acute leukemia and institutional experience: a Quality Assurance Review Center-Pediatric Oncology Group study.” Int J Radiat Oncol Biol Phys 53, no. 4 (July 15, 2002): 1001–4. https://doi.org/10.1016/s0360-3016(02)02833-x.
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    • Halperin, E. C. “Should academic medical centers conduct clinical trials of the efficacy of intercessory prayer?” Acad Med 76, no. 8 (August 2001): 791–97. https://doi.org/10.1097/00001888-200108000-00008.
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    • Halperin, E. C. “Non-human to human organ transplantation: its biologic basis and a potential role for radiation therapy.” Int J Cancer 96, no. 2 (April 20, 2001): 76–89. https://doi.org/10.1002/ijc.1010.
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    • Halperin, E. C., D. M. Watson, and S. L. George. “Duration of symptoms prior to diagnosis is related inversely to presenting disease stage in children with medulloblastoma.” Cancer 91, no. 8 (April 15, 2001): 1444–50. https://doi.org/10.1002/1097-0142(20010415)91:8<1444::aid-cncr1151>3.0.co;2-u.
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    • Halperin, E. C. “The Jewish problem in U.S. medical education, 1920-1955.” J Hist Med Allied Sci 56, no. 2 (April 2001): 140–67. https://doi.org/10.1093/jhmas/56.2.140.
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    • Wenzel, C. T., E. C. Halperin, and S. R. Fisher. “Second malignant neoplasms of the head and neck in survivors of retinoblastoma.” Ear Nose Throat J 80, no. 2 (February 2001): 106–12.
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    • Halperin, E. C. “Overpriced technology in radiation oncology.” Int J Radiat Oncol Biol Phys 48, no. 4 (November 1, 2000): 917–18. https://doi.org/10.1016/s0360-3016(00)00756-2.
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    • Halperin, E. C. “Grievances against physicians: 11 years' experience of a medical society grievance committee.” West J Med 173, no. 4 (October 2000): 235–38. https://doi.org/10.1136/ewjm.173.4.235.
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    • Halperin, E. C. “Neonatal neoplasms.” Int J Radiat Oncol Biol Phys 47, no. 1 (April 1, 2000): 171–78. https://doi.org/10.1016/s0360-3016(00)00424-7.
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    • Halperin, E. C. “A completely efficient life. Francis Henry Williams, MD, pioneer radiologist.” N C Med J 61, no. 4 (2000): 199–202.
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    • Halperin, E. C. “Whatever happened to psychotherapy?” N C Med J 61, no. 1 (2000): 423–24.
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    • DeBacker, C. M., J. J. Dutton, A. D. Proia, E. C. Halperin, T. N. Wagle, and D. E. Holck. “The influence of hyperbaric oxygen therapy and irradiation on hydroxyapatite ocular implant exposure and fibrovascular ingrowth in New Zealand white rabbits.” Ophthalmic Plast Reconstr Surg 15, no. 6 (November 1999): 412–19. https://doi.org/10.1097/00002341-199911000-00009.
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    • Fortney, J. T., E. C. Halperin, C. M. Hertz, and S. R. Schulman. “Anesthesia for pediatric external beam radiation therapy.” Int J Radiat Oncol Biol Phys 44, no. 3 (June 1, 1999): 587–91. https://doi.org/10.1016/s0360-3016(99)00058-9.
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    • Halperin, E. C. “Publish or perish--and bankrupt the medical library while we're at it.” Acad Med 74, no. 5 (May 1999): 470–72. https://doi.org/10.1097/00001888-199905000-00009.
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    • Maguire, P. D., R. Clough, A. H. Friedman, and E. C. Halperin. “Fractionated external-beam radiation therapy for meningiomas of the cavernous sinus.” Int J Radiat Oncol Biol Phys 44, no. 1 (April 1, 1999): 75–79. https://doi.org/10.1016/s0360-3016(98)00558-6.
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    • Halperin, E. C. “Kidney cancer.” Lancet 353, no. 9152 (February 13, 1999): 594. https://doi.org/10.1016/S0140-6736(05)75656-7.
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    • Halperin, E. C. “The North Carolina Medical Journal finds itself in the vanguard of progressive medical journalism or, the deputy editor finds his fifteen minutes of fame.” N C Med J 60, no. 3 (1999): 138–39.
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    • Drayer, J. A., L. B. Marks, G. Bentel, and E. C. Halperin. “Defining the superior border of posterior fossa radiation treatment fields.” Int J Radiat Oncol Biol Phys 41, no. 3 (June 1, 1998): 625–29. https://doi.org/10.1016/s0360-3016(98)00075-3.
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    • Graham, M. L., B. L. Asselin, J. E. Herndon, J. R. Casey, S. Chaffee, G. H. Ciocci, C. W. Daeschner, et al. “Toxicity, pharmacology and feasibility of administration of PEG-L-asparaginase as consolidation therapy in patients undergoing bone marrow transplantation for acute lymphoblastic leukemia.” Bone Marrow Transplant 21, no. 9 (May 1998): 879–85. https://doi.org/10.1038/sj.bmt.1701223.
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    • Halperin, E. C. “Let's abolish the Office of Alternative Medicine of the National Institutes of Health.” N C Med J 59, no. 1 (1998): 21–23.
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    • Strother, D., J. van Hoff, P. V. Rao, E. I. Smith, R. C. Shamberger, E. C. Halperin, K. J. Murray, and R. P. Castleberry. “Event-free survival of children with biologically favourable neuroblastoma based on the degree of initial tumour resection: results from the Pediatric Oncology Group.” Eur J Cancer 33, no. 12 (October 1997): 2121–25. https://doi.org/10.1016/s0959-8049(97)00293-1.
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    • Halperin, E. C., and G. J. Broadwater. “Are there sex biases in standardized tests of radiation oncology knowledge?” J Clin Oncol 15, no. 7 (July 1997): 2722–27. https://doi.org/10.1200/JCO.1997.15.7.2722.
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    • Halperin, E. C. “Why is female sex an independent predictor of shortened overall survival after proton/photon radiation therapy for skull base chordomas?” Int J Radiat Oncol Biol Phys 38, no. 2 (May 1, 1997): 225–30. https://doi.org/10.1016/s0360-3016(97)00041-2.
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    • Halperin, E. C. “Long-term results of therapy for stage C neuroblastoma.” J Surg Oncol 63, no. 3 (November 1996): 172–78. https://doi.org/10.1002/(SICI)1096-9098(199611)63:3<172::AID-JSO7>3.0.CO;2-A.
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    • Merrill, P. T., E. G. Buckley, and E. C. Halperin. “New and recurrent tumors in germinal retinoblastoma: is there a treatment effect?” Ophthalmic Genet 17, no. 3 (September 1996): 115–18. https://doi.org/10.3109/13816819609057114.
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    • Halperin, E. C., and H. S. Friedman. “Is there a correlation between duration of presenting symptoms and stage of medulloblastoma at the time of diagnosis?” Cancer 78, no. 4 (August 15, 1996): 874–80. https://doi.org/10.1002/(SICI)1097-0142(19960815)78:4<874::AID-CNCR26>3.0.CO;2-R.
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    • Halperin, E. C. “Impact of radiation technique upon the outcome of treatment for medulloblastoma.” Int J Radiat Oncol Biol Phys 36, no. 1 (August 1, 1996): 233–39. https://doi.org/10.1016/s0360-3016(96)00276-3.
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    • Kurtzberg, J., M. Laughlin, M. L. Graham, C. Smith, J. F. Olson, E. C. Halperin, G. Ciocci, C. Carrier, C. E. Stevens, and P. Rubinstein. “Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients.” N Engl J Med 335, no. 3 (July 18, 1996): 157–66. https://doi.org/10.1056/NEJM199607183350303.
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    • Halperin, E. C., J. Herndon, S. C. Schold, M. Brown, N. Vick, J. G. Cairncross, D. R. Macdonald, et al. “A phase III randomized prospective trial of external beam radiotherapy, mitomycin C, carmustine, and 6-mercaptopurine for the treatment of adults with anaplastic glioma of the brain. CNS Cancer Consortium.” Int J Radiat Oncol Biol Phys 34, no. 4 (March 1, 1996): 793–802. https://doi.org/10.1016/0360-3016(95)02025-x.
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    • Graham, M. L., W. F. Rosse, E. C. Halperin, C. R. Miller, and R. E. Ware. “Resolution of Budd-Chiari syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria.” Br J Haematol 92, no. 3 (March 1996): 707–10. https://doi.org/10.1046/j.1365-2141.1996.365901.x.
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    • Halperin, E. C., T. Samulski, W. J. Oakes, and H. S. Friedman. “Fabrication and testing of a device capable of reducing the incidence of ventricular shunt promoted metastasis.” J Neurooncol 27, no. 1 (January 1996): 39–46. https://doi.org/10.1007/BF00146082.
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    • Halperin, E. C. “The North Carolina Mutual Life Insurance Company, Dr. Clyde Henry Donnell, and the health education of blacks.” N C Med J 56, no. 11 (November 1995): 570–74.
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    • Halperin, E. C. “Is tenure irrelevant for academic clinicians?” South Med J 88, no. 11 (November 1995): 1099–1106. https://doi.org/10.1097/00007611-199511000-00003.
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    • Halperin, E. C., R. L. Byyny, S. Moore, and P. S. Morahan. “What medical schools and universities can learn from one another.” Acad Med 70, no. 10 (October 1995): 879–83. https://doi.org/10.1097/00001888-199510000-00010.
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    • Halperin, E. C. “Three rear ends on the beach. Debating the ethics of medical advertising.” N C Med J 56, no. 8 (August 1995): 402–3.
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    • Constine, L. S., R. B. Marcus, and E. C. Halperin. “The future of therapy for childhood rhabdomyosarcoma: clues from molecular biology.” Int J Radiat Oncol Biol Phys 32, no. 4 (July 15, 1995): 1245–49. https://doi.org/10.1016/0360-3016(95)00237-s.
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    • Marks, L. B., and E. C. Halperin. “Radiosurgery is not "standard of care" for solitary brain metastases: regarding Flickinger et al., IJROBP 28:797-802; 1994.” Int J Radiat Oncol Biol Phys 32, no. 2 (May 15, 1995): 557–59. https://doi.org/10.1016/0360-3016(95)98591-U.
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    • Halperin, E. C. “Malignant gliomas in older adults with poor prognostic signs. Getting nowhere, and taking a long time to do it.” Oncology (Williston Park) 9, no. 3 (March 1995): 229–34.
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    • Yamaguchi, Y., E. C. Halperin, K. Mori, R. R. Bollinger, and M. Ogawa. “Recipient Kupffer cell influx into xenografted liver.” Dig Dis Sci 40, no. 3 (March 1995): 548–51. https://doi.org/10.1007/BF02064367.
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    • Halperin, E. C., and M. R. Sontag. “Techniques of experimental animal radiotherapy.” Lab Anim Sci 44, no. 5 (October 1994): 417–23.
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    • Lachance, D. H., D. M. Brizel, J. P. Gockerman, E. C. Halperin, P. C. Burger, O. B. Boyko, M. T. Brown, and S. C. Schold. “Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma: short-duration response and multifocal intracerebral recurrence preceding radiotherapy.” Neurology 44, no. 9 (September 1994): 1721–27. https://doi.org/10.1212/wnl.44.9.1721.
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    • Bauman, G. S., L. E. Gaspar, B. J. Fisher, E. C. Halperin, D. R. Macdonald, and J. G. Cairncross. “A prospective study of short-course radiotherapy in poor prognosis glioblastoma multiforme.” Int J Radiat Oncol Biol Phys 29, no. 4 (July 1, 1994): 835–39. https://doi.org/10.1016/0360-3016(94)90573-8.
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    • Halperin, E. C. “Oral contraceptives as an over-the-counter medication.” N C Med J 55, no. 5 (May 1994): 183–86.
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    • Halperin, E. C. “Eureka! It's a negative study!.” N C Med J 55, no. 2 (February 1994): 68–69.
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    • Moghrabi, A., H. S. Friedman, R. McLendon, B. Hockenberger, R. D. Tien, E. C. Halperin, and W. J. Oakes. “Arteriovenous malformation mimicking recurrent medulloblastoma.” Med Pediatr Oncol 22, no. 2 (1994): 140–43. https://doi.org/10.1002/mpo.2950220216.
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    • Nashold, J. R., W. J. Oakes, H. S. Friedman, E. C. Halperin, M. Soo, B. Hockenberger, G. N. Fuller, and R. Tien. “Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein.” Med Pediatr Oncol 22, no. 2 (1994): 137–39. https://doi.org/10.1002/mpo.2950220215.
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    • Osumi, A. K., R. E. Mclendon, R. D. Tien, H. S. Friedman, M. Graham, B. Hockenberger, E. C. Halperin, and W. J. Oakes. “Well differentiated astrocytoma occurring nine years after radiation therapy for medulloblastoma.” Clin Neuropathol 13, no. 5 (1994): 281–85.
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    • Halperin, E. C., H. S. Friedman, S. C. Schold, H. E. Fuchs, W. J. Oakes, B. Hockenberger, and P. C. Burger. “Surgery, hyperfractionated craniospinal irradiation, and adjuvant chemotherapy in the management of supratentorial embryonal neuroepithelial neoplasms in children.” Surg Neurol 40, no. 4 (October 1993): 278–83. https://doi.org/10.1016/0090-3019(93)90138-q.
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    • Freeman, C. R., J. P. Krischer, R. A. Sanford, M. E. Cohen, P. C. Burger, R. del Carpio, E. C. Halperin, L. Munoz, H. S. Friedman, and L. E. Kun. “Final results of a study of escalating doses of hyperfractionated radiotherapy in brain stem tumors in children: a Pediatric Oncology Group study.” Int J Radiat Oncol Biol Phys 27, no. 2 (September 30, 1993): 197–206. https://doi.org/10.1016/0360-3016(93)90228-n.
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    • Halperin, E. C. “Screening for prostate cancer utilizing the prostate-specific antigen (PSA).” N C Med J 54, no. 9 (September 1993): 443–46.
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    • Acker, J. C., E. H. Bossen, and E. C. Halperin. “The management of desmoid tumors.” Int J Radiat Oncol Biol Phys 26, no. 5 (August 1, 1993): 851–58. https://doi.org/10.1016/0360-3016(93)90501-l.
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    • Halperin, E. C., L. Gaspar, J. Imperato, M. Salter, J. Herndon, and S. Dowling. “An analysis of radiotherapy data from the CNS cancer consortium's randomized prospective trial comparing AZQ to BCNU in the treatment of patients with primary malignant brain tumors. The CNS cancer consortium.” Am J Clin Oncol 16, no. 4 (August 1993): 277–83. https://doi.org/10.1097/00000421-199308000-00001.
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    • Marks, L. B., and E. C. Halperin. “The use of G-CSF during craniospinal irradiation.” Int J Radiat Oncol Biol Phys 26, no. 5 (August 1, 1993): 905–6. https://doi.org/10.1016/0360-3016(93)90509-t.
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    • Gravatt, L. C., S. Chaffee, M. E. Hebert, E. C. Halperin, H. S. Friedman, and J. Kurtzberg. “Efficacy and toxicity of 9-beta-D-arabinofuranosylguanine (araG) as an agent to purge malignant T cells from murine bone marrow: application to an in vivo T-leukemia model.” Leukemia 7, no. 8 (August 1993): 1261–67.
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    • Hebert, M. E., E. C. Halperin, W. J. Oakes, and O. B. Boyko. “Multiple fraction-per-day radiotherapy for patients with brain stem tumors.” J Neurooncol 17, no. 2 (August 1993): 131–38. https://doi.org/10.1007/BF01050215.
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    • Gockerman, J. P., E. C. Halperin, G. C. Magrinat, B. M. Hendrix, and W. P. Peters. “Physician-assisted suicide and advance directives concerning life support.” N C Med J 54, no. 7 (July 1993): 312–16.
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    • Kavanagh, B. D., E. C. Halperin, and G. Nilaver. “Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx.” Cancer 72, no. 1 (July 1, 1993): 299. https://doi.org/10.1002/1097-0142(19930701)72:1<299::aid-cncr2820720152>3.0.co;2-8.
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    • Halperin, E. C., L. Gaspar, S. George, D. Darr, and S. Pinnell. “A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. CNS Cancer Consortium.” Int J Radiat Oncol Biol Phys 26, no. 3 (June 15, 1993): 413–16. https://doi.org/10.1016/0360-3016(93)90958-x.
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    • Halperin, E. C. “Concerning the inferior portion of the spinal radiotherapy field for malignancies that disseminate via the cerebrospinal fluid.” Int J Radiat Oncol Biol Phys 26, no. 2 (May 20, 1993): 357–62. https://doi.org/10.1016/0360-3016(93)90218-k.
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    • Gaspar, L. E., B. J. Fisher, D. R. MacDonald, D. V. LeBer, E. C. Halperin, S. C. Schold, and J. G. Cairncross. “Malignant glioma--timing of response to radiation therapy.” Int J Radiat Oncol Biol Phys 25, no. 5 (April 2, 1993): 877–79. https://doi.org/10.1016/0360-3016(93)90318-p.
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    • Schold, S. C., J. E. Herndon, P. C. Burger, E. C. Halperin, N. A. Vick, J. G. Cairncross, D. R. Macdonald, E. J. Dropcho, R. Morawetz, and D. D. Bigner. “Randomized comparison of diaziquone and carmustine in the treatment of adults with anaplastic glioma.” J Clin Oncol 11, no. 1 (January 1993): 77–83. https://doi.org/10.1200/JCO.1993.11.1.77.
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    • Bentel, G. C., E. C. Halperin, and E. G. Buckley. “125I embedded in an orbital prosthesis for retreatment of recurrent retinoblastoma.” Med Dosim 18, no. 1 (1993): 1–5. https://doi.org/10.1016/0958-3947(93)90019-p.
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    • Bruggers, C. S., H. S. Friedman, G. N. Fuller, R. D. Tien, L. B. Marks, E. C. Halperin, B. Hockenberger, W. J. Oakes, and J. M. Hoffman. “Comparison of serial PET and MRI scans in a pediatric patient with a brainstem glioma.” Med Pediatr Oncol 21, no. 4 (1993): 301–6. https://doi.org/10.1002/mpo.2950210414.
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    • Halperin, E. C., J. Scott, and S. L. George. “Multiple authorship in two English-language journals in radiation oncology.” Acad Med 67, no. 12 (December 1992): 850–56. https://doi.org/10.1097/00001888-199212000-00012.
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    • Halperin, E. C. “Multiple-fraction-per-day external beam radiotherapy for adults with supratentorial malignant gliomas.” J Neurooncol 14, no. 3 (November 1992): 255–62. https://doi.org/10.1007/BF00172601.
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    • Malik, R. K., G. N. Fuller, W. J. Oakes, R. Tien, B. Hockenberger, H. S. Friedman, and E. C. Halperin. “Back pain and paraplegia in a fifteen-year-old boy.” J Pediatr 121, no. 4 (October 1992): 652–58. https://doi.org/10.1016/s0022-3476(05)81166-7.
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    • Nelson, S. C., H. S. Friedman, W. J. Oakes, E. C. Halperin, R. Tien, G. N. Fuller, B. Hockenberger, M. W. Scroggs, M. Moncino, and J. Kurtzberg. “Successful therapy for trilateral retinoblastoma.” Am J Ophthalmol 114, no. 1 (July 15, 1992): 23–29. https://doi.org/10.1016/s0002-9394(14)77408-2.
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    • Halperin, E. C. “Medical oaths.” Acad Med 67, no. 4 (April 1992): 252–53. https://doi.org/10.1097/00001888-199204000-00011.
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    • Tomberlin, J. K., E. C. Halperin, P. Kusin, K. Leopold, G. Bentel, S. George, M. Powers, and W. Wolfe. “Endobronchial interstitial Au-198 implantation in the treatment of recurrent bronchogenic carcinoma.” J Surg Oncol 49, no. 4 (April 1992): 213–19. https://doi.org/10.1002/jso.2930490403.
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    • Kavanagh, B. D., E. C. Halperin, L. C. Rosenbaum, E. M. Shannon, and G. Nilaver. “Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx.” Cancer 69, no. 6 (March 15, 1992): 1315–19. https://doi.org/10.1002/1097-0142(19920315)69:6<1315::aid-cncr2820690602>3.0.co;2-2.
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    • Arora, V., K. Weeks, E. C. Halperin, and J. J. Dutton. “Influence of coralline hydroxyapatite used as an ocular implant on the dose distribution of external beam photon radiation therapy.” Ophthalmology 99, no. 3 (March 1992): 380–82. https://doi.org/10.1016/s0161-6420(92)31977-3.
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    • Halperin, E. C., D. M. Brizel, G. Honore, M. R. Sontag, O. W. Griffith, D. D. Bigner, and H. S. Friedman. “The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine.” Int J Radiat Oncol Biol Phys 24, no. 1 (1992): 103–9. https://doi.org/10.1016/0360-3016(92)91028-l.
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    • Donnal, J., E. C. Halperin, H. S. Friedman, and O. B. Boyko. “Subfrontal recurrence of medulloblastoma.” Ajnr Am J Neuroradiol 13, no. 6 (1992): 1617–18.
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    • Gaspar, L. E., B. J. Fisher, D. R. Macdonald, D. V. LeBer, E. C. Halperin, S. C. Schold, and J. G. Cairncross. “Supratentorial malignant glioma: patterns of recurrence and implications for external beam local treatment.” Int J Radiat Oncol Biol Phys 24, no. 1 (1992): 55–57. https://doi.org/10.1016/0360-3016(92)91021-e.
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    • Hoffman, J. M., M. W. Hanson, H. S. Friedman, B. M. Hockenberger, W. J. Oakes, E. C. Halperin, and R. E. Coleman. “FDG-PET in pediatric posterior fossa brain tumors.” J Comput Assist Tomogr 16, no. 1 (1992): 62–68. https://doi.org/10.1097/00004728-199201000-00011.
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    • Kligerman, A. D., M. F. Bryant, C. L. Doerr, E. C. Halperin, P. Kwanyuen, M. R. Sontag, and G. L. Erexson. “Interspecies cytogenetic comparisons: studies with X-radiation and bleomycin sulfate.” Environ Mol Mutagen 19, no. 3 (1992): 235–43. https://doi.org/10.1002/em.2850190308.
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    • Marks, L. B., E. C. Halperin, L. R. Prosnitz, M. Ross, J. J. Vredenburgh, G. L. Rosner, and W. Peters. “Post-mastectomy radiotherapy following adjuvant chemotherapy and autologous bone marrow transplantation for breast cancer patients with greater than or equal to 10 positive axillary lymph nodes. Cancer and Leukemia Group B.” Int J Radiat Oncol Biol Phys 23, no. 5 (1992): 1021–26. https://doi.org/10.1016/0360-3016(92)90908-z.
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    • Halperin, E. C. “A groundless hypothesis, megaloblastic madness, and the founding of Duke University.” Med Hypotheses 36, no. 3 (November 1991): 200–203. https://doi.org/10.1016/0306-9877(91)90130-q.
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    • Erexson, G. L., A. D. Kligerman, M. F. Bryant, M. R. Sontag, and E. C. Halperin. “Induction of micronuclei by X-radiation in human, mouse and rat peripheral blood lymphocytes.” Mutat Res 253, no. 2 (October 1991): 193–98. https://doi.org/10.1016/0165-1161(91)90132-r.
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    • Freeman, C. R., J. Krischer, R. A. Sanford, M. E. Cohen, P. C. Burger, L. Kun, E. C. Halperin, I. Crocker, and M. Wharam. “Hyperfractionated radiation therapy in brain stem tumors. Results of treatment at the 7020 cGy dose level of Pediatric Oncology Group study #8495.” Cancer 68, no. 3 (August 1, 1991): 474–81. https://doi.org/10.1002/1097-0142(19910801)68:3<474::aid-cncr2820680305>3.0.co;2-7.
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    • Scroggs, M. W., A. D. Proia, C. F. Smith, E. C. Halperin, and G. K. Klintworth. “The effect of total-body irradiation on corneal neovascularization in the Fischer 344 rat after chemical cauterization.” Invest Ophthalmol Vis Sci 32, no. 7 (June 1991): 2105–11.
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    • Halperin, E. C. “Suspicionless drug testing of physicians.” N C Med J 52, no. 4 (April 1991): 131–35.
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    • Yamaguchi, Y., E. C. Halperin, K. Mori, M. Misumi, T. Katsumori, N. Takata, M. Goto, Y. Makino, N. Kikuchi, and K. Takahashi. “Macrophage migration into hepatic xenografts in the hamster-to-rat combination.” Transplant Proc 23, no. 1 Pt 1 (February 1991): 220–21.
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    • Bollinger, R. R., M. A. Fabian, R. C. Harland, W. J. Murray, W. M. Baldwin, K. Abernethy, L. Britt, M. Sontag, and E. C. Halperin. “Total lymphoid irradiation for cardiac xenotransplantation in nonhuman primates.” Transplant Proc 23, no. 1 Pt 1 (February 1991): 587–88.
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    • Pruitt, S. K., E. C. Halperin, and R. R. Bollinger. “The effect of 15-deoxyspergualin on hamster-to-rat cardiac xenograft survival.” Transplant Proc 23, no. 1 Pt 1 (February 1991): 585–86.
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    • Griebel, M., H. S. Friedman, E. C. Halperin, M. D. Wiener, L. Marks, W. J. Oakes, J. M. Hoffman, G. R. DeLong, S. C. Schold, and B. Hockenberger. “Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma.” Med Pediatr Oncol 19, no. 3 (1991): 182–86. https://doi.org/10.1002/mpo.2950190307.
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    • Bentel, G. C., and E. C. Halperin. “High-dose areas are unintentionally created as a result of gap shifts when the prescribed dose in the two adjacent areas are different.” Med Dosim 15, no. 4 (December 1990): 179–83. https://doi.org/10.1016/0958-3947(90)90004-2.
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    • Kligerman, A. D., E. C. Halperin, G. L. Erexson, and G. Honoré. “The persistence of lymphocytes with dicentric chromosomes following whole-body X irradiation of mice.” Radiat Res 124, no. 1 (October 1990): 22–27.
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    • Halperin, E. C. “Doublespeak in high places.” N C Med J 51, no. 8 (August 1990): 393–95.
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    • Green, D. M., T. V. Samulski, C. Vervaert, E. C. Halperin, J. R. Oleson, and H. Seigler. “Effects of hyperthermia and irradiation on the growth of mouse melanoma tumors following immunotherapy.” J Surg Oncol 44, no. 4 (August 1990): 256–59. https://doi.org/10.1002/jso.2930440413.
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    • Halperin, E. C., S. J. Knechtle, R. C. Harland, Y. Yamaguchi, M. Sontag, and R. R. Bollinger. “Irradiation for xenogeneic transplantation.” Radiother Oncol 18, no. 1 (May 1990): 29–37. https://doi.org/10.1016/0167-8140(90)90020-w.
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    • Halperin, E. C. “Informed consent for AIDS testing. Or: whose vein is it anyway?” N C Med J 51, no. 4 (April 1990): 145–49.
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    • Lippitz, B. E., E. C. Halperin, O. W. Griffith, O. M. Colvin, G. Honore, C. B. Ostertag, D. D. Bigner, and H. S. Friedman. “L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice.” Neurosurgery 26, no. 2 (February 1990): 255–60. https://doi.org/10.1097/00006123-199002000-00012.
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    • Halperin, E. C. “The North Carolina Medical Journal and its peers.” N C Med J 51, no. 1 (January 1990): 23–25.
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    • Yamaguchi, Y., E. C. Halperin, R. C. Harland, C. Wyble, and R. R. Bollinger. “Significant prolongation of hamster liver transplant survival in Lewis rats by total-lymphoid irradiation, cyclosporine, and splenectomy.” Transplantation 49, no. 1 (January 1990): 13–17. https://doi.org/10.1097/00007890-199001000-00003.
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    • Halperin, E. C., G. Bentel, E. R. Heinz, and P. C. Burger. “Radiation therapy treatment planning in supratentorial glioblastoma multiforme: an analysis based on post mortem topographic anatomy with CT correlations.” Int J Radiat Oncol Biol Phys 17, no. 6 (December 1989): 1347–50. https://doi.org/10.1016/0360-3016(89)90548-8.
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    • Halperin, E. C., and S. T. Morrow. “Reducing infant mortality in North Carolina.” N C Med J 50, no. 8 (August 1989): 419–20.
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    • Friedman, H. S., S. C. Schold, M. S. Mahaley, O. M. Colvin, W. J. Oakes, N. A. Vick, P. C. Burger, S. H. Bigner, M. Borowitz, and E. C. Halperin. “Phase II treatment of medulloblastoma and pineoblastoma with melphalan: clinical therapy based on experimental models of human medulloblastoma.” J Clin Oncol 7, no. 7 (July 1989): 904–11. https://doi.org/10.1200/JCO.1989.7.7.904.
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    • Yamaguchi, Y., E. C. Halperin, R. C. Harland, C. Wyble, and R. R. Bollinger. “A synergistic effect of total lymphoid irradiation, cyclosporine, and splenectomy in a hamster-to-rat hepatic xenograft model.” Transplant Proc 21, no. 3 (June 1989): 3556.
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    • Halperin, E. C. “Consent for a minor's abortion.” N C Med J 50, no. 4 (April 1989): 214–15.
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    • Suvarnamani, C., E. C. Halperin, A. D. Proia, and G. K. Klintworth. “The effects of total lymphoid irradiation upon corneal vascularization in the rat following chemical cautery.” Radiat Res 117, no. 2 (February 1989): 259–72.
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    • Harland, R. C., E. C. Halperin, Y. Yamaguchi, P. Ruiz, M. W. Scroggs, F. Sanfilippo, and R. R. Bollinger. “Total lymphoid irradiation and cyclosporine prolongs cardiac allograft survival in the sensitized rat model.” Transplant Proc 21, no. 1 Pt 1 (February 1989): 1118–19.
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    • Friedman, H. S., S. C. Schold, W. T. Djang, J. Kurtzberg, D. C. Longee, E. C. Halperin, J. M. Falletta, R. E. Coleman, and W. J. Oakes. “Criteria for termination of phase II chemotherapy for patients with progressive or recurrent brain tumor.” Neurology 39, no. 1 (January 1989): 62–66. https://doi.org/10.1212/wnl.39.1.62.
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    • Erexson, G. L., A. D. Kligerman, E. C. Halperin, G. M. Honoré, and J. W. Allen. “Micronuclei in binucleated lymphocytes of mice following exposure to gamma radiation.” Environ Mol Mutagen 13, no. 2 (1989): 128–32. https://doi.org/10.1002/em.2850130207.
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    • Halperin, E. C. “Physician awareness of the contents of the Hippocratic Oath.” J Med Humanit 10, no. 2 (1989): 107–14. https://doi.org/10.1007/BF01137575.
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    • Halperin, E. C., S. M. Wehn, J. W. Scott, W. Djang, W. J. Oakes, and H. S. Friedman. “Selection of a management strategy for pediatric brainstem tumors.” Med Pediatr Oncol 17, no. 2 (1989): 117–26. https://doi.org/10.1002/mpo.2950170209.
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    • Weaver, J. P., J. D. Bobbitt, and E. C. Halperin. “The Model Health Care Provider Liability Reform Act. A summary and commentary.” N C Med J 49, no. 12 (December 1988): 621–24.
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    • Halperin, E. C. “The right to privacy and the duty to protect.” South Med J 81, no. 10 (October 1988): 1286–90. https://doi.org/10.1097/00007611-198810000-00019.
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    • Halperin, E. C., and R. R. Bollinger. “The role of irradiation in solid organ transplantation.” Int J Radiat Oncol Biol Phys 15, no. 4 (October 1988): 979–88. https://doi.org/10.1016/0360-3016(88)90135-6.
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    • Halperin, E. C. “George Bush, Michael Dukakis, and health policy issues in the 1988 presidential campaign.” N C Med J 49, no. 9 (September 1988): 433–38.
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    • Halperin, E. C. “The audition elective.” Int J Radiat Oncol Biol Phys 15, no. 3 (September 1988): 791–92. https://doi.org/10.1016/0360-3016(88)90330-6.
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    • Halperin, E. C. “X-rays at the bar, 1896-1910.” Invest Radiol 23, no. 8 (August 1988): 639–46. https://doi.org/10.1097/00004424-198808000-00020.
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    • Halperin, E. C., P. C. Burger, and D. E. Bullard. “The fallacy of the localized supratentorial malignant glioma.” Int J Radiat Oncol Biol Phys 15, no. 2 (August 1988): 505–9. https://doi.org/10.1016/s0360-3016(98)90036-0.
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    • Kligerman, A. D., E. C. Halperin, G. L. Erexson, G. Honoré, B. Westbrook-Collins, and J. W. Allen. “A cytogenetic comparison of the responses of mouse and human peripheral blood lymphocytes to 60Co gamma radiation.” Radiat Res 115, no. 2 (August 1988): 334–46.
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    • Werner, M. H., P. C. Burger, E. R. Heinz, A. H. Friedman, E. C. Halperin, and S. C. Schold. “Intracranial atherosclerosis following radiotherapy.” Neurology 38, no. 7 (July 1988): 1158–60. https://doi.org/10.1212/wnl.38.7.1158.
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    • Friedman, H. S., P. C. Burger, S. H. Bigner, J. Q. Trojanowski, G. M. Brodeur, X. M. He, C. J. Wikstrand, J. Kurtzberg, M. E. Berens, and E. C. Halperin. “Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc.” Am J Pathol 130, no. 3 (March 1988): 472–84.
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    • Frantz, F. W., D. J. Terris, C. W. Wyble, E. C. Halperin, F. Sanfilippo, M. W. Scroggs, G. Honoré, and R. R. Bollinger. “Allogeneic small bowel transplantation with cyclosporine and donor whole-body irradiation.” Transplant Proc 20, no. 1 Suppl 1 (February 1988): 193–96.
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    • Halperin, E. C., R. W. Fraser, and J. Hughes. “The management of clinically localized prostate cancer. A summary of the Consensus Statement of the National Institutes of Health.” N C Med J 49, no. 2 (February 1988): 75–79.
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    • Halperin, E. C. “Desegregation of hospitals and medical societies in North Carolina.” N Engl J Med 318, no. 1 (January 7, 1988): 58–63. https://doi.org/10.1056/NEJM198801073180127.
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    • Halperin, E. C. “Medical origins of Duke University?” N C Med J 48, no. 12 (December 1987): 664–66.
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    • Halperin, E. C. “Hepatic metastasis from neuroblastoma.” South Med J 80, no. 11 (November 1987): 1370–73. https://doi.org/10.1097/00007611-198711000-00010.
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    • Bullard, D. E., C. E. Rawlings, B. Phillips, E. B. Cox, S. C. Schold, P. Burger, and E. C. Halperin. “Oligodendroglioma. An analysis of the value of radiation therapy.” Cancer 60, no. 9 (November 1, 1987): 2179–88. https://doi.org/10.1002/1097-0142(19871101)60:9<2179::aid-cncr2820600912>3.0.co;2-g.
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    • Halperin, E. C., S. Knechtle, K. Abernethy, T. Saad, D. Miller, W. B. Vernon, and R. R. Bollinger. “The influence of dose and dose rate of total lymphoid irradiation in the rat cardiac allograft model.” Radiother Oncol 9, no. 4 (August 1987): 311–18. https://doi.org/10.1016/s0167-8140(87)80152-4.
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    • Knechtle, S. J., E. C. Halperin, and R. R. Bollinger. “Xenograft survival in two species combinations using total-lymphoid irradiation and cyclosporine.” Transplantation 43, no. 2 (February 1987): 173–75. https://doi.org/10.1097/00007890-198702000-00002.
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    • Knechtle, S. J., E. C. Halperin, and R. R. Bollinger. “Combined total lymphoid irradiation and cyclosporine promote xenograft survival.” Transplant Proc 19, no. 1 Pt 2 (February 1987): 1137–39.
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    • Halperin, E. C., and E. B. Cox. “Radiation therapy in the management of neuroblastoma: the Duke University Medical Center experience 1967-1984.” Int J Radiat Oncol Biol Phys 12, no. 10 (October 1986): 1829–37. https://doi.org/10.1016/0360-3016(86)90326-3.
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    • Hershatter, B. W., E. C. Halperin, and E. B. Cox. “Medulloblastoma: the Duke University Medical Center experience.” Int J Radiat Oncol Biol Phys 12, no. 10 (October 1986): 1771–77. https://doi.org/10.1016/0360-3016(86)90318-4.
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    • Halperin, E. C. “Pediatric radiation oncology.” Invest Radiol 21, no. 5 (May 1986): 429–36. https://doi.org/10.1097/00004424-198605000-00016.
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    • Knechtle, S. J., E. C. Halperin, T. Saad, and R. R. Bollinger. “Prolonged heart xenograft survival using combined total lymphoid irradiation and cyclosporine.” J Heart Transplant 5, no. 3 (1986): 254–61.
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    • Friedman, H. S., P. C. Burger, S. H. Bigner, J. Q. Trojanowski, C. J. Wikstrand, E. C. Halperin, and D. D. Bigner. “Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.” J Neuropathol Exp Neurol 44, no. 6 (November 1985): 592–605. https://doi.org/10.1097/00005072-198511000-00005.
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    • Halperin, E. C., and P. C. Burger. “Conventional external beam radiotherapy for central nervous system malignancies.” Neurol Clin 3, no. 4 (November 1985): 867–82.
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    • Halperin, E. C. “Pediatric brain stem tumors: patterns of treatment failure and their implications for radiotherapy.” Int J Radiat Oncol Biol Phys 11, no. 7 (July 1985): 1293–98. https://doi.org/10.1016/0360-3016(85)90244-5.
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    • Halperin, E. C. “Total lymphoid irradiation as an immunosuppressive agent for transplantation and the treatment of 'autoimmune' disease: a review.” Clin Radiol 36, no. 2 (March 1985): 125–30. https://doi.org/10.1016/s0009-9260(85)80094-5.
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    • Knechtle, S. J., E. C. Halperin, C. E. Murphy, T. Saad, K. Abernethy, D. Miller, and R. R. Bollinger. “The effect of cyclosporine, total lymphoid irradiation, and cobra venom factor on hyperacute rejection.” J Heart Transplant 4, no. 5 (1985): 541–45.
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    • Halperin, E. C., F. L. Delmonico, P. W. Nelson, W. U. Shipley, and A. B. Cosimi. “The use of local allograft irradiation following renal transplantation.” Int J Radiat Oncol Biol Phys 10, no. 7 (July 1984): 987–90. https://doi.org/10.1016/0360-3016(84)90168-8.
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    • Halperin, E. C., M. S. Greenberg, and H. D. Suit. “Sarcoma of bone and soft tissue following treatment of Hodgkin's disease.” Cancer 53, no. 2 (January 15, 1984): 232–36. https://doi.org/10.1002/1097-0142(19840115)53:2<232::aid-cncr2820530208>3.0.co;2-f.
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    • Meyer, J. E., E. C. Halperin, S. R. Levene, and P. C. Stomper. “Adrenal insufficiency secondary to metastatic lung carcinoma: CT aided diagnosis.” J Comput Assist Tomogr 7, no. 6 (December 1983): 1107–8. https://doi.org/10.1097/00004728-198312000-00037.
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    • Halperin, E. C., G. Haas, D. E. Dosoretz, M. Gitterman, L. Barrett, A. B. Cosimi, and H. D. Suit. “1982 resident's essay award: the immunologic effects of lymphoid irradiation in human and non-human primates: cellular changes and the potential for renal transplantation.” Int J Radiat Oncol Biol Phys 9, no. 7 (July 1983): 1083–89. https://doi.org/10.1016/0360-3016(83)90400-5.
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    • Halperin, E. C., and L. Harisiadis. “The role of radiation therapy in the management of metastatic renal cell carcinoma.” Cancer 51, no. 4 (February 15, 1983): 614–17. https://doi.org/10.1002/1097-0142(19830215)51:4<614::aid-cncr2820510411>3.0.co;2-j.
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    • Halperin, E. C., D. E. Dosoretz, M. Goodman, and C. C. Wang. “Radiotherapy of polymorphic reticulosis.” Br J Radiol 55, no. 657 (September 1982): 645–49. https://doi.org/10.1259/0007-1285-55-657-645.
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    • Meyer, J. E., E. C. Halperin, and R. M. Linggood. “Upper extremity lymphangiography as an aid to treatment planning for stage 1A epitrochlear hodgkin's disease.” Cardiovasc Intervent Radiol 5, no. 5 (1982): 279–80. https://doi.org/10.1007/BF02565413.
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    • Halperin, E. C., S. O. Thier, and L. E. Rosenberg. “The use of D-penicillamine in cystinuria: efficacy and untoward reactions.” Yale J Biol Med 54, no. 6 (1981): 439–46.
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  • Other Articles

    • Knechtle, S. J., E. C. Halperin, and R. R. Bollinger. “The effect of TLI and cyclosporine on xenograft survival.” Transplantation, December 1990. https://doi.org/10.1097/00007890-199012000-00046.
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