Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Yale University 1979
• 

  Duke Appointment History

  • Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 1993 - 2006
  • Professor in Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 1997 - 2006
  • Vice Dean for Education and Clinical Affairs in the School of Medicine, and Associate Vice Chancellor for Academic Affairs, School of Medicine, Duke University 2002 - 2006
  • Chair, Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 1996 - 2003
  • Associate Professor in Pediatrics, Pediatrics, Clinical Science Departments 1994 - 1997
  • Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 1987 - 1993
  • Assistant Professor of Radiology, Radiology, Clinical Science Departments 1983 - 1987
• Research
• 

  Selected Grants

  • Race, Religion, and Desegregation in Southern Medical Education awarded by Josiah Charles Trent Memorial Foundation 2006 - 2007
  • Is it a gift or a bribe? awarded by Josiah Charles Trent Memorial Foundation 2001 - 2002
  • History of Jewish Quota for Medical Internships awarded by Josiah Charles Trent Memorial Foundation 1999 - 2000
  • Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
  • Src On Malignant Human Gliomas And Medulloblastomas awarded by National Institutes of Health 1993 - 1994
  • Incidence Of Religious Discrimination At Unc In 1933 awarded by Josiah Charles Trent Memorial Foundation 1989
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Halperin, EC. "Particle therapy and treatment of cancer." The Lancet. Oncology 7, no. 8 (August 2006): 676-685.  Full Text
    • Halperin, Edward C. “What or who killed Alexander the Great?.” The Pharos of Alpha Omega Alpha Honor Medical Society. Alpha Omega Alpha 69, no. 3 (January 2006): 19–25.
    • Halperin, Edward C., William J. Fulkerson, Russel Kaufman, Paul Newman, and Gary L. Stiles. “Should an academic radiation oncologist be allowed to "opt out" of medicare?.” Journal of the American College of Radiology : Jacr 2, no. 10 (October 2005): 841–45. https://doi.org/10.1016/j.jacr.2005.03.009.
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    • Halperin, E. C., W. J. Fulkerson, R. Kaufman, P. Newman, and G. L. Stiles. “Should an academic radiation oncologist be allowed to "opt out" of Medicare?.” Journal of the American College of Radiology 2, no. 10 (2005): 841–45. https://doi.org/10.1016/j.jacr.2005.03.009.
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    • Halperin, Edward C., Paul Hutchison, and Robert C. Barrier. “A population-based study of the prevalence and influence of gifts to radiation oncologists from pharmaceutical companies and medical equipment manufacturers..” International Journal of Radiation Oncology, Biology, Physics 59, no. 5 (August 2004): 1477–83. https://doi.org/10.1016/j.ijrobp.2004.01.052.
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    • Halperin, Edward C. “Paleo-oncology: the role of ancient remains in the study of cancer..” Perspectives in Biology and Medicine 47, no. 1 (January 2004): 1–14.
    • Long, Gwynn D., Mary Laughlin, Bella Madan, Joanne Kurtzberg, Cristina Gasparetto, Ashley Morris, David Rizzieri, et al. “Unrelated umbilical cord blood transplantation in adult patients..” Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 9, no. 12 (December 2003): 772–80. https://doi.org/10.1016/j.bbmt.2003.08.007.
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    • Halperin, Edward C. “Free speech and snake oil..” International Journal of Radiation Oncology, Biology, Physics 57, no. 4 (November 2003): 910–11. https://doi.org/10.1016/s0360-3016(03)00645-x.
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    • McLendon, RE, and Halperin, EC. "Is the long-term survival of patients with intracranial glioblastoma multiforme overstated?." Cancer 98, no. 8 (October 2003): 1745-1748.  Full Text
    • Harrison, BE, Johnson, JL, Clough, RW, and Halperin, EC. "Selection of patients with melanoma brain metastases for aggressive treatment." American Journal of Clinical Oncology 26, no. 4 (August 2003): 354-357.  Full Text
    • Gururangan, Sridharan, Colleen McLaughlin, Jennifer Quinn, Jeremy Rich, David Reardon, Edward C. Halperin, James Herndon, et al. “High-dose chemotherapy with autologous stem-cell rescue in children and adults with newly diagnosed pineoblastomas..” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 21, no. 11 (June 2003): 2187–91. https://doi.org/10.1200/jco.2003.10.096.
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    • Kang, SK, Kirkpatrick, JP, and Halperin, EC. "Low-dose radiation for posttransplant lymphoproliferative disorder." American Journal of Clinical Oncology 26, no. 2 (April 2003): 210-214.  Full Text
    • Hahn, C. A., R. H. Dunn, P. E. Logue, J. H. King, C. L. Edwards, and E. C. Halperin. “Prospective study of neuropsychologic testing and quality-of-life assessment of adults with primary malignant brain tumors..” International Journal of Radiation Oncology, Biology, Physics 55, no. 4 (March 2003): 992–99. https://doi.org/10.1016/s0360-3016(02)04205-0.
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    • Hutchison, Paul, and Edward C. Halperin. “The hidden persuaders: subtle advertising in radiation oncology..” International Journal of Radiation Oncology, Biology, Physics 54, no. 4 (November 2002): 989–91. https://doi.org/10.1016/s0360-3016(02)03789-6.
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    • Halperin, EC. "The corporate presence at oncology meetings." American Journal of Clinical Oncology 25, no. 5 (October 2002): 535-536.  Full Text
    • Halperin, Edward C., Fran Laurie, and T. J. Fitzgerald. “An evaluation of the relationship between the quality of prophylactic cranial radiotherapy in childhood acute leukemia and institutional experience: a Quality Assurance Review Center-Pediatric Oncology Group study..” International Journal of Radiation Oncology, Biology, Physics 53, no. 4 (July 2002): 1001–4. https://doi.org/10.1016/s0360-3016(02)02833-x.
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    • Halperin, EC. "Should academic medical centers conduct clinical trials of the efficacy of intercessory prayer?." Academic Medicine 76, no. 8 (August 2001): 791-797. (Review)  Full Text
    • Halperin, E. C. “The Jewish problem in U.S. medical education, 1920-1955..” Journal of the History of Medicine and Allied Sciences 56, no. 2 (April 2001): 140–67. https://doi.org/10.1093/jhmas/56.2.140.
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    • Halperin, E. C. “Non-human to human organ transplantation: its biologic basis and a potential role for radiation therapy..” International Journal of Cancer 96, no. 2 (April 2001): 76–89. https://doi.org/10.1002/ijc.1010.
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    • Halperin, EC, Watson, DM, and George, SL. "Duration of symptoms prior to diagnosis is related inversely to presenting disease stage in children with medulloblastoma." Cancer 91, no. 8 (April 2001): 1444-1450.  Full Text
    • Wenzel, C. T., E. C. Halperin, and S. R. Fisher. “Second malignant neoplasms of the head and neck in survivors of retinoblastoma..” Ear, Nose, & Throat Journal 80, no. 2 (February 2001): 106–12.
    • Halperin, E. C. “Overpriced technology in radiation oncology..” International Journal of Radiation Oncology, Biology, Physics 48, no. 4 (November 2000): 917–18. https://doi.org/10.1016/s0360-3016(00)00756-2.
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    • Halperin, EC. "Grievances against physicians: 11 years' experience of a medical society grievance committee." The Western Journal of Medicine 173, no. 4 (October 2000): 235-238.  Full Text
    • Halperin, E. C. “A completely efficient life. Francis Henry Williams, MD, pioneer radiologist..” North Carolina Medical Journal 61, no. 4 (July 2000): 199–202.
    • Halperin, E. C. “Neonatal neoplasms..” International Journal of Radiation Oncology, Biology, Physics 47, no. 1 (April 2000): 171–78. https://doi.org/10.1016/s0360-3016(00)00424-7.
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    • Halperin, E. C. “Whatever happened to psychotherapy?.” North Carolina Medical Journal 61, no. 1 (January 2000): 423–24.
    • DeBacker, CM, Dutton, JJ, Proia, AD, Halperin, EC, Wagle, TN, and Holck, DE. "The influence of hyperbaric oxygen therapy and irradiation on hydroxyapatite ocular implant exposure and fibrovascular ingrowth in New Zealand white rabbits." Ophthalmic Plastic and Reconstructive Surgery 15, no. 6 (November 1999): 412-419.
    • Fortney, J. T., E. C. Halperin, C. M. Hertz, and S. R. Schulman. “Anesthesia for pediatric external beam radiation therapy..” International Journal of Radiation Oncology, Biology, Physics 44, no. 3 (June 1999): 587–91. https://doi.org/10.1016/s0360-3016(99)00058-9.
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    • Halperin, E. C. “The North Carolina Medical Journal finds itself in the vanguard of progressive medical journalism or, the deputy editor finds his fifteen minutes of fame..” North Carolina Medical Journal 60, no. 3 (May 1999): 138–39.
    • Halperin, EC. "Publish or perish--and bankrupt the medical library while we're at it." Academic Medicine 74, no. 5 (May 1999): 470-472. (Review)  Full Text
    • Maguire, PD, Clough, R, Friedman, AH, and Halperin, EC. "Fractionated external-beam radiation therapy for meningiomas of the cavernous sinus." International Journal of Radiation Oncology, Biology, Physics 44, no. 1 (April 1999): 75-79.  Full Text
    • Halperin, E. C. “Kidney cancer..” Lancet (London, England) 353, no. 9152 (February 1999). https://doi.org/10.1016/s0140-6736(05)75656-7.
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    • Drayer, J. A., L. B. Marks, G. Bentel, and E. C. Halperin. “Defining the superior border of posterior fossa radiation treatment fields..” International Journal of Radiation Oncology, Biology, Physics 41, no. 3 (June 1998): 625–29. https://doi.org/10.1016/s0360-3016(98)00075-3.
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    • Graham, M. L., B. L. Asselin, J. E. Herndon, J. R. Casey, S. Chaffee, G. H. Ciocci, C. W. Daeschner, et al. “Toxicity, pharmacology and feasibility of administration of PEG-L-asparaginase as consolidation therapy in patients undergoing bone marrow transplantation for acute lymphoblastic leukemia..” Bone Marrow Transplantation 21, no. 9 (May 1998): 879–85. https://doi.org/10.1038/sj.bmt.1701223.
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    • Halperin, E. C. “Let's abolish the Office of Alternative Medicine of the National Institutes of Health..” North Carolina Medical Journal 59, no. 1 (January 1998): 21–23.
    • Strother, D, van Hoff, J, Rao, PV, Smith, EI, Shamberger, RC, Halperin, EC, Murray, KJ, and Castleberry, RP. "Event-free survival of children with biologically favourable neuroblastoma based on the degree of initial tumour resection: results from the Pediatric Oncology Group." European Journal of Cancer (Oxford, England : 1990) 33, no. 12 (October 1997): 2121-2125.  Full Text
    • Halperin, EC, and Broadwater, GJ. "Are there sex biases in standardized tests of radiation oncology knowledge?." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 15, no. 7 (July 1997): 2722-2727.  Full Text
    • Halperin, EC. "Why is female sex an independent predictor of shortened overall survival after proton/photon radiation therapy for skull base chordomas?." International Journal of Radiation Oncology, Biology, Physics 38, no. 2 (May 1997): 225-230. (Review)  Full Text
    • Halperin, EC. "Long-term results of therapy for stage C neuroblastoma." Journal of Surgical Oncology 63, no. 3 (November 1996): 172-178.  Full Text
    • Merrill, P. T., E. G. Buckley, and E. C. Halperin. “New and recurrent tumors in germinal retinoblastoma: is there a treatment effect?.” Ophthalmic Genetics 17, no. 3 (September 1996): 115–18. https://doi.org/10.3109/13816819609057114.
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    • Halperin, E. C. “Impact of radiation technique upon the outcome of treatment for medulloblastoma..” International Journal of Radiation Oncology, Biology, Physics 36, no. 1 (August 1996): 233–39. https://doi.org/10.1016/s0360-3016(96)00276-3.
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    • Halperin, EC, and Friedman, HS. "Is there a correlation between duration of presenting symptoms and stage of medulloblastoma at the time of diagnosis?." Cancer 78, no. 4 (August 1996): 874-880.  Full Text
    • Kurtzberg, J, Laughlin, M, Graham, ML, Smith, C, Olson, JF, Halperin, EC, Ciocci, G, Carrier, C, Stevens, CE, and Rubinstein, P. "Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients." The New England Journal of Medicine 335, no. 3 (July 1996): 157-166.  Full Text
    • Graham, M. L., W. F. Rosse, E. C. Halperin, C. R. Miller, and R. E. Ware. “Resolution of Budd-Chiari syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria..” British Journal of Haematology 92, no. 3 (March 1996): 707–10. https://doi.org/10.1046/j.1365-2141.1996.365901.x.
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    • Halperin, E. C., J. Herndon, S. C. Schold, M. Brown, N. Vick, J. G. Cairncross, D. R. Macdonald, et al. “A phase III randomized prospective trial of external beam radiotherapy, mitomycin C, carmustine, and 6-mercaptopurine for the treatment of adults with anaplastic glioma of the brain. CNS Cancer Consortium..” International Journal of Radiation Oncology, Biology, Physics 34, no. 4 (March 1996): 793–802. https://doi.org/10.1016/0360-3016(95)02025-x.
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    • Halperin, E. C., T. Samulski, W. J. Oakes, and H. S. Friedman. “Fabrication and testing of a device capable of reducing the incidence of ventricular shunt promoted metastasis..” Journal of Neuro Oncology 27, no. 1 (January 1996): 39–46. https://doi.org/10.1007/bf00146082.
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    • Halperin, E. C. “The North Carolina Mutual Life Insurance Company, Dr. Clyde Henry Donnell, and the health education of blacks..” North Carolina Medical Journal 56, no. 11 (November 1995): 570–74.
    • Halperin, E. C. “Is tenure irrelevant for academic clinicians?.” Southern Medical Journal 88, no. 11 (November 1995): 1099–1106.
    • Halperin, EC, Byyny, RL, Moore, S, and Morahan, PS. "What medical schools and universities can learn from one another." Academic Medicine 70, no. 10 (October 1995): 879-883.  Full Text
    • Halperin, E. C. “Three rear ends on the beach. Debating the ethics of medical advertising..” North Carolina Medical Journal 56, no. 8 (August 1995): 402–3.
    • Constine, L. S., R. B. Marcus, and E. C. Halperin. “The future of therapy for childhood rhabdomyosarcoma: clues from molecular biology..” International Journal of Radiation Oncology, Biology, Physics 32, no. 4 (July 1995): 1245–63. https://doi.org/10.1016/0360-3016(95)00237-s.
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    • Marks, L. B., and E. C. Halperin. “Radiosurgery is not "standard of care" for solitary brain metastases: regarding Flickinger et al., IJROBP 28:797-802; 1994..” International Journal of Radiation Oncology, Biology, Physics 32, no. 2 (May 1995): 557–59. https://doi.org/10.1016/0360-3016(95)98591-u.
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    • Yamaguchi, Y., E. C. Halperin, K. Mori, R. R. Bollinger, and M. Ogawa. “Recipient Kupffer cell influx into xenografted liver..” Digestive Diseases and Sciences 40, no. 3 (March 1995): 548–51. https://doi.org/10.1007/bf02064367.
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    • Halperin, EC. "Malignant gliomas in older adults with poor prognostic signs. Getting nowhere, and taking a long time to do it." Oncology (Williston Park, N.Y.) 9, no. 3 (March 1995): 229-243. (Review)
    • Halperin, E. C., and M. R. Sontag. “Techniques of experimental animal radiotherapy..” Laboratory Animal Science 44, no. 5 (October 1994): 417–23.
    • Osumi, A. K., R. E. Mclendon, R. D. Tien, H. S. Friedman, M. Graham, B. Hockenberger, E. C. Halperin, and W. J. Oakes. “Well differentiated astrocytoma occurring nine years after radiation therapy for medulloblastoma..” Clinical Neuropathology 13, no. 5 (September 1994): 281–85.
    • Lachance, DH, Brizel, DM, Gockerman, JP, Halperin, EC, Burger, PC, Boyko, OB, Brown, MT, and Schold, SC. "Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma: short-duration response and multifocal intracerebral recurrence preceding radiotherapy." Neurology 44, no. 9 (September 1994): 1721-1727.  Full Text
    • Bauman, GS, Gaspar, LE, Fisher, BJ, Halperin, EC, Macdonald, DR, and Cairncross, JG. "A prospective study of short-course radiotherapy in poor prognosis glioblastoma multiforme." International Journal of Radiation Oncology, Biology, Physics 29, no. 4 (July 1994): 835-839.  Full Text
    • Halperin, E. C. “Oral contraceptives as an over-the-counter medication..” North Carolina Medical Journal 55, no. 5 (May 1994): 183–86.
    • Halperin, E. C. “Eureka! It's a negative study!.” North Carolina Medical Journal 55, no. 2 (February 1994): 68–69.
    • Moghrabi, A., H. S. Friedman, R. McLendon, B. Hockenberger, R. D. Tien, E. C. Halperin, and W. J. Oakes. “Arteriovenous malformation mimicking recurrent medulloblastoma..” Medical and Pediatric Oncology 22, no. 2 (January 1994): 140–43. https://doi.org/10.1002/mpo.2950220216.
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    • Nashold, J. R., W. J. Oakes, H. S. Friedman, E. C. Halperin, M. Soo, B. Hockenberger, G. N. Fuller, and R. Tien. “Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein..” Medical and Pediatric Oncology 22, no. 2 (January 1994): 137–39. https://doi.org/10.1002/mpo.2950220215.
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    • Halperin, E. C., H. S. Friedman, S. C. Schold, H. E. Fuchs, W. J. Oakes, B. Hockenberger, and P. C. Burger. “Surgery, hyperfractionated craniospinal irradiation, and adjuvant chemotherapy in the management of supratentorial embryonal neuroepithelial neoplasms in children..” Surgical Neurology 40, no. 4 (October 1993): 278–83. https://doi.org/10.1016/0090-3019(93)90138-q.
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    • Halperin, E. C. “Screening for prostate cancer utilizing the prostate-specific antigen (PSA)..” North Carolina Medical Journal 54, no. 9 (September 1993): 443–46.
    • Freeman, CR, Krischer, JP, Sanford, RA, Cohen, ME, Burger, PC, del Carpio, R, Halperin, EC, Munoz, L, Friedman, HS, and Kun, LE. "Final results of a study of escalating doses of hyperfractionated radiotherapy in brain stem tumors in children: a Pediatric Oncology Group study." International Journal of Radiation Oncology, Biology, Physics 27, no. 2 (September 1993): 197-206.  Full Text
    • Acker, J. C., E. H. Bossen, and E. C. Halperin. “The management of desmoid tumors..” International Journal of Radiation Oncology, Biology, Physics 26, no. 5 (August 1993): 851–58. https://doi.org/10.1016/0360-3016(93)90501-l.
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    • Halperin, E. C., L. Gaspar, J. Imperato, M. Salter, J. Herndon, and S. Dowling. “An analysis of radiotherapy data from the CNS cancer consortium's randomized prospective trial comparing AZQ to BCNU in the treatment of patients with primary malignant brain tumors. The CNS cancer consortium..” American Journal of Clinical Oncology 16, no. 4 (August 1993): 277–83.
    • Hebert, M. E., E. C. Halperin, W. J. Oakes, and O. B. Boyko. “Multiple fraction-per-day radiotherapy for patients with brain stem tumors..” Journal of Neuro Oncology 17, no. 2 (August 1993): 131–38. https://doi.org/10.1007/bf01050215.
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    • Marks, L. B., and E. C. Halperin. “The use of G-CSF during craniospinal irradiation..” International Journal of Radiation Oncology, Biology, Physics 26, no. 5 (August 1993): 905–7. https://doi.org/10.1016/0360-3016(93)90509-t.
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    • Gravatt, LC, Chaffee, S, Hebert, ME, Halperin, EC, Friedman, HS, and Kurtzberg, J. "Efficacy and toxicity of 9-beta-D-arabinofuranosylguanine (araG) as an agent to purge malignant T cells from murine bone marrow: application to an in vivo T-leukemia model." Leukemia 7, no. 8 (August 1993): 1261-1267.
    • Gockerman, J. P., E. C. Halperin, G. C. Magrinat, B. M. Hendrix, and W. P. Peters. “Physician-assisted suicide and advance directives concerning life support..” North Carolina Medical Journal 54, no. 7 (July 1993): 312–16.
    • Kavanagh, BD, Halperin, EC, and Nilaver, G. "Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx." Cancer 72, no. 1 (July 1993): 299-null. (Letter)  Full Text
    • Halperin, E. C., L. Gaspar, S. George, D. Darr, and S. Pinnell. “A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. CNS Cancer Consortium..” International Journal of Radiation Oncology, Biology, Physics 26, no. 3 (June 1993): 413–16. https://doi.org/10.1016/0360-3016(93)90958-x.
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    • Halperin, E. C. “Concerning the inferior portion of the spinal radiotherapy field for malignancies that disseminate via the cerebrospinal fluid..” International Journal of Radiation Oncology, Biology, Physics 26, no. 2 (May 1993): 357–62. https://doi.org/10.1016/0360-3016(93)90218-k.
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    • Gaspar, L. E., B. J. Fisher, D. R. MacDonald, D. V. LeBer, E. C. Halperin, S. C. Schold, and J. G. Cairncross. “Malignant glioma--timing of response to radiation therapy..” International Journal of Radiation Oncology, Biology, Physics 25, no. 5 (April 1993): 877–79. https://doi.org/10.1016/0360-3016(93)90318-p.
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    • Bruggers, C. S., H. S. Friedman, G. N. Fuller, R. D. Tien, L. B. Marks, E. C. Halperin, B. Hockenberger, W. J. Oakes, and J. M. Hoffman. “Comparison of serial PET and MRI scans in a pediatric patient with a brainstem glioma..” Medical and Pediatric Oncology 21, no. 4 (January 1993): 301–6. https://doi.org/10.1002/mpo.2950210414.
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    • Schold, S. C., J. E. Herndon, P. C. Burger, E. C. Halperin, N. A. Vick, J. G. Cairncross, D. R. Macdonald, E. J. Dropcho, R. Morawetz, and D. D. Bigner. “Randomized comparison of diaziquone and carmustine in the treatment of adults with anaplastic glioma..” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 11, no. 1 (January 1993): 77–83. https://doi.org/10.1200/jco.1993.11.1.77.
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    • Bentel, GC, Halperin, EC, and Buckley, EG. "125I embedded in an orbital prosthesis for retreatment of recurrent retinoblastoma." Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists 18, no. 1 (January 1993): 1-5.  Full Text
    • Halperin, EC, Scott, J, and George, SL. "Multiple authorship in two English-language journals in radiation oncology." Academic Medicine 67, no. 12 (December 1992): 850-856.  Full Text
    • Halperin, E. C. “Multiple-fraction-per-day external beam radiotherapy for adults with supratentorial malignant gliomas..” Journal of Neuro Oncology 14, no. 3 (November 1992): 255–62. https://doi.org/10.1007/bf00172601.
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    • Donnal, J, Halperin, EC, Friedman, HS, and Boyko, OB. "Subfrontal recurrence of medulloblastoma." Ajnr. American Journal of Neuroradiology 13, no. 6 (November 1992): 1617-1618.
    • Malik, R. K., G. N. Fuller, W. J. Oakes, R. Tien, B. Hockenberger, H. S. Friedman, and E. C. Halperin. “Back pain and paraplegia in a fifteen-year-old boy..” The Journal of Pediatrics 121, no. 4 (October 1992): 652–58. https://doi.org/10.1016/s0022-3476(05)81166-7.
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    • Nelson, S. C., H. S. Friedman, W. J. Oakes, E. C. Halperin, R. Tien, G. N. Fuller, B. Hockenberger, M. W. Scroggs, M. Moncino, and J. Kurtzberg. “Successful therapy for trilateral retinoblastoma..” American Journal of Ophthalmology 114, no. 1 (July 1992): 23–29.
    • Tomberlin, J. K., E. C. Halperin, P. Kusin, K. Leopold, G. Bentel, S. George, M. Powers, and W. Wolfe. “Endobronchial interstitial Au-198 implantation in the treatment of recurrent bronchogenic carcinoma..” Journal of Surgical Oncology 49, no. 4 (April 1992): 213–19. https://doi.org/10.1002/jso.2930490403.
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    • Halperin, EC. "Medical oaths." Academic Medicine 67, no. 4 (April 1992): 252-253. (Letter)  Full Text
    • Arora, V, Weeks, K, Halperin, EC, and Dutton, JJ. "Influence of coralline hydroxyapatite used as an ocular implant on the dose distribution of external beam photon radiation therapy." Ophthalmology 99, no. 3 (March 1992): 380-382.  Full Text
    • Kavanagh, BD, Halperin, EC, Rosenbaum, LC, Shannon, EM, and Nilaver, G. "Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx." Cancer 69, no. 6 (March 1992): 1315-1319.  Full Text
    • Gaspar, L. E., B. J. Fisher, D. R. Macdonald, D. V. LeBer, E. C. Halperin, S. C. Schold, and J. G. Cairncross. “Supratentorial malignant glioma: patterns of recurrence and implications for external beam local treatment..” International Journal of Radiation Oncology, Biology, Physics 24, no. 1 (January 1992): 55–57.
    • Hoffman, J. M., M. W. Hanson, H. S. Friedman, B. M. Hockenberger, W. J. Oakes, E. C. Halperin, and R. E. Coleman. “FDG-PET in pediatric posterior fossa brain tumors..” Journal of Computer Assisted Tomography 16, no. 1 (January 1992): 62–68.
    • Kligerman, A. D., M. F. Bryant, C. L. Doerr, E. C. Halperin, P. Kwanyuen, M. R. Sontag, and G. L. Erexson. “Interspecies cytogenetic comparisons: studies with X-radiation and bleomycin sulfate..” Environmental and Molecular Mutagenesis 19, no. 3 (January 1992): 235–43. https://doi.org/10.1002/em.2850190308.
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    • Marks, L. B., E. C. Halperin, L. R. Prosnitz, M. Ross, J. J. Vredenburgh, G. L. Rosner, and W. Peters. “Post-mastectomy radiotherapy following adjuvant chemotherapy and autologous bone marrow transplantation for breast cancer patients with greater than or equal to 10 positive axillary lymph nodes. Cancer and Leukemia Group B..” International Journal of Radiation Oncology, Biology, Physics 23, no. 5 (January 1992): 1021–26.
    • Halperin, EC, Brizel, DM, Honore, G, Sontag, MR, Griffith, OW, Bigner, DD, and Friedman, HS. "The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine." International Journal of Radiation Oncology, Biology, Physics 24, no. 1 (January 1992): 103-109.
    • Halperin, E. C. “A groundless hypothesis, megaloblastic madness, and the founding of Duke University..” Medical Hypotheses 36, no. 3 (November 1991): 200–203. https://doi.org/10.1016/0306-9877(91)90130-q.
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    • Erexson, G. L., A. D. Kligerman, M. F. Bryant, M. R. Sontag, and E. C. Halperin. “Induction of micronuclei by X-radiation in human, mouse and rat peripheral blood lymphocytes..” Mutation Research 253, no. 2 (October 1991): 193–98. https://doi.org/10.1016/0165-1161(91)90132-r.
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    • Freeman, CR, Krischer, J, Sanford, RA, Cohen, ME, Burger, PC, Kun, L, Halperin, EC, Crocker, I, and Wharam, M. "Hyperfractionated radiation therapy in brain stem tumors. Results of treatment at the 7020 cGy dose level of Pediatric Oncology Group study #8495." Cancer 68, no. 3 (August 1991): 474-481.  Full Text
    • Scroggs, MW, Proia, AD, Smith, CF, Halperin, EC, and Klintworth, GK. "The effect of total-body irradiation on corneal neovascularization in the Fischer 344 rat after chemical cauterization." Investigative Ophthalmology & Visual Science 32, no. 7 (June 1991): 2105-2111.
    • Halperin, E. C. “Suspicionless drug testing of physicians..” North Carolina Medical Journal 52, no. 4 (April 1991): 131–35.
    • Bollinger, R. R., M. A. Fabian, R. C. Harland, W. J. Murray, W. M. Baldwin, K. Abernethy, L. Britt, M. Sontag, and E. C. Halperin. “Total lymphoid irradiation for cardiac xenotransplantation in nonhuman primates..” Transplantation Proceedings 23, no. 1 Pt 1 (February 1991): 587–88.
    • Pruitt, S. K., E. C. Halperin, and R. R. Bollinger. “The effect of 15-deoxyspergualin on hamster-to-rat cardiac xenograft survival..” Transplantation Proceedings 23, no. 1 Pt 1 (February 1991): 585–86.
    • Yamaguchi, Y., E. C. Halperin, K. Mori, M. Misumi, T. Katsumori, N. Takata, M. Goto, Y. Makino, N. Kikuchi, and K. Takahashi. “Macrophage migration into hepatic xenografts in the hamster-to-rat combination..” Transplantation Proceedings 23, no. 1 Pt 1 (February 1991): 220–21.
    • Griebel, M, Friedman, HS, Halperin, EC, Wiener, MD, Marks, L, Oakes, WJ, Hoffman, JM, DeLong, GR, Schold, SC, and Hockenberger, B. "Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma." Medical and Pediatric Oncology 19, no. 3 (January 1991): 182-186.  Full Text
    • Bentel, GC, and Halperin, EC. "High-dose areas are unintentionally created as a result of gap shifts when the prescribed dose in the two adjacent areas are different." Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists 15, no. 4 (December 1990): 179-183.  Full Text
    • Kligerman, A. D., E. C. Halperin, G. L. Erexson, and G. Honoré. “The persistence of lymphocytes with dicentric chromosomes following whole-body X irradiation of mice..” Radiation Research 124, no. 1 (October 1990): 22–27. https://doi.org/10.2307/3577689.
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    • Green, D. M., T. V. Samulski, C. Vervaert, E. C. Halperin, J. R. Oleson, and H. Seigler. “Effects of hyperthermia and irradiation on the growth of mouse melanoma tumors following immunotherapy..” Journal of Surgical Oncology 44, no. 4 (August 1990): 256–59. https://doi.org/10.1002/jso.2930440413.
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    • Halperin, E. C. “Doublespeak in high places..” North Carolina Medical Journal 51, no. 8 (August 1990): 393–95.
    • Halperin, E. C., S. J. Knechtle, R. C. Harland, Y. Yamaguchi, M. Sontag, and R. R. Bollinger. “Irradiation for xenogeneic transplantation..” Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology 18, no. 1 (May 1990): 29–37. https://doi.org/10.1016/0167-8140(90)90020-w.
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    • Halperin, E. C. “Informed consent for AIDS testing. Or: whose vein is it anyway?.” North Carolina Medical Journal 51, no. 4 (April 1990): 145–49.
    • Lippitz, B. E., E. C. Halperin, O. W. Griffith, O. M. Colvin, G. Honore, C. B. Ostertag, D. D. Bigner, and H. S. Friedman. “L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice..” Neurosurgery 26, no. 2 (February 1990): 255–60. https://doi.org/10.1097/00006123-199002000-00012.
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    • Halperin, E. C. “The North Carolina Medical Journal and its peers..” North Carolina Medical Journal 51, no. 1 (January 1990): 23–25.
    • Yamaguchi, Y., E. C. Halperin, R. C. Harland, C. Wyble, and R. R. Bollinger. “Significant prolongation of hamster liver transplant survival in Lewis rats by total-lymphoid irradiation, cyclosporine, and splenectomy..” Transplantation 49, no. 1 (January 1990): 13–17.
    • Halperin, E. C., G. Bentel, E. R. Heinz, and P. C. Burger. “Radiation therapy treatment planning in supratentorial glioblastoma multiforme: an analysis based on post mortem topographic anatomy with CT correlations..” International Journal of Radiation Oncology, Biology, Physics 17, no. 6 (December 1989): 1347–50. https://doi.org/10.1016/0360-3016(89)90548-8.
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    • Halperin, E. C. “Physician awareness of the contents of the Hippocratic Oath..” The Journal of Medical Humanities 10, no. 2 (September 1989): 107–14. https://doi.org/10.1007/bf01137575.
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    • Halperin, E. C., and S. T. Morrow. “Reducing infant mortality in North Carolina..” North Carolina Medical Journal 50, no. 8 (August 1989): 419–20.
    • Friedman, HS, Schold, SC, Mahaley, MS, Colvin, OM, Oakes, WJ, Vick, NA, Burger, PC, Bigner, SH, Borowitz, M, and Halperin, EC. "Phase II treatment of medulloblastoma and pineoblastoma with melphalan: clinical therapy based on experimental models of human medulloblastoma." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 7, no. 7 (July 1989): 904-911.  Full Text
    • Yamaguchi, Y., E. C. Halperin, R. C. Harland, C. Wyble, and R. R. Bollinger. “A synergistic effect of total lymphoid irradiation, cyclosporine, and splenectomy in a hamster-to-rat hepatic xenograft model..” Transplantation Proceedings 21, no. 3 (June 1989).
    • Halperin, E. C. “Consent for a minor's abortion..” North Carolina Medical Journal 50, no. 4 (April 1989): 214–15.
    • Harland, R. C., E. C. Halperin, Y. Yamaguchi, P. Ruiz, M. W. Scroggs, F. Sanfilippo, and R. R. Bollinger. “Total lymphoid irradiation and cyclosporine prolongs cardiac allograft survival in the sensitized rat model..” Transplantation Proceedings 21, no. 1 Pt 1 (February 1989): 1118–19.
    • Suvarnamani, C, Halperin, EC, Proia, AD, and Klintworth, GK. "The effects of total lymphoid irradiation upon corneal vascularization in the rat following chemical cautery." Radiation Research 117, no. 2 (February 1989): 259-272.  Full Text
    • Erexson, G. L., A. D. Kligerman, E. C. Halperin, G. M. Honoré, and J. W. Allen. “Micronuclei in binucleated lymphocytes of mice following exposure to gamma radiation..” Environmental and Molecular Mutagenesis 13, no. 2 (January 1989): 128–32. https://doi.org/10.1002/em.2850130207.
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    • Friedman, H. S., S. C. Schold, W. T. Djang, J. Kurtzberg, D. C. Longee, E. C. Halperin, J. M. Falletta, R. E. Coleman, and W. J. Oakes. “Criteria for termination of phase II chemotherapy for patients with progressive or recurrent brain tumor..” Neurology 39, no. 1 (January 1989): 62–66. https://doi.org/10.1212/wnl.39.1.62.
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    • Halperin, E. C., S. M. Wehn, J. W. Scott, W. Djang, W. J. Oakes, and H. S. Friedman. “Selection of a management strategy for pediatric brainstem tumors..” Medical and Pediatric Oncology 17, no. 2 (January 1989): 117–26. https://doi.org/10.1002/mpo.2950170209.
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    • Weaver, J. P., J. D. Bobbitt, and E. C. Halperin. “The Model Health Care Provider Liability Reform Act. A summary and commentary..” North Carolina Medical Journal 49, no. 12 (December 1988): 621–24.
    • Halperin, E. C. “The right to privacy and the duty to protect..” Southern Medical Journal 81, no. 10 (October 1988): 1286–90.
    • Halperin, E. C., and R. R. Bollinger. “The role of irradiation in solid organ transplantation..” International Journal of Radiation Oncology, Biology, Physics 15, no. 4 (October 1988): 979–88. https://doi.org/10.1016/0360-3016(88)90135-6.
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    • Halperin, E. C. “George Bush, Michael Dukakis, and health policy issues in the 1988 presidential campaign..” North Carolina Medical Journal 49, no. 9 (September 1988): 433–38.
    • Halperin, E. C. “The audition elective..” International Journal of Radiation Oncology, Biology, Physics 15, no. 3 (September 1988): 791–92. https://doi.org/10.1016/0360-3016(88)90330-6.
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    • Halperin, E. C. “X-rays at the bar, 1896-1910..” Investigative Radiology 23, no. 8 (August 1988): 639–46.
    • Halperin, E. C., P. C. Burger, and D. E. Bullard. “The fallacy of the localized supratentorial malignant glioma..” International Journal of Radiation Oncology, Biology, Physics 15, no. 2 (August 1988): 505–9. https://doi.org/10.1016/s0360-3016(98)90036-0.
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    • Kligerman, A. D., E. C. Halperin, G. L. Erexson, G. Honoré, B. Westbrook-Collins, and J. W. Allen. “A cytogenetic comparison of the responses of mouse and human peripheral blood lymphocytes to 60Co gamma radiation..” Radiation Research 115, no. 2 (August 1988): 334–46. https://doi.org/10.2307/3577169.
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    • Werner, M. H., P. C. Burger, E. R. Heinz, A. H. Friedman, E. C. Halperin, and S. C. Schold. “Intracranial atherosclerosis following radiotherapy..” Neurology 38, no. 7 (July 1988): 1158–60. https://doi.org/10.1212/wnl.38.7.1158.
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    • Friedman, HS, Burger, PC, Bigner, SH, Trojanowski, JQ, Brodeur, GM, He, XM, Wikstrand, CJ, Kurtzberg, J, Berens, ME, and Halperin, EC. "Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc." The American Journal of Pathology 130, no. 3 (March 1988): 472-484.
    • Frantz, F. W., D. J. Terris, C. W. Wyble, E. C. Halperin, F. Sanfilippo, M. W. Scroggs, G. Honoré, and R. R. Bollinger. “Allogeneic small bowel transplantation with cyclosporine and donor whole-body irradiation..” Transplantation Proceedings 20, no. 1 Suppl 1 (February 1988): 193–96.
    • Halperin, E. C., R. W. Fraser, and J. Hughes. “The management of clinically localized prostate cancer. A summary of the Consensus Statement of the National Institutes of Health..” North Carolina Medical Journal 49, no. 2 (February 1988): 75–79.
    • Halperin, E. C. “Desegregation of hospitals and medical societies in North Carolina..” The New England Journal of Medicine 318, no. 1 (January 1988): 58–63. https://doi.org/10.1056/nejm198801073180127.
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    • Halperin, E. C. “Medical origins of Duke University?.” North Carolina Medical Journal 48, no. 12 (December 1987): 664–66.
    • Halperin, E. C. “Hepatic metastasis from neuroblastoma..” Southern Medical Journal 80, no. 11 (November 1987): 1370–73.
    • Bullard, DE, Rawlings, CE, Phillips, B, Cox, EB, Schold, SC, Burger, P, and Halperin, EC. "Oligodendroglioma. An analysis of the value of radiation therapy." Cancer 60, no. 9 (November 1987): 2179-2188.  Full Text
    • Halperin, E. C., S. Knechtle, K. Abernethy, T. Saad, D. Miller, W. B. Vernon, and R. R. Bollinger. “The influence of dose and dose rate of total lymphoid irradiation in the rat cardiac allograft model..” Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology 9, no. 4 (August 1987): 311–18. https://doi.org/10.1016/s0167-8140(87)80152-4.
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    • Knechtle, S. J., E. C. Halperin, and R. R. Bollinger. “Combined total lymphoid irradiation and cyclosporine promote xenograft survival..” Transplantation Proceedings 19, no. 1 Pt 2 (February 1987): 1137–39.
    • Knechtle, SJ, Halperin, EC, and Bollinger, RR. "Xenograft survival in two species combinations using total-lymphoid irradiation and cyclosporine." Transplantation 43, no. 2 (February 1987): 173-175.
    • Halperin, E. C., and E. B. Cox. “Radiation therapy in the management of neuroblastoma: the Duke University Medical Center experience 1967-1984..” International Journal of Radiation Oncology, Biology, Physics 12, no. 10 (October 1986): 1829–37. https://doi.org/10.1016/0360-3016(86)90326-3.
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    • Hershatter, B. W., E. C. Halperin, and E. B. Cox. “Medulloblastoma: the Duke University Medical Center experience..” International Journal of Radiation Oncology, Biology, Physics 12, no. 10 (October 1986): 1771–77. https://doi.org/10.1016/0360-3016(86)90318-4.
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    • Halperin, E. C. “Pediatric radiation oncology..” Investigative Radiology 21, no. 5 (May 1986): 429–36.
    • Knechtle, S. J., E. C. Halperin, T. Saad, and R. R. Bollinger. “Prolonged heart xenograft survival using combined total lymphoid irradiation and cyclosporine..” The Journal of Heart Transplantation 5, no. 3 (May 1986): 254–61.
    • Halperin, E. C., and P. C. Burger. “Conventional external beam radiotherapy for central nervous system malignancies..” Neurologic Clinics 3, no. 4 (November 1985): 867–82. https://doi.org/10.1016/s0733-8619(18)31015-6.
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    • Friedman, HS, Burger, PC, Bigner, SH, Trojanowski, JQ, Wikstrand, CJ, Halperin, EC, and Bigner, DD. "Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med." Journal of Neuropathology and Experimental Neurology 44, no. 6 (November 1985): 592-605.  Full Text
    • Knechtle, S. J., E. C. Halperin, C. E. Murphy, T. Saad, K. Abernethy, D. Miller, and R. R. Bollinger. “The effect of cyclosporine, total lymphoid irradiation, and cobra venom factor on hyperacute rejection..” The Journal of Heart Transplantation 4, no. 5 (September 1985): 541–45.
    • Halperin, E. C. “Pediatric brain stem tumors: patterns of treatment failure and their implications for radiotherapy..” International Journal of Radiation Oncology, Biology, Physics 11, no. 7 (July 1985): 1293–98. https://doi.org/10.1016/0360-3016(85)90244-5.
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    • Halperin, E. C. “Total lymphoid irradiation as an immunosuppressive agent for transplantation and the treatment of 'autoimmune' disease: a review..” Clinical Radiology 36, no. 2 (March 1985): 125–30. https://doi.org/10.1016/s0009-9260(85)80094-5.
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    • Halperin, E. C., F. L. Delmonico, P. W. Nelson, W. U. Shipley, and A. B. Cosimi. “The use of local allograft irradiation following renal transplantation..” International Journal of Radiation Oncology, Biology, Physics 10, no. 7 (July 1984): 987–90. https://doi.org/10.1016/0360-3016(84)90168-8.
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    • Halperin, EC, Greenberg, MS, and Suit, HD. "Sarcoma of bone and soft tissue following treatment of Hodgkin's disease." Cancer 53, no. 2 (January 1984): 232-236. (Review)  Full Text
    • Meyer, J. E., E. C. Halperin, S. R. Levene, and P. C. Stomper. “Adrenal insufficiency secondary to metastatic lung carcinoma: CT aided diagnosis..” Journal of Computer Assisted Tomography 7, no. 6 (December 1983): 1107–8.
    • Halperin, EC, Haas, G, Dosoretz, DE, Gitterman, M, Barrett, L, Cosimi, AB, and Suit, HD. "1982 resident's essay award: the immunologic effects of lymphoid irradiation in human and non-human primates: cellular changes and the potential for renal transplantation." International Journal of Radiation Oncology, Biology, Physics 9, no. 7 (July 1983): 1083-1089.
    • Halperin, EC, and Harisiadis, L. "The role of radiation therapy in the management of metastatic renal cell carcinoma." Cancer 51, no. 4 (February 1983): 614-617.  Full Text
    • Halperin, E. C., D. E. Dosoretz, M. Goodman, and C. C. Wang. “Radiotherapy of polymorphic reticulosis..” The British Journal of Radiology 55, no. 657 (September 1982): 645–49. https://doi.org/10.1259/0007-1285-55-657-645.
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    • Meyer, J. E., E. C. Halperin, and R. M. Linggood. “Upper extremity lymphangiography as an aid to treatment planning for stage 1A epitrochlear hodgkin's disease..” Cardiovascular and Interventional Radiology 5, no. 5 (January 1982): 279–80. https://doi.org/10.1007/bf02565413.
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    • Halperin, EC, Thier, SO, and Rosenberg, LE. "The use of D-penicillamine in cystinuria: efficacy and untoward reactions." The Yale Journal of Biology and Medicine 54, no. 6 (November 1981): 439-446.

  • Other Articles

    • Knechtle, S. J., E. C. Halperin, and R. R. Bollinger. “The effect of TLI and cyclosporine on xenograft survival..” Transplantation, December 1990.

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