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Adriamycin in the treatment of childhood acute leukemia. A Southwest Oncology Group study.

Publication ,  Journal Article
Ragab, AH; Sutow, WW; Komp, DM; Starling, KA; Lyon, GM; George, S
Published in: Cancer
October 1975

Sixty-six children with acute leukemia, in advanced stages of their disease and resistant to conventional chemotherapy, received adriamycin for remssion induction. Seventeen of 46 (37%) evaluable children with acute lymphocytic leukemia achieved a complete remission, and 5 (11%) achieved a partial remission. Two of 12 evaluable children with acute myelogenous leukemia achieved a complete remission, while an additional 3 achieved a partial remission. Two children with erythroleukemia also achieved a complete remission. Previous therapy with daunorubicin did not affect the response rate. The main toxicities observed with adriamycin were myelosuppression, fever, nausea and vomiting, stomatitis, alopecia, and cardiac toxicity (ST segment changes and arrhythmias).

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Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

October 1975

Volume

36

Issue

4

Start / End Page

1223 / 1226

Location

United States

Related Subject Headings

  • Stomatitis
  • Remission, Spontaneous
  • Oncology & Carcinogenesis
  • Nausea
  • Male
  • Leukemia, Myeloid, Acute
  • Leukemia, Lymphoid
  • Leukemia, Erythroblastic, Acute
  • Leukemia
  • Infant
 

Citation

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MLA
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Ragab, A. H., Sutow, W. W., Komp, D. M., Starling, K. A., Lyon, G. M., & George, S. (1975). Adriamycin in the treatment of childhood acute leukemia. A Southwest Oncology Group study. Cancer, 36(4), 1223–1226. https://doi.org/10.1002/1097-0142(197510)36:4<1223::aid-cncr2820360407>3.0.co;2-7
Ragab, A. H., W. W. Sutow, D. M. Komp, K. A. Starling, G. M. Lyon, and S. George. “Adriamycin in the treatment of childhood acute leukemia. A Southwest Oncology Group study.Cancer 36, no. 4 (October 1975): 1223–26. https://doi.org/10.1002/1097-0142(197510)36:4<1223::aid-cncr2820360407>3.0.co;2-7.
Ragab AH, Sutow WW, Komp DM, Starling KA, Lyon GM, George S. Adriamycin in the treatment of childhood acute leukemia. A Southwest Oncology Group study. Cancer. 1975 Oct;36(4):1223–6.
Ragab, A. H., et al. “Adriamycin in the treatment of childhood acute leukemia. A Southwest Oncology Group study.Cancer, vol. 36, no. 4, Oct. 1975, pp. 1223–26. Pubmed, doi:10.1002/1097-0142(197510)36:4<1223::aid-cncr2820360407>3.0.co;2-7.
Ragab AH, Sutow WW, Komp DM, Starling KA, Lyon GM, George S. Adriamycin in the treatment of childhood acute leukemia. A Southwest Oncology Group study. Cancer. 1975 Oct;36(4):1223–1226.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

October 1975

Volume

36

Issue

4

Start / End Page

1223 / 1226

Location

United States

Related Subject Headings

  • Stomatitis
  • Remission, Spontaneous
  • Oncology & Carcinogenesis
  • Nausea
  • Male
  • Leukemia, Myeloid, Acute
  • Leukemia, Lymphoid
  • Leukemia, Erythroblastic, Acute
  • Leukemia
  • Infant