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Routine therapeutic monitoring of lamotrigine in epileptic patients using a simple and rapid high performance liquid chromatographic technique.

Publication ,  Journal Article
George, S; Wood, AJ; Braithwaite, RA
Published in: Ann Clin Biochem
November 1995

We have developed a simple and rapid high performance liquid chromatographic technique to determine lamotrigine concentrations in epileptic patients and validated it using external quality control material. The method has been used to monitor the lamotrigine concentration in 70 specimens from 61 patients. Only 50% of the specimens had concentrations within the proposed target range of 1 mg/L to 4 mg/L, and there was no relationship between lamotrigine concentration and age, sex, other anti-epileptic treatments, or dose, although this could in part be explained by concomitant anti-epileptic therapy. We suggest that lamotrigine should be monitored therapeutically in order to assess its efficacy and audit its use as an anti-epileptic treatment, especially with the introduction of this relatively new drug as monotherapy.

Duke Scholars

Published In

Ann Clin Biochem

DOI

ISSN

0004-5632

Publication Date

November 1995

Volume

32 ( Pt 6)

Start / End Page

584 / 588

Location

England

Related Subject Headings

  • Triazines
  • Sex Factors
  • Middle Aged
  • Male
  • Linear Models
  • Lamotrigine
  • Humans
  • General Clinical Medicine
  • Female
  • Epilepsy
 

Citation

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George, S., Wood, A. J., & Braithwaite, R. A. (1995). Routine therapeutic monitoring of lamotrigine in epileptic patients using a simple and rapid high performance liquid chromatographic technique. Ann Clin Biochem, 32 ( Pt 6), 584–588. https://doi.org/10.1177/000456329503200611
George, S., A. J. Wood, and R. A. Braithwaite. “Routine therapeutic monitoring of lamotrigine in epileptic patients using a simple and rapid high performance liquid chromatographic technique.Ann Clin Biochem 32 ( Pt 6) (November 1995): 584–88. https://doi.org/10.1177/000456329503200611.
George, S., et al. “Routine therapeutic monitoring of lamotrigine in epileptic patients using a simple and rapid high performance liquid chromatographic technique.Ann Clin Biochem, vol. 32 ( Pt 6), Nov. 1995, pp. 584–88. Pubmed, doi:10.1177/000456329503200611.
Journal cover image

Published In

Ann Clin Biochem

DOI

ISSN

0004-5632

Publication Date

November 1995

Volume

32 ( Pt 6)

Start / End Page

584 / 588

Location

England

Related Subject Headings

  • Triazines
  • Sex Factors
  • Middle Aged
  • Male
  • Linear Models
  • Lamotrigine
  • Humans
  • General Clinical Medicine
  • Female
  • Epilepsy