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The protein binding of timegadine determined by equilibrium dialysis.

Publication ,  Journal Article
George, S; McBurney, A; Ward, J
Published in: Br J Clin Pharmacol
November 1984

The protein binding of timegadine to albumin, serum, plasma and plasma enriched with the acute phase reactants alpha 1-acid glycoprotein, alpha 1-anti-trypsin and C-reactive protein was determined by equilibrium dialysis. The effects of other analgesic and anti-inflammatories (indomethacin, ketoprofen, paracetamol and sodium salicylate) and other basic drugs (disopyramide, lignocaine, propranolol and quinidine) on the binding of timegadine were also determined. Timegadine binding was concentration-dependent up to 0.5 micrograms/ml, but independent above this level up to 10.0 micrograms/ml, the mean and standard error being 93.8 +/- 0.5%. Albumin accounted for only 32.4% of timegadine bound to plasma. Plasma enrichment with the acute phase reactants led to significant increases in timegadine binding. Simultaneous dialysis with other drugs caused significant decreases in timegadine binding.

Duke Scholars

Published In

Br J Clin Pharmacol

DOI

ISSN

0306-5251

Publication Date

November 1984

Volume

18

Issue

5

Start / End Page

785 / 790

Location

England

Related Subject Headings

  • Serum Albumin
  • Protein Binding
  • Pharmacology & Pharmacy
  • In Vitro Techniques
  • Humans
  • Guanidines
  • Dialysis
  • Blood Proteins
  • Anticoagulants
  • Anti-Inflammatory Agents
 

Citation

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George, S., McBurney, A., & Ward, J. (1984). The protein binding of timegadine determined by equilibrium dialysis. Br J Clin Pharmacol, 18(5), 785–790. https://doi.org/10.1111/j.1365-2125.1984.tb02543.x
George, S., A. McBurney, and J. Ward. “The protein binding of timegadine determined by equilibrium dialysis.Br J Clin Pharmacol 18, no. 5 (November 1984): 785–90. https://doi.org/10.1111/j.1365-2125.1984.tb02543.x.
George S, McBurney A, Ward J. The protein binding of timegadine determined by equilibrium dialysis. Br J Clin Pharmacol. 1984 Nov;18(5):785–90.
George, S., et al. “The protein binding of timegadine determined by equilibrium dialysis.Br J Clin Pharmacol, vol. 18, no. 5, Nov. 1984, pp. 785–90. Pubmed, doi:10.1111/j.1365-2125.1984.tb02543.x.
George S, McBurney A, Ward J. The protein binding of timegadine determined by equilibrium dialysis. Br J Clin Pharmacol. 1984 Nov;18(5):785–790.
Journal cover image

Published In

Br J Clin Pharmacol

DOI

ISSN

0306-5251

Publication Date

November 1984

Volume

18

Issue

5

Start / End Page

785 / 790

Location

England

Related Subject Headings

  • Serum Albumin
  • Protein Binding
  • Pharmacology & Pharmacy
  • In Vitro Techniques
  • Humans
  • Guanidines
  • Dialysis
  • Blood Proteins
  • Anticoagulants
  • Anti-Inflammatory Agents