Ha-ras polymorphisms in epithelial ovarian cancer.
Publication
, Journal Article
O'Briant, K; Chrysson, N; Hunter, V; Tyson, F; Tanner, M; Daly, L; George, SL; Berchuck, A; Soper, J; Fowler, W
Published in: Gynecol Oncol
June 1992
Unusual restriction fragment length polymorphisms (RFLPs) of the Ha-ras locus have been found in DNA from leukocytes and tumor tissue of cancer patients. To determine whether rare alleles would be observed frequently in patients with ovarian cancer, Ha-ras RFLPs were studied in DNA from 42 different ovarian epithelial tumors and from the peripheral blood leukocytes of 76 normal individuals. Four common, seven intermediate, and seven rare alleles were detected overall. Similar fractions of rare alleles were found in DNA from ovarian cancers and from the peripheral blood of normal individuals. Thus, the frequency of unusual Ha-ras RFLPs did not distinguish patients with ovarian cancers from apparently healthy individuals.
Duke Scholars
Published In
Gynecol Oncol
DOI
ISSN
0090-8258
Publication Date
June 1992
Volume
45
Issue
3
Start / End Page
299 / 302
Location
United States
Related Subject Headings
- Reference Values
- Polymorphism, Restriction Fragment Length
- Ovarian Neoplasms
- Oncology & Carcinogenesis
- Middle Aged
- Humans
- Genes, ras
- Female
- DNA, Neoplasm
- Blotting, Southern
Citation
APA
Chicago
ICMJE
MLA
NLM
O’Briant, K., Chrysson, N., Hunter, V., Tyson, F., Tanner, M., Daly, L., … Fowler, W. (1992). Ha-ras polymorphisms in epithelial ovarian cancer. Gynecol Oncol, 45(3), 299–302. https://doi.org/10.1016/0090-8258(92)90308-6
O’Briant, K., N. Chrysson, V. Hunter, F. Tyson, M. Tanner, L. Daly, S. L. George, A. Berchuck, J. Soper, and W. Fowler. “Ha-ras polymorphisms in epithelial ovarian cancer.” Gynecol Oncol 45, no. 3 (June 1992): 299–302. https://doi.org/10.1016/0090-8258(92)90308-6.
O’Briant K, Chrysson N, Hunter V, Tyson F, Tanner M, Daly L, et al. Ha-ras polymorphisms in epithelial ovarian cancer. Gynecol Oncol. 1992 Jun;45(3):299–302.
O’Briant, K., et al. “Ha-ras polymorphisms in epithelial ovarian cancer.” Gynecol Oncol, vol. 45, no. 3, June 1992, pp. 299–302. Pubmed, doi:10.1016/0090-8258(92)90308-6.
O’Briant K, Chrysson N, Hunter V, Tyson F, Tanner M, Daly L, George SL, Berchuck A, Soper J, Fowler W. Ha-ras polymorphisms in epithelial ovarian cancer. Gynecol Oncol. 1992 Jun;45(3):299–302.
Published In
Gynecol Oncol
DOI
ISSN
0090-8258
Publication Date
June 1992
Volume
45
Issue
3
Start / End Page
299 / 302
Location
United States
Related Subject Headings
- Reference Values
- Polymorphism, Restriction Fragment Length
- Ovarian Neoplasms
- Oncology & Carcinogenesis
- Middle Aged
- Humans
- Genes, ras
- Female
- DNA, Neoplasm
- Blotting, Southern