Dependence of germinal center B cells on expression of CD21/CD35 for survival.

Journal Article (Journal Article)

Affinity-driven selection of B lymphocytes within germinal centers is critical for the development of high-affinity memory cells and host protection. To investigate the role of the CD21/CD35 coreceptor in B cell competition for follicular retention and survival within the germinal center, either Cr2+ or Cr2null lysozyme-specific transgenic B cells were adoptively transferred into normal mice immunized with duck (DEL) or turkey (TEL) lysozyme, which bind with different affinities. In mice injected with high-affinity turkey lysozyme, Cr2null B cells responded by follicular retention; however, they could not survive within germinal centers. This suggests that CD21 provides a signal independent of antigen that is required for survival of B cells in the germinal center.

Full Text

Duke Authors

Cited Authors

  • Fischer, MB; Goerg, S; Shen, L; Prodeus, AP; Goodnow, CC; Kelsoe, G; Carroll, MC

Published Date

  • April 24, 1998

Published In

Volume / Issue

  • 280 / 5363

Start / End Page

  • 582 - 585

PubMed ID

  • 9554848

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.280.5363.582


  • eng

Conference Location

  • United States