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beta-Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart.

Publication ,  Journal Article
Garofolo, MC; Seidler, FJ; Auman, JT; Slotkin, TA
Published in: Am J Physiol Regul Integr Comp Physiol
May 2002

Imbalances of beta-adrenoceptor (beta-AR) and muscarinic ACh receptor (mAChR) input are thought to underlie perinatal cardiovascular abnormalities in conditions such as sudden infant death syndrome. Administration of isoproterenol, a beta(1)/beta(2)-AR agonist, to neonatal rats on postnatal days (PN) 2-5 caused downregulation of cardiac m(2)AChRs and a corresponding decrement in their control of adenylyl cyclase activity. Terbutaline, a beta(2)-selective agonist that crosses the placenta and the blood-brain barrier, was also effective when given either on PN 2-5 or during gestational days 17-20. Terbutaline failed to downregulate brain m(2)AChRs, even though it downregulated beta-ARs; beta-ARs and m(2)AChRs are located on different cell populations in the brain, but they are on the same cells in the heart. Destruction of catecholaminergic neurons with neonatal 6-hydroxydopamine upregulated cardiac but not brain m(2)AChRs. These results suggest that perinatal beta-AR stimulation shifts cardiac receptor production away from the generation of m(2)AChRs so that the development of sympathetic innervation acts as a negative modulator of cholinergic function. Accordingly, tocolytic therapy with beta-AR agonists may compromise the perinatal balance of adrenergic and cholinergic inputs.

Duke Scholars

Published In

Am J Physiol Regul Integr Comp Physiol

DOI

ISSN

0363-6119

Publication Date

May 2002

Volume

282

Issue

5

Start / End Page

R1356 / R1363

Location

United States

Related Subject Headings

  • Terbutaline
  • Receptors, Muscarinic
  • Receptors, Adrenergic, beta
  • Receptor, Muscarinic M2
  • Receptor Cross-Talk
  • Rats, Sprague-Dawley
  • Rats
  • Physiology
  • Oxidopamine
  • Myocardium
 

Citation

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Chicago
ICMJE
MLA
NLM
Garofolo, M. C., Seidler, F. J., Auman, J. T., & Slotkin, T. A. (2002). beta-Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart. Am J Physiol Regul Integr Comp Physiol, 282(5), R1356–R1363. https://doi.org/10.1152/ajpregu.00598.2001
Garofolo, M. C., F. J. Seidler, J. T. Auman, and T. A. Slotkin. “beta-Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart.Am J Physiol Regul Integr Comp Physiol 282, no. 5 (May 2002): R1356–63. https://doi.org/10.1152/ajpregu.00598.2001.
Garofolo MC, Seidler FJ, Auman JT, Slotkin TA. beta-Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart. Am J Physiol Regul Integr Comp Physiol. 2002 May;282(5):R1356–63.
Garofolo, M. C., et al. “beta-Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart.Am J Physiol Regul Integr Comp Physiol, vol. 282, no. 5, May 2002, pp. R1356–63. Pubmed, doi:10.1152/ajpregu.00598.2001.
Garofolo MC, Seidler FJ, Auman JT, Slotkin TA. beta-Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart. Am J Physiol Regul Integr Comp Physiol. 2002 May;282(5):R1356–R1363.

Published In

Am J Physiol Regul Integr Comp Physiol

DOI

ISSN

0363-6119

Publication Date

May 2002

Volume

282

Issue

5

Start / End Page

R1356 / R1363

Location

United States

Related Subject Headings

  • Terbutaline
  • Receptors, Muscarinic
  • Receptors, Adrenergic, beta
  • Receptor, Muscarinic M2
  • Receptor Cross-Talk
  • Rats, Sprague-Dawley
  • Rats
  • Physiology
  • Oxidopamine
  • Myocardium