Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 1986
• 

  Previous Appointments & Affiliations

  • Assistant Research Professor in the Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1986 - 2022
• Research
• 

  Selected Grants

  • Paternal Transgenerational Epigenetic Legacy from Use of Cannabis awarded by John Templeton Foundation 2017 - 2022
  • Alzheimer's Disease, Genes, and Pesticide Use in the Agricultural Health Study awarded by National Institutes of Health 2014 - 2021
  • Drugs and Development of the Adrenergic Nervous System awarded by National Institutes of Health 1976 - 2005
  • Study Of Depression awarded by National Institutes of Health 1994 - 2000
  • Crc/Pe For The Study Of Depression awarded by National Institutes of Health 1984 - 1999
  • Drugs And Development Of Adrenergic Nervous System awarded by National Institutes of Health 1997 - 1999
  • Drugs And Development Of The Adrenergic Nervous System awarded by National Institutes of Health 1996 - 1999
  • Molecular And Cellular Mechanisms Underlying Dose-Response awarded by Environmental Protection Agency 1992 - 1995
  • Molecular And Cellular Mechanisms Underlying Dose-Response awarded by Environmental Protection Agency 1992 - 1995
  • Maternal Cocaine & Neonatal Nervous System Development awarded by National Institutes of Health 1991 - 1992
  • Maternal Cocaine And Neonatal Nervous System Development awarded by National Institutes of Health 1990 - 1992
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Hawkey, Andrew B., Janequia Evans, Zade R. Holloway, Erica Pippen, Olivia Jarrett, Bruny Kenou, Theodore A. Slotkin, Frederic J. Seidler, and Edward D. Levin. “Developmental exposure to the flame retardant, triphenyl phosphate, causes long-lasting neurobehavioral and neurochemical dysfunction.” Birth Defects Res 115, no. 3 (February 1, 2023): 357–70. https://doi.org/10.1002/bdr2.2125.
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    • Hawkey, Andrew B., Erica Pippen, Bruny Kenou, Zade Holloway, Theodore A. Slotkin, Frederic J. Seidler, and Edward D. Levin. “Persistent neurobehavioral and neurochemical anomalies in middle-aged rats after maternal diazinon exposure.” Toxicology 472 (April 30, 2022): 153189. https://doi.org/10.1016/j.tox.2022.153189.
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    • Slotkin, Theodore A., Edward D. Levin, and Frederic J. Seidler. “Paternal Cannabis Exposure Prior to Mating, but Not Δ9-Tetrahydrocannabinol, Elicits Deficits in Dopaminergic Synaptic Activity in the Offspring.” Toxicol Sci 184, no. 2 (November 24, 2021): 252–64. https://doi.org/10.1093/toxsci/kfab117.
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    • Hawkey, Andrew B., Zade Holloway, Cassandra Dean, Reese Koburov, Theodore A. Slotkin, Frederic J. Seidler, and Edward D. Levin. “Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?” Neurotoxicol Teratol 87 (2021): 106985. https://doi.org/10.1016/j.ntt.2021.106985.
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    • Slotkin, Theodore A., Samantha Skavicus, Edward D. Levin, and Frederic J. Seidler. “Paternal Δ9-Tetrahydrocannabinol Exposure Prior to Mating Elicits Deficits in Cholinergic Synaptic Function in the Offspring.” Toxicol Sci 174, no. 2 (April 1, 2020): 210–17. https://doi.org/10.1093/toxsci/kfaa004.
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    • Hawkey, Andrew B., Lilah Glazer, Cassandra Dean, Corinne N. Wells, Kathryn-Ann Odamah, Theodore A. Slotkin, Frederic J. Seidler, and Edward D. Levin. “Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish.” Neurotoxicol Teratol 78 (2020): 106853. https://doi.org/10.1016/j.ntt.2019.106853.
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    • Slotkin, Theodore A., Samantha Skavicus, Ashley Ko, Edward D. Levin, and Frederic J. Seidler. “Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems.” Toxicology 424 (August 1, 2019): 152240. https://doi.org/10.1016/j.tox.2019.152240.
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    • Slotkin, Theodore A., Samantha Skavicus, Ashley Ko, Edward D. Levin, and Frederic J. Seidler. “Corrigendum to "The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]pyrene: Effects on Cholinergic and Serotonergic Systems".” Toxicol Sci 168, no. 1 (March 1, 2019): 280. https://doi.org/10.1093/toxsci/kfy304.
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    • Slotkin, Theodore A., Samantha Skavicus, Ashley Ko, Edward D. Levin, and Frederic J. Seidler. “The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]Pyrene: Effects on Cholinergic and Serotonergic Systems.” Toxicol Sci 167, no. 1 (January 1, 2019): 293–304. https://doi.org/10.1093/toxsci/kfy241.
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    • Slotkin, Theodore A., Ashley Ko, and Frederic J. Seidler. “Does growth impairment underlie the adverse effects of dexamethasone on development of noradrenergic systems?” Toxicology 408 (September 1, 2018): 11–21. https://doi.org/10.1016/j.tox.2018.06.008.
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    • Slotkin, Theodore A., Samantha Skavicus, and Frederic J. Seidler. “Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together.” Toxicology 400–401 (May 1, 2018): 57–64. https://doi.org/10.1016/j.tox.2018.03.001.
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    • Slotkin, Theodore A., Samantha Skavicus, Heather M. Stapleton, and Frederic J. Seidler. “Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells.” Toxicology 390 (September 2017): 32–42. https://doi.org/10.1016/j.tox.2017.08.009.
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    • Slotkin, Theodore A., Samantha Skavicus, and Frederic J. Seidler. “Diazinon and parathion diverge in their effects on development of noradrenergic systems.” Brain Res Bull 130 (April 2017): 268–73. https://doi.org/10.1016/j.brainresbull.2017.02.004.
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    • Slotkin, Theodore A., Samantha Skavicus, Jennifer Card, Richard T Di Giulio, and Frederic J. Seidler. “In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells.” Toxicology 377 (February 15, 2017): 49–56. https://doi.org/10.1016/j.tox.2016.12.008.
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    • Slotkin, Theodore A., Ashley Stadler, Samantha Skavicus, Jennifer Card, Jonathan Ruff, Edward D. Levin, and Frederic J. Seidler. “Is There a Critical Period for the Developmental Neurotoxicity of Low-Level Tobacco Smoke Exposure?” Toxicol Sci 155, no. 1 (January 2017): 75–84. https://doi.org/10.1093/toxsci/kfw180.
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    • Slotkin, Theodore A., Samantha Skavicus, Jennifer Card, Edward D. Levin, and Frederic J. Seidler. “Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes.” Toxicology 372 (November 30, 2016): 42–51. https://doi.org/10.1016/j.tox.2016.10.015.
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    • Slotkin, Theodore A., Ashley Stadler, Samantha Skavicus, and Frederic J. Seidler. “Adolescents and adults differ in the immediate and long-term impact of nicotine administration and withdrawal on cardiac norepinephrine.” Brain Res Bull 122 (April 2016): 71–75. https://doi.org/10.1016/j.brainresbull.2016.03.006.
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    • Slotkin, Theodore A., Samantha Skavicus, and Frederic J. Seidler. “Prenatal drug exposures sensitize noradrenergic circuits to subsequent disruption by chlorpyrifos.” Toxicology 338 (December 2, 2015): 8–16. https://doi.org/10.1016/j.tox.2015.09.005.
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    • Slotkin, Theodore A., Samantha Skavicus, Jennifer Card, Ashley Stadler, Edward D. Levin, and Frederic J. Seidler. “Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine.” Toxicol Sci 147, no. 1 (September 2015): 178–89. https://doi.org/10.1093/toxsci/kfv123.
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    • Slotkin, Theodore A., Samantha Skavicus, Jennifer Card, Edward D. Levin, and Frederic J. Seidler. “Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors.” Toxicology 333 (July 3, 2015): 63–75. https://doi.org/10.1016/j.tox.2015.04.005.
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    • Slotkin, Theodore A., Samantha Skavicus, Edward D. Levin, and Frederic J. Seidler. “Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition.” Brain Res Bull 111 (February 2015): 84–96. https://doi.org/10.1016/j.brainresbull.2015.01.003.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?".” Brain Res Bull 110 (January 2015): 54–67. https://doi.org/10.1016/j.brainresbull.2014.12.003.
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    • Slotkin, Theodore A., Jennifer Card, and Frederic J. Seidler. “Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function.” Brain Res Bull 102 (March 2014): 1–8. https://doi.org/10.1016/j.brainresbull.2014.01.004.
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    • Levin, Edward D., Marty Cauley, Joshua E. Johnson, Ellen M. Cooper, Heather M. Stapleton, P Lee Ferguson, Frederic J. Seidler, and Theodore A. Slotkin. “Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor.” Neurotoxicol Teratol 41 (2014): 35–42. https://doi.org/10.1016/j.ntt.2013.10.004.
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    • Slotkin, Theodore A., Jennifer Card, Ashley Stadler, Edward D. Levin, and Frederic J. Seidler. “Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene.” Neurotoxicol Teratol 43 (2014): 19–24. https://doi.org/10.1016/j.ntt.2014.03.002.
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    • Slotkin, Theodore A., Jennifer Card, and Frederic J. Seidler. “Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways.” Brain Res Bull 100 (January 2014): 44–54. https://doi.org/10.1016/j.brainresbull.2013.10.014.
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    • Slotkin, Theodore A., Ellen M. Cooper, Heather M. Stapleton, and Frederic J. Seidler. “Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?” Environ Toxicol Pharmacol 36, no. 2 (September 2013): 284–87. https://doi.org/10.1016/j.etap.2013.04.003.
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    • Slotkin, Theodore A., Jennifer Card, and Frederic J. Seidler. “Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells.” Environ Health Perspect 121, no. 7 (July 2013): 825–31. https://doi.org/10.1289/ehp.1306528.
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    • Slotkin, Theodore A., Jennifer Card, Alice Infante, and Frederic J. Seidler. “Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: Implications for vulnerability after pharmacotherapy for preterm labor.” Neurotoxicology and Teratology 37 (May 1, 2013): 1–12. https://doi.org/10.1016/j.ntt2013.02.002.
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    • Slotkin, Theodore A., Jennifer Card, Alice Infante, and Frederic J. Seidler. “BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells.” Neurotoxicol Teratol 37 (2013): 13–17. https://doi.org/10.1016/j.ntt.2013.02.001.
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    • Slotkin, Theodore A., Jennifer Card, Alice Infante, and Frederic J. Seidler. “Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: implications for vulnerability after pharmacotherapy for preterm labor.” Neurotoxicol Teratol 37 (2013): 1–12. https://doi.org/10.1016/j.ntt.2013.02.002.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Terbutaline impairs the development of peripheral noradrenergic projections: potential implications for autism spectrum disorders and pharmacotherapy of preterm labor.” Neurotoxicol Teratol 36 (2013): 91–96. https://doi.org/10.1016/j.ntt.2012.07.003.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation.” Neurotoxicol Teratol 34, no. 4 (July 2012): 395–402. https://doi.org/10.1016/j.ntt.2012.04.008.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro.” Neurotoxicol Teratol 34, no. 2 (March 2012): 232–41. https://doi.org/10.1016/j.ntt.2011.12.001.
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    • Slotkin, Theodore A., Jennifer Card, and Frederic J. Seidler. “Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells.” Neurotoxicol Teratol 34, no. 5 (2012): 505–12. https://doi.org/10.1016/j.ntt.2012.07.002.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Mimicking maternal smoking and pharmacotherapy of preterm labor: fetal nicotine exposure enhances the effect of late gestational dexamethasone treatment on noradrenergic circuits.” Brain Res Bull 86, no. 5–6 (November 25, 2011): 435–40. https://doi.org/10.1016/j.brainresbull.2011.08.009.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo.” Brain Res Bull 86, no. 5–6 (November 25, 2011): 340–47. https://doi.org/10.1016/j.brainresbull.2011.09.017.
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    • Dishaw, Laura V., Christina M. Powers, Ian T. Ryde, Simon C. Roberts, Frederic J. Seidler, Theodore A. Slotkin, and Heather M. Stapleton. “Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells.” Toxicol Appl Pharmacol 256, no. 3 (November 1, 2011): 281–89. https://doi.org/10.1016/j.taap.2011.01.005.
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    • Seidler, Frederic J., and Theodore A. Slotkin. “Developmental neurotoxicity targeting hepatic and cardiac sympathetic innervation: effects of organophosphates are distinct from those of glucocorticoids.” Brain Res Bull 85, no. 3–4 (May 30, 2011): 225–30. https://doi.org/10.1016/j.brainresbull.2011.03.021.
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    • Powers, Christina M., Appala R. Badireddy, Ian T. Ryde, Frederic J. Seidler, and Theodore A. Slotkin. “Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition.” Environ Health Perspect 119, no. 1 (January 2011): 37–44. https://doi.org/10.1289/ehp.1002337.
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    • Powers, Christina M., Edward D. Levin, Frederic J. Seidler, and Theodore A. Slotkin. “Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes.” Neurotoxicol Teratol 33, no. 2 (2011): 329–32. https://doi.org/10.1016/j.ntt.2010.10.006.
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    • Powers, Christina M., Theodore A. Slotkin, Frederic J. Seidler, Appala R. Badireddy, and Stephanie Padilla. “Silver nanoparticles alter zebrafish development and larval behavior: distinct roles for particle size, coating and composition.” Neurotoxicol Teratol 33, no. 6 (2011): 708–14. https://doi.org/10.1016/j.ntt.2011.02.002.
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    • Slotkin, Theodore A., Frederic J. Seidler, and Eliot R. Spindel. “Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C.” Neurotoxicol Teratol 33, no. 3 (2011): 431–34. https://doi.org/10.1016/j.ntt.2011.02.001.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.” Brain Res 1353 (September 24, 2010): 36–52. https://doi.org/10.1016/j.brainres.2010.07.073.
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    • Slotkin, Theodore A., Doug Lobner, and Frederic J. Seidler. “Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants.” Brain Res Bull 83, no. 1–2 (August 30, 2010): 76–83. https://doi.org/10.1016/j.brainresbull.2010.06.010.
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    • Adigun, Abayomi A., Ian T. Ryde, Frederic J. Seidler, and Theodore A. Slotkin. “Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells.” Brain Res 1329 (May 6, 2010): 36–44. https://doi.org/10.1016/j.brainres.2010.03.025.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Mimicking maternal smoking and pharmacotherapy of preterm labor: interactions of fetal nicotine and dexamethasone on serotonin and dopamine synaptic function in adolescence and adulthood.” Brain Res Bull 82, no. 1–2 (April 29, 2010): 124–34. https://doi.org/10.1016/j.brainresbull.2010.02.015.
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    • Adigun, Abayomi A., Nicola Wrench, Edward D. Levin, Frederic J. Seidler, and Theodore A. Slotkin. “Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum.” Brain Res Bull 81, no. 6 (April 5, 2010): 605–12. https://doi.org/10.1016/j.brainresbull.2010.01.003.
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    • Slotkin, Theodore A., Ian T. Ryde, and Frederic J. Seidler. “Additive and synergistic effects of fetal nicotine and dexamethasone exposure on cholinergic synaptic function in adolescence and adulthood: Implications for the adverse consequences of maternal smoking and pharmacotherapy of preterm delivery.” Brain Res Bull 81, no. 6 (April 5, 2010): 552–60. https://doi.org/10.1016/j.brainresbull.2009.11.003.
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    • Levin, Edward D., Olga A. Timofeeva, Liwei Yang, Ann Petro, Ian T. Ryde, Nicola Wrench, Frederic J. Seidler, and Theodore A. Slotkin. “Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging.” Behav Brain Res 208, no. 2 (April 2, 2010): 319–27. https://doi.org/10.1016/j.bbr.2009.11.007.
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    • Adigun, Abayomi A., Frederic J. Seidler, and Theodore A. Slotkin. “Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo.” Brain Res 1316 (February 26, 2010): 1–16. https://doi.org/10.1016/j.brainres.2009.12.025.
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    • Adigun, Abayomi A., Nicola Wrench, Frederic J. Seidler, and Theodore A. Slotkin. “Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion.” Environ Health Perspect 118, no. 2 (February 2010): 210–15. https://doi.org/10.1289/ehp.0901237.
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    • Lassiter, T Leon, Ian T. Ryde, Edward D. Levin, Frederic J. Seidler, and Theodore A. Slotkin. “Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits.” Brain Res Bull 81, no. 1 (January 15, 2010): 85–91. https://doi.org/10.1016/j.brainresbull.2009.07.002.
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    • Powers, Christina M., Nicola Wrench, Ian T. Ryde, Amanda M. Smith, Frederic J. Seidler, and Theodore A. Slotkin. “Silver impairs neurodevelopment: studies in PC12 cells.” Environ Health Perspect 118, no. 1 (January 2010): 73–79. https://doi.org/10.1289/ehp.0901149.
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    • Adigun, Abayomi A., Nicola Wrench, Frederic J. Seidler, and Theodore A. Slotkin. “Neonatal dexamethasone treatment leads to alterations in cell signaling cascades controlling hepatic and cardiac function in adulthood.” Neurotoxicol Teratol 32, no. 2 (2010): 193–99. https://doi.org/10.1016/j.ntt.2009.10.002.
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    • Powers, Christina M., Jerry Yen, Elwood A. Linney, Frederic J. Seidler, and Theodore A. Slotkin. “Silver exposure in developing zebrafish (Danio rerio): persistent effects on larval behavior and survival.” Neurotoxicol Teratol 32, no. 3 (2010): 391–97. https://doi.org/10.1016/j.ntt.2010.01.009.
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    • Slotkin, Theodore A., Frederic J. Seidler, and Fabio Fumagalli. “Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model.” Neurotoxicol Teratol 32, no. 1 (2010): 42–51. https://doi.org/10.1016/j.ntt.2008.11.006.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss.” Neurotoxicol Teratol 32, no. 2 (2010): 124–31. https://doi.org/10.1016/j.ntt.2009.12.001.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Benzo[a]pyrene impairs neurodifferentiation in PC12 cells.” Brain Res Bull 80, no. 1–2 (August 28, 2009): 17–21. https://doi.org/10.1016/j.brainresbull.2009.06.003.
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    • Slotkin, Theodore A., T Leon Lassiter, Ian T. Ryde, Nicola Wrench, Edward D. Levin, and Frederic J. Seidler. “Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions.” Environ Health Perspect 117, no. 6 (June 2009): 916–22. https://doi.org/10.1289/ehp.0800459.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells.” Environ Health Perspect 117, no. 4 (April 2009): 587–96. https://doi.org/10.1289/ehp.0800251.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.” Brain Res 1263 (March 31, 2009): 23–32. https://doi.org/10.1016/j.brainres.2009.01.049.
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    • Lassiter, T Leon, Emiko A. MacKillop, Ian T. Ryde, Frederic J. Seidler, and Theodore A. Slotkin. “Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells.” Brain Res Bull 78, no. 6 (March 30, 2009): 313–22. https://doi.org/10.1016/j.brainresbull.2008.09.020.
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    • Slotkin, Theodore, and Frederic Seidler. “Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells.” Brain Res Bull 78, no. 4–5 (March 16, 2009): 211–25. https://doi.org/10.1016/j.brainresbull.2008.08.021.
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    • Slotkin, Theodore A., Frederic J. Seidler, Changlong Wu, Emiko A. MacKillop, and Karl G. Linden. “Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells.” Environ Health Perspect 117, no. 3 (March 2009): 338–43. https://doi.org/10.1289/ehp.11592.
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    • Powers, Christina M., Emiko A. MacKillop, Nicola Wrench, Ian Ryde, Amanda M. Smith, Frederic J. Seidler, and Theodore A. Slotkin. “Transitioning Silver: From Big to Small, Safe to Unsafe?” International Journal of Toxicology 28, no. 1 (January 1, 2009): 61–62.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Nicotine exposure in adolescence alters the response of serotonin systems to nicotine administered subsequently in adulthood.” Dev Neurosci 31, no. 1–2 (2009): 58–70. https://doi.org/10.1159/000207494.
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    • Slotkin, Theodore A., Edward D. Levin, and Frederic J. Seidler. “Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood.” Neurotoxicol Teratol 31, no. 1 (2009): 11–17. https://doi.org/10.1016/j.ntt.2008.08.004.
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    • Slotkin, Theodore A., Ian T. Ryde, Nicola Wrench, Jennifer A. Card, and Frederic J. Seidler. “Nonenzymatic role of acetylcholinesterase in neuritic sprouting: regional changes in acetylcholinesterase and choline acetyltransferase after neonatal 6-hydroxydopamine lesions.” Neurotoxicol Teratol 31, no. 3 (2009): 183–86. https://doi.org/10.1016/j.ntt.2008.12.007.
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    • Slotkin, Theodore A., Nicola Wrench, Ian T. Ryde, T Leon Lassiter, Edward D. Levin, and Frederic J. Seidler. “Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood.” Neurotoxicol Teratol 31, no. 6 (2009): 390–99. https://doi.org/10.1016/j.ntt.2009.07.003.
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    • Yanai, Joseph, Adi Pinkas, Frederic J. Seidler, Ian T. Ryde, Eddy A. Van der Zee, and Theodore A. Slotkin. “Neurobehavioral teratogenicity of sarin in an avian model.” Neurotoxicol Teratol 31, no. 6 (2009): 406–12. https://doi.org/10.1016/j.ntt.2009.07.007.
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    • Timofeeva, Olga A., David Sanders, Kristen Seemann, Liwei Yang, Daniel Hermanson, Sam Regenbogen, Samantha Agoos, et al. “Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion.” Brain Res Bull 77, no. 6 (December 16, 2008): 404–11. https://doi.org/10.1016/j.brainresbull.2008.08.019.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel.” Toxicol Appl Pharmacol 233, no. 2 (December 1, 2008): 211–19. https://doi.org/10.1016/j.taap.2008.08.020.
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    • Lassiter, T Leon, Ian T. Ryde, Emiko A. Mackillop, Kathleen K. Brown, Edward D. Levin, Frederic J. Seidler, and Theodore A. Slotkin. “Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood.” Environ Health Perspect 116, no. 11 (November 2008): 1456–62. https://doi.org/10.1289/ehp.11673.
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    • Slotkin, Theodore A., Bethany E. Bodwell, Ian T. Ryde, Edward D. Levin, and Frederic J. Seidler. “Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood.” Environ Health Perspect 116, no. 10 (October 2008): 1308–14. https://doi.org/10.1289/ehp.11451.
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    • Slotkin, Theodore A., Frederic J. Seidler, Carmen R. Wood, and Christopher Lau. “Development of glucocorticoid receptor regulation in the rat forebrain: implications for adverse effects of glucocorticoids in preterm infants.” Brain Res Bull 76, no. 5 (July 30, 2008): 531–35. https://doi.org/10.1016/j.brainresbull.2008.03.002.
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    • Slotkin, Theodore A., Ian T. Ryde, Emiko A. Mackillop, Bethany E. Bodwell, and Frederic J. Seidler. “Adolescent nicotine administration changes the responses to nicotine given subsequently in adulthood: adenylyl cyclase cell signaling in brain regions during nicotine administration and withdrawal, and lasting effects.” Brain Res Bull 76, no. 5 (July 30, 2008): 522–30. https://doi.org/10.1016/j.brainresbull.2008.03.001.
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    • Slotkin, Theodore A., Frederic J. Seidler, and Fabio Fumagalli. “Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro.” Brain Res Bull 76, no. 4 (July 1, 2008): 424–38. https://doi.org/10.1016/j.brainresbull.2008.01.001.
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    • Slotkin, Theodore A., Emiko A. MacKillop, Ronald L. Melnick, Kristina A. Thayer, and Frederic J. Seidler. “Developmental neurotoxicity of perfluorinated chemicals modeled in vitro.” Environ Health Perspect 116, no. 6 (June 2008): 716–22. https://doi.org/10.1289/ehp.11253.
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    • Slotkin, Theodore A., Bethany E. Bodwell, Ian T. Ryde, and Frederic J. Seidler. “Adolescent nicotine treatment changes the response of acetylcholine systems to subsequent nicotine administration in adulthood.” Brain Res Bull 76, no. 1–2 (May 15, 2008): 152–65. https://doi.org/10.1016/j.brainresbull.2007.12.009.
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    • Slotkin, Theodore A., Ian T. Ryde, Edward D. Levin, and Frederic J. Seidler. “Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood.” Brain Res Bull 75, no. 5 (March 28, 2008): 640–47. https://doi.org/10.1016/j.brainresbull.2007.10.008.
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    • Slotkin, Theodore A., Bethany E. Bodwell, Edward D. Levin, and Frederic J. Seidler. “Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems.” Environ Health Perspect 116, no. 3 (March 2008): 340–48. https://doi.org/10.1289/ehp.11005.
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    • Roegge, Cindy S., Olga A. Timofeeva, Frederic J. Seidler, Theodore A. Slotkin, and Edward D. Levin. “Developmental diazinon neurotoxicity in rats: later effects on emotional response.” Brain Res Bull 75, no. 1 (January 31, 2008): 166–72. https://doi.org/10.1016/j.brainresbull.2007.08.008.
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    • Yanai, Joseph, Sharon Dotan, Roman Goz, Adi Pinkas, Frederic J. Seidler, Theodore A. Slotkin, and Frederic Zimmerman. “Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development.” J Toxicol Environ Health A 71, no. 2 (2008): 131–33. https://doi.org/10.1080/15287390701613280.
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    • Buznikov, Gennady A., Lyudmila A. Nikitina, Frederic J. Seidler, Theodore A. Slotkin, Vladimir V. Bezuglov, Ivan Milosević, Lidija Lazarević, Ljubica Rogac, Sabera Ruzdijić, and Ljubisa M. Rakić. “Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids.” Neurotoxicol Teratol 30, no. 6 (2008): 503–9. https://doi.org/10.1016/j.ntt.2008.05.003.
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    • Slotkin, Theodore A., Frederic J. Seidler, Ian T. Ryde, and Joseph Yanai. “Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model.” Neurotoxicol Teratol 30, no. 5 (2008): 433–39. https://doi.org/10.1016/j.ntt.2008.02.005.
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    • Timofeeva, Olga A., Cindy S. Roegge, Frederic J. Seidler, Theodore A. Slotkin, and Edward D. Levin. “Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon.” Neurotoxicol Teratol 30, no. 1 (2008): 38–45. https://doi.org/10.1016/j.ntt.2007.10.002.
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    • Slotkin, Theodore A., Ian T. Ryde, and Frederic J. Seidler. “Separate or sequential exposure to nicotine prenatally and in adulthood: persistent effects on acetylcholine systems in rat brain regions.” Brain Res Bull 74, no. 1–3 (September 14, 2007): 91–103. https://doi.org/10.1016/j.brainresbull.2007.05.007.
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    • Slotkin, Theodore A., Emiko A. MacKillop, Ian T. Ryde, and Frederic J. Seidler. “Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells.” Environ Health Perspect 115, no. 9 (September 2007): 1306–13. https://doi.org/10.1289/ehp.10194.
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    • Slotkin, Theodore A., Ian T. Ryde, Charlotte A. Tate, and Frederic J. Seidler. “Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: separate or sequential exposure during fetal development and adulthood.” Brain Res Bull 73, no. 4–6 (July 12, 2007): 259–72. https://doi.org/10.1016/j.brainresbull.2007.03.012.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats.” Brain Res Bull 73, no. 4–6 (July 12, 2007): 301–9. https://doi.org/10.1016/j.brainresbull.2007.04.004.
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    • Zerrate, M. C., M. Pletnikov, S. L. Connors, D. L. Vargas, F. J. Seidler, A. W. Zimmerman, T. A. Slotkin, and C. A. Pardo. “Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism.” J Pharmacol Exp Ther 322, no. 1 (July 2007): 16–22. https://doi.org/10.1124/jpet.107.121483.
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    • Slotkin, Theodore A., Frederic J. Seidler, and Fabio Fumagalli. “Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily.” Environ Health Perspect 115, no. 6 (June 2007): 909–16. https://doi.org/10.1289/ehp.9901.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems.” Brain Res Bull 72, no. 4–6 (May 30, 2007): 232–74. https://doi.org/10.1016/j.brainresbull.2007.01.005.
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    • Slotkin, Theodore A., Emiko A. MacKillop, Charles L. Rudder, Ian T. Ryde, Charlotte A. Tate, and Frederic J. Seidler. “Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age.” Neuropsychopharmacology 32, no. 5 (May 2007): 1082–97. https://doi.org/10.1038/sj.npp.1301231.
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    • Jameson, Ruth R., Frederic J. Seidler, and Theodore A. Slotkin. “Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon.” Environ Health Perspect 115, no. 1 (January 2007): 65–70. https://doi.org/10.1289/ehp.9487.
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    • Slotkin, Theodore A., Emiko A. MacKillop, Ian T. Ryde, Charlotte A. Tate, and Frederic J. Seidler. “Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel.” Environ Health Perspect 115, no. 1 (January 2007): 93–101. https://doi.org/10.1289/ehp.9527.
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    • Levin, Edward D., Susan Slade Lawrence, Ann Petro, Kofi Horton, Amir H. Rezvani, Frederic J. Seidler, and Theodore A. Slotkin. “Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates.” Neurotoxicol Teratol 29, no. 4 (2007): 458–65. https://doi.org/10.1016/j.ntt.2007.02.002.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration.” Neurotoxicol Teratol 29, no. 1 (2007): 10–16. https://doi.org/10.1016/j.ntt.2006.06.001.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects.” Reprod Toxicol 23, no. 3 (2007): 421–27. https://doi.org/10.1016/j.reprotox.2006.07.010.
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    • Levin, Edward D., Susan Lawrence, Ann Petro, Kofi Horton, Frederic J. Seidler, and Theodore A. Slotkin. “Increased nicotine self-administration following prenatal exposure in female rats.” Pharmacol Biochem Behav 85, no. 3 (November 2006): 669–74. https://doi.org/10.1016/j.pbb.2006.11.006.
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    • Slotkin, Theodore A., Charlotte A. Tate, Mandy M. Cousins, and Frederic J. Seidler. “Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: Serotonin receptors and cell signaling.” Neuropsychopharmacology 31, no. 11 (November 2006): 2462–75. https://doi.org/10.1038/sj.npp.1300988.
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    • Slotkin, Theodore A., Charlotte A. Tate, Ian T. Ryde, Edward D. Levin, and Frederic J. Seidler. “Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition.” Environ Health Perspect 114, no. 10 (October 2006): 1542–46. https://doi.org/10.1289/ehp.9337.
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    • Slotkin, Theodore A., Kent E. Pinkerton, Charlotte A. Tate, and Frederic J. Seidler. “Alterations of serotonin synaptic proteins in brain regions of neonatal Rhesus monkeys exposed to perinatal environmental tobacco smoke.” Brain Res 1111, no. 1 (September 21, 2006): 30–35. https://doi.org/10.1016/j.brainres.2006.06.094.
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    • Jameson, Ruth R., Frederic J. Seidler, Dan Qiao, and Theodore A. Slotkin. “Adverse neurodevelopmental effects of dexamethasone modeled in PC12 cells: identifying the critical stages and concentration thresholds for the targeting of cell acquisition, differentiation and viability.” Neuropsychopharmacology 31, no. 8 (August 2006): 1647–58. https://doi.org/10.1038/sj.npp.1300967.
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    • Jameson, Ruth R., Frederic J. Seidler, Dan Qiao, and Theodore A. Slotkin. “Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells.” Environ Health Perspect 114, no. 5 (May 2006): 667–72. https://doi.org/10.1289/ehp.8750.
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    • Slotkin, Theodore A., Edward D. Levin, and Frederic J. Seidler. “Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity.” Environ Health Perspect 114, no. 5 (May 2006): 746–51. https://doi.org/10.1289/ehp.8828.
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    • Slotkin, Theodore A., Marisa L. Kreider, Charlotte A. Tate, and Frederic J. Seidler. “Critical prenatal and postnatal periods for persistent effects of dexamethasone on serotonergic and dopaminergic systems.” Neuropsychopharmacology 31, no. 5 (May 2006): 904–11. https://doi.org/10.1038/sj.npp.1300892.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Anomalous regulation of beta-adrenoceptor signaling in brain regions of the newborn rat.” Brain Res 1077, no. 1 (March 10, 2006): 54–58. https://doi.org/10.1016/j.brainres.2006.01.047.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “Cholinergic receptor subtypes in the olfactory bulbectomy model of depression.” Brain Res Bull 68, no. 5 (January 30, 2006): 341–45. https://doi.org/10.1016/j.brainresbull.2005.09.005.
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    • Kreider, Marisa L., Charlotte A. Tate, Mandy M. Cousins, Colleen A. Oliver, Frederic J. Seidler, and Theodore A. Slotkin. “Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity.” Neuropsychopharmacology 31, no. 1 (January 2006): 12–35. https://doi.org/10.1038/sj.npp.1300783.
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    • Slotkin, Theodore A., Kent E. Pinkerton, and Frederic J. Seidler. “Perinatal environmental tobacco smoke exposure in rhesus monkeys: critical periods and regional selectivity for effects on brain cell development and lipid peroxidation.” Environ Health Perspect 114, no. 1 (January 2006): 34–39. https://doi.org/10.1289/ehp.8286.
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    • Slotkin, Theodore A., Charlotte A. Tate, Mandy M. Cousins, and Frederic J. Seidler. “Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination.” Brain Res Dev Brain Res 160, no. 2 (December 7, 2005): 219–30. https://doi.org/10.1016/j.devbrainres.2005.09.006.
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    • Kreider, Marisa L., Justin E. Aldridge, Mandy M. Cousins, Colleen A. Oliver, Frederic J. Seidler, and Theodore A. Slotkin. “Disruption of rat forebrain development by glucocorticoids: critical perinatal periods for effects on neural cell acquisition and on cell signaling cascades mediating noradrenergic and cholinergic neurotransmitter/neurotrophic responses.” Neuropsychopharmacology 30, no. 10 (October 2005): 1841–55. https://doi.org/10.1038/sj.npp.1300743.
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    • Slotkin, Theodore A., Kathleen K. Brown, and Frederic J. Seidler. “Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood.” Environ Health Perspect 113, no. 10 (October 2005): 1291–94. https://doi.org/10.1289/ehp.8133.
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    • Kreider, Marisa L., Edward D. Levin, Frederic J. Seidler, and Theodore A. Slotkin. “Gestational dexamethasone treatment elicits sex-dependent alterations in locomotor activity, reward-based memory and hippocampal cholinergic function in adolescent and adult rats.” Neuropsychopharmacology 30, no. 9 (September 2005): 1617–23. https://doi.org/10.1038/sj.npp.1300716.
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    • Slotkin, Theodore A., and Frederic J. Seidler. “The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent.” Brain Res Dev Brain Res 158, no. 1–2 (August 8, 2005): 115–19. https://doi.org/10.1016/j.devbrainres.2005.06.008.
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    • Aldridge, Justin E., Armando Meyer, Frederic J. Seidler, and Theodore A. Slotkin. “Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure.” Environ Health Perspect 113, no. 8 (August 2005): 1027–31. https://doi.org/10.1289/ehp.7968.
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    • Qiao, Dan, Frederic J. Seidler, and Theodore A. Slotkin. “Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos.” Toxicol Appl Pharmacol 206, no. 1 (August 1, 2005): 17–26. https://doi.org/10.1016/j.taap.2004.11.003.
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    • Slotkin, Theodore A., Colleen A. Oliver, and Frederic J. Seidler. “Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination.” Brain Res Dev Brain Res 157, no. 2 (June 30, 2005): 172–80. https://doi.org/10.1016/j.devbrainres.2005.04.001.
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    • Aldridge, Justin E., Edward D. Levin, Frederic J. Seidler, and Theodore A. Slotkin. “Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression.” Environ Health Perspect 113, no. 5 (May 2005): 527–31. https://doi.org/10.1289/ehp.7867.
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    • Garcia, Stephanie J., Frederic J. Seidler, and Theodore A. Slotkin. “Developmental neurotoxicity of chlorpyrifos: targeting glial cells.” Environ Toxicol Pharmacol 19, no. 3 (May 2005): 455–61. https://doi.org/10.1016/j.etap.2004.12.007.
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    • Roy, Tara Sankar, Vikram Sharma, Frederic J. Seidler, and Theodore A. Slotkin. “Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats.” Brain Res Dev Brain Res 155, no. 1 (March 22, 2005): 71–80. https://doi.org/10.1016/j.devbrainres.2004.12.004.
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    • Aldridge, Justin E., Armando Meyer, Frederic J. Seidler, and Theodore A. Slotkin. “Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions.” Toxicol Appl Pharmacol 203, no. 2 (March 1, 2005): 132–44. https://doi.org/10.1016/j.taap.2004.08.002.
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    • Meyer, Armando, Frederic J. Seidler, Justin E. Aldridge, and Theodore A. Slotkin. “Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos.” Toxicol Appl Pharmacol 203, no. 2 (March 1, 2005): 154–66. https://doi.org/10.1016/j.taap.2004.08.005.
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    • Abreu-Villaça, Yael, Frederic J. Seidler, Dan Qiao, and Theodore A. Slotkin. “Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells.” Brain Res Dev Brain Res 154, no. 2 (February 8, 2005): 239–46. https://doi.org/10.1016/j.devbrainres.2004.10.018.
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    • Beer, Avital, Theodore A. Slotkin, Frederic J. Seidler, Justin E. Aldridge, and Joseph Yanai. “Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital.” Neuropsychopharmacology 30, no. 1 (January 2005): 156–65. https://doi.org/10.1038/sj.npp.1300582.
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    • Slotkin, Theodore A., Frederic J. Seidler, Dan Qiao, Justin E. Aldridge, Charlotte A. Tate, Mandy M. Cousins, Becky J. Proskocil, et al. “Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys.” Neuropsychopharmacology 30, no. 1 (January 2005): 129–44. https://doi.org/10.1038/sj.npp.1300544.
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    • Slotkin, Theodore A., Mandy M. Cousins, Charlotte A. Tate, and Frederic J. Seidler. “Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats.” Neuropsychopharmacology 30, no. 1 (January 2005): 52–57. https://doi.org/10.1038/sj.npp.1300569.
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    • Slotkin, Theodore A., Mandy M. Cousins, and Frederic J. Seidler. “Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors.” Brain Res 1030, no. 1 (December 24, 2004): 159–63. https://doi.org/10.1016/j.brainres.2004.10.009.
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    • Slotkin, Theodore A., Matthew C. Southard, Stacey J. Adam, Mandy M. Cousins, and Frederic J. Seidler. “Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos.” Brain Res Bull 64, no. 3 (September 30, 2004): 227–35. https://doi.org/10.1016/j.brainresbull.2004.07.005.
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    • Kreider, Marisa L., Frederic J. Seidler, Mandy M. Cousins, Charlotte A. Tate, and Theodore A. Slotkin. “Transiently overexpressed alpha2-adrenoceptors and their control of DNA synthesis in the developing brain.” Brain Res Dev Brain Res 152, no. 2 (September 17, 2004): 233–39. https://doi.org/10.1016/j.devbrainres.2004.07.001.
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    • Abreu-Villaça, Yael, Frederic J. Seidler, and Theodore A. Slotkin. “Does prenatal nicotine exposure sensitize the brain to nicotine-induced neurotoxicity in adolescence?” Neuropsychopharmacology 29, no. 8 (August 2004): 1440–50. https://doi.org/10.1038/sj.npp.1300443.
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    • Abreu-Villaça, Yael, Frederic J. Seidler, Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. “Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal.” Neuropsychopharmacology 29, no. 5 (May 2004): 879–90. https://doi.org/10.1038/sj.npp.1300401.
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    • Meyer, Armando, Frederic J. Seidler, Justin E. Aldridge, Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. “Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure.” Environ Health Perspect 112, no. 3 (March 2004): 295–301. https://doi.org/10.1289/ehp.6755.
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    • Rhodes, Melissa C., Frederic J. Seidler, Dan Qiao, Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. “Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats.” Toxicol Appl Pharmacol 195, no. 2 (March 1, 2004): 203–17. https://doi.org/10.1016/j.taap.2003.11.008.
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    • Roy, Tara Sankar, Frederic J. Seidler, and Theodore A. Slotkin. “Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia.” Brain Res Dev Brain Res 148, no. 2 (February 20, 2004): 197–206. https://doi.org/10.1016/j.devbrainres.2003.12.004.
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    • Aldridge, Justin E., Frederic J. Seidler, and Theodore A. Slotkin. “Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling.” Environ Health Perspect 112, no. 2 (February 2004): 148–55. https://doi.org/10.1289/ehp.6713.
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    • Meyer, Armando, Frederic J. Seidler, and Theodore A. Slotkin. “Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling.” Environ Health Perspect 112, no. 2 (February 2004): 170–78. https://doi.org/10.1289/ehp.6690.
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    • Rhodes, Melissa C., Frederic J. Seidler, Ali Abdel-Rahman, Charlotte A. Tate, Abraham Nyska, Heather L. Rincavage, and Theodore A. Slotkin. “Terbutaline is a developmental neurotoxicant: effects on neuroproteins and morphology in cerebellum, hippocampus, and somatosensory cortex.” J Pharmacol Exp Ther 308, no. 2 (February 2004): 529–37. https://doi.org/10.1124/jpet.103.060095.
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    • Qiao, Dan, Frederic J. Seidler, Yael Abreu-Villaça, Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. “Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood.” Brain Res Dev Brain Res 148, no. 1 (January 31, 2004): 43–52. https://doi.org/10.1016/j.devbrainres.2003.10.004.
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    • Kreider, Marisa L., Frederic J. Seidler, and Theodore A. Slotkin. “Beta-adrenoceptor modulation of transiently overexpressed alpha 2-adrenoceptors in brain and peripheral tissues: cellular mechanisms underlying the developmental toxicity of terbutaline.” Brain Res Bull 62, no. 4 (January 15, 2004): 305–14. https://doi.org/10.1016/j.brainresbull.2003.09.017.
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    • Icenogle, Laura M., N Channelle Christopher, W Paul Blackwelder, D Patrick Caldwell, Dan Qiao, Frederic J. Seidler, Theodore A. Slotkin, and Edward D. Levin. “Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation.” Neurotoxicol Teratol 26, no. 1 (2004): 95–101. https://doi.org/10.1016/j.ntt.2003.09.001.
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    • Qiao, Dan, Frederic J. Seidler, Jonathan D. Violin, and Theodore A. Slotkin. “Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.” Brain Res Dev Brain Res 147, no. 1–2 (December 30, 2003): 183–90. https://doi.org/10.1016/s0165-3806(03)00222-0.
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    • Meyer, Armando, Frederic J. Seidler, Mandy M. Cousins, and Theodore A. Slotkin. “Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target?” Environ Health Perspect 111, no. 16 (December 2003): 1871–76. https://doi.org/10.1289/ehp.6468.
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    • Navarro, Hernán A., Patricia V. Basta, Frederic J. Seidler, and Theodore A. Slotkin. “Short-term adolescent nicotine exposure in rats elicits immediate and delayed deficits in T-lymphocyte function: critical periods, patterns of exposure, dose thresholds.” Nicotine Tob Res 5, no. 6 (December 2003): 859–68. https://doi.org/10.1080/14622200310001614610.
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    • Xu, Zengjun, Frederic J. Seidler, Charlotte A. Tate, Stephanie J. Garcia, William Slikker, and Theodore A. Slotkin. “Sex-selective hippocampal alterations after adolescent nicotine administration: effects on neurospecific proteins.” Nicotine Tob Res 5, no. 6 (December 2003): 955–60. https://doi.org/10.1080/14622200310001615321.
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    • Rhodes, Melissa C., Abraham Nyska, Frederic J. Seidler, and Theodore A. Slotkin. “Does terbutaline damage the developing heart?” Birth Defects Res B Dev Reprod Toxicol 68, no. 6 (December 2003): 449–55. https://doi.org/10.1002/bdrb.10043.
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    • Aldridge, Justin E., Frederic J. Seidler, Armando Meyer, Indira Thillai, and Theodore A. Slotkin. “Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods.” Environ Health Perspect 111, no. 14 (November 2003): 1736–43. https://doi.org/10.1289/ehp.6489.
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    • Qiao, Dan, Lyudmila A. Nikitina, Gennady A. Buznikov, Jean M. Lauder, Frederic J. Seidler, and Theodore A. Slotkin. “The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity.” Environ Health Perspect 111, no. 14 (November 2003): 1730–35. https://doi.org/10.1289/ehp.6429.
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    • Abreu-Villaça, Yael, Frederic J. Seidler, Dan Qiao, Charlotte A. Tate, Mandy M. Cousins, Indira Thillai, and Theodore A. Slotkin. “Short-term adolescent nicotine exposure has immediate and persistent effects on cholinergic systems: critical periods, patterns of exposure, dose thresholds.” Neuropsychopharmacology 28, no. 11 (November 2003): 1935–49. https://doi.org/10.1038/sj.npp.1300221.
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    • Abreu-Villaça, Yael, Frederic J. Seidler, and Theodore A. Slotkin. “Impact of adolescent nicotine exposure on adenylyl cyclase-mediated cell signaling: enzyme induction, neurotransmitter-specific effects, regional selectivities, and the role of withdrawal.” Brain Res 988, no. 1–2 (October 24, 2003): 164–72. https://doi.org/10.1016/s0006-8993(03)03368-7.
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    • Slotkin, Theodore A., Frederic J. Seidler, and Joseph Yanai. “Heroin neuroteratogenicity: delayed-onset deficits in catecholaminergic synaptic activity.” Brain Res 984, no. 1–2 (September 12, 2003): 189–97. https://doi.org/10.1016/s0006-8993(03)03152-4.
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    • Slotkin, Theodore A., Brian D. Freibaum, Charlotte A. Tate, Indira Thillai, Sherry A. Ferguson, Amy M. Cada, and Frederic J. Seidler. “Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood.” Brain Res 981, no. 1–2 (August 15, 2003): 118–25. https://doi.org/10.1016/s0006-8993(03)02993-7.
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    • Abreu-Villaça, Yael, Frederic J. Seidler, Charlotte A. Tate, and Theodore A. Slotkin. “Nicotine is a neurotoxin in the adolescent brain: critical periods, patterns of exposure, regional selectivity, and dose thresholds for macromolecular alterations.” Brain Res 979, no. 1–2 (July 25, 2003): 114–28. https://doi.org/10.1016/s0006-8993(03)02885-3.
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    • Slotkin, Theodore A., J Todd Auman, and Frederic J. Seidler. “Ontogenesis of beta-adrenoceptor signaling: implications for perinatal physiology and for fetal effects of tocolytic drugs.” J Pharmacol Exp Ther 306, no. 1 (July 2003): 1–7. https://doi.org/10.1124/jpet.102.048421.
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    • Qiao, Dan, Frederic J. Seidler, Charlotte A. Tate, Mandy M. Cousins, and Theodore A. Slotkin. “Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood.” Environ Health Perspect 111, no. 4 (April 2003): 536–44. https://doi.org/10.1289/ehp.5828.
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    • Garcia, Stephanie J., Frederic J. Seidler, and Theodore A. Slotkin. “Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities.” Environ Health Perspect 111, no. 3 (March 2003): 297–303. https://doi.org/10.1289/ehp.5791.
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    • Dam, Kristina, Frederic J. Seidler, and Theodore A. Slotkin. “Transcriptional biomarkers distinguish between vulnerable periods for developmental neurotoxicity of chlorpyrifos: Implications for toxicogenomics.” Brain Res Bull 59, no. 4 (January 15, 2003): 261–65. https://doi.org/10.1016/s0361-9230(02)00874-2.
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    • Garofolo, Melissa C., Frederic J. Seidler, Mandy M. Cousins, Charlotte A. Tate, Dan Qiao, and Theodore A. Slotkin. “Developmental toxicity of terbutaline: critical periods for sex-selective effects on macromolecules and DNA synthesis in rat brain, heart, and liver.” Brain Res Bull 59, no. 4 (January 15, 2003): 319–29. https://doi.org/10.1016/s0361-9230(02)00925-5.
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    • Auman, J. T., F. J. Seidler, and T. A. Slotkin. “Beta-adrenoceptor control of G protein function in the neonate: determinant of desensitization or sensitization.” Am J Physiol Regul Integr Comp Physiol 283, no. 5 (November 2002): R1236–44. https://doi.org/10.1152/ajpregu.00409.2002.
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    • Qiao, Dan, Frederic J. Seidler, Stephanie Padilla, and Theodore A. Slotkin. “Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?” Environ Health Perspect 110, no. 11 (November 2002): 1097–1103. https://doi.org/10.1289/ehp.021101097.
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    • Xu, Z., F. J. Seidler, M. M. Cousins, W. Slikker, and T. A. Slotkin. “Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase.” Brain Res 951, no. 2 (October 4, 2002): 280–92. https://doi.org/10.1016/s0006-8993(02)03174-8.
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    • Auman, J. T., F. J. Seidler, C. A. Tate, and T. A. Slotkin. “Are developing β-adrenoceptors able to desensitize? Acute and chronic effects of β-agonists in neonatal heart and liver.” American Journal of Physiology  Regulatory Integrative and Comparative Physiology 283, no. 1 52-1 (August 20, 2002).
    • Auman, J. T., F. J. Seidler, C. A. Tate, and T. A. Slotkin. “Are developing beta-adrenoceptors able to desensitize? Acute and chronic effects of beta-agonists in neonatal heart and liver.” Am J Physiol Regul Integr Comp Physiol 283, no. 1 (July 2002): R205–17. https://doi.org/10.1152/ajpregu.00122.2002.
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    • Garofolo, M. C., F. J. Seidler, J. T. Auman, and T. A. Slotkin. “beta-Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart.” Am J Physiol Regul Integr Comp Physiol 282, no. 5 (May 2002): R1356–63. https://doi.org/10.1152/ajpregu.00598.2001.
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    • Garofolo, M. C., F. J. Seidler, and T. A. Slotkin. “Terbutaline tocolysis: a source of developmental brain damage?” Faseb Journal 16, no. 5 (March 22, 2002): A949–A949.
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    • Qiao, D., F. J. Seidler, E. D. Levin, S. Padilla, and T. A. Slotkin. “Developmental neurotoxicity of chlorpyrifos: Defining the vulnerable period.” Faseb Journal 16, no. 5 (March 22, 2002): A949–A949.
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    • Auman, J. T., F. J. Seidler, and T. A. Slotkin. “Heterologous sensitization and desensitization of beta-adrenoceptor/adenylyl cyclase signaling in neonatal rat heart.” Faseb Journal 16, no. 4 (March 20, 2002): A576–77.
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    • Garcia, Stephanie J., Frederic J. Seidler, Dan Qiao, and Theodore A. Slotkin. “Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein.” Brain Res Dev Brain Res 133, no. 2 (February 28, 2002): 151–61. https://doi.org/10.1016/s0165-3806(02)00283-3.
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    • Slotkin, T. A., K. E. Pinkerton, J. T. Auman, D. Qiao, and F. J. Seidler. “Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain.” Brain Res Dev Brain Res 133, no. 2 (February 28, 2002): 175–79. https://doi.org/10.1016/s0165-3806(02)00281-x.
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    • Roy, Tara Sankar, Frederic J. Seidler, and Theodore A. Slotkin. “Prenatal nicotine exposure evokes alterations of cell structure in hippocampus and somatosensory cortex.” J Pharmacol Exp Ther 300, no. 1 (January 2002): 124–33. https://doi.org/10.1124/jpet.300.1.124.
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    • Levin, Edward D., Nii Addy, Avanti Baruah, Alana Elias, N Channelle Christopher, Frederic J. Seidler, and Theodore A. Slotkin. “Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations.” Neurotoxicol Teratol 24, no. 6 (2002): 733–41. https://doi.org/10.1016/s0892-0362(02)00272-6.
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    • Slotkin, T. A., F. J. Seidler, and J. Yanai. “Heroin neuroteratogenicity: targeting adenylyl cyclase as an underlying biochemical mechanism.” Brain Res Dev Brain Res 132, no. 1 (December 14, 2001): 69–79. https://doi.org/10.1016/s0165-3806(01)00296-6.
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    • Auman, J. T., F. J. Seidler, C. A. Tate, and T. A. Slotkin. “Beta-adrenoceptor-mediated cell signaling in the neonatal heart and liver: responses to terbutaline.” Am J Physiol Regul Integr Comp Physiol 281, no. 6 (December 2001): R1895–1901. https://doi.org/10.1152/ajpregu.2001.281.6.R1895.
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    • Slotkin, T. A., C. A. Tate, M. M. Cousins, and F. J. Seidler. “Beta-adrenoceptor signaling in the developing brain: sensitization or desensitization in response to terbutaline.” Brain Res Dev Brain Res 131, no. 1–2 (November 26, 2001): 113–25. https://doi.org/10.1016/s0165-3806(01)00282-6.
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    • Navarro, H. A., P. V. Basta, F. J. Seidler, and T. A. Slotkin. “Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect?” Brain Res Dev Brain Res 130, no. 2 (October 24, 2001): 249–52. https://doi.org/10.1016/s0165-3806(01)00254-1.
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    • Navarro, H. A., P. V. Basta, F. J. Seidler, and T. A. Slotkin. “Adolescent nicotine: deficits in immune function.” Brain Res Dev Brain Res 130, no. 2 (October 24, 2001): 253–56. https://doi.org/10.1016/s0165-3806(01)00256-5.
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    • Auman, J. T., F. J. Seidler, and T. A. Slotkin. “Regulation of fetal cardiac and hepatic beta-adrenoceptors and adenylyl cyclase signaling: terbutaline effects.” Am J Physiol Regul Integr Comp Physiol 281, no. 4 (October 2001): R1079–89. https://doi.org/10.1152/ajpregu.2001.281.4.R1079.
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    • Xu, Z., F. J. Seidler, S. F. Ali, W. Slikker, and T. A. Slotkin. “Fetal and adolescent nicotine administration: effects on CNS serotonergic systems.” Brain Res 914, no. 1–2 (September 28, 2001): 166–78. https://doi.org/10.1016/s0006-8993(01)02797-4.
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    • Levin, E. D., N. Addy, A. Nakajima, N. C. Christopher, F. J. Seidler, and T. A. Slotkin. “Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats.” Brain Res Dev Brain Res 130, no. 1 (September 23, 2001): 83–89. https://doi.org/10.1016/s0165-3806(01)00215-2.
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    • Raines, K. W., F. J. Seidler, and T. A. Slotkin. “Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos.” Brain Res Dev Brain Res 130, no. 1 (September 23, 2001): 65–72. https://doi.org/10.1016/s0165-3806(01)00211-5.
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    • Qiao, D., F. J. Seidler, and T. A. Slotkin. “Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells.” Environ Health Perspect 109, no. 9 (September 2001): 909–13. https://doi.org/10.1289/ehp.01109909.
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    • Slotkin, T. A., M. M. Cousins, C. A. Tate, and F. J. Seidler. “Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure.” Brain Res 902, no. 2 (June 1, 2001): 229–43. https://doi.org/10.1016/s0006-8993(01)02387-3.
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    • Slotkin, T. A., K. E. Pinkerton, M. C. Garofolo, J. T. Auman, E. C. McCook, and F. J. Seidler. “Perinatal exposure to environmental tobacco smoke induces adenylyl cyclase and alters receptor-mediated cell signaling in brain and heart of neonatal rats.” Brain Res 898, no. 1 (April 13, 2001): 73–81. https://doi.org/10.1016/s0006-8993(01)02145-x.
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    • Auman, J. T., F. J. Seidler, and T. A. Slotkin. “Are fetal or neonatal beta-adrenergic receptors capable of downregulation or desensitization?” Faseb Journal 15, no. 4 (March 7, 2001): A217–A217.
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    • Garofolo, M. C., F. J. Seidler, and T. A. Slotkin. “Signalling crosstalk during development: Does early stimulation of beta-adrenergic receptors control the expression of muscarinic cholinergic receptors?” Faseb Journal 15, no. 4 (March 7, 2001): A219–A219.
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    • Crumpton, T. L., F. J. Seidler, and T. A. Slotkin. “Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells.” Breast Cancer Res Treat 66, no. 2 (March 2001): 143–46. https://doi.org/10.1023/a:1010603816003.
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    • Trauth, J. A., F. J. Seidler, S. F. Ali, and T. A. Slotkin. “Adolescent nicotine exposure produces immediate and long-term changes in CNS noradrenergic and dopaminergic function.” Brain Res 892, no. 2 (February 23, 2001): 269–80. https://doi.org/10.1016/s0006-8993(00)03227-3.
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    • Garcia, S. J., F. J. Seidler, T. L. Crumpton, and T. A. Slotkin. “Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells.” Brain Res 891, no. 1–2 (February 9, 2001): 54–68. https://doi.org/10.1016/s0006-8993(00)03189-9.
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    • Slotkin, T. A., S. A. Ferguson, A. M. Cada, E. C. McCook, and F. J. Seidler. “Neonatal polyamine depletion by alpha-difluoromethylornithine: effects on adenylyl cyclase cell signaling are separable from effects on brain region growth.” Brain Res 887, no. 1 (December 22, 2000): 16–22. https://doi.org/10.1016/s0006-8993(00)02961-9.
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    • Slotkin, T. A., and F. J. Seidler. “Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells.” Breast Cancer Res Treat 64, no. 3 (December 2000): 259–67. https://doi.org/10.1023/a:1026508605951.
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    • Slotkin, T. A., K. E. Pinkerton, and F. J. Seidler. “Perinatal exposure to environmental tobacco smoke alters cell signaling in a primate model: autonomic receptors and the control of adenylyl cyclase activity in heart and lung.” Brain Res Dev Brain Res 124, no. 1–2 (November 30, 2000): 53–58. https://doi.org/10.1016/s0165-3806(00)00105-x.
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    • Slotkin, T. A., F. J. Seidler, and J. C. Ritchie. “Regional differences in brain monoamine oxidase subtypes in an animal model of geriatric depression: effects of olfactory bulbectomy in young versus aged rats.” Brain Res 882, no. 1–2 (November 3, 2000): 149–54. https://doi.org/10.1016/s0006-8993(00)02859-6.
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    • Trauth, J. A., F. J. Seidler, and T. A. Slotkin. “Persistent and delayed behavioral changes after nicotine treatment in adolescent rats.” Brain Res 880, no. 1–2 (October 13, 2000): 167–72. https://doi.org/10.1016/s0006-8993(00)02823-7.
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    • Slotkin, T. A., F. J. Seidler, and S. F. Ali. “Cellular determinants of reduced adaptability of the aging brain: neurotransmitter utilization and cell signaling responses after MDMA lesions.” Brain Res 879, no. 1–2 (October 6, 2000): 163–73. https://doi.org/10.1016/s0006-8993(00)02767-0.
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    • Chow, F. A., F. J. Seidler, E. C. McCook, and T. A. Slotkin. “Adolescent nicotine exposure alters cardiac autonomic responsiveness: beta-adrenergic and m2-muscarinic receptors and their linkage to adenylyl cyclase.” Brain Res 878, no. 1–2 (September 29, 2000): 119–26. https://doi.org/10.1016/s0006-8993(00)02697-4.
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    • Trauth, J. A., E. C. McCook, F. J. Seidler, and T. A. Slotkin. “Modeling adolescent nicotine exposure: effects on cholinergic systems in rat brain regions.” Brain Res 873, no. 1 (August 4, 2000): 18–25. https://doi.org/10.1016/s0006-8993(00)02465-3.
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    • Crumpton, T. L., F. J. Seidler, and T. A. Slotkin. “Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?” Brain Res Dev Brain Res 121, no. 2 (June 30, 2000): 189–95. https://doi.org/10.1016/s0165-3806(00)00045-6.
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    • Dam, K., F. J. Seidler, and T. A. Slotkin. “Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity.” Brain Res Dev Brain Res 121, no. 2 (June 30, 2000): 179–87. https://doi.org/10.1016/s0165-3806(00)00044-4.
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    • Trauth, J. A., F. J. Seidler, and T. A. Slotkin. “An animal model of adolescent nicotine exposure: effects on gene expression and macromolecular constituents in rat brain regions.” Brain Res 867, no. 1–2 (June 9, 2000): 29–39. https://doi.org/10.1016/s0006-8993(00)02208-3.
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    • Auman, J. T., F. J. Seidler, and T. A. Slotkin. “Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity.” Brain Res Dev Brain Res 121, no. 1 (May 11, 2000): 19–27. https://doi.org/10.1016/s0165-3806(00)00021-3.
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    • Zeiders, J. L., F. J. Seidler, and T. A. Slotkin. “Ontogeny of G-protein expression: control by beta-adrenoceptors.” Brain Res Dev Brain Res 120, no. 2 (April 14, 2000): 125–34. https://doi.org/10.1016/s0165-3806(99)00188-1.
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    • Slotkin, T. A., J. Zhang, R. Dancel, S. J. Garcia, C. Willis, and F. J. Seidler. “Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells.” Breast Cancer Res Treat 60, no. 2 (March 2000): 153–66. https://doi.org/10.1023/a:1006338232150.
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    • Crumpton, T. L., F. J. Seidler, and T. A. Slotkin. “Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation.” Brain Res 857, no. 1–2 (February 28, 2000): 87–98. https://doi.org/10.1016/s0006-8993(99)02357-4.
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    • Trauth, J. A., F. J. Seidler, E. C. McCook, and T. A. Slotkin. “Adolescent nicotine exposure causes persistent upregulation of nicotinic cholinergic receptors in rat brain regions.” Brain Res 851, no. 1–2 (December 18, 1999): 9–19. https://doi.org/10.1016/s0006-8993(99)01994-0.
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    • Dam, K., F. J. Seidler, and T. A. Slotkin. “Chlorpyrifos releases norepinephrine from adult and neonatal rat brain synaptosomes.” Brain Res Dev Brain Res 118, no. 1–2 (December 10, 1999): 129–33. https://doi.org/10.1016/s0165-3806(99)00139-x.
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    • Zeiders, J. L., F. J. Seidler, and T. A. Slotkin. “Agonist-induced sensitization of beta-adrenoceptor signaling in neonatal rat heart: expression and catalytic activity of adenylyl cyclase.” J Pharmacol Exp Ther 291, no. 2 (November 1999): 503–10.
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    • Dam, K., S. J. Garcia, F. J. Seidler, and T. A. Slotkin. “Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways.” Brain Res Dev Brain Res 116, no. 1 (August 5, 1999): 9–20. https://doi.org/10.1016/s0165-3806(99)00067-x.
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    • Slotkin, T. A., D. B. Miller, F. Fumagalli, E. C. McCook, J. Zhang, G. Bissette, and F. J. Seidler. “Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats.” J Pharmacol Exp Ther 289, no. 1 (April 1999): 334–45.
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    • Slotkin, T. A., T. A. Epps, M. L. Stenger, K. J. Sawyer, and F. J. Seidler. “Cholinergic receptors in heart and brainstem of rats exposed to nicotine during development: implications for hypoxia tolerance and perinatal mortality.” Brain Res Dev Brain Res 113, no. 1–2 (March 12, 1999): 1–12. https://doi.org/10.1016/s0165-3806(98)00173-4.
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    • Trauth, J. A., F. J. Seidler, and T. A. Slotkin. “Prenatal nicotine exposure induces genes associated with apoptosis in the developing brain.” Faseb Journal 13, no. 4 (March 12, 1999): A137–A137.
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    • Zeiders, J. L., F. J. Seidler, and T. A. Slotkin. “Cellular mechanisms underlying agonist-induced heterologous sensitization of beta-adrenergic receptor signaling in neonatal rat heart.” Faseb Journal 13, no. 4 (March 12, 1999): A142–A142.
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    • Zeiders, J. L., F. J. Seidler, G. Iaccarino, W. J. Koch, and T. A. Slotkin. “Ontogeny of cardiac beta-adrenoceptor desensitization mechanisms: agonist treatment enhances receptor/G-protein transduction rather than eliciting uncoupling.” J Mol Cell Cardiol 31, no. 2 (February 1999): 413–23. https://doi.org/10.1006/jmcc.1998.0875.
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    • Trauth, J. A., F. J. Seidler, E. C. McCook, and T. A. Slotkin. “Persistent c-fos induction by nicotine in developing rat brain regions: interaction with hypoxia.” Pediatr Res 45, no. 1 (January 1999): 38–45. https://doi.org/10.1203/00006450-199901000-00007.
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    • Roy, T. S., J. E. Andrews, F. J. Seidler, and T. A. Slotkin. “Nicotine evokes cell death in embryonic rat brain during neurulation.” J Pharmacol Exp Ther 287, no. 3 (December 1998): 1136–44.
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    • Slotkin, T. A., F. J. Seidler, and J. C. Ritchie. “Effects of aging and glucocorticoid treatment on monoamine oxidase subtypes in rat cerebral cortex: therapeutic implications.” Brain Res Bull 47, no. 4 (November 1, 1998): 345–48. https://doi.org/10.1016/s0361-9230(98)00111-7.
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    • Slotkin, T. A., J. Zhang, E. C. McCook, and F. J. Seidler. “Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids.” Brain Res Dev Brain Res 111, no. 1 (November 1, 1998): 11–24. https://doi.org/10.1016/s0165-3806(98)00115-1.
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    • Slotkin, T. A., J. Zhang, E. C. McCook, and F. J. Seidler. “Glucocorticoid-targeting of the adenylyl cyclase signaling pathway in the cerebellum of young vs. aged rats.” Brain Res 800, no. 2 (August 3, 1998): 236–44. https://doi.org/10.1016/s0006-8993(98)00518-6.
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    • Roy, T. S., J. E. Andrews, F. J. Seidler, and T. A. Slotkin. “Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos.” Teratology 58, no. 2 (August 1998): 62–68. https://doi.org/10.1002/(SICI)1096-9926(199808)58:2<62::AID-TERA7>3.0.CO;2-2.
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    • Song, X., J. D. Violin, F. J. Seidler, and T. A. Slotkin. “Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells.” Toxicol Appl Pharmacol 151, no. 1 (July 1998): 182–91. https://doi.org/10.1006/taap.1998.8424.
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    • Dam, K., F. J. Seidler, and T. A. Slotkin. “Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration.” Brain Res Dev Brain Res 108, no. 1–2 (June 15, 1998): 39–45. https://doi.org/10.1016/s0165-3806(98)00028-5.
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    • Lee, T. H., K. R. Gee, E. H. Ellinwood, and F. J. Seidler. “Altered cocaine potency in the nucleus accumbens following 7-day withdrawal from intermittent but not continuous treatment: voltammetric assessment of dopamine uptake in the rat.” Psychopharmacology (Berl) 137, no. 3 (June 1998): 303–10. https://doi.org/10.1007/s002130050623.
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    • Johnson, D. E., F. J. Seidler, and T. A. Slotkin. “Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos.” Brain Res Bull 45, no. 2 (1998): 143–47. https://doi.org/10.1016/s0361-9230(97)00329-8.
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    • Zeiders, J. L., F. J. Seidler, and T. A. Slotkin. “Unique mechanisms of β-adrenoceptor sensitization and desensitization during development.” Faseb Journal 12, no. 4 (1998): A444.
    • McGrath, K. E., F. J. Seidler, and T. A. Slotkin. “Convergent control of serotonin transporter expression by glucocorticoids and cocaine in fetal and neonatal rat brain.” Brain Res Dev Brain Res 104, no. 1–2 (December 19, 1997): 209–13. https://doi.org/10.1016/s0165-3806(97)00144-2.
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    • Song, X., F. J. Seidler, J. L. Saleh, J. Zhang, S. Padilla, and T. A. Slotkin. “Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade.” Toxicol Appl Pharmacol 145, no. 1 (July 1997): 158–74. https://doi.org/10.1006/taap.1997.8171.
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    • Tan, J. P., F. J. Seidler, D. A. Schwinn, S. O. Page, and T. A. Slotkin. “A critical period for the role of thyroid hormone in development of renal alpha-adrenergic receptors.” Pediatr Res 42, no. 1 (July 1997): 93–102. https://doi.org/10.1203/00006450-199707000-00015.
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    • Slotkin, T. A., X. F. Wang, H. S. Symonds, and F. J. Seidler. “Expression of mRNAs coding for the transforming growth factor-beta receptors in brain regions of euthyroid and hypothyroid neonatal rats and in adult brain.” Brain Res Dev Brain Res 99, no. 1 (March 17, 1997): 61–65. https://doi.org/10.1016/s0165-3806(96)00199-x.
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    • Slotkin, T. A., E. C. McCook, and F. J. Seidler. “Cryptic brain cell injury caused by fetal nicotine exposure is associated with persistent elevations of c-fos protooncogene expression.” Brain Res 750, no. 1–2 (March 7, 1997): 180–88. https://doi.org/10.1016/s0006-8993(96)01345-5.
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    • Renick, S. E., F. J. Seidler, E. C. McCook, and T. A. Slotkin. “Neuronal control of cardiac and hepatic macromolecule synthesis in the neonatal rat: effects of sympathectomy.” Pediatr Res 41, no. 3 (March 1997): 359–63. https://doi.org/10.1203/00006450-199703000-00009.
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    • Slotkin, T. A., J. L. Saleh, E. C. McCook, and F. J. Seidler. “Impaired cardiac function during postnatal hypoxia in rats exposed to nicotine prenatally: implications for perinatal morbidity and mortality, and for sudden infant death syndrome.” Teratology 55, no. 3 (March 1997): 177–84. https://doi.org/10.1002/(SICI)1096-9926(199703)55:3<177::AID-TERA2>3.0.CO;2-#.
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    • Zeiders, J. L., F. J. Seidler, and T. A. Slotkin. “Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit.” J Mol Cell Cardiol 29, no. 2 (February 1997): 603–15. https://doi.org/10.1006/jmcc.1996.0303.
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    • Slotkin, T. A., E. C. McCook, J. C. Ritchie, B. J. Carroll, and F. J. Seidler. “Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects.” Biol Psychiatry 41, no. 2 (January 15, 1997): 172–83. https://doi.org/10.1016/S0006-3223(96)00215-6.
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    • Campbell, C. G., F. J. Seidler, and T. A. Slotkin. “Chlorpyrifos interferes with cell development in rat brain regions.” Brain Res Bull 43, no. 2 (1997): 179–89. https://doi.org/10.1016/s0361-9230(96)00436-4.
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    • Slotkin, T. A., J. L. Saleh, J. Zhang, and F. J. Seidler. “Ontogeny of beta-adrenoceptor/adenylyl cyclase desensitization mechanisms: the role of neonatal innervation.” Brain Res 742, no. 1–2 (December 2, 1996): 317–28. https://doi.org/10.1016/s0006-8993(96)00978-x.
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    • Slotkin, T. A., L. Thai, E. C. McCook, J. L. Saleh, J. Zhang, and F. J. Seidler. “Aging and glucocorticoids: effects on cell signaling mediated through adenylyl cyclase.” J Pharmacol Exp Ther 279, no. 2 (November 1996): 478–91.
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    • Slotkin, T. A., E. C. McCook, J. C. Ritchie, and F. J. Seidler. “Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model.” Biol Psychiatry 40, no. 7 (October 1, 1996): 576–84. https://doi.org/10.1016/0006-3223(95)00469-6.
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    • Lee, T. H., K. R. Gee, E. H. Ellinwood, and F. J. Seidler. “Combining 'caged-dopamine' photolysis with fast-scan cyclic voltammetry to assess dopamine clearance and release autoinhibition in vitro.” J Neurosci Methods 67, no. 2 (August 1996): 221–31.
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    • Slotkin, T. A., G. A. Barnes, E. C. McCook, and F. J. Seidler. “Programming of brainstem serotonin transporter development by prenatal glucocorticoids.” Brain Res Dev Brain Res 93, no. 1–2 (May 31, 1996): 155–61. https://doi.org/10.1016/0165-3806(96)00027-2.
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    • Fumagalli, F., S. R. Jones, M. G. Caron, F. J. Seidler, and T. A. Slotkin. “Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids.” Brain Res 719, no. 1–2 (May 6, 1996): 225–28. https://doi.org/10.1016/0006-8993(96)00119-9.
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    • Metz, L. D., F. J. Seidler, E. C. McCook, and T. A. Slotkin. “Cardiac alpha-adrenergic receptor expression is regulated by thyroid hormone during a critical developmental period.” J Mol Cell Cardiol 28, no. 5 (May 1996): 1033–44. https://doi.org/10.1006/jmcc.1996.0096.
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    • Thai, L., J. M. Galluzzo, E. C. McCook, F. J. Seidler, and T. A. Slotkin. “Atypical regulation of hepatic adenylyl cyclase and adrenergic receptors during a critical developmental period: agonists evoke supersensitivity accompanied by failure of receptor down-regulation.” Pediatr Res 39, no. 4 Pt 1 (April 1996): 697–707. https://doi.org/10.1203/00006450-199604000-00023.
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    • Bissette, G., F. J. Seidler, C. B. Nemeroff, and T. A. Slotkin. “High affinity choline transporter status in Alzheimer's disease tissue from rapid autopsy.” Ann N Y Acad Sci 777 (January 17, 1996): 197–204. https://doi.org/10.1111/j.1749-6632.1996.tb34419.x.
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    • Slotkin, T. A., C. Lau, S. E. Lappi, and F. J. Seidler. “Can intracellular signalling pathways predict developmental abnormalities?” Biomarkers 1, no. 2 (1996): 115–22. https://doi.org/10.3109/13547509609088679.
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    • Tolson, C. M., F. J. Seidler, E. C. McCook, and T. A. Slotkin. “Does concurrent or prior nicotine exposure interact with neonatal hypoxia to produce cardiac cell damage?” Teratology 52, no. 5 (November 1995): 298–305. https://doi.org/10.1002/tera.1420520508.
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    • Giannuzzi, C. E., F. J. Seidler, and T. A. Slotkin. “Beta-adrenoceptor control of cardiac adenylyl cyclase during development: agonist pretreatment in the neonate uniquely causes heterologous sensitization, not desensitization.” Brain Res 694, no. 1–2 (October 2, 1995): 271–78. https://doi.org/10.1016/0006-8993(95)00781-k.
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    • Whitney, K. D., F. J. Seidler, and T. A. Slotkin. “Developmental neurotoxicity of chlorpyrifos: cellular mechanisms.” Toxicol Appl Pharmacol 134, no. 1 (September 1995): 53–62. https://doi.org/10.1006/taap.1995.1168.
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    • Slotkin, T. A., B. A. Lorber, E. C. McCook, G. A. Barnes, and F. J. Seidler. “Neural input and the development of adrenergic intracellular signaling: neonatal denervation evokes neither receptor upregulation nor persistent supersensitivity of adenylate cyclase.” Brain Res Dev Brain Res 88, no. 1 (August 28, 1995): 17–29. https://doi.org/10.1016/0165-3806(95)00067-n.
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    • Slotkin, T. A., S. E. Lappi, and F. J. Seidler. “Beta-adrenergic control of c-fos expression in fetal and neonatal rat tissues: relationship to cell differentiation and teratogenesis.” Toxicol Appl Pharmacol 133, no. 2 (August 1995): 188–95. https://doi.org/10.1006/taap.1995.1141.
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    • Wagner, J. P., F. J. Seidler, S. E. Lappi, E. C. McCook, and T. A. Slotkin. “Role of presynaptic input in the ontogeny of adrenergic cell signaling in rat brain: beta receptors, adenylate cyclase and c-fos protooncogene expression.” J Pharmacol Exp Ther 273, no. 1 (April 1995): 415–26.
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    • Seidler, F. J., S. W. Temple, E. C. McCook, and T. A. Slotkin. “Cocaine inhibits central noradrenergic and dopaminergic activity during the critical developmental period in which catecholamines influence cell development.” Brain Res Dev Brain Res 85, no. 1 (March 16, 1995): 48–53. https://doi.org/10.1016/0165-3806(94)00186-4.
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    • Rao, G. S., F. J. Seidler, and T. A. Slotkin. “Modulation of hepatic adrenergic receptor ontogeny by thyroid hormone.” Res Commun Mol Pathol Pharmacol 87, no. 1 (January 1995): 27–42.
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    • Schachat, F., F. J. Seidler, and T. A. Slotkin. “The developmental switch in ventricular myosin expression in vivo is not triggered by an increase in cyclic AMP.” Reprod Fertil Dev 7, no. 5 (1995): 1361–67. https://doi.org/10.1071/rd9951361.
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    • Slotkin, T. A., S. E. Lappi, E. C. McCook, B. A. Lorber, and F. J. Seidler. “Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: implications for sudden infant death syndrome.” Brain Res Bull 38, no. 1 (1995): 69–75. https://doi.org/10.1016/0361-9230(95)00073-n.
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    • Slotkin, T. A., C. Lau, and F. J. Seidler. “Beta-adrenergic receptor overexpression in the fetal rat: distribution, receptor subtypes, and coupling to adenylate cyclase activity via G-proteins.” Toxicol Appl Pharmacol 129, no. 2 (December 1994): 223–34. https://doi.org/10.1006/taap.1994.1247.
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    • Seidler, F. J., E. S. Albright, S. E. Lappi, and T. A. Slotkin. “In search of a mechanism for receptor-mediated neurobehavioral teratogenesis by nicotine: catecholamine release by nicotine in immature rat brain regions.” Brain Res Dev Brain Res 82, no. 1–2 (October 14, 1994): 1–8. https://doi.org/10.1016/0165-3806(94)90142-2.
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    • Wagner, J. P., F. J. Seidler, S. E. Lappi, E. C. McCook, and T. A. Slotkin. “Role of thyroid status in the ontogeny of adrenergic cell signaling in rat brain: beta receptors, adenylate cyclase, ornithine decarboxylase and c-fos protooncogene expression.” J Pharmacol Exp Ther 271, no. 1 (October 1994): 472–83.
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    • Slotkin, T. A., C. B. Nemeroff, G. Bissette, and F. J. Seidler. “Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's disease. Evidence from rapid autopsy studies.” J Clin Invest 94, no. 2 (August 1994): 696–702. https://doi.org/10.1172/JCI117387.
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    • Slotkin, T. A., C. Lau, E. C. McCook, S. E. Lappi, and F. J. Seidler. “Glucocorticoids enhance intracellular signaling via adenylate cyclase at three distinct loci in the fetus: a mechanism for heterologous teratogenic sensitization?” Toxicol Appl Pharmacol 127, no. 1 (July 1994): 64–75. https://doi.org/10.1006/taap.1994.1140.
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    • Wagner, J. P., F. J. Seidler, F. H. Schachat, and T. A. Slotkin. “beta Adrenergic control of c-fos protooncogene expression in developing rat brain regions.” J Pharmacol Exp Ther 269, no. 3 (June 1994): 1292–99.
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    • Kauffman, K. S., F. J. Seidler, and T. A. Slotkin. “Prenatal dexamethasone exposure causes loss of neonatal hypoxia tolerance: cellular mechanisms.” Pediatr Res 35, no. 5 (May 1994): 515–22.
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    • Miller, D. B., and F. J. Seidler. “Prenatal cocaine eliminates the sex-dependent differences in activation observed in adult rats after cocaine challenge.” Brain Res Bull 33, no. 2 (1994): 179–82. https://doi.org/10.1016/0361-9230(94)90248-8.
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    • Spraggins, Y. R., F. J. Seidler, and T. A. Slotkin. “Cocaine exacerbates hypoxia-induced cell damage in the developing brain: effects on ornithine decarboxylase activity and protein synthesis.” Biol Neonate 66, no. 5 (1994): 254–66. https://doi.org/10.1159/000244115.
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    • Zahalka, E. A., F. J. Seidler, and T. A. Slotkin. “Dexamethasone treatment in utero enhances neonatal cholinergic nerve terminal development in rat brain.” Res Commun Chem Pathol Pharmacol 81, no. 2 (August 1993): 191–98.
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    • Bian, X., F. J. Seidler, C. Olsen, J. R. Raymond, and T. A. Slotkin. “Effects of fetal dexamethasone exposure on postnatal control of cardiac adenylate cyclase: beta-adrenergic receptor coupling to Gs regulatory protein.” Teratology 48, no. 2 (August 1993): 169–77. https://doi.org/10.1002/tera.1420480211.
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    • Wood, M. W., F. J. Seidler, and T. A. Slotkin. “Immediate decline in DNA synthesis in neonatal rat lung caused by exposure to 100% oxygen.” Res Commun Chem Pathol Pharmacol 80, no. 3 (June 1993): 323–28.
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    • KAUFFMAN, K. S., F. J. SEIDLER, and T. A. SLOTKIN. “FETAL DEXAMETHASONE EXPOSURE INCREASES VULNERABILITY TO HYPOXIA - CARDIAC CELLULAR MECHANISMS AND MORTALITY.” Faseb Journal 7, no. 4 (February 23, 1993): A783–A783.
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    • SPRAGGINS, Y. R., F. J. SEIDLER, and T. A. SLOTKIN. “ACUTE COCAINE EXPOSURE SENSITIZES NEONATAL RAT-BRAIN TO HYPOXIA.” Faseb Journal 7, no. 3 (February 19, 1993): A252–A252.
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    • Bian, X., F. J. Seidler, and T. A. Slotkin. “Fetal dexamethasone exposure interferes with establishment of cardiac noradrenergic innervation and sympathetic activity.” Teratology 47, no. 2 (February 1993): 109–17. https://doi.org/10.1002/tera.1420470203.
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    • Yanai, J., Y. Rogel-Fuchs, C. G. Pick, T. Slotkin, F. J. Seidler, E. A. Zahalka, and M. E. Newman. “Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways.” Neuropharmacology 32, no. 2 (February 1993): 113–17. https://doi.org/10.1016/0028-3908(93)90090-p.
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    • Zahalka, E. A., F. J. Seidler, S. E. Lappi, J. Yanai, and T. A. Slotkin. “Differential development of cholinergic nerve terminal markers in rat brain regions: implications for nerve terminal density, impulse activity and specific gene expression.” Brain Res 601, no. 1–2 (January 22, 1993): 221–29. https://doi.org/10.1016/0006-8993(93)91714-4.
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    • Levin, E. D., and F. J. Seidler. “Sex-related spatial learning differences after prenatal cocaine exposure in the young adult rat.” Neurotoxicology 14, no. 1 (1993): 23–28.
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    • Seidler, F. J., and T. A. Slotkin. “Prenatal cocaine and cell development in rat brain regions: effects on ornithine decarboxylase and macromolecules.” Brain Res Bull 30, no. 1–2 (1993): 91–99. https://doi.org/10.1016/0361-9230(93)90043-b.
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    • Slotkin, T. A., E. C. McCook, and F. J. Seidler. “Glucocorticoids regulate the development of intracellular signaling: enhanced forebrain adenylate cyclase catalytic subunit activity after fetal dexamethasone exposure.” Brain Res Bull 32, no. 4 (1993): 359–64. https://doi.org/10.1016/0361-9230(93)90200-u.
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    • Slotkin, T. A., S. E. Lappi, and F. J. Seidler. “Impact of fetal nicotine exposure on development of rat brain regions: critical sensitive periods or effects of withdrawal?” Brain Res Bull 31, no. 3–4 (1993): 319–28. https://doi.org/10.1016/0361-9230(93)90224-y.
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    • Slotkin, T. A., D. J. Johnson, and F. J. Seidler. “Acute effects of cocaine on ornithine decarboxylase activity in fetal and neonatal rat heart: evidence for cardiotoxicity.” Biol Neonate 63, no. 5 (1993): 290–96. https://doi.org/10.1159/000243944.
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    • Zahalka, E. A., F. J. Seidler, J. Yanai, and T. A. Slotkin. “Fetal nicotine exposure alters ontogeny of M1-receptors and their link to G-proteins.” Neurotoxicol Teratol 15, no. 2 (1993): 107–15. https://doi.org/10.1016/0892-0362(93)90069-z.
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    • O’Callaghan, J. P., and F. J. Seidler. “1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced astrogliosis does not require activation of ornithine decarboxylase.” Neurosci Lett 148, no. 1–2 (December 14, 1992): 105–8. https://doi.org/10.1016/0304-3940(92)90815-o.
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    • Seidler, F. J., and T. A. Slotkin. “Fetal cocaine exposure causes persistent noradrenergic hyperactivity in rat brain regions: effects on neurotransmitter turnover and receptors.” J Pharmacol Exp Ther 263, no. 2 (November 1992): 413–21.
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    • Seidler, F. J., E. D. Levin, S. E. Lappi, and T. A. Slotkin. “Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions.” Brain Res Dev Brain Res 69, no. 2 (October 23, 1992): 288–91. https://doi.org/10.1016/0165-3806(92)90170-2.
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    • Pracyk, J. B., F. J. Seidler, E. C. McCook, and T. A. Slotkin. “Pituitary-thyroid axis reactivity to hyper- and hypothyroidism in the perinatal period: ontogeny of regulation of regulation and long-term programming of responses.” J Dev Physiol 18, no. 3 (September 1992): 105–9.
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    • Slotkin, T. A., E. C. McCook, S. E. Lappi, and F. J. Seidler. “Altered development of basal and forskolin-stimulated adenylate cyclase activity in brain regions of rats exposed to nicotine prenatally.” Brain Res Dev Brain Res 68, no. 2 (August 21, 1992): 233–39. https://doi.org/10.1016/0165-3806(92)90065-5.
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    • Bian, X., M. M. Briggs, F. H. Schachat, F. J. Seidler, and T. A. Slotkin. “Glucocorticoids accelerate the ontogenetic transition of cardiac ventricular myosin heavy-chain isoform expression in the rat: promotion by prenatal exposure to a low dose of dexamethasone.” J Dev Physiol 18, no. 1 (July 1992): 35–42.
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    • Carlos, R. Q., F. J. Seidler, and T. A. Slotkin. “Fetal dexamethasone exposure alters macromolecular characteristics of rat brain development: a critical period for regionally selective alterations?” Teratology 46, no. 1 (July 1992): 45–59. https://doi.org/10.1002/tera.1420460108.
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    • Bian, X. P., F. J. Seidler, and T. A. Slotkin. “Promotional role for glucocorticoids in the development of intracellular signalling: enhanced cardiac and renal adenylate cyclase reactivity to beta-adrenergic and non-adrenergic stimuli after low-dose fetal dexamethasone exposure.” J Dev Physiol 17, no. 6 (June 1992): 289–97.
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    • Slotkin, T. A., and F. J. Seidler. “Transient postnatal elevation of norepinephrine content and turnover in brain regions of rats exposed to terbutaline prenatally: evidence for autoregulation of noradrenergic development?” Res Commun Chem Pathol Pharmacol 76, no. 3 (June 1992): 269–78.
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    • Briggs, M. M., F. J. Seidler, T. A. Slotkin, and F. H. Schachat. “Ontogenetic transition of cardiac myosin heavy chain isoforms in rat ventricle: effects of fetal exposure to beta-adrenergic agonists or antagonists.” J Dev Physiol 17, no. 4 (April 1992): 201–6.
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    • Lin, W., F. J. Seidler, E. C. McCook, and T. A. Slotkin. “Overexpression of alpha 2-adrenergic receptors in fetal rat heart: receptors in search of a function.” J Dev Physiol 17, no. 4 (April 1992): 183–87.
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    • Slotkin, T. A., F. J. Seidler, R. J. Kavlock, and J. V. Bartolome. “Thyroid hormone differentially regulates cellular development in neonatal rat heart and kidney.” Teratology 45, no. 3 (March 1992): 303–12. https://doi.org/10.1002/tera.1420450309.
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    • BIAN, X. P., M. M. BRIGGS, F. H. SCHACHAT, F. J. SEIDLER, and T. A. SLOTKIN. “DO GLUCOCORTICOIDS PROMOTE THE DEVELOPMENTAL SHIFT OF CARDIAC MYOSIN HEAVY-CHAIN (MHC) EXPRESSION.” Faseb Journal 6, no. 4 (February 26, 1992): A1307–A1307.
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    • Slotkin, T. A., F. J. Seidler, R. J. Kavlock, and J. A. Gray. “Fetal dexamethasone exposure accelerates development of renal function: relationship to dose, cell differentiation and growth inhibition.” J Dev Physiol 17, no. 2 (February 1992): 55–61.
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    • Seidler, F. J., S. E. Lappi, and T. A. Slotkin. “Effects of prenatal cocaine exposure on development of rat cardiac adrenergic receptors and their control of adenylate cyclase activity.” Research Communications in Substances of Abuse 13, no. 3 (January 1, 1992): 237–46.
    • Slotkin, T. A., S. E. Lappi, E. C. McCook, M. I. Tayyeb, J. P. Eylers, and F. J. Seidler. “Glucocorticoids and the development of neuronal function: effects of prenatal dexamethasone exposure on central noradrenergic activity.” Biol Neonate 61, no. 5 (1992): 326–36. https://doi.org/10.1159/000243761.
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    • Zahalka, E. A., F. J. Seidler, S. E. Lappi, E. C. McCook, J. Yanai, and T. A. Slotkin. “Deficits in development of central cholinergic pathways caused by fetal nicotine exposure: differential effects on choline acetyltransferase activity and [3H]hemicholinium-3 binding.” Neurotoxicol Teratol 14, no. 6 (1992): 375–82. https://doi.org/10.1016/0892-0362(92)90047-e.
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    • Carlos, R. Q., F. J. Seidler, and T. A. Slotkin. “Fetal dexamethasone exposure sensitizes neonatal rat brain to hypoxia: effects on protein and DNA synthesis.” Brain Res Dev Brain Res 64, no. 1–2 (December 17, 1991): 161–66. https://doi.org/10.1016/0165-3806(91)90220-d.
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    • Bian, X. P., F. J. Seidler, and T. A. Slotkin. “Promotional role for glucocorticoids in the development of intracellular signalling: enhanced cardiac and renal adenylate cyclase reactivity to beta-adrenergic and non-adrenergic stimuli after low-dose fetal dexamethasone exposure.” J Dev Physiol 16, no. 6 (December 1991): 331–39.
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    • Koegler, S. M., F. J. Seidler, J. R. Spencer, and T. A. Slotkin. “Ischemia contributes to adverse effects of cocaine on brain development: suppression of ornithine decarboxylase activity in neonatal rat.” Brain Res Bull 27, no. 6 (December 1991): 829–34. https://doi.org/10.1016/0361-9230(91)90217-8.
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    • Nye, H. E., F. J. Seidler, and T. A. Slotkin. “Developmental shift from local to central control of norepinephrine release in the cardiac-sympathetic axis: effects of cocaine and related drugs.” J Pharmacol Exp Ther 259, no. 3 (December 1991): 976–81.
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    • Smith, W. T., F. J. Seidler, and T. A. Slotkin. “Acute stimulation of ornithine decarboxylase in neonatal rat brain regions by nicotine: a central receptor-mediated process?” Brain Res Dev Brain Res 63, no. 1–2 (November 19, 1991): 85–93. https://doi.org/10.1016/0165-3806(91)90069-u.
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    • Slotkin, T. A., S. E. Lappi, M. I. Tayyeb, and F. J. Seidler. “Dose-dependent glucocorticoid effects on noradrenergic synaptogenesis in rat brain: ontogeny of [3H]desmethylimipramine binding sites after fetal exposure to dexamethasone.” Res Commun Chem Pathol Pharmacol 73, no. 1 (July 1991): 3–19.
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    • Gray, J. A., R. J. Kavlock, F. J. Seidler, and T. A. Slotkin. “Neural factors in the development of renal function: effect of neonatal central catecholaminergic lesions with 6-hydroxydopamine.” J Dev Physiol 15, no. 6 (June 1991): 325–30.
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    • Slotkin, T. A., E. C. McCook, C. B. Nemeroff, and F. J. Seidler. “Species differences in alpha 2-adrenergic regulation of platelet adenylate cyclase.” Res Commun Chem Pathol Pharmacol 72, no. 3 (June 1991): 259–71.
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    • Wagner, J. P., F. J. Seidler, and T. A. Slotkin. “Presynaptic input regulates development of beta-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol.” Brain Res Bull 26, no. 6 (June 1991): 885–90. https://doi.org/10.1016/0361-9230(91)90253-g.
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    • Slotkin, T. A., F. J. Seidler, R. J. Kavlock, and J. V. Bartolome. “Fetal dexamethasone exposure impairs cellular development in neonatal rat heart and kidney: effects on DNA and protein in whole tissues.” Teratology 43, no. 4 (April 1991): 301–6. https://doi.org/10.1002/tera.1420430404.
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    • BIAN, X. P., F. J. SEIDLER, and T. A. SLOTKIN. “GLUCOCORTICOIDS REGULATE ONTOGENY OF CARDIAC BETA-ADRENERGIC-RECEPTOR TRANSDUCTION MECHANISMS.” Faseb Journal 5, no. 5 (March 15, 1991): A1235–A1235.
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    • CARLOS, R. Q., F. J. SEIDLER, and T. A. SLOTKIN. “CELLULAR MECHANISMS UNDERLYING IMPAIRMENT OF BRAIN-DEVELOPMENT BY FETAL GLUCOCORTICOID EXPOSURE.” Faseb Journal 5, no. 5 (March 15, 1991): A1235–A1235.
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    • HUFF, R. A., F. J. SEIDLER, and T. A. SLOTKIN. “ONTOGENIC TRANSITION OF ADRENERGIC-RECEPTOR SUBTYPES IN NEONATAL RAT-LIVER IS UNDER GLUCOCORTICOID CONTROL.” Faseb Journal 5, no. 5 (March 15, 1991): A1236–A1236.
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    • NYE, H. E., T. A. SLOTKIN, and F. J. SEIDLER. “EFFECTS OF ACUTE COCAINE CHALLENGE ON NOREPINEPHRINE RELEASE IN THE DEVELOPING CARDIAC-SYMPATHETIC AXIS.” Faseb Journal 5, no. 5 (March 15, 1991): A1235–A1235.
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    • SMITH, W. T., F. J. SEIDLER, and T. A. SLOTKIN. “ACUTE STIMULATION OF ORNITHINE DECARBOXYLASE IN NEONATAL RAT-BRAIN REGIONS BY NICOTINE - A RECEPTOR-MEDIATED PROCESS.” Faseb Journal 5, no. 5 (March 15, 1991): A1235–A1235.
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    • WAGNER, J. P., F. J. SEIDLER, and T. A. SLOTKIN. “NEUROTRANSMITTER CONTROL OF BETA-ADRENOCEPTOR COUPLING TO ORNITHINE DECARBOXYLASE IN NEONATAL RAT-BRAIN - EFFECTS OF 6-HYDROXYDOPAMINE OR PROPRANOLOL.” Faseb Journal 5, no. 5 (March 15, 1991): A1236–A1236.
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    • McFarland, B. J., F. J. Seidler, and T. A. Slotkin. “Inhibition of DNA synthesis in neonatal rat brain regions caused by acute nicotine administration.” Brain Res Dev Brain Res 58, no. 2 (February 22, 1991): 223–29. https://doi.org/10.1016/0165-3806(91)90008-7.
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    • Duncan, C. P., F. J. Seidler, and T. A. Slotkin. “Effects of MK-801 on DNA synthesis in neonatal rat brain regions under normoxic and hypoxic conditions.” Brain Res Dev Brain Res 58, no. 1 (January 15, 1991): 67–71. https://doi.org/10.1016/0165-3806(91)90238-e.
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    • Carlos, R. Q., F. J. Seidler, S. E. Lappi, and T. A. Slotkin. “Fetal dexamethasone exposure affects basal ornithine decarboxylase activity in developing rat brain regions and alters acute responses to hypoxia and maternal separation.” Biol Neonate 59, no. 2 (1991): 69–77. https://doi.org/10.1159/000243325.
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    • Huff, R. A., F. J. Seidler, and T. A. Slotkin. “Glucocorticoids regulate the ontogenetic transition of adrenergic receptor subtypes in rat liver.” Life Sci 48, no. 11 (1991): 1059–65. https://doi.org/10.1016/0024-3205(91)90507-8.
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    • Nemeroff, C. B., G. Bissette, T. A. Slotkin, F. J. Seidler, B. E. Miller, and H. Ghanbari. “Recent advances in the neurochemical pathology of Alzheimer's disease. Studies of neuropeptides, cholinergic function and Alzheimer's disease-associated protein.” Ann N Y Acad Sci 640 (1991): 193–96. https://doi.org/10.1111/j.1749-6632.1991.tb00216.x.
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    • Slotkin, T. A., S. E. Lappi, M. I. Tayyeb, and F. J. Seidler. “Chronic prenatal nicotine exposure sensitizes rat brain to acute postnatal nicotine challenge as assessed with ornithine decarboxylase.” Life Sci 49, no. 9 (1991): 665–70. https://doi.org/10.1016/0024-3205(91)90113-p.
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    • Anderson-Brown, T., T. A. Slotkin, and F. J. Seidler. “Cocaine acutely inhibits DNA synthesis in developing rat brain regions: evidence for direct actions.” Brain Res 537, no. 1–2 (December 24, 1990): 197–202. https://doi.org/10.1016/0006-8993(90)90358-i.
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    • Bian, X. P., F. J. Seidler, J. Bartolome, R. J. Kavlock, M. Bartolome, and T. A. Slotkin. “Dose-dependent effect of prenatal dexamethasone treatment on beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic AMP.” J Dev Physiol 14, no. 3 (September 1990): 125–30.
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    • Duncan, C. P., F. J. Seidler, S. E. Lappi, and T. A. Slotkin. “Dual control of DNA synthesis by alpha- and beta-adrenergic mechanisms in normoxic and hypoxic neonatal rat brain.” Brain Res Dev Brain Res 55, no. 1 (August 1, 1990): 29–33. https://doi.org/10.1016/0165-3806(90)90102-5.
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    • Navarro, H. A., E. Mills, F. J. Seidler, F. E. Baker, S. E. Lappi, M. I. Tayyeb, J. R. Spencer, and T. A. Slotkin. “Prenatal nicotine exposure impairs beta-adrenergic function: persistent chronotropic subsensitivity despite recovery from deficits in receptor binding.” Brain Res Bull 25, no. 2 (August 1990): 233–37. https://doi.org/10.1016/0361-9230(90)90066-9.
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    • Slotkin, T. A., F. J. Seidler, B. J. Crain, J. M. Bell, G. Bissette, and C. B. Nemeroff. “Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy.” Proc Natl Acad Sci U S A 87, no. 7 (April 1990): 2452–55. https://doi.org/10.1073/pnas.87.7.2452.
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    • Seidler, F. J., J. M. Bell, and T. A. Slotkin. “Undernutrition and overnutrition in the neonatal rat: long-term effects on noradrenergic pathways in brain regions.” Pediatr Res 27, no. 2 (February 1990): 191–97. https://doi.org/10.1203/00006450-199002000-00021.
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    • Seidler, F. J., and T. A. Slotkin. “Effects of acute hypoxia on neonatal rat brain: regionally selective, long-term alterations in catecholamine levels and turnover.” Brain Res Bull 24, no. 2 (February 1990): 157–61. https://doi.org/10.1016/0361-9230(90)90200-j.
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    • Navarro, H. A., T. A. Slotkin, M. I. Tayyeb, S. E. Lappi, and F. J. Seidler. “Effects of fetal nicotine exposure on development of adrenergic receptor binding in rat brain regions: Selective changes in α1-receptors.” Research Communications in Substances of Abuse 11, no. 3 (January 1, 1990): 95–103.
    • Slotkin, T. A., E. M. Kudlacz, S. E. Lappi, M. I. Tayyeb, and F. J. Seidler. “Fetal terbutaline exposure causes selective postnatal increases in cerebellar alpha-adrenergic receptor binding.” Life Sci 47, no. 22 (1990): 2051–57. https://doi.org/10.1016/0024-3205(90)90440-3.
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    • Slotkin, T. A., H. A. Navarro, E. C. McCook, and F. J. Seidler. “Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues.” Life Sci 47, no. 17 (1990): 1561–67. https://doi.org/10.1016/0024-3205(90)90185-t.
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    • Navarro, H. A., F. J. Seidler, J. P. Eylers, F. E. Baker, S. S. Dobbins, S. E. Lappi, and T. A. Slotkin. “Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain.” J Pharmacol Exp Ther 251, no. 3 (December 1989): 894–900.
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    • Sylvia, A. L., F. J. Seidler, and T. A. Slotkin. “Effect of transient hypoxia on oxygenation of the developing rat brain: relationships among haemoglobin saturation, autoregulation of blood flow and mitochondrial redox state.” J Dev Physiol 12, no. 5 (November 1989): 287–92.
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    • Navarro, H. A., F. J. Seidler, R. D. Schwartz, F. E. Baker, S. S. Dobbins, and T. A. Slotkin. “Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth.” Brain Res Bull 23, no. 3 (September 1989): 187–92. https://doi.org/10.1016/0361-9230(89)90146-9.
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    • Hou, Q. C., F. J. Seidler, and T. A. Slotkin. “Development of the linkage of beta-adrenergic receptors to cardiac hypertrophy and heart rate control: neonatal sympathectomy with 6-hydroxydopamine.” J Dev Physiol 11, no. 5 (May 1989): 305–11.
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    • Hou, Q. C., F. E. Baker, F. J. Seidler, M. Bartolome, J. Bartolome, and T. A. Slotkin. “Role of sympathetic neurons in development of beta-adrenergic control of ornithine decarboxylase activity in peripheral tissues: effects of neonatal 6-hydroxydopamine treatment.” J Dev Physiol 11, no. 3 (March 1989): 139–46.
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    • Seidler, F. J., and E. Mills. “Non-neurogenic stimulation of adrenomedullary secretion during endotoxicosis in the one day old rat.” Life Sci 45, no. 5 (1989): 379–81. https://doi.org/10.1016/0024-3205(89)90623-1.
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    • Slotkin, T. A., F. E. Baker, S. S. Dobbins, J. P. Eylers, S. E. Lappi, and F. J. Seidler. “Prenatal terbutaline exposure in the rat: selective effects on development of noradrenergic projections to cerebellum.” Brain Res Bull 23, no. 4–5 (1989): 263–65. https://doi.org/10.1016/0361-9230(89)90206-2.
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    • Slotkin, T. A., F. J. Seidler, K. Haim, A. M. Cameron, L. Antolick, and C. Lau. “Neonatal central catecholaminergic lesions with intracisternal 6-hydroxydopamine: effects on development of presynaptic and postsynaptic components of peripheral sympathetic pathways and on the ornithine decarboxylase/polyamine system in heart, lung and kidney.” J Pharmacol Exp Ther 247, no. 3 (December 1988): 975–82.
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    • Lau, C., F. J. Seidler, A. M. Cameron, H. A. Navarro, J. M. Bell, J. Bartolome, and T. A. Slotkin. “Nutritional influences on adrenal chromaffin cell development: comparison with central neurons.” Pediatr Res 24, no. 5 (November 1988): 583–87. https://doi.org/10.1203/00006450-198811000-00009.
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    • Slotkin, T. A., R. Windh, W. L. Whitmore, and F. J. Seidler. “Adrenergic control of DNA synthesis in developing rat brain regions: effects of intracisternal administration of isoproterenol.” Brain Res Bull 21, no. 5 (November 1988): 737–40. https://doi.org/10.1016/0361-9230(88)90040-8.
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    • Navarro, H. A., F. J. Seidler, W. L. Whitmore, and T. A. Slotkin. “Prenatal exposure to nicotine via maternal infusions: effects on development of catecholamine systems.” J Pharmacol Exp Ther 244, no. 3 (March 1988): 940–44.
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    • Slotkin, T. A., and F. J. Seidler. “Adrenomedullary catecholamine release in the fetus and newborn: secretory mechanisms and their role in stress and survival.” J Dev Physiol 10, no. 1 (February 1988): 1–16.
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    • Slotkin, T. A., and F. J. Seidler. “Stress in the fetus and newborn.” Adv Exp Med Biol 245 (1988): 283–94. https://doi.org/10.1007/978-1-4899-2064-5_23.
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    • Seidler, F. J., K. K. Brown, P. G. Smith, and T. A. Slotkin. “Toxic effects of hypoxia on neonatal cardiac function in the rat: alpha-adrenergic mechanisms.” Toxicol Lett 37, no. 1 (June 1987): 79–84. https://doi.org/10.1016/0378-4274(87)90170-6.
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    • Slotkin, T. A., L. Orband-Miller, K. L. Queen, W. L. Whitmore, and F. J. Seidler. “Effects of prenatal nicotine exposure on biochemical development of rat brain regions: maternal drug infusions via osmotic minipumps.” J Pharmacol Exp Ther 240, no. 2 (February 1987): 602–11.
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    • Friedman, L., D. W. Gaines, F. R. Alleva, F. J. Seidler, T. J. Flynn, T. A. Slotkin, and T. Balazs. “Macromolecular levels, DNA synthesis and ornithine decarboxylase activity in leg muscles from 6-mercaptopurine-treated rats.” Toxicol Ind Health 2, no. 2 (September 1986): 57–68. https://doi.org/10.1177/074823378600200207.
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    • Seidler, F. J., and T. A. Slotkin. “Non-neurogenic adrenal catecholamine release in the neonatal rat: exocytosis or diffusion?” Brain Res 393, no. 2 (August 1986): 274–77. https://doi.org/10.1016/0165-3806(86)90031-3.
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    • Slotkin, T. A., N. Greer, J. Faust, H. Cho, and F. J. Seidler. “Effects of maternal nicotine injections on brain development in the rat: ornithine decarboxylase activity, nucleic acids and proteins in discrete brain regions.” Brain Res Bull 17, no. 1 (July 1986): 41–50. https://doi.org/10.1016/0361-9230(86)90159-0.
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    • Bell, J. M., W. L. Whitmore, G. Barnes, F. J. Seidler, and T. A. Slotkin. “Perinatal dietary exposure to soy lecithin: altered sensitivity to central cholinergic stimulation.” Int J Dev Neurosci 4, no. 6 (1986): 497–501. https://doi.org/10.1016/0736-5748(86)90001-8.
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    • Seidler, F. J., and T. A. Slotkin. “Ontogeny of adrenomedullary responses to hypoxia and hypoglycemia: role of splanchnic innervation.” Brain Res Bull 16, no. 1 (January 1986): 11–14. https://doi.org/10.1016/0361-9230(86)90005-5.
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    • Seidler, F. J., and T. A. Slotkin. “Adrenomedullary function in the neonatal rat: responses to acute hypoxia.” J Physiol 358 (January 1985): 1–16. https://doi.org/10.1113/jphysiol.1985.sp015536.
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    • Bartolome, J., W. L. Whitmore, F. J. Seidler, and T. A. Slotkin. “Exposure to methylmercury in utero: effects on biochemical development of catecholamine neurotransmitter systems.” Life Sci 35, no. 6 (August 6, 1984): 657–70. https://doi.org/10.1016/0024-3205(84)90261-3.
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    • SEIDLER, F. J., and T. A. SLOTKIN. “ADRENOMEDULLARY CATECHOLAMINE (CA) RELEASE IN THE NEONATAL RAT.” Federation Proceedings 43, no. 3 (January 1, 1984): 332–332.
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    • Seidler, F. J., and T. A. Slotkin. “Adrenomedullary catecholamine (CA) release in the neonatal rat.” Federation Proceedings 43, no. 3 (January 1, 1984).
    • Morris, G., F. J. Seidler, and T. A. Slotkin. “Stimulation of ornithine decarboxylase by histamine or norepinephrine in brain regions of the developing rat: evidence for biogenic amines as trophic agents in neonatal brain development.” Life Sci 32, no. 14 (April 4, 1983): 1565–71. https://doi.org/10.1016/0024-3205(83)90862-7.
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    • Slotkin, T. A., F. J. Seidler, W. L. Whitmore, S. J. Weigel, R. J. Slepetis, L. Lerea, P. A. Trepanier, and J. Bartolome. “Critical periods for the role of ornithine decarboxylase and the polyamines in growth and development of the rat: Effects of exposure to α-difluoromethylornithine during discrete prenatal or postnatal intervals.” Int J Dev Neurosci 1, no. 2 (1983): 113–27. https://doi.org/10.1016/0736-5748(83)90038-2.
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    • Slotkin, T. A., W. L. Whitmore, L. Lerea, R. J. Slepetis, S. J. Weigel, P. A. Trepanier, and F. J. Seidler. “Role of ornithine decarboxylase and the polyamines in nervous system development: Short-term postnatal administration of α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.” Int J Dev Neurosci 1, no. 1 (1983): 7–16. https://doi.org/10.1016/0736-5748(83)90004-7.
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    • Grignolo, A., F. J. Seidler, M. Bartolome, C. M. Kuhn, T. A. Slotkin, and S. M. Schanberg. “Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone.” Life Sci 31, no. 26 (December 27, 1982): 3009–16. https://doi.org/10.1016/0024-3205(82)90068-6.
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    • Slotkin, T. A., S. J. Weigel, F. J. Seidler, and W. L. Whitmore. “Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.” Toxicol Lett 14, no. 3–4 (December 1982): 131–35. https://doi.org/10.1016/0378-4274(82)90041-8.
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    • Slotkin, T. A., A. Grignolo, W. L. Whitmore, L. Lerea, P. A. Trepanier, G. A. Barnes, S. J. Weigel, F. J. Seidler, and J. Bartolome. “Impaired development of central and peripheral catecholamine neurotransmitter systems in preweanling rats treated with alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.” J Pharmacol Exp Ther 222, no. 3 (September 1982): 746–51.
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    • Slotkin, T. A., F. J. Seidler, P. A. Trepanier, W. L. Whitmore, L. Lerea, G. A. Barnes, S. J. Weigel, and J. Bartolome. “Ornithine decarboxylase and polyamines in tissues of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.” J Pharmacol Exp Ther 222, no. 3 (September 1982): 741–45.
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    • Bartolome, J., P. Trepanier, E. A. Chait, F. J. Seidler, R. Deskin, and T. A. Slotkin. “Neonatal methylmercury poisoning in the rat: effects on development of central catecholamine neurotransmitter systems.” Toxicol Appl Pharmacol 65, no. 1 (August 1982): 92–99. https://doi.org/10.1016/0041-008x(82)90366-0.
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    • Slotkin, T. A., G. Barnes, C. Lau, F. J. Seidler, P. Trepanier, S. J. Weigel, and W. L. Whitmore. “Development of polyamine and biogenic amine systems in brains and hearts of neonatal rats given dexamethasone: role of biochemical alterations in cellular maturation for producing deficits in ontogeny of neurotransmitter levels, uptake, storage and turnover.” J Pharmacol Exp Ther 221, no. 3 (June 1982): 686–93.
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    • Slotkin, T. A., S. J. Weigel, W. L. Whitmore, and F. J. Seidler. “Maternal methadone administration: deficit in development of alpha-noradrenergic responses in developing rat brain as assessed by norepinephrine stimulation of 33Pi incorporation into phospholipids in vivo.” Biochem Pharmacol 31, no. 10 (May 15, 1982): 1899–1902. https://doi.org/10.1016/0006-2952(82)90494-4.
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    • Chantry, C. J., F. J. Seidler, and T. A. Slotkin. “Non-neurogenic mechanism for reserpine-induced release of catecholamines from the adrenal medulla of neonatal rats: possible modulation by opiate receptors.” Neuroscience 7, no. 3 (March 1982): 673–78. https://doi.org/10.1016/0306-4522(82)90073-2.
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    • Seidler, F. J., W. L. Whitmore, and T. A. Slotkin. “Delays in growth and biochemical development of rat brain caused by maternal methadone administration: are the alterations in synaptogenesis and cellular maturation independent of reduced maternal food intake?” Dev Neurosci 5, no. 1 (1982): 13–18. https://doi.org/10.1159/000112657.
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    • Slotkin, T. A., S. J. Weigel, G. A. Barnes, W. L. Whitmore, and F. J. Seidler. “Alterations in the development of catecholamine turnover induced by perinatal methadone: differences in central vs. peripheral sympathetic nervous systems.” Life Sci 29, no. 24 (December 14, 1981): 2519–25. https://doi.org/10.1016/0024-3205(81)90707-4.
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    • Deskin, R., F. J. Seidler, W. L. Whitmore, and T. A. Slotkin. “Development of alpha-noradrenergic and Dopaminergic receptor systems depends on maturation of their presynaptic nerve terminals in the rat brain.” J Neurochem 36, no. 5 (May 1981): 1683–90. https://doi.org/10.1111/j.1471-4159.1981.tb00419.x.
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    • Subramanian, N., W. L. Whitmore, F. J. Seidler, and T. A. Slotkin. “Ontogeny of histaminergic neurotransmission in the rat brain: concomitant development of neuronal histamine, H-1 receptors, and H-1 receptor-mediated stimulation of phospholipid turnover.” J Neurochem 36, no. 3 (March 1981): 1137–41. https://doi.org/10.1111/j.1471-4159.1981.tb01710.x.
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    • DESKIN, R., F. J. SEIDLER, W. L. WHITMORE, and T. A. SLOTKIN. “DEVELOPMENT OF RAT-BRAIN ALPHA-NORADRENERGIC AND DOPAMINERGIC RECEPTOR SYSTEMS DEPENDS UPON MATURATION OF THEIR PRESYNAPTIC NERVE-TERMINALS.” Federation Proceedings 40, no. 3 (January 1, 1981): 250–250.
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    • Deskin, R., F. J. Seidler, W. L. Whitmore, and T. A. Slotkin. “Development of rat brain alpha-noradrenergic and dopaminergic receptor systems depends upon maturation of their presynaptic nerve terminals.” Federation Proceedings 40, no. 3 I (January 1, 1981): 78.
    • SEIDLER, F. J., and T. A. SLOTKIN. “DEVELOPMENT OF CENTRAL CONTROL OF CARDIAC NOREPINEPHRINE TURNOVER IN THE RAT-HEART.” Federation Proceedings 40, no. 3 (January 1, 1981): 250–250.
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    • Seidler, F. J., and T. A. Slotkin. “Development of central control of norepinephrine turnover and release in the rat heart: responses to tyramine, 2-deoxyglucose and hydralazine.” Neuroscience 6, no. 10 (1981): 2081–86. https://doi.org/10.1016/0306-4522(81)90047-6.
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    • Seidler, F. J., and T. A. Slotkin. “Development of central control of cardiac norepinephrine turnover in the rat heart.” Federation Proceedings 40, no. 3 I (January 1, 1981): 82.
    • Deskin, R., E. Mills, W. L. Whitmore, F. J. Seidler, and T. A. Slotkin. “Maturation of sympathetic neurotransmission in the rat heart. VI. The effect of neonatal central catecholaminergic lesions.” J Pharmacol Exp Ther 215, no. 2 (November 1980): 342–47.
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    • Subramanian, N., W. L. Whitmore, F. J. Seidler, and T. A. Slotkin. “Histamine stimulates brain phospholipid turnover through a direct, H-1 receptor-mediated mechanism.” Life Sci 27, no. 14 (October 6, 1980): 1315–19. https://doi.org/10.1016/0024-3205(80)90225-8.
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    • Slotkin, T. A., F. J. Seidler, and W. L. Whitmore. “Precocious development of sympatho-adrenal function in rats whose mothers received methadone.” Life Sci 26, no. 20 (May 19, 1980): 1657–63. https://doi.org/10.1016/0024-3205(80)90173-3.
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    • Slotkin, T. A., F. J. Seidler, and W. L. Whitmore. “Effects of maternal methadone administration on ornithine decarboxylase in brain and heart of the offspring: relationships of enzyme activity to dose and to growth impairment in the rat.” Life Sci 26, no. 11 (March 17, 1980): 861–67. https://doi.org/10.1016/0024-3205(80)90348-3.
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    • Slotkin, T. A., F. J. Seidler, W. L. Whitmore, M. Salvaggio, and D. L. Bareis. “Release of [3H]norepinephrine from synaptic vesicles isolated from rat brain after the intracisternal administration of [3H]norepinephrine: influence of nucleotides, ions and drugs, and destabilization of transmitter storage caused by acute or chronic lithium administration.” Neuroscience 5, no. 4 (1980): 753–62. https://doi.org/10.1016/0306-4522(80)90168-2.
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    • Slotkin, T. A., M. Salvaggio, F. J. Seidler, and W. L. Whitmore. “Structural characteristics for inhibition of [3H] norepinephrine uptake into rat brain synaptic vesicles by beta-carboline, indolealkylamine, phenethylamine and n-alkylamine derivatives.” Mol Pharmacol 15, no. 3 (May 1979): 607–19.
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    • Slotkin, T. A., W. L. Whitmore, M. Salvaggio, and F. J. Seidler. “Perinatal methadone addiction affects brain synaptic development of biogenic amine systems in the rat.” Life Sci 24, no. 13 (March 26, 1979): 1223–29. https://doi.org/10.1016/0024-3205(79)90059-6.
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    • Seidler, F. J., and T. A. Slotkin. “Presynaptic and postsynaptic contributions to ontogeny of sympathetic control of heart rate in the pre-weanling rat.” Br J Pharmacol 65, no. 3 (March 1979): 431–34. https://doi.org/10.1111/j.1476-5381.1979.tb07847.x.
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    • Slotkin, T. A., F. J. Seidler, W. L. Whitmore, C. Lau, M. Salvaggio, and D. F. Kirksey. “Rat brain synaptic vesicles: uptake specificities of [3H]norepinephrine and [3H]serotonin in preparations from whole brain and brain regions.” J Neurochem 31, no. 4 (October 1978): 961–68. https://doi.org/10.1111/j.1471-4159.1978.tb00134.x.
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    • Seidler, F. J., W. L. Whitmore, and T. A. Slotkin. “Age-dependence of inhibition of rat brain synaptic vesicle [3H]norepinephrine uptake caused by administration of a single dose of reserpine: persistence of inhibition in adults but not in neonates.” J Pharmacol Exp Ther 206, no. 3 (September 1978): 652–60.
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    • Slotkin, T. A., F. J. Seidler, W. L. Whitmore, M. Salvaggio, and C. Lau. “Ionic and nucleotide cofactor requirements for uptake of [3H]norepinephrine by rat brain synaptic vesicle preparations.” Mol Pharmacol 14, no. 5 (September 1978): 868–78.
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    • Kirksey, D. F., F. J. Seidler, and T. A. Slotkin. “Ontogeny of (--)-[3H]norepinephrine uptake properties of synaptic storage vesicles of rat brain.” Brain Res 150, no. 2 (July 14, 1978): 367–75. https://doi.org/10.1016/0006-8993(78)90287-1.
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    • Slotkin, T. A., F. J. Seidler, and W. L. Whitmore. “Methadone inhibits serotonin and norephinephrine uptake into rat brain synaptosomes and synaptic vesicles in vitro but not in vivo.” Eur J Pharmacol 49, no. 4 (June 15, 1978): 357–62. https://doi.org/10.1016/0014-2999(78)90309-6.
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    • Seidler, F. J., D. F. Kirksey, C. Lau, W. L. Whitmore, and T. A. Slotkin. “Uptake of (-) 3H-norepinephrine by storage vesicles prepared from whole rat brain: properties of the uptake system and its inhibition by drugs.” Life Sci 21, no. 8 (October 15, 1977): 1075–85. https://doi.org/10.1016/0024-3205(77)90105-9.
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    • Lau, C., J. Bartolomé, F. J. Seidler, and T. A. Slotkin. “Critical periods for effects of prenatal reserpine administration on development of rat brain and adrenal medulla.” Neuropharmacology 16, no. 12 (January 1, 1977): 799–809. https://doi.org/10.1016/0028-3908(77)90141-1.
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    • Slotkin, T. A., C. Lau, M. Bartolomé, and F. J. Seidler. “Catecholamine synthesis, storage and release in adrenal medulla and whole brain during acute and chronic methadone administration.” Biochem Pharmacol 25, no. 22 (November 15, 1976): 2523–27. https://doi.org/10.1016/0006-2952(76)90459-7.
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    • Bartolomé, J., M. Bartolomé, J. Seidler, T. R. Anderson, and T. A. Slotkin. “Effects of early postnatal guanethidine administration on adrenal medulla and brain of developing rats.” Biochem Pharmacol 25, no. 21 (November 1, 1976): 2387–90. https://doi.org/10.1016/0006-2952(76)90033-2.
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    • Slotkin, T. A., C. Lau, M. Bartolomé, and F. J. Seidler. “Alteration by methadone of catecholamine uptake and release in isolated rat adrenomedullary storage vesicles.” Life Sci 19, no. 4 (August 15, 1976): 483–91. https://doi.org/10.1016/0024-3205(76)90226-5.
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    • Anderson, T. R., J. Bartolomé, F. J. Seidler, C. Lau, and T. A. Slotkin. “Morphine-reserpine interactions in the adrenal medulla.” Toxicol Appl Pharmacol 36, no. 3 (June 1976): 533–41. https://doi.org/10.1016/0041-008x(76)90232-5.
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    • Slotkin, T. A., F. J. Seidler, C. Lau, J. Bartolomé, and S. M. Schanberg. “Effects of chronic chlorisondamine administration on the sympatho-adrenal axis.” Biochem Pharmacol 25, no. 11 (June 1, 1976): 1311–15. https://doi.org/10.1016/0006-2952(76)90095-2.
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    • Bartolomé, J., F. J. Seidler, T. R. Anderson, and T. A. Slotkin. “Effects of prenatal reserpine administration on development of the rat adrenal medulla and central nervous system.” J Pharmacol Exp Ther 197, no. 2 (May 1976): 293–302.
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    • Seidler, F. J., and T. A. Slotkin. “Effects of chronic nicotine administration on the denervated rat adrenal medulla.” Br J Pharmacol 56, no. 2 (February 1976): 201–7. https://doi.org/10.1111/j.1476-5381.1976.tb07443.x.
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    • Slotkin, T. A., T. R. Anderson, F. J. Seidler, and C. Lau. “Inhibition of epinephrine and metaraminol uptake into adrenal medullary vesicles by aralkylamines and alkylamines.” Biochemical Pharmacology 24, no. 15 (August 1, 1975): 1413–19. https://doi.org/10.1016/0006-2952(75)90365-2.
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    • Slotkin, T. A., and F. J. Seidler. “Acute and chronic effects of nicotine on synthesis and storage of catecholamines in the rat adrenal medulla.” Life Sci 16, no. 10 (May 15, 1975): 1613–22. https://doi.org/10.1016/0024-3205(75)90079-x.
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    • Slotkin, T. A., F. J. Seidler, and M. D. Abou Donia. “Effects of tryptamines on epinephrine uptake into adrenal medullary vesicles.” Pharmacologist 16, no. 2 (January 1, 1974).

  • Conference Papers

    • Cauley, M., D. Burke, B. J. Hall, F. J. Seidler, T. A. Slotkin, and E. D. Levin. “Sex-selective interaction of prenatal nicotine with neonatal chlorpyrifos on novel object recognition in rats.” In Neurotoxicology and Teratology, 43:88–89. Elsevier BV, 2014. https://doi.org/10.1016/j.ntt.2014.04.043.
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    • Jameson, R. R., F. J. Seidler, and T. A. Slotkin. “Are nonenzymatic functions of acetylcholinesterase (AChE) involved in the developmental neurotoxicity of organophosphates? Effects of chlorpyrifos and diazinon on expression of AChE splice variants in vitro and in vivo.” In Neurotoxicology, 27:1186–1186. ELSEVIER SCIENCE BV, 2006.
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    • Levin, Edward D., Cindy Roegge, Olga Timofeeva, Frederic J. Seidler, and Theodore A. Slotkin. “Low dose early postnatal diazinon exposure causes impaired working memory on the radial-arm maze in rats during adulthood.” In Neurotoxicology, 27:1165–1165. ELSEVIER SCIENCE BV, 2006.
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    • Jameson, R. R., F. J. Seidler, D. Qiao, and T. A. Slotkin. “Chlorpyrifos affects neuronal cell replication and phenotypic outcomes.” In Neurotoxicology, 27:912–912. ELSEVIER SCIENCE BV, 2006.
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    • Roy, T. S., F. J. Seidler, and T. A. Slotkin. “Neonatal chlorpyrifos exposure: Regionally-selective alterations in neuronal cell dimensions and in the number of neurons and glia in developing rat brain.” In Faseb Journal, 17:A236–A236. FEDERATION AMER SOC EXP BIOL, 2003.
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    • Abreu-Villaca, Y., F. J. Seidler, and T. A. Slotkin. “Short-term nicotine exposure in adolescent rats elicits brain cell damage.” In Toxicological Sciences, 72:124–124. OXFORD UNIV PRESS, 2003.
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    • Garofolo, M. C., F. J. Seidler, and T. A. Slotkin. “Developmental neuro-and cardiotoxicity of terbutaline: DNA synthesis and neural biomarkers.” In Toxicological Sciences, 72:124–124. OXFORD UNIV PRESS, 2003.
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    • Qiao, D., F. J. Seidler, and T. A. Slotkin. “Fetal chlorpyrifos exposure: Adverse effects on brain cell development and cholinergic biomarkers.” In Toxicological Sciences, 72:124–124. OXFORD UNIV PRESS, 2003.
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    • Xu, Z. A., F. J. Seidler, W. Slikker, and T. A. Slotkin. “Adolescent nicotine elicits glial and neuronal damage in rat brain.” In Neurotoxicology, 24:307–307. ELSEVIER SCIENCE BV, 2003.
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    • SEIDLER, F. J. “PRENATAL COCAINE EXPOSURE EVOKES LONG-LASTING CENTRAL NORADRENERGIC HYPERACTIVITY - PRESYNAPTIC AND POSTSYNAPTIC EVALUATIONS.” In Faseb Journal, 5:A1236–A1236. FEDERATION AMER SOC EXP BIOL, 1991.
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    • NEMEROFF, C. B., G. BISSETTE, T. A. SLOTKIN, F. J. SEIDLER, B. E. MILLER, and H. GHANBARI. “RECENT ADVANCES IN THE NEUROCHEMICAL PATHOLOGY OF ALZHEIMERS-DISEASE - STUDIES OF NEUROPEPTIDES, CHOLINERGIC FUNCTION AND ALZHEIMERS DISEASE-ASSOCIATED PROTEIN.” In Aging and Alzheimers Disease, edited by J. H. GROWDON, S. CORKIN, E. RITTERWALKER, and R. J. WURTMAN, 640:193–96. NEW YORK ACAD SCIENCES, 1991.
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    • SLOTKIN, T. A., E. M. KUDLACZ, Q. C. HOU, and F. J. SEIDLER. “MATURATION OF THE SYMPATHETIC NERVOUS-SYSTEM - ROLE IN NEONATAL PHYSIOLOGICAL ADAPTATIONS AND IN CELLULAR-DEVELOPMENT OF PERIPHERAL-TISSUES.” In Endocrine and Biochemical Development of the Fetus and the Neonate, edited by J. M. CUEZVA, A. M. PASCUALLEONE, and M. S. PATEL, 67–75. PLENUM PRESS DIV PLENUM PUBLISHING CORP, 1990.
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