Anxiolytic effects of acute morphine can be modulated by nitric oxide systems.

Journal Article (Journal Article)

This study was performed to investigate whether nitric oxide (NO) precursor (L-arginine), NO donor (S-nitroso-N-acetylpenicillamine, SNAP) and NO synthase inhibitors [N(G)-nitro-L-arginine-methylester (L-NAME) and N(G)-nitro-L-arginine (L-NOARG)] modulate morphine-induced anxiolytic effects in the plus-maze. L-Arginine (100, 200 and 300 mg kg(-1), i.p.) and SNAP (4, 8 and 10 mg kg(-1), i.p.) reduced the anxiolytic effect of morphine (20 mg kg(-1), s.c.). L-NAME (10, 20 and 40 mg/kg, i.p.) and L-NOARG (10, 15 and 20 mg kg(-1), i.p.) enhanced the anxiolytic effects of morphine (20 mg kg(-1), s.c.). On the other hand, L-arginine and SNAP increased the morphine-induced locomotor activity. L-NAME decreased the morphine-induced locomotor activity, but L-NOARG did not modify the morphine-induced locomotor activity. Therefore, these results suggest that the anxiolytic effects of morphine can be modulated by NO systems.

Full Text

Duke Authors

Cited Authors

  • Shin, I-C; Kim, H-C; Swanson, J; Hong, J-T; Oh, K-W

Published Date

  • August 2003

Published In

Volume / Issue

  • 68 / 4

Start / End Page

  • 183 - 189

PubMed ID

  • 12837972

International Standard Serial Number (ISSN)

  • 0031-7012

Digital Object Identifier (DOI)

  • 10.1159/000070457


  • eng

Conference Location

  • Switzerland