Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain.
The effect of acute swim stress on the functional activity of the gamma-aminobutyric acid (GABA) receptor/chloride ion channel was studied using an assay to measure 36chloride (36Cl-) uptake into rat brain synaptoneurosomes. Muscimol-stimulated 36Cl- uptake in cerebral cortex, hippocampus, but not cerebellum, was enhanced (increased potency and efficacy) in rats subjected to 10 min of swimming, compared to non-stressed, control rats. The effect of swim stress on the activity of the GABA receptor/Cl ion channel was prevented by adrenalectomy.
Schwartz, RD; Wess, MJ; Labarca, R; Skolnick, P; Paul, SM
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