Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain.
Journal Article (Journal Article)
The effect of acute swim stress on the functional activity of the gamma-aminobutyric acid (GABA) receptor/chloride ion channel was studied using an assay to measure 36chloride (36Cl-) uptake into rat brain synaptoneurosomes. Muscimol-stimulated 36Cl- uptake in cerebral cortex, hippocampus, but not cerebellum, was enhanced (increased potency and efficacy) in rats subjected to 10 min of swimming, compared to non-stressed, control rats. The effect of swim stress on the activity of the GABA receptor/Cl ion channel was prevented by adrenalectomy.
Full Text
Duke Authors
Cited Authors
- Schwartz, RD; Wess, MJ; Labarca, R; Skolnick, P; Paul, SM
Published Date
- May 12, 1987
Published In
Volume / Issue
- 411 / 1
Start / End Page
- 151 - 155
PubMed ID
- 2440512
International Standard Serial Number (ISSN)
- 0006-8993
Digital Object Identifier (DOI)
- 10.1016/0006-8993(87)90692-5
Language
- eng
Conference Location
- Netherlands