Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain.

Journal Article

The effect of acute swim stress on the functional activity of the gamma-aminobutyric acid (GABA) receptor/chloride ion channel was studied using an assay to measure 36chloride (36Cl-) uptake into rat brain synaptoneurosomes. Muscimol-stimulated 36Cl- uptake in cerebral cortex, hippocampus, but not cerebellum, was enhanced (increased potency and efficacy) in rats subjected to 10 min of swimming, compared to non-stressed, control rats. The effect of swim stress on the activity of the GABA receptor/Cl ion channel was prevented by adrenalectomy.

Full Text

Duke Authors

Cited Authors

  • Schwartz, RD; Wess, MJ; Labarca, R; Skolnick, P; Paul, SM

Published Date

  • May 12, 1987

Published In

Volume / Issue

  • 411 / 1

Start / End Page

  • 151 - 155

PubMed ID

  • 2440512

International Standard Serial Number (ISSN)

  • 0006-8993

Language

  • eng

Conference Location

  • Netherlands