Casein kinase I in the mammalian circadian clock.

Journal Article (Journal Article)

The circadian clock is characterized by daily fluctuations in gene expression, protein abundance, and posttranslational modification of regulatory proteins. The Drosophila PERIOD (dPER) protein is phosphorylated by the serine?threonine protein kinase, DOUBLETIME (DBT). Similarly, the murine PERIOD proteins, mPER1 and mPER2, are phosphorylated by casein kinase I epsilon (CKI), the mammalian homolog of DBT. CKIepsilon also phosphorylates and partially activates the transcription factor BMAL1. Given the variety of potential targets for CKIepsilon and other cellular kinases, the precise role of phosphorylation is likely to be a complex one. Biochemical analysis of these and other circadian regulatory proteins has proven to be a fruitful approach in determining how they function within the context of the molecular clockworks.

Full Text

Duke Authors

Cited Authors

  • Eide, EJ; Kang, H; Crapo, S; Gallego, M; Virshup, DM

Published Date

  • 2005

Published In

Volume / Issue

  • 393 /

Start / End Page

  • 408 - 418

PubMed ID

  • 15817302

Pubmed Central ID

  • PMC1513158

Electronic International Standard Serial Number (EISSN)

  • 1557-7988

Digital Object Identifier (DOI)

  • 10.1016/S0076-6879(05)93019-X


  • eng

Conference Location

  • United States