A physical map of the human genome.

Journal Article (Journal Article)

The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions. We also describe the integration of sequence data with the map.

Full Text

Duke Authors

Cited Authors

  • McPherson, JD; Marra, M; Hillier, L; Waterston, RH; Chinwalla, A; Wallis, J; Sekhon, M; Wylie, K; Mardis, ER; Wilson, RK; Fulton, R; Kucaba, TA; Wagner-McPherson, C; Barbazuk, WB; Gregory, SG; Humphray, SJ; French, L; Evans, RS; Bethel, G; Whittaker, A; Holden, JL; McCann, OT; Dunham, A; Soderlund, C; Scott, CE; Bentley, DR; Schuler, G; Chen, HC; Jang, W; Green, ED; Idol, JR; Maduro, VV; Montgomery, KT; Lee, E; Miller, A; Emerling, S; Kucherlapati, ; Gibbs, R; Scherer, S; Gorrell, JH; Sodergren, E; Clerc-Blankenburg, K; Tabor, P; Naylor, S; Garcia, D; de Jong, PJ; Catanese, JJ; Nowak, N; Osoegawa, K; Qin, S; Rowen, L; Madan, A; Dors, M; Hood, L; Trask, B; Friedman, C; Massa, H; Cheung, VG; Kirsch, IR; Reid, T; Yonescu, R; Weissenbach, J; Bruls, T; Heilig, R; Branscomb, E; Olsen, A; Doggett, N; Cheng, JF; Hawkins, T; Myers, RM; Shang, J; Ramirez, L; Schmutz, J; Velasquez, O; Dixon, K; Stone, NE; Cox, DR; Haussler, D; Kent, WJ; Furey, T; Rogic, S; Kennedy, S; Jones, S; Rosenthal, A; Wen, G; Schilhabel, M; Gloeckner, G; Nyakatura, G; Siebert, R; Schlegelberger, B; Korenberg, J; Chen, XN; Fujiyama, A; Hattori, M; Toyoda, A; Yada, T; Park, HS; Sakaki, Y; Shimizu, N; Asakawa, S; Kawasaki, K; Sasaki, T; Shintani, A; Shimizu, A; Shibuya, K; Kudoh, J; Minoshima, S; Ramser, J; Seranski, P; Hoff, C; Poustka, A; Reinhardt, R; Lehrach, H; International Human Genome Mapping Consortium,

Published Date

  • February 15, 2001

Published In

Volume / Issue

  • 409 / 6822

Start / End Page

  • 934 - 941

PubMed ID

  • 11237014

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/35057157

Language

  • eng

Conference Location

  • England