Simon Gray Gregory | Scholars@Duke

Simon Gray Gregory
Professor in Neurology

My principal area of research involves elucidating the molecular mechanisms underlying multi-factorial diseases. My lab is primarily interested identifying the complex genetic factors that give rise to multiple sclerosis (MS) and autism. We are using targeted approaches to identify differential methylation of the oxytocin receptor gene (OXTR) in individuals with autism, and applying these data to an NICHD funded ACE award, SOARS-B, to assess long term use of oxytocin nasal spray to improve social reciprocity in 300 children with autism, and for which we are developing e/genetic and transcriptomic predictors of response and effects of long term drug exposure.

My MS laboratory at Duke University is using cell signaling and immune cell flow sorting to establish the role of IL7R signaling in the development of MS; we are exploring the use of high sensitivity assays to develop a trajectory of disease development in progressive MS; we are exploring the use of endogenous oxysterols to trigger remyelination of white matter injury in MS; and establishing the immune expression and receptor profile of MS patients who do or do not respond to drug treatment.

I am PI of the MURDOCK-MS collection, a cross sectional MS cohort of ~1000 MS patients that will provide the basis for genetic, genomic and metabolomic biomarker identification of MS disease development and progression. I am Director of the Duke Center for Research in Autoimmunity and MS within the Duke Department of Neurology, and also Director of the Molecular Genomics Core at the DMPI in which we are applying a panoply of single cell approaches to basic and translation research.

Current Research Interests

Multiple Sclerosis

Autism

Coronary Artery Disease

Prostate and Lung cancer

Epigenetics of human disease

Application of single cell technologies to basic and translational research

Precision medicine of neurological disease

Current Appointments & Affiliations

Professor in Neurology, Neurology, MS & Neuroimmunology, Neurology 2016
Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2016
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003
Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2013

Contact Information

300 N. Duke Street, Room 51-102, Duke Molecular Physiology Institute, Durham, NC 27701
Duke Box 104775, Durham, NC 27701
simon.gregory@duke.edu (919) 684-0726
https://dmpi.duke.edu/faculty/simon-gregory-phd
https://genome.duke.edu/directory/cbb-faculty/simon-gregory-phd

Background
Education, Training, & Certifications
- Ph.D., Open University, Milton Keynes (U.K.) 2003
- B.A.Sc., RMIT University (Australia) 1990
Duke Appointment History
- Professor - TrackV of Medicine, Medicine, Medical Genetics, Medicine 2016
- Associate Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2010 - 2016
- Associate Professor in Medicine, Medicine, Medical Genetics, Medicine 2013 - 2016
- Associate Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2010 - 2013
- Assistant Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2006 - 2010
- Assistant Research Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2004 - 2006
Academic Positions Outside Duke
- Adjunct Graduate Faculty, Department of Biological and Biomedical Sciences, North Carolina Central University. 2018 - 2019
Recognition
In the News
- MAR 23, 2017 Duke Health News
  
  New Gene Interaction Appears to be Associated with Increased MS Risk
- NOV 7, 2016
  
  Mapping the Biology of Drug-Resistant Multiple Sclerosis
- JUN 26, 2015
  
  Allen Song Named Interim Director of Brain Institute
- JUN 11, 2015 NPR
  
  Simon Gregory quoted: More evidence that parents' ages could influence autism risk
- NOV 21, 2014
  
  Simon Gregory Inducted to MS Hall of Fame
- SEP 25, 2013 WRAL
  
  Community comes together for 9-year-old with rare condition
- AUG 13, 2013 CNN
  
  Autism linked to induced or augmented labor, study says
- AUG 13, 2013 BBC News
  
  Induced labor 'linked to autism'
- AUG 13, 2013
  
  Inducing and Augmenting Labor May be Associated with Increased Risk of Autism
- AUG 13, 2013 Wall Street Journal
  
  Study finds link between induced labor and autism diagnoses
Awards & Honors
Research
Selected Grants
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Mechanisms of oxysterol-induced oligodendrogenesis awarded by National Institutes of Health 2019 - 2024
- The role of gastrin in esophageal submucosal gland acinar ductal metaplasia awarded by National Institutes of Health 2018 - 2023
- Social Relationship Qualities as Predictors of Health & Aging from Adolescence thru Midlife 2018 - 2023
- Copper Homeostasis in Mammals awarded by National Institutes of Health 2004 - 2022
- Characterizing the (epi)genetics of oxytocin response in clinical and animal models awarded by National Institutes of Health 2017 - 2022
- Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma? awarded by National Institutes of Health 2019 - 2021
- Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2021
- Metabolic Pathways Of Pathogenic Th17 Cells In Myasthenia Gravis 2020
- Networks of nutritional stress in human pancreatic islet cells 2018 - 2020
- Development of Circulating Molecular Predictors of Chemotherapy and Novel Hormonal Therapy Benefit in Men with Metastatic Castration Resistant Prostate Cancer (mCRPC) 2014 - 2020
- Specific and Pervasive Symptoms in Adults with Multiple Sclerosis Using the MURDOCK-MS Dataset: A Secondary Analysis awarded by National Institutes of Health 2017 - 2020
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- 10X Single Cell Paired B/TCR Alpha and Beta Receptor and Transcriptome Pilot 2019 - 2020
- Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution awarded by Department of Defense 2015 - 2019
- Systems Biology Approaches for Predicting Cardiometabolic Risk in Persons Living with HIV awarded by National Institutes of Health 2015 - 2018
- Identifying Genetic and Epigenetic Signatures of Treatment Response to Oxytocin in Humans and Mice 2016 - 2018
- SOARS-B awarded by National Institutes of Health 2012 - 2018
- Integration of CT imaging features with cell-free plasma DNA as biomarkers for early lung cancer detection in patients with indeterminate pulmonary nodules 2016 - 2018
- SRA for Stephanie Arvai awarded by University of Texas Medical Branch 2016
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD awarded by National Institutes of Health 2009 - 2016
- A role for pathogen-induced IL-10 production in susceptibility to MS awarded by National Multiple Sclerosis Society 2014 - 2015
- Study of Oxytocin in Autism to improve Reciprocal Social Behaviors (SOARS-B) awarded by University of North Carolina - Chapel Hill 2012 - 2015
- Defining the Functional Role of a Novel MS Susceptibility Gene, IL7R alpha chain awarded by National Institutes of Health 2009 - 2015
- Linkage and candidate gene analysis in non-syndromic Chiari type I awarded by National Institutes of Health 2009 - 2015
- Study of Genetic Basis of Fuchs Corneal Dystrophy awarded by National Institutes of Health 2007 - 2013
- Genetic Mediators of Metabolic Cardiovascular Disease Risk awarded by National Institutes of Health 2009 - 2012
- Candidate Genes and Longitudinal Disability Phenotypes awarded by National Institutes of Health 2006 - 2012
- Molecular mechanisms of altered calcium sensing in human parathyroid disease awarded by National Institutes of Health 2010 - 2012
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- Hereditary basis of neural tube defects awarded by National Institutes of Health 1999 - 2010
- Genotyping - Illumina Methylation Analysis of DNA Samples awarded by National Institute of Environmental Health Sciences 2008 - 2010
- Genotyping - Methlylation Infinium Chips awarded by National Institute of Environmental Health Sciences 2008 - 2010
- Molecular Dissection of Cardiovascular Disease: From Genes to Models to Function awarded by National Institutes of Health 2007 - 2009
- GENECARD: Gene identification in Early-Onset CAD awarded by National Institutes of Health 2003 - 2009
- Molecular Genetics of Coronary Artery Disease awarded by National Institutes of Health 2006 - 2007
- High-Resolution CGH Characterization of Brain Tumors awarded by National Institutes of Health 2004 - 2006
External Relationships
- David H Murdock Research Institute
- Tellus Therapeutics
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Becker, Kristian C., Lydia Coulter Kwee, Megan L. Neely, Elizabeth Grass, Joseph A. Jakubowski, Keith A. A. Fox, Harvey D. White, et al. “Circulating MicroRNA Profiling in Non-ST Elevated Coronary Artery Syndrome Highlights Genomic Associations with Serial Platelet Reactivity Measurements.” Sci Rep 10, no. 1 (April 10, 2020): 6169. https://doi.org/10.1038/s41598-020-63263-6.
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  - Gupta, Santosh, Daniel H. Hovelson, Gabor Kemeny, Susan Halabi, Wen-Chi Foo, Monika Anand, Jason A. Somarelli, et al. “Discordant and heterogeneous clinically relevant genomic alterations in circulating tumor cells vs plasma DNA from men with metastatic castration resistant prostate cancer.” Genes Chromosomes Cancer 59, no. 4 (April 2020): 225–39. https://doi.org/10.1002/gcc.22824.
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  - Baht, G. S., A. Bareja, D. E. Lee, R. R. Rao, R. Huang, J. L. Huebner, D. B. Bartlett, et al. “Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nature Metabolism 2, no. 3 (March 1, 2020): 278–89. https://doi.org/10.1038/s42255-020-0184-y.
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  - Jewell, Mark L., Jason R. Gibson, Cynthia D. Guy, Jeongeun Hyun, Kuo Du, Seh-Hoon Oh, Richard T. Premont, et al. “Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1-Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma.” Am J Pathol 190, no. 1 (January 2020): 93–107. https://doi.org/10.1016/j.ajpath.2019.09.018.
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  - Yahara, Yasuhito, Tomasa Barrientos, Yuning J. Tang, Vijitha Puviindran, Puviindran Nadesan, Hongyuan Zhang, Jason R. Gibson, et al. “Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair.” Nat Cell Biol 22, no. 1 (January 2020): 49–59. https://doi.org/10.1038/s41556-019-0437-8.
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  - Abdulrahim, Jawan W., Lydia Coulter Kwee, Elizabeth Grass, Ilene C. Siegler, Redford Williams, Ravi Karra, William E. Kraus, Simon G. Gregory, and Svati H. Shah. “Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1).” J Am Heart Assoc 8, no. 21 (November 5, 2019): e013228. https://doi.org/10.1161/JAHA.119.013228.
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  - Kwee, Lydia Coulter, Megan L. Neely, Elizabeth Grass, Simon G. Gregory, Matthew T. Roe, E Magnus Ohman, Keith A. A. Fox, et al. “Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.” Physiol Genomics 51, no. 10 (October 1, 2019): 506–15. https://doi.org/10.1152/physiolgenomics.00033.2019.
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  - Andersen, S. L., F. B. S. Briggs, J. H. Winnike, Y. Natanzon, S. Maichle, K. J. Knagge, L. K. Newby, and S. G. Gregory. “Metabolome-based signature of disease pathology in MS.” Mult Scler Relat Disord 31 (June 2019): 12–21. https://doi.org/10.1016/j.msard.2019.03.006.
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  - Kousa, Youssef A., Huiping Zhu, Walid D. Fakhouri, Yunping Lei, Akira Kinoshita, Raeuf R. Roushangar, Nicole K. Patel, et al. “The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation.” Hum Mol Genet 28, no. 10 (May 15, 2019): 1726–37. https://doi.org/10.1093/hmg/ddz010.
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  - Armstrong, Andrew J., Susan Halabi, Jun Luo, David M. Nanus, Paraskevi Giannakakou, Russell Z. Szmulewitz, Daniel C. Danila, et al. “Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study.” J Clin Oncol 37, no. 13 (May 1, 2019): 1120–29. https://doi.org/10.1200/JCO.18.01731.
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  - Armstrong, Andrew J., Santosh Gupta, Patrick Healy, Gabor Kemeny, Beth Leith, Michael R. Zalutsky, Charles Spritzer, et al. “Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer.” Plos One 14, no. 5 (January 2019): e0216934. https://doi.org/10.1371/journal.pone.0216934.
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  - Dhingra, Radhika, Lydia Coulter Kwee, David Diaz-Sanchez, Robert B. Devlin, Wayne Cascio, Elizabeth R. Hauser, Simon Gregory, et al. “Evaluating DNA methylation age on the Illumina MethylationEPIC Bead Chip.” Plos One 14, no. 4 (2019): e0207834. https://doi.org/10.1371/journal.pone.0207834.
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  - Perkeybile, Allison M., C Sue Carter, Kelly L. Wroblewski, Meghan H. Puglia, William M. Kenkel, Travis S. Lillard, Themistoclis Karaoli, et al. “Early nurture epigenetically tunes the oxytocin receptor.” Psychoneuroendocrinology 99 (January 2019): 128–36. https://doi.org/10.1016/j.psyneuen.2018.08.037.
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  - Tailor, Tina D., Xiayu Rao, Michael J. Campa, Jing Wang, Simon G. Gregory, and Edward F. Patz. “Whole Exome Sequencing of Cell-Free DNA for Early Lung Cancer: A Pilot Study to Differentiate Benign From Malignant CT-Detected Pulmonary Lesions.” Front Oncol 9 (2019): 317. https://doi.org/10.3389/fonc.2019.00317.
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  - Towers, Aaron J., Martine W. Tremblay, Leeyup Chung, Xin-Lei Li, Alexandra L. Bey, Wenhao Zhang, Xinyu Cao, et al. “Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders.” Jci Insight 3, no. 23 (December 6, 2018). https://doi.org/10.1172/jci.insight.120592.
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  - Ward-Caviness, Cavin K., William E. Kraus, Colette Blach, Carol S. Haynes, Elaine Dowdy, Marie Lynn Miranda, Robert Devlin, et al. “Associations Between Residential Proximity to Traffic and Vascular Disease in a Cardiac Catheterization Cohort.” Arterioscler Thromb Vasc Biol 38, no. 1 (January 2018): 275–82. https://doi.org/10.1161/ATVBAHA.117.310003.
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  - Kanayama, Masashi, Shengjie Xu, Keiko Danzaki, Jason R. Gibson, Makoto Inoue, Simon G. Gregory, and Mari L. Shinohara. “Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.” Nat Immunol 18, no. 9 (September 2017): 973–84. https://doi.org/10.1038/ni.3791.
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  - Wang, Alice, Lydia Coulter Kwee, Elizabeth Grass, Megan L. Neely, Simon G. Gregory, Keith A. A. Fox, Paul W. Armstrong, et al. “Whole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome.” Atherosclerosis 261 (June 2017): 19–25. https://doi.org/10.1016/j.atherosclerosis.2017.03.041.
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  - Afshari, Natalie A., Robert P. Igo, Nathan J. Morris, Dwight Stambolian, Shiwani Sharma, V Lakshmi Pulagam, Steven Dunn, et al. “Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy.” Nat Commun 8 (March 30, 2017): 14898. https://doi.org/10.1038/ncomms14898.
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  - Galarza-Muñoz, Gaddiel, Farren B. S. Briggs, Irina Evsyukova, Geraldine Schott-Lerner, Edward M. Kennedy, Tinashe Nyanhete, Liuyang Wang, et al. “Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.” Cell 169, no. 1 (March 23, 2017): 72-84.e13. https://doi.org/10.1016/j.cell.2017.03.007.
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  - Gupta, Santosh, Jing Li, Gabor Kemeny, Rhonda L. Bitting, Joshua Beaver, Jason A. Somarelli, Kathryn E. Ware, Simon Gregory, and Andrew J. Armstrong. “Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer.” Clin Cancer Res 23, no. 5 (March 1, 2017): 1346–57. https://doi.org/10.1158/1078-0432.CCR-16-1211.
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  - Ward-Caviness, Cavin K., Lucas M. Neas, Colette Blach, Carol S. Haynes, Karen LaRocque-Abramson, Elizabeth Grass, Z Elaine Dowdy, et al. “A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic.” Plos One 12, no. 3 (2017): e0173880. https://doi.org/10.1371/journal.pone.0173880.
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  - Inoue, Makoto, Po-Han Chen, Stephen Siecinski, Qi-Jing Li, Chunlei Liu, Lawrence Steinman, Simon G. Gregory, Eric Benner, and Mari L. Shinohara. “An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage.” Nat Neurosci 19, no. 12 (December 2016): 1599–1609. https://doi.org/10.1038/nn.4421.
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  - Sullivan, Lori L., Kristin A. Maloney, Aaron J. Towers, Simon G. Gregory, and Beth A. Sullivan. “Human centromere repositioning within euchromatin after partial chromosome deletion.” Chromosome Res 24, no. 4 (December 2016): 451–66. https://doi.org/10.1007/s10577-016-9536-6.
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  - Zeng, Yi, Huashuai Chen, Ting Ni, Rongping Ruan, Chao Nie, Xiaomin Liu, Lei Feng, et al. “Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.” Rejuvenation Res 19, no. 3 (June 2016): 195–203. https://doi.org/10.1089/rej.2015.1737.
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  - Zeng, Yi, Chao Nie, Junxia Min, Xiaomin Liu, Mengmeng Li, Huashuai Chen, Hanshi Xu, et al. “Novel loci and pathways significantly associated with longevity.” Sci Rep 6 (February 25, 2016): 21243. https://doi.org/10.1038/srep21243.
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  - Dungan, Jennifer R., Xuejun Qin, Benjamin D. Horne, John F. Carlquist, Abanish Singh, Melissa Hurdle, Elizabeth Grass, et al. “Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship.” Plos One 11, no. 5 (2016): e0154856. https://doi.org/10.1371/journal.pone.0154856.
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  - Ward-Caviness, Cavin K., Lucas M. Neas, Colette Blach, Carol S. Haynes, Karen LaRocque-Abramson, Elizabeth Grass, Elaine Dowdy, et al. “Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease.” Plos One 11, no. 4 (2016): e0152670. https://doi.org/10.1371/journal.pone.0152670.
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  - Kraus, William E., Deborah M. Muoio, Robert Stevens, Damian Craig, James R. Bain, Elizabeth Grass, Carol Haynes, et al. “Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.” Plos Genet 11, no. 11 (November 2015): e1005553. https://doi.org/10.1371/journal.pgen.1005553.
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  - Riley, Ronald T., Olga Torres, Jorge Matute, Simon G. Gregory, Allison E. Ashley-Koch, Jency L. Showker, Trevor Mitchell, Kenneth A. Voss, Joyce R. Maddox, and Janee B. Gelineau-van Waes. “Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala.” Mol Nutr Food Res 59, no. 11 (November 2015): 2209–24. https://doi.org/10.1002/mnfr.201500499.
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  - Ward-Caviness, Cavin K., William E. Kraus, Colette Blach, Carol S. Haynes, Elaine Dowdy, Marie Lynn Miranda, Robert B. Devlin, et al. “Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients.” Environ Health Perspect 123, no. 10 (October 2015): 1007–14. https://doi.org/10.1289/ehp.1306980.
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  - Shah, Asad A., Simon G. Gregory, Deidre Krupp, Sheng Feng, Allison Dorogi, Carol Haynes, Elizabeth Grass, et al. “Epigenetic profiling identifies novel genes for ascending aortic aneurysm formation with bicuspid aortic valves.” Heart Surg Forum 18, no. 4 (August 30, 2015): E134–39. https://doi.org/10.1532/hsf.1247.
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  - Cope, Heidi, Melanie E. Garrett, Simon Gregory, and Allison Ashley-Koch. “Pregnancy continuation and organizational religious activity following prenatal diagnosis of a lethal fetal defect are associated with improved psychological outcome.” Prenat Diagn 35, no. 8 (August 2015): 761–68. https://doi.org/10.1002/pd.4603.
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  - Roberson, Elle C., William E. Dowdle, Aysegul Ozanturk, Francesc R. Garcia-Gonzalo, Chunmei Li, Jan Halbritter, Nadia Elkhartoufi, et al. “TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.” J Cell Biol 209, no. 1 (April 13, 2015): 129–42. https://doi.org/10.1083/jcb.201411087.
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  - Winnike, Jason H., Xiaoli Wei, Kevin J. Knagge, Steven D. Colman, Simon G. Gregory, and Xiang Zhang. “Comparison of GC-MS and GC×GC-MS in the analysis of human serum samples for biomarker discovery.” J Proteome Res 14, no. 4 (April 3, 2015): 1810–17. https://doi.org/10.1021/pr5011923.
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  - Shah, Asad A., Carol Haynes, Damian M. Craig, Jacqueline Sebek, Elizabeth Grass, Karen Abramson, Elizabeth Hauser, et al. “Genetic variants associated with vein graft stenosis after coronary artery bypass grafting.” Heart Surg Forum 18, no. 1 (February 27, 2015): E1–5. https://doi.org/10.1532/hsf.1214.
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  - Lock, Eric F., Karen L. Soldano, Melanie E. Garrett, Heidi Cope, Christina A. Markunas, Herbert Fuchs, Gerald Grant, David B. Dunson, Simon G. Gregory, and Allison E. Ashley-Koch. “Joint eQTL assessment of whole blood and dura mater tissue from individuals with Chiari type I malformation.” Bmc Genomics 16 (January 22, 2015): 11. https://doi.org/10.1186/s12864-014-1211-8.
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  - Li, Jing, Simon G. Gregory, Mariano A. Garcia-Blanco, and Andrew J. Armstrong. “Using circulating tumor cells to inform on prostate cancer biology and clinical utility.” Crit Rev Clin Lab Sci 52, no. 4 (2015): 191–210. https://doi.org/10.3109/10408363.2015.1023430.
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  - Riley, Ronald T., Jency L. Showker, Christine M. Lee, Cody E. Zipperer, Trevor R. Mitchell, Kenneth A. Voss, Nicholas C. Zitomer, et al. “A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans.” Food Addit Contam Part a Chem Anal Control Expo Risk Assess 32, no. 6 (2015): 934–49. https://doi.org/10.1080/19440049.2015.1027746.
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  - Torres, O., J. Matute, J. Gelineau-Van Waes, J. R. Maddox, S. G. Gregory, A. E. Ashley-Koch, J. L. Showker, K. A. Voss, and R. T. Riley. “Human health implications from co-exposure to aflatoxins and fumonisins in maize-based foods in Latin America: Guatemala as a case study.” World Mycotoxin Journal 8, no. 2 (January 1, 2015): 143–59. https://doi.org/10.3920/WMJ2014.1736.
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  - Krupp, Deidre R., Karen L. Soldano, Melanie E. Garrett, Heidi Cope, Allison E. Ashley-Koch, and Simon G. Gregory. “Missing genetic risk in neural tube defects: can exome sequencing yield an insight?” Birth Defects Res a Clin Mol Teratol 100, no. 8 (August 2014): 642–46. https://doi.org/10.1002/bdra.23276.
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  - Markunas, Christina A., Eric Lock, Karen Soldano, Heidi Cope, Chien-Kuang C. Ding, David S. Enterline, Gerald Grant, Herbert Fuchs, Allison E. Ashley-Koch, and Simon G. Gregory. “Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics.” Bmc Med Genomics 7 (June 25, 2014): 39. https://doi.org/10.1186/1755-8794-7-39.
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  - Li, Yi-Ju, Mollie A. Minear, Xuejun Qin, Jacqueline Rimmler, Michael A. Hauser, R Rand Allingham, Robert P. Igo, et al. “Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy.” Invest Ophthalmol Vis Sci 55, no. 7 (June 10, 2014): 4577–84. https://doi.org/10.1167/iovs.13-13517.
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  - Miranda, Marie Lynn, Rebecca Anthopolos, and Simon G. Gregory. “Association of autism with induced or augmented childbirth.” Am J Obstet Gynecol 210, no. 5 (May 2014): 492–93. https://doi.org/10.1016/j.ajog.2013.12.038.
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  - Torres, Olga, Jorge Matute, Janee Gelineau-van Waes, Joyce R. Maddox, Simon G. Gregory, Allison E. Ashley-Koch, Jency L. Showker, Nicholas C. Zitomer, Kenneth A. Voss, and Ronald T. Riley. “Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala.” Mol Nutr Food Res 58, no. 5 (May 2014): 973–83. https://doi.org/10.1002/mnfr.201300481.
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  - McGarrah, Robert, Damian M. Craig, Carol Haynes, Elizabeth Hauser, Christopher B. Newgard, Simon G. Gregory, William Kraus, and Svati Shah. “OMICS PROFILING HIGHLIGHTS ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION AND UBIQUITIN PROTEASOME PATHWAYS IN INSULIN RESISTANCE AND GLYCEMIC CONTROL.” Journal of the American College of Cardiology 63, no. 12 (April 2014): A1600–A1600. https://doi.org/10.1016/s0735-1097(14)61603-x.
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  - Gregory, Simon G. “Genetic predisposition of behavioral response.” Proc Natl Acad Sci U S A 111, no. 5 (February 4, 2014): 1672–73. https://doi.org/10.1073/pnas.1323421111.
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  - Miranda, Marie Lynn, Rebecca Anthopolos, and Simon G. Gregory. “Induction or augmentation of labor and autism--reply.” Jama Pediatr 168, no. 2 (February 2014): 191–92. https://doi.org/10.1001/jamapediatrics.2013.4792.
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  - Gregory, Simon G., Rebecca Anthopolos, Claire E. Osgood, Chad A. Grotegut, and Marie Lynn Miranda. “Association of Autism With Induced or Augmented Childbirth in North Carolina Birth Record (1990–1998) and Education Research (1997–2007) Databases.” Obstetrical & Gynecological Survey 69, no. 1 (January 2014): 7–9. https://doi.org/10.1097/01.ogx.0000442814.50107.fa.
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  - Markunas, Christina A., David S. Enterline, Kaitlyn Dunlap, Karen Soldano, Heidi Cope, Jeffrey Stajich, Gerald Grant, Herbert Fuchs, Simon G. Gregory, and Allison E. Ashley-Koch. “Genetic evaluation and application of posterior cranial fossa traits as endophenotypes for Chiari type I malformation.” Ann Hum Genet 78, no. 1 (January 2014): 1–12. https://doi.org/10.1111/ahg.12041.
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  - Connelly, Jessica J., Olga A. Cherepanova, Jennifer F. Doss, Themistoclis Karaoli, Travis S. Lillard, Christina A. Markunas, Sarah Nelson, et al. “Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis.” Hum Mol Genet 22, no. 25 (December 20, 2013): 5107–20. https://doi.org/10.1093/hmg/ddt365.
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  - International Human Genome Sequencing Consortium, Adrian F. “Finishing the euchromatic sequence of the human genome.” Nature 431, no. 7011 (October 21, 2004): 931–45. https://doi.org/10.1038/nature03001.
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  - Mallon, Ann-Marie, Laurens Wilming, Joseph Weekes, James G. R. Gilbert, Jennifer Ashurst, Sandrine Peyrefitte, Lucy Matthews, et al. “Organization and evolution of a gene-rich region of the mouse genome: a 12.7-Mb region deleted in the Del(13)Svea36H mouse.” Genome Res 14, no. 10A (October 2004): 1888–1901. https://doi.org/10.1101/gr.2478604.
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  - Sawcer, Stephen J., Mel Maranian, Sara Singlehurst, TaiWai Yeo, Alastair Compston, Mark J. Daly, Philip L. De Jager, et al. “Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.” Hum Mol Genet 13, no. 17 (September 1, 2004): 1943–49. https://doi.org/10.1093/hmg/ddh202.
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  - Wicker, Linda S., Giselle Chamberlain, Kara Hunter, Dan Rainbow, Sarah Howlett, Paul Tiffen, Jan Clark, et al. “Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.” J Immunol 173, no. 1 (July 1, 2004): 164–73. https://doi.org/10.4049/jimmunol.173.1.164.
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  - Penha-Gonçalves, Carlos, Carolyn Moule, Luc J. Smink, Joanna Howson, Simon Gregory, Jane Rogers, Paul A. Lyons, et al. “Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice.” Diabetes 52, no. 6 (June 2003): 1551–56. https://doi.org/10.2337/diabetes.52.6.1551.
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  - Ueda, Hironori, Joanna M. M. Howson, Laura Esposito, Joanne Heward, Hywel Snook, Giselle Chamberlain, Daniel B. Rainbow, et al. “Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.” Nature 423, no. 6939 (May 2003): 506–11. https://doi.org/10.1038/nature01621.
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  - Hoffman, Hal M., Simon G. Gregory, James L. Mueller, Mark Tresierras, David H. Broide, Alan A. Wanderer, and Richard D. Kolodner. “Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P.” Hum Genet 112, no. 2 (February 2003): 209–16. https://doi.org/10.1007/s00439-002-0860-x.
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  - Mouse Genome Sequencing Consortium, Eric S., Robert H. Waterston, Kerstin Lindblad-Toh, Ewan Birney, Jane Rogers, Josep F. Abril, Pankaj Agarwal, et al. “Initial sequencing and comparative analysis of the mouse genome.” Nature 420, no. 6915 (December 5, 2002): 520–62. https://doi.org/10.1038/nature01262.
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  - Ewens, Kathryn G., Lindsey N. Johnson, Beth Wapelhorst, Kristin O’Brien, Sarah Gutin, V Anne Morrison, Craig Street, Simon G. Gregory, Richard S. Spielman, and Patrick Concannon. “Linkage and association with type 1 diabetes on chromosome 1q42.” Diabetes 51, no. 11 (November 2002): 3318–25. https://doi.org/10.2337/diabetes.51.11.3318.
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  - Parvari, Ruti, Eli Hershkovitz, Nili Grossman, Rafael Gorodischer, Bart Loeys, Alexandra Zecic, Geert Mortier, et al. “Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism and autosomal recessive Kenny-Caffey syndrome.” Nature Genetics 32, no. 3 (November 2002): 448–52. https://doi.org/10.1038/ng1012.
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  - Gregory, Simon G., Mandeep Sekhon, Jacqueline Schein, Shaying Zhao, Kazutoyo Osoegawa, Carol E. Scott, Richard S. Evans, et al. “A physical map of the mouse genome.” Nature 418, no. 6899 (August 15, 2002): 743–50. https://doi.org/10.1038/nature00957.
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  - McMullan, Tristan W., John A. Crolla, Simon G. Gregory, Nigel P. Carter, Rachel A. Cooper, Gareth R. Howell, and David O. Robinson. “A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation.” Hum Genet 110, no. 3 (March 2002): 244–50. https://doi.org/10.1007/s00439-002-0679-5.
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  - Watanabe, Y., J. C. Murray, B. C. Bjork, C. P. Bird, P. W. Chiang, S. G. Gregory, D. M. Kurnit, and B. C. Schutte. “Matroshka and ectopic polymorphisms: Two new classes of DNA sequence variation identified at the Van der Woude syndrome locus on 1q32-q41.” Hum Mutat 18, no. 5 (November 2001): 422–34. https://doi.org/10.1002/humu.1213.
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  - Cai, W. W., C. W. Chow, S. Damani, S. G. Gregory, M. Marra, and A. Bradley. “An SSLP marker-anchored BAC framework map of the mouse genome.” Nat Genet 29, no. 2 (October 2001): 133–34. https://doi.org/10.1038/ng1001-133.
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  - Lander, E. S., L. M. Linton, B. Birren, C. Nusbaum, M. C. Zody, J. Baldwin, K. Devon, et al. “Erratum: Initial sequencing and analysis of the human genome: International Human Genome Sequencing Consortium (Nature (2001) 409 (860-921)).” Nature 412, no. 6846 (August 2, 2001): 565–66. https://doi.org/10.1038/35087627.
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  - Stover, C., Y. Endo, M. Takahashi, N. J. Lynch, C. Constantinescu, T. Vorup-Jensen, S. Thiel, et al. “The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.” Genes and Immunity 2, no. 3 (May 2001): 119–27. https://doi.org/10.1038/sj.gene.6363745.
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  - Doudney, K., J. N. Murdoch, C. Paternotte, L. Bentley, S. Gregory, A. J. Copp, and P. Stanier. “Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23.” Genomics 72, no. 2 (March 1, 2001): 180–92. https://doi.org/10.1006/geno.2000.6463.
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  - Lander, E. S., L. M. Linton, B. Birren, C. Nusbaum, M. C. Zody, J. Baldwin, K. Devon, et al. “Initial sequencing and analysis of the human genome.” Nature 409, no. 6822 (February 15, 2001): 860–921. https://doi.org/10.1038/35057062.
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  - Bentley, D. R., P. Deloukas, A. Dunham, L. French, S. G. Gregory, S. J. Humphray, A. J. Mungall, et al. “The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X.” Nature 409, no. 6822 (February 2001): 942–43. https://doi.org/10.1038/35057165.
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  - McPherson, J. D., M. Marra, L. Hillier, R. H. Waterston, A. Chinwalla, J. Wallis, M. Sekhon, et al. “A physical map of the human genome.” Nature 409, no. 6822 (February 2001): 934–41. https://doi.org/10.1038/35057157.
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  - Schutte, B. C., J. D. Carpten, A. Forus, S. G. Gregory, A. Horii, and P. S. White. “Report of the sixth international workshop on human chromosome 1 mapping 2000.” Cytogenetics and Cell Genetics 92, no. 1–2 (January 1, 2001): 23–48.
  - White, P. S., P. M. Thompson, B. A. Seifried, E. P. Sulman, S. J. Jensen, C. Guo, J. M. Maris, et al. “Detailed molecular analysis of 1p36 in neuroblastoma.” Med Pediatr Oncol 36, no. 1 (January 2001): 37–41. https://doi.org/10.1002/1096-911X(20010101)36:1<37::AID-MPO1010>3.0.CO;2-L.
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  - Carpten, J. D., I. Makalowska, C. M. Robbins, N. Scott, R. Sood, T. D. Connors, T. I. Bonner, et al. “A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region.” Genomics 64, no. 1 (February 15, 2000): 1–14. https://doi.org/10.1006/geno.1999.6051.
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  - Shackleton, S., D. J. Lloyd, S. N. Jackson, R. Evans, M. F. Niermeijer, B. M. Singh, H. Schmidt, et al. “LMNA, encoding lamin A/C, is mutated in partial lipodystrophy.” Nature Genetics 24, no. 2 (February 2000): 153–56. https://doi.org/10.1038/72807.
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  - Schutte, B. C., B. C. Bjork, K. B. Coppage, M. I. Malik, S. G. Gregory, D. J. Scott, L. M. Brentzell, Y. Watanabe, M. J. Dixon, and J. C. Murray. “A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41.” Genome Res 10, no. 1 (January 2000): 81–94.
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  - White, P. S., A. Forus, T. C. Matise, B. C. Schutte, N. Spieker, P. Stanier, J. M. Vance, and S. G. Gregory. “Fifth International Workshop on Human Chromosome 1 Mapping 1999, the Sanger Centre, Cambridge, UK, August 5-7 1999: Report.” Cytogenetics and Cell Genetics 87, no. 3–4 (December 1, 1999): 143–63.
  - Labay, V., T. Raz, D. Baron, H. Mandel, H. Williams, T. Barrett, R. Szargel, et al. “Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness.” Nat Genet 22, no. 3 (July 1999): 300–304. https://doi.org/10.1038/10372.
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  - Gregory, S. G., M. Vaudin, R. Wooster, M. Coleman, D. Mischke, C. Porter, B. C. Schutte, P. White, and J. M. Vance. “Fourth International Workshop on Human Chromosome 1 Mapping 1998, Sanger Centre, Cambridge, United Kingdom, June 25-27 1998: Report.” Cytogenetics and Cell Genetics 83, no. 3–4 (December 1, 1998): 147–67.
  - Gregory, S. G., M. Vaudin, R. Wooster, M. Coleman, D. Mischke, C. Porter, B. C. Schutte, P. White, and J. M. Vance. “Report of the fourth international workshop on human chromosome 1 mapping 1998.” Cytogenetics and Cell Genetics 83, no. 3–4 (January 1, 1998): 148–67.
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  - Gregory, S. G., G. R. Howell, and D. R. Bentley. “Genome mapping by fluorescent fingerprinting.” Genome Res 7, no. 12 (December 1997): 1162–68. https://doi.org/10.1101/gr.7.12.1162.
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  - Roest Crollius, H., M. T. Ross, A. Grigoriev, C. J. Knights, E. Holloway, J. Misfud, K. Li, et al. “An integrated YAC map of the human X chromosome.” Genome Res 6, no. 10 (October 1996): 943–55. https://doi.org/10.1101/gr.6.10.943.
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  - Forbes, S. A., L. Brennan, M. Richardson, A. Coffey, C. G. Cole, S. G. Gregory, D. R. Bentley, S. Mumm, G. E. Moore, and P. Stanier. “Refined mapping and YAC contig construction of the X-linked cleft palate and ankyloglossia locus (CPX) including the proximal X-Y homology breakpoint within Xq21.3.” Genomics 31, no. 1 (January 1, 1996): 36–43. https://doi.org/10.1006/geno.1996.0006.
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  - Van de Vosse, E., A. A. Bergen, E. J. Meershoek, J. C. Oosterwijk, S. Gregory, B. Bakker, J. Weissenbach, A. J. Coffey, G. J. van Ommen, and J. T. Den Dunnen. “An Xp22.1-p22.2 YAC contig encompassing the disease loci for RS, KFSD, CLS, HYP and RP15: refined localization of RS.” Eur J Hum Genet 4, no. 2 (1996): 101–4. https://doi.org/10.1159/000472177.
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  - Wooster, R., G. Bignell, J. Lancaster, S. Swift, S. Seal, J. Mangion, N. Collins, et al. “Addendum: Identification of the breast cancer susceptibility gene BRCA2 (Nature (1995) 378 (789-792)).” Nature 379, no. 6567 (January 1, 1996): 749.
  - Wooster, R., G. Bignell, J. Lancaster, S. Swift, S. Seal, J. Mangion, N. Collins, S. Gregory, C. Gumbs, and G. Micklem. “Identification of the breast cancer susceptibility gene BRCA2.” Nature 378, no. 6559 (December 21, 1995): 789–92. https://doi.org/10.1038/378789a0.
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  - Fantes, J. A., K. Oghene, S. Boyle, S. Danes, J. M. Fletcher, E. A. Bruford, K. Williamson, A. Seawright, A. Schedl, and I. Hanson. “A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1.” Genomics 25, no. 2 (January 20, 1995): 447–61. https://doi.org/10.1016/0888-7543(95)80045-n.
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  - Redeker, E., J. M. Hoovers, M. Alders, C. J. van Moorsel, A. C. Ivens, S. Gregory, L. Kalikin, J. Bliek, L. de Galan, and R. van den Bogaard. “An integrated physical map of 210 markers assigned to the short arm of human chromosome 11.” Genomics 21, no. 3 (June 1994): 538–50. https://doi.org/10.1006/geno.1994.1312.
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  - Heding, I. J., A. C. Ivens, J. Wilson, M. Strivens, S. Gregory, J. M. Hoovers, M. Mannens, B. Redeker, D. Porteous, and V. van Heyningen. “The generation of ordered sets of cosmid DNA clones from human chromosome region 11p.” Genomics 13, no. 1 (May 1992): 89–94. https://doi.org/10.1016/0888-7543(92)90206-8.
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- Book Sections
  - Gregory, S. G. “The epigenetics of Autism-Running beyond the bases.” In Frontiers in Autism Research: New Horizons for Diagnosis and Treatment, 303–33, 2014. https://doi.org/10.1142/9789814602167_0013.
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  - Markunas, C. A., A. E. Ashley-Koch, and S. G. Gregory. “Genetics of the Chiari i and II malformations.” In The Chiari Malformations, 9781461463696:93–101, 2013. https://doi.org/10.1007/978-1-4614-6369-6_7.
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  - Gregory, S. G. “Genomic Rearrangements in Autism: The Contribution of Copy Number Loss and Gain to the Etiology of Autism Spectrum Disorders.,” 52:S17–S17. WILEY-BLACKWELL, 2011.
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  - Gregory, Simon, and John Gilbert. “Strategies for genotype generation.,” Chapter 1:Unit-1.3, 2005. https://doi.org/10.1002/0471142905.hg0103s47.
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  - Stenger, J. E., and S. G. Gregory. “Genomics and Bioinformatics.” In Genetic Analysis of Complex Diseases: Second Edition, 423–54, 2005. https://doi.org/10.1002/9780471781141.ch15.
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  - Coffey, A., S. Gregory, and C. G. Cole. “Alu-PCR fingerprinting of YACs.,” 54:97–114, 1996. https://doi.org/10.1385/0-89603-313-9:97.
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- Reports
  - Schutte, B. C., J. D. Carpten, A. Forus, S. G. Gregory, A. Horii, and P. S. White. “Report and abstracts of the sixth international workshop on human chromosome 1 mapping 2000. Iowa City, Iowa, USA. 30 September-3 October 2000.,” 2001. https://doi.org/10.1159/000056867.
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  - White, P. S., A. Forus, T. C. Matise, B. C. Schutte, N. Spieker, P. Stanier, J. M. Vance, and S. G. Gregory. “Report of the fifth international workshop on human chromosome 1 mapping 1999.,” 1999. https://doi.org/10.1159/000015458.
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  - Gregory, S. G., M. Vaudin, R. Wooster, M. Coleman, D. Mischke, C. Porter, B. C. Schutte, P. White, and J. M. Vance. “Report of the fourth international workshop on human chromosome 1 mapping 1998,” 1998. https://doi.org/10.1159/000015174.
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  - Vance, J. M., T. C. Matise, R. Wooster, B. C. Schutte, G. A. P. Bruns, N. Van Roy, G. M. Brodeur, et al. “Third International Chromosome 1 Maping Workshop, Duke University, Durham, NC, USA, 25-27 April 1997: Report of the third international workshop on human chromosome 1 mapping 1997,” December 1, 1997.
  - Vance, J. M., T. C. Matise, R. Wooster, B. C. Schutte, G. A. Bruns, N. van Roy, G. M. Brodeur, et al. “Report and abstracts of the third international workshop on human chromosome 1 mapping 1997.,” 1997.
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- Conference Papers
  - Oh, Seh-Hoon, Mark Jewell, Richard T. Premont, Jason Gibson, Wayne Glover, Simon G. Gregory, David Hsu, Cynthia D. Guy, and Anna Mae Diehl. “Yap1 AS A THERAPEUTIC TARGET IN FIBROLAMELLAR CARCINOMA.” In Hepatology, 70:888A-889A. WILEY, 2019.
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  - Jewell, Mark, Richard T. Premont, Jason Gibson, Wayne Glover, Timothy A. Dinh, Eliane L. Wauthier, Lola M. Reid, et al. “Yap1 As a Therapeutic Target in Fibrolamellar Carcinoma.” In Hepatology, 68:1243A-1243A. WILEY, 2018.
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  - Kanayama, Masashi, Shengjie Xu, Keiko Danzaki, Jason R. Gibson, Makoto Inoue, Simon G. Gregory, and Mari L. Shinohara. “Skewing the population balance between lymphoid and myeloid cells by osteopontin isoforms.” In Cytokine, 100:161–161. ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2017.
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  - Cote, Sabrina A., Simon G. Gregory, Jason Winnike, Kevin Knagge, Olga Ilkayeva, Thomas O’Connell, James Bain, et al. “Integrated metabolomic and transcriptomic profiles of males with multiple sclerosis.” In Multiple Sclerosis Journal, 22:9–10. SAGE PUBLICATIONS LTD, 2016.
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  - Shah, Svati H., Lydia Kwee, Nathan Stitziel, Elizabeth R. Hauser, Carol Haynes, Sekar Kathiresan, Simon G. Gregory, and William E. Kraus. “Rare Variants Identified With Whole Exome Chip Genotyping Are Associated With Insulin Resistance and Glycemic Control.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Kraus, William E., Sheng Feng, Elizabeth R. Hauser, Simon G. Gregory, Carol Haynes, Z. E. Dowdy, Damian M. Craig, and Svati H. Shah. “Association of Gene Expression Signatures with Small Molecule Metabolic Intermediates that Predict Cardiovascular Mortality in CATHGEN.” In Circulation, Vol. 127. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Shah, Asad A., Damian M. Craig, Carol Haynes, Jacqueline K. Sebek, Elizabeth Grass, Karen Abramson, Peter K. Smith, et al. “Genome-Wide Association Identifies Genetic Variants Associated With Vein Graft Stenosis After Coronary Artery Bypass Grafting.” In Circulation, Vol. 124. LIPPINCOTT WILLIAMS & WILKINS, 2011.
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  - Minear, M. A., N. A. Afshari, E. Balajonda, B. Zhao, J. Rimmler, Y. -. J. Li, G. K. Klintworth, and S. G. Gregory. “Analysis of SLC4A11 and COL8A2 Mutations in Fuchs Endothelial Corneal Dystrophy (FECD).” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.
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  - Wang, Liyong, Elizabeth R. Hauser, David Crosslin, Sarah Nelson, A. B. Hale, Simon G. Gregory, Svati H. Shah, William E. Kraus, Pascal J. Goldschmidt-Clermont, and Jeffery M. Vance. “Genomic convergence identified CAPG and VAMP8 as candidate genes for CAD.” In Circulation, 116:807–807. LIPPINCOTT WILLIAMS & WILKINS, 2007.
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  - Wang, Liyong, Elizabeth R. Hauser, Svati H. Shah, Carol Haynes, Jason M. Rose, Marco Harris, Julie Rombaut, et al. “Identification of kalirin gene as a novel coronary artery disease gene through peak-wide association mapping on chromosome 3q13-21.” In Circulation, 114:887–887. LIPPINCOTT WILLIAMS & WILKINS, 2006.
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  - Gregory, S. G., N. V. Johnson, J. J. Connelly, J. Virgadamo, R. E. McLendon, J. M. Vance, and D. D. Bigner. “Characterizing genomic rearrangements in oligodendroglioma using whole genome tilepath hrCGH arrays.” In Neuro Oncology, 8:421–421. DUKE UNIV PRESS, 2006.
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  - Johnson, Nicole V., Jessica J. Connelly, Josh Virigadamo, Roger E. McLendon, Jeffrey M. Vance, Darell D. Bigner, and Simon G. Gregory. “Characterizing oligodendroglioma rearrangements using whole genome hrCGH arrays.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.
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  - Meza-Zepeda, Leonardo A., Stine H. Kresse, Ana H. Barragan-Polania, Junbai Wang, Bjorn E. Kristiansen, Wen-Lin Kuo, Simon G. Gregory, Joe W. Gray, and Ola Myklebost. “Profiling of DNA copy number changes in sarcomas by array comparative genomic hybridization.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.
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  - Wang, L. Y., E. R. Hauser, S. H. Shah, W. E. Kraus, D. Seo, L. L. Huang, J. M. Rose, et al. “Identification of a novel locus for left main coronary artery disease.” In Circulation, 112:U413–U413. LIPPINCOTT WILLIAMS & WILKINS, 2005.
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  - Haines, J. L., S. Schmidt, S. Sawcer, L. F. Barcellos, S. G. Gregory, J. Sims, M. Booze, et al. “Comprehensive analysis of candidate modifier genes for multiple sclerosis (MS) on chromosome 19q13.” In American Journal of Human Genetics, 73:368–368. UNIV CHICAGO PRESS, 2003.
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  - Maris, J. M., C. Guo, D. Blake, P. S. White, M. D. Hogarty, P. M. Thompson, V. Rajalingam, et al. “Comprehensive analysis of chromosome 1p deletions in neuroblastoma.” In Med Pediatr Oncol, 36:32–36, 2001. https://doi.org/10.1002/1096-911X(20010101)36:1<32::AID-MPO1009>3.0.CO;2-0.
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  - Little, D., C. L. Wu, R. D’Amico, D. Corcoran, S. Gregory, and F. Guilak. “Epigenetic Analysis of Adipose Stem Cells in Obesity Identifies Dysregulation of Critical Pathways in Musculoskeletal Regeneration and Disease.,” n.d.
Teaching & Mentoring
Recent Courses
Advising & Mentoring
- Dr. Gregory is/has mentored high school (12), undergraduate (14), graduate candidate rotation (9), graduate candidate thesis committee (14), graduate candidate primary mentor (6), Masters candidate (1), Post-doctoral fellow (4) and junior faculty (5) trainees.
Teaching Activities
- 2003, 2004 and 2011 Lecturer, “Molecules and Cells” (IND100B),
  2004 and 2005 Co-Director, Lecturer, “Fundamentals in Genetics” (MGTP),
  
  2004 – 2013 Director and Instructor, Duke Bioinformatics Workshop
  
  2005 Lecturer, “Algorithms in computational biology” (BGT 203)
  2005 – 2010, 2012 – present Lecturer, "Human Genetics" (MGM/UPGG 732)
  2006 – 2008, 2014, 2016 Lecturer, Open Door Workshop, Montevideo, Uruguay
  
  2006 – present Director, Lecturer, Clinical Research Training Program, “Introduction to Medical Genetics” (CRTP 243)
  
  2010-11, 2013-14, 2016 Guest Lecturer, “Genetic Engineer/Biotech” (BIO 280S)
  
  2011 Lecturer, Open Door Workshop, Dubai, UAE.
  
  2012 Lecturer, “Applied Genomics and Personalized Medicine” (N562)
  
  2012 Lecturer, Open Door Workshop, Ho Chi Minh City, Vietnam, 2012
  2013 – present Lecturer, "Genome Technologies" (MGM/UPGG 778)
  2015 – present Faculty reviewer, “Grant writing” (UPGEN 702)
  
  2016 Lecturer, Open Door Workshop, Bangkok, Thailand
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Outreach & Engaged Scholarship
- Faculty Mentor. Durham School of the Arts Independent Study Partnership with DMPI. 2014 - 2020 2014 - 2020
Service to the Profession
Service to Duke
Academic & Administrative Activities
- Director and Instructor - Duke Bioinformatics Workshop 2004-2013
  
  Founding Co-Director - Duke Epigenetics an Epigenomics Program (DEEP) 2011-present
  
  Co-Director - Genetics and Genomics Basic Sciences Program 2014-2017
  
  Director - Duke Center for Research in Autoimmunity and Multiple Sclerosis (DREAMS), Department of Neurology.
  Organizer of DREAMS Seminar Speaker Series 2015-present
  
  Director of Graduate Studies - Duke University Program of Genetics and Genomics 2017-Present

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Education, Training, & Certifications

Duke Appointment History

Academic Positions Outside Duke

In the News

Awards & Honors

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Reports

Conference Papers

Recent Courses

Advising & Mentoring

Teaching Activities

Presentations & Appearances

Outreach & Engaged Scholarship

Service to the Profession

Service to Duke

Academic & Administrative Activities