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Simon Gray Gregory

Margaret Harris and David Silverman Distinguished Professor
Neurosurgery, Neuro-Oncology
Duke Box 104775, Durham, NC 27701
300 N. Duke Street, Room 51-102, Duke Molecular Physiology Institute, Durham, NC 27701

Overview


Dr. Gregory is the Margaret Harris and David Silverman Distinguished Professor and Director of the Brain Tumor Omics Program in the Duke Department of Neurosurgery, the Vice Chair of Research in the Department of Neurology, and Director of the Molecular Genomics Core at the Duke Molecular Physiology Institute. 

As a neurogenomicist, Dr. Gregory applies the experience gained from leading the sequencing of chromosome 1 for the Human Genome Project to elucidating the mechanisms underlying multi-factorial diseases using genetic, genomic, and epigenetic approaches. Dr. Gregory’s primary areas of research involve understanding the molecular processes associated with disease development and progression in brain tumors and Alzheimer’s disease, drug induced white matter injury repair in multiple sclerosis, and the characterization of lesion microenvironmental changes in MS.

He is broadly regarded across Duke as a leader in the development of novel single cell and spatial molecular technologies towards understanding the pathogenic mechanisms of disease development. Dr. Gregory is also the Section Chair of Genomics and Epigenetics at the DMPI and Director of the Duke Center of Autoimmunity and MS in the Department of Neurology.

Current Appointments & Affiliations


Margaret Harris and David Silverman Distinguished Professor · 2024 - Present Neurosurgery, Neuro-Oncology, Neurosurgery
Professor in Neurosurgery · 2022 - Present Neurosurgery, Neuro-Oncology, Neurosurgery
Vice Chair for Research in the Department of Neurology · 2020 - Present Neurology, Clinical Science Departments
Professor in Molecular Genetics and Microbiology · 2021 - Present Molecular Genetics and Microbiology, Basic Science Departments
Professor in Neurology · 2022 - Present Neurology, Clinical Science Departments
Member of the Duke Cancer Institute · 2003 - Present Duke Cancer Institute, Institutes and Centers
Member of Duke Molecular Physiology Institute · 2013 - Present Duke Molecular Physiology Institute, Institutes and Centers

In the News


Published March 19, 2024
Duke Awards 32 New Distinguished Professorships for 2024
Published March 20, 2022
Alzheimer's Research: Unlocking the Secrets of the Brain
Published March 23, 2017
New Gene Interaction Appears to be Associated with Increased MS Risk

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Recent Publications


Insights into Keratinocyte and Immunologic Landscape in Cutaneous Graft-Versus-Host Disease through Single-Cell Transcriptomics.

Journal Article JID Innov · July 2025 Cutaneous manifestations are the most common presenting sign of chronic graft-versus-host disease (GVHD), and the extent of cutaneous involvement is also highly correlated with prognosis. Very little is understood about the underlying pathogenesis underpin ... Full text Link to item Cite

Disruption of ataxia telangiectasia-mutated kinase enhances radiation therapy efficacy in spatially directed diffuse midline glioma models.

Journal Article J Clin Invest · June 16, 2025 Diffuse midline gliomas (DMGs) are lethal brain tumors characterized by p53-inactivating mutations and oncohistone H3.3K27M mutations that rewire the cellular response to genotoxic stress. We used RCAS/tv-a retroviruses and Cre recombinase to inactivate p5 ... Full text Link to item Cite

Cutaneous dysbiosis characterizes the post-allogeneic hematopoietic stem cell transplantation period.

Journal Article Blood Adv · May 13, 2025 Gut dysbiosis is linked to mortality and the development of graft-versus-host disease after hematopoietic stem cell transplantation (HSCT), but the impact of cutaneous dysbiosis remains unexplored. We performed a pilot observational study, obtained retroau ... Full text Link to item Cite
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Recent Grants


Pathogenic Mechanisms of Inflammatory Subventricular Zone Injury in Preterm Infants

ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2030

Targeting Hepatocyte Senescence to Improve NAFLD

ResearchAdvisor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029

Pathways of Injury and Repair in Barrett's Carcinogenesis

ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2023 - 2028

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Education, Training & Certifications


Open University, Milton Keynes (United Kingdom) · 2003 Ph.D.
RMIT University (Australia) · 1990 B.A.Sc.