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Simon Gray Gregory

Professor in Neurosurgery
Duke Box 104775, Durham, NC 27701
300 N. Duke Street, Room 51-102, Duke Molecular Physiology Institute, Durham, NC 27701


Dr. Gregory is a tenured Professor and Director of the Brain Tumor Omics Program (BTOP) in the Duke Department of Neurosurgery, the Vice Chair of Research in the Department of Neurology, and Director of the Molecular Genomics Core at the Duke Molecular Physiology Institute. 

As a neurogenomicist, Dr. Gregory applies the experience gained from leading the sequencing of chromosome 1 for the Human Genome Project to elucidating the mechanisms underlying multi-factorial diseases using genetic, genomic, and epigenetic approaches. Dr. Gregory’s primary areas of research involve understanding the molecular processes associated with disease development and progression in brain tumors and Alzheimer’s disease, novel drug induced white matter injury repair in multiple sclerosis, and social and behavioral response to oxytocin treatment animal models of autism. 

He is broadly regarded across Duke as a leader in the development of novel single cell and spatial molecular technologies towards understanding the pathogenic mechanisms of disease development. Dr. Gregory is also the Section Chair of Genomics and Epigenetics at the DMPI and Director of the Duke Center of Autoimmunity and MS in the Department of Neurology.

Current Appointments & Affiliations

Professor in Neurosurgery · 2022 - Present Neurosurgery, Clinical Science Departments
Vice Chair for Research in the Department of Neurology · 2020 - Present Neurology, Clinical Science Departments
Professor in Molecular Genetics and Microbiology · 2021 - Present Molecular Genetics and Microbiology, Basic Science Departments
Professor in Neurology · 2022 - Present Neurology, Clinical Science Departments
Member of the Duke Cancer Institute · 2003 - Present Duke Cancer Institute, Institutes and Centers
Member of Duke Molecular Physiology Institute · 2013 - Present Duke Molecular Physiology Institute, Duke Molecular Physiology Institute

Education, Training & Certifications

Open University, Milton Keynes (United Kingdom) · 2003 Ph.D.
RMIT University (Australia) · 1990 B.A.Sc.