Simon Gray Gregory
Professor in Neurosurgery
Dr. Gregory is a tenured Professor and Director of the Brain Tumor Omics Program (BTOP) in the Duke Department of Neurosurgery, the Vice Chair of Research in the Department of Neurology, and Director of the Molecular Genomics Core at the Duke Molecular Physiology Institute.
As a neurogenomicist, Dr. Gregory applies the experience gained from leading the sequencing of chromosome 1 for the Human Genome Project to elucidating the mechanisms underlying multi-factorial diseases using genetic, genomic, and epigenetic approaches. Dr. Gregory’s primary areas of research involve understanding the molecular processes associated with disease development and progression in brain tumors and Alzheimer’s disease, novel drug induced white matter injury repair in multiple sclerosis, and social and behavioral response to oxytocin treatment animal models of autism.
He is broadly regarded across Duke as a leader in the development of novel single cell and spatial molecular technologies towards understanding the pathogenic mechanisms of disease development. Dr. Gregory is also the Section Chair of Genomics and Epigenetics at the DMPI and Director of the Duke Center of Autoimmunity and MS in the Department of Neurology.
Current Research Interests
Brain tumors
Multiple Sclerosis
Autism
Alzheimer Disease
Application of single cell and spatial technologies to basic and translational research
Current Appointments & Affiliations
- Professor in Neurosurgery, Neurosurgery, Clinical Science Departments 2022
- Vice Chair for Research in the Department of Neurology, Neurology, Clinical Science Departments 2020
- Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2021
- Professor in Neurology, Neurology, Clinical Science Departments 2022
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003
- Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2013
Contact Information
- 300 N. Duke Street, Room 51-102, Duke Molecular Physiology Institute, Durham, NC 27701
- Duke Box 104775, Durham, NC 27701
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simon.gregory@duke.edu
(919) 684-0726
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Gregory lab page
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Gregory_Google scholar
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LinkedIn page
- Background
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Education, Training, & Certifications
- Ph.D., Open University, Milton Keynes (United Kingdom) 2003
- B.A.Sc., RMIT University (Australia) 1990
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Previous Appointments & Affiliations
- Professor in Neurology, Neurology, MS & Neuroimmunology, Neurology 2020 - 2022
- Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2016 - 2021
- Professor in Neurology, Neurology, MS & Neuroimmunology, Neurology 2016 - 2020
- Professor - TrackV of Medicine, Medicine, Medical Genetics, Medicine 2016
- Associate Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2010 - 2016
- Associate Professor in Medicine, Medicine, Medical Genetics, Medicine 2013 - 2016
- Associate Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2010 - 2013
- Assistant Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2006 - 2010
- Assistant Research Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2004 - 2006
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Academic Positions Outside Duke
- Adjunct Graduate Faculty, Department of Biological and Biomedical Sciences, North Carolina Central University. 2018 - 2019
- Recognition
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In the News
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MAR 20, 2022 -
MAR 23, 2017 Duke Health News -
NOV 7, 2016 -
JUN 26, 2015 -
JUN 11, 2015 NPR -
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NOV 21, 2014 -
SEP 25, 2013 WRAL -
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AUG 13, 2013 CNN -
AUG 13, 2013 CNN -
AUG 13, 2013 BBC News -
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AUG 13, 2013 Wall Street Journal
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Awards & Honors
- Nominated, Outstanding Postdoc Mentor. Duke University. 2015
- Inducted into Volunteer Hall of Fame for contribution as Scientific Researcher. National Multiple Sclerosis Society. 2014
- Breakthrough Research Award. North Carolina Health & Life Science. 2010
- Axons in Action Award for Cutting Edge Research. National Multiple Sclerosis Society (Eastern North Carolina chapter). 2007
- Research
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Selected Grants
- Reviving cancer immune surveillance with CD4 T cell help awarded by National Institutes of Health 2022 - 2025
- Mechanisms of oxysterol-induced oligodendrogenesis awarded by National Institutes of Health 2019 - 2024
- VA agreement - 10x Genomics - 48 samples - Molecular Genomics Core & the GCB Sequencing Core awarded by Durham Veterans Affairs Medical Center 2022 - 2023
- Biomarkers predicting response to eculizumab in myasthenia gravis (fed) awarded by The George Washington University 2021 - 2023
- Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma? awarded by National Institutes of Health 2019 - 2022
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Metabolic Pathways Of Pathogenic Th17 Cells In Myasthenia Gravis awarded by Myasthenia Gravis Foundation 2020 - 2021
- Networks of nutritional stress in human pancreatic islet cells awarded by Merck Sharp & Dohme 2018 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Development of Circulating Molecular Predictors of Chemotherapy and Novel Hormonal Therapy Benefit in Men with Metastatic Castration Resistant Prostate Cancer (mCRPC) awarded by Prostate Cancer Foundation 2014 - 2020
- Specific and Pervasive Symptoms in Adults with Multiple Sclerosis Using the MURDOCK-MS Dataset: A Secondary Analysis awarded by National Institutes of Health 2017 - 2020
- Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution awarded by Department of Defense 2015 - 2019
- Systems Biology Approaches for Predicting Cardiometabolic Risk in Persons Living with HIV awarded by National Institutes of Health 2015 - 2018
- Identifying Genetic and Epigenetic Signatures of Treatment Response to Oxytocin in Humans and Mice awarded by Autism Speaks 2016 - 2018
- Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors (SOARS-B) awarded by National Institutes of Health 2012 - 2018
- Integration of CT imaging features with cell-free plasma DNA as biomarkers for early lung cancer detection in patients with indeterminate pulmonary nodules awarded by Society of Thoracic Radiology 2016 - 2018
- SRA for Stephanie Arvai awarded by University of Texas Medical Branch 2016
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD awarded by National Institutes of Health 2009 - 2016
- A role for pathogen-induced IL-10 production in susceptibility to MS awarded by National Multiple Sclerosis Society 2014 - 2015
- Study of Oxytocin in Autism to improve Reciprocal Social Behaviors (SOARS-B) awarded by University of North Carolina - Chapel Hill 2012 - 2015
- Defining the Functional Role of a Novel MS Susceptibility Gene, IL7R alpha chain awarded by National Institutes of Health 2009 - 2015
- Linkage and candidate gene analysis in non-syndromic Chiari type I awarded by National Institutes of Health 2009 - 2015
- Study of Genetic Basis of Fuchs Corneal Dystrophy awarded by National Institutes of Health 2007 - 2013
- Genetic Mediators of Metabolic Cardiovascular Disease Risk awarded by National Institutes of Health 2009 - 2012
- Candidate Genes and Longitudinal Disability Phenotypes awarded by National Institutes of Health 2006 - 2012
- Molecular mechanisms of altered calcium sensing in human parathyroid disease awarded by National Institutes of Health 2010 - 2012
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- Hereditary basis of neural tube defects awarded by National Institutes of Health 1999 - 2010
- Genotyping - Illumina Methylation Analysis of DNA Samples awarded by National Institute of Environmental Health Sciences 2008 - 2010
- Genotyping - Methlylation Infinium Chips awarded by National Institute of Environmental Health Sciences 2008 - 2010
- Molecular Dissection of Cardiovascular Disease: From Genes to Models to Function awarded by National Institutes of Health 2007 - 2009
- GENECARD: Gene identification in Early-Onset CAD awarded by National Institutes of Health 2003 - 2009
- Molecular Genetics of Coronary Artery Disease awarded by National Institutes of Health 2006 - 2007
- High-Resolution CGH Characterization of Brain Tumors awarded by National Institutes of Health 2004 - 2006
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External Relationships
- 10x Genomics Inc.
- Autoimmunity Biologic Solutions, Inc
- Cellarity Inc.
- David H Murdock Research Institute
- Tellus Therapeutics
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Siecinski, Stephen K., Stephanie N. Giamberardino, Marina Spanos, Annalise C. Hauser, Jason R. Gibson, Tara Chandrasekhar, Maria Del Pilar Trelles, et al. “Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder.” Autism Res, January 7, 2023. https://doi.org/10.1002/aur.2884.Full Text Open Access Copy Link to Item
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Schott, Benjamin H., Liuyang Wang, Xinyu Zhu, Alfred T. Harding, Emily R. Ko, Jeffrey S. Bourgeois, Erica J. Washington, et al. “Single-cell genome-wide association reveals that a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus.” Cell Genom 2, no. 11 (November 9, 2022). https://doi.org/10.1016/j.xgen.2022.100207.Full Text Link to Item
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Leuthner, Tess C., Laura Benzing, Brendan F. Kohrn, Christina M. Bergemann, Michael J. Hipp, Kathleen A. Hershberger, Danielle F. Mello, et al. “Resistance of mitochondrial DNA to cadmium and Aflatoxin B1 damage-induced germline mutation accumulation in C. elegans.” Nucleic Acids Res 50, no. 15 (August 26, 2022): 8626–42. https://doi.org/10.1093/nar/gkac666.Full Text Link to Item
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Low, Justin T., Vidyalakshmi Chandramohan, Michelle L. Bowie, Michael C. Brown, Matthew S. Waitkus, Aaron Briley, Kevin Stevenson, et al. “Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.” Cancer Cell 40, no. 5 (May 9, 2022): 439–40. https://doi.org/10.1016/j.ccell.2022.04.009.Full Text Link to Item
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Dungan, Jennifer R., Xue Qin, Simon G. Gregory, Rhonda Cooper-Dehoff, Julio D. Duarte, Huaizhen Qin, Martha Gulati, et al. “Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease.” Am Heart J Plus 17 (May 2022). https://doi.org/10.1016/j.ahjo.2022.100152.Full Text Link to Item
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Allen, Joseph P., Joshua S. Danoff, Meghan A. Costello, Emily L. Loeb, Alida A. Davis, Gabrielle L. Hunt, Simon G. Gregory, Stephanie N. Giamberardino, and Jessica J. Connelly. “Adolescent peer struggles predict accelerated epigenetic aging in midlife.” Dev Psychopathol, April 5, 2022, 1–14. https://doi.org/10.1017/S0954579422000153.Full Text Link to Item
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Allen, Joseph P., Joshua S. Danoff, Meghan A. Costello, Gabrielle L. Hunt, Amanda F. Hellwig, Kathleen M. Krol, Simon G. Gregory, Stephanie N. Giamberardino, Karen Sugden, and Jessica J. Connelly. “Lifetime marijuana use and epigenetic age acceleration: A 17-year prospective examination.” Drug Alcohol Depend 233 (April 1, 2022): 109363. https://doi.org/10.1016/j.drugalcdep.2022.109363.Full Text Link to Item
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Kadur Lakshminarasimha Murthy, Preetish, Vishwaraj Sontake, Aleksandra Tata, Yoshihiko Kobayashi, Lauren Macadlo, Kenichi Okuda, Ansley S. Conchola, et al. “Human distal lung maps and lineage hierarchies reveal a bipotent progenitor.” Nature 604, no. 7904 (April 2022): 111–19. https://doi.org/10.1038/s41586-022-04541-3.Full Text Link to Item
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Jain, Vaibhav, Wen-Hsuan Yang, Jianli Wu, John D. Roback, Simon G. Gregory, and Jen-Tsan Chi. “Single Cell RNA-Seq Analysis of Human Red Cells.” Front Physiol 13 (2022): 828700. https://doi.org/10.3389/fphys.2022.828700.Full Text Link to Item
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SoRelle, Elliott D., Joanne Dai, Emmanuela N. Bonglack, Emma M. Heckenberg, Jeffrey Y. Zhou, Stephanie N. Giamberardino, Jeffrey A. Bailey, Simon G. Gregory, Cliburn Chan, and Micah A. Luftig. “Correction: Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host-pathogen dynamics in lymphoblastoid cell lines.” Elife 10 (November 11, 2021). https://doi.org/10.7554/eLife.75422.Full Text Link to Item
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Sikich, Linmarie, Alexander Kolevzon, Bryan H. King, Christopher J. McDougle, Kevin B. Sanders, Soo-Jeong Kim, Marina Spanos, et al. “Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder.” N Engl J Med 385, no. 16 (October 14, 2021): 1462–73. https://doi.org/10.1056/NEJMoa2103583.Full Text Open Access Copy Link to Item
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Brown, Landon C., Susan Halabi, Joseph D. Schonhoft, Qian Yang, Jun Luo, David M. Nanus, Paraskevi Giannakakou, et al. “Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide.” Clin Cancer Res 27, no. 14 (July 15, 2021): 4077–88. https://doi.org/10.1158/1078-0432.CCR-20-3471.Full Text Link to Item
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Giarraputo, James, Stephanie Giamberardino, Stephanie Arvai, Sarah Maichle, Christopher Eckstein, L Kristin Newby, and Simon Gregory. “Profiling serum neurofilament light chain and glial fibrillary acidic protein in primary progressive multiple sclerosis.” J Neuroimmunol 354 (May 15, 2021): 577541. https://doi.org/10.1016/j.jneuroim.2021.577541.Full Text Link to Item
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Cronan, Mark R., Erika J. Hughes, W Jared Brewer, Gopinath Viswanathan, Emily G. Hunt, Bindu Singh, Smriti Mehra, et al. “A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization.” Cell 184, no. 7 (April 1, 2021): 1757-1774.e14. https://doi.org/10.1016/j.cell.2021.02.046.Full Text Link to Item
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Schott, Geraldine, Gaddiel Galarza-Muñoz, Noe Trevino, Xiaoting Chen, Matthew Weirauch, Simon G. Gregory, Shelton S. Bradrick, and Mariano A. Garcia-Blanco. “U2AF2 binds IL7R exon 6 ectopically and represses its inclusion.” Rna 27, no. 5 (February 10, 2021): 571–83. https://doi.org/10.1261/rna.078279.120.Full Text Link to Item
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Danoff, Joshua S., Kelly L. Wroblewski, Andrew J. Graves, Graham C. Quinn, Allison M. Perkeybile, William M. Kenkel, Travis S. Lillard, et al. “Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression.” Clin Epigenetics 13, no. 1 (January 30, 2021): 23. https://doi.org/10.1186/s13148-021-01017-5.Full Text Link to Item
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SoRelle, Elliott D., Joanne Dai, Emmanuela N. Bonglack, Emma M. Heckenberg, Jeffrey Y. Zhou, Stephanie N. Giamberardino, Jeffrey A. Bailey, Simon G. Gregory, Cliburn Chan, and Micah A. Luftig. “Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host-pathogen dynamics in lymphoblastoid cell lines.” Elife 10 (January 27, 2021). https://doi.org/10.7554/eLife.62586.Full Text Link to Item
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Mariottoni, Paula, Simon W. Jiang, Courtney A. Prestwood, Vaibhav Jain, Jutamas Suwanpradid, Melodi Javid Whitley, Margaret Coates, et al. “Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa.” Front Med (Lausanne) 8 (2021): 665873. https://doi.org/10.3389/fmed.2021.665873.Full Text Open Access Copy Link to Item
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Chen, Tianyi, Sehhoon Oh, Simon Gregory, Xiling Shen, and Anna Mae Diehl. “Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration.” Jci Insight 5, no. 22 (November 19, 2020). https://doi.org/10.1172/jci.insight.141024.Full Text Link to Item
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Spanos, Marina, Tara Chandrasekhar, Soo-Jeong Kim, Robert M. Hamer, Bryan H. King, Christopher J. McDougle, Kevin B. Sanders, et al. “Rationale, design, and methods of the Autism Centers of Excellence (ACE) network Study of Oxytocin in Autism to improve Reciprocal Social Behaviors (SOARS-B).” Contemp Clin Trials 98 (November 2020): 106103. https://doi.org/10.1016/j.cct.2020.106103.Full Text Link to Item
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Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Author Correction: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nat Metab 2, no. 8 (August 2020): 794. https://doi.org/10.1038/s42255-020-0257-y.Full Text Link to Item
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Chou, Ching-Heng, Vaibhav Jain, Jason Gibson, David E. Attarian, Collin A. Haraden, Christopher B. Yohn, Remi-Martin Laberge, Simon Gregory, and Virginia B. Kraus. “Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis.” Sci Rep 10, no. 1 (July 2, 2020): 10868. https://doi.org/10.1038/s41598-020-67730-y.Full Text Link to Item
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Becker, Kristian C., Lydia Coulter Kwee, Megan L. Neely, Elizabeth Grass, Joseph A. Jakubowski, Keith A. A. Fox, Harvey D. White, et al. “Circulating MicroRNA Profiling in Non-ST Elevated Coronary Artery Syndrome Highlights Genomic Associations with Serial Platelet Reactivity Measurements.” Sci Rep 10, no. 1 (April 10, 2020): 6169. https://doi.org/10.1038/s41598-020-63263-6.Full Text Open Access Copy Link to Item
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Gupta, Santosh, Daniel H. Hovelson, Gabor Kemeny, Susan Halabi, Wen-Chi Foo, Monika Anand, Jason A. Somarelli, et al. “Discordant and heterogeneous clinically relevant genomic alterations in circulating tumor cells vs plasma DNA from men with metastatic castration resistant prostate cancer.” Genes Chromosomes Cancer 59, no. 4 (April 2020): 225–39. https://doi.org/10.1002/gcc.22824.Full Text Link to Item
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Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nat Metab 2, no. 3 (March 2020): 278–89. https://doi.org/10.1038/s42255-020-0184-y.Full Text Link to Item
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Jewell, Mark L., Jason R. Gibson, Cynthia D. Guy, Jeongeun Hyun, Kuo Du, Seh-Hoon Oh, Richard T. Premont, et al. “Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1-Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma.” Am J Pathol 190, no. 1 (January 2020): 93–107. https://doi.org/10.1016/j.ajpath.2019.09.018.Full Text Link to Item
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Yahara, Yasuhito, Tomasa Barrientos, Yuning J. Tang, Vijitha Puviindran, Puviindran Nadesan, Hongyuan Zhang, Jason R. Gibson, et al. “Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair.” Nat Cell Biol 22, no. 1 (January 2020): 49–59. https://doi.org/10.1038/s41556-019-0437-8.Full Text Link to Item
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Abdulrahim, Jawan W., Lydia Coulter Kwee, Elizabeth Grass, Ilene C. Siegler, Redford Williams, Ravi Karra, William E. Kraus, Simon G. Gregory, and Svati H. Shah. “Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1).” J Am Heart Assoc 8, no. 21 (November 5, 2019): e013228. https://doi.org/10.1161/JAHA.119.013228.Full Text Link to Item
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Kwee, Lydia Coulter, Megan L. Neely, Elizabeth Grass, Simon G. Gregory, Matthew T. Roe, E Magnus Ohman, Keith A. A. Fox, et al. “Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.” Physiol Genomics 51, no. 10 (October 1, 2019): 506–15. https://doi.org/10.1152/physiolgenomics.00033.2019.Full Text Link to Item
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Andersen, S. L., F. B. S. Briggs, J. H. Winnike, Y. Natanzon, S. Maichle, K. J. Knagge, L. K. Newby, and S. G. Gregory. “Metabolome-based signature of disease pathology in MS.” Mult Scler Relat Disord 31 (June 2019): 12–21. https://doi.org/10.1016/j.msard.2019.03.006.Full Text Link to Item
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Kousa, Youssef A., Huiping Zhu, Walid D. Fakhouri, Yunping Lei, Akira Kinoshita, Raeuf R. Roushangar, Nicole K. Patel, et al. “The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation.” Hum Mol Genet 28, no. 10 (May 15, 2019): 1726–37. https://doi.org/10.1093/hmg/ddz010.Full Text Link to Item
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Armstrong, Andrew J., Susan Halabi, Jun Luo, David M. Nanus, Paraskevi Giannakakou, Russell Z. Szmulewitz, Daniel C. Danila, et al. “Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study.” J Clin Oncol 37, no. 13 (May 1, 2019): 1120–29. https://doi.org/10.1200/JCO.18.01731.Full Text Link to Item
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Armstrong, Andrew J., Santosh Gupta, Patrick Healy, Gabor Kemeny, Beth Leith, Michael R. Zalutsky, Charles Spritzer, et al. “Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer.” Plos One 14, no. 5 (January 2019): e0216934. https://doi.org/10.1371/journal.pone.0216934.Full Text
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Dhingra, Radhika, Lydia Coulter Kwee, David Diaz-Sanchez, Robert B. Devlin, Wayne Cascio, Elizabeth R. Hauser, Simon Gregory, et al. “Evaluating DNA methylation age on the Illumina MethylationEPIC Bead Chip.” Plos One 14, no. 4 (2019): e0207834. https://doi.org/10.1371/journal.pone.0207834.Full Text Link to Item
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Perkeybile, Allison M., C Sue Carter, Kelly L. Wroblewski, Meghan H. Puglia, William M. Kenkel, Travis S. Lillard, Themistoclis Karaoli, et al. “Early nurture epigenetically tunes the oxytocin receptor.” Psychoneuroendocrinology 99 (January 2019): 128–36. https://doi.org/10.1016/j.psyneuen.2018.08.037.Full Text Link to Item
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Tailor, Tina D., Xiayu Rao, Michael J. Campa, Jing Wang, Simon G. Gregory, and Edward F. Patz. “Whole Exome Sequencing of Cell-Free DNA for Early Lung Cancer: A Pilot Study to Differentiate Benign From Malignant CT-Detected Pulmonary Lesions.” Front Oncol 9 (2019): 317. https://doi.org/10.3389/fonc.2019.00317.Full Text Link to Item
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Towers, Aaron J., Martine W. Tremblay, Leeyup Chung, Xin-Lei Li, Alexandra L. Bey, Wenhao Zhang, Xinyu Cao, et al. “Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders.” Jci Insight 3, no. 23 (December 6, 2018). https://doi.org/10.1172/jci.insight.120592.Full Text Link to Item
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Ward-Caviness, Cavin K., William E. Kraus, Colette Blach, Carol S. Haynes, Elaine Dowdy, Marie Lynn Miranda, Robert Devlin, et al. “Associations Between Residential Proximity to Traffic and Vascular Disease in a Cardiac Catheterization Cohort.” Arterioscler Thromb Vasc Biol 38, no. 1 (January 2018): 275–82. https://doi.org/10.1161/ATVBAHA.117.310003.Full Text Link to Item
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Kanayama, Masashi, Shengjie Xu, Keiko Danzaki, Jason R. Gibson, Makoto Inoue, Simon G. Gregory, and Mari L. Shinohara. “Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.” Nat Immunol 18, no. 9 (September 2017): 973–84. https://doi.org/10.1038/ni.3791.Full Text Open Access Copy Link to Item
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Wang, Alice, Lydia Coulter Kwee, Elizabeth Grass, Megan L. Neely, Simon G. Gregory, Keith A. A. Fox, Paul W. Armstrong, et al. “Whole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome.” Atherosclerosis 261 (June 2017): 19–25. https://doi.org/10.1016/j.atherosclerosis.2017.03.041.Full Text Link to Item
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Galarza-Muñoz, Gaddiel, Farren B. S. Briggs, Irina Evsyukova, Geraldine Schott-Lerner, Edward M. Kennedy, Tinashe Nyanhete, Liuyang Wang, et al. “Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.” Cell 169, no. 1 (March 23, 2017): 72-84.e13. https://doi.org/10.1016/j.cell.2017.03.007.Full Text Link to Item
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Afshari, Natalie A., Robert P. Igo, Nathan J. Morris, Dwight Stambolian, Shiwani Sharma, V Lakshmi Pulagam, Steven Dunn, et al. “Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy.” Nature Communications 8 (March 2017): 14898. https://doi.org/10.1038/ncomms14898.Full Text
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Gupta, Santosh, Jing Li, Gabor Kemeny, Rhonda L. Bitting, Joshua Beaver, Jason A. Somarelli, Kathryn E. Ware, Simon Gregory, and Andrew J. Armstrong. “Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer.” Clin Cancer Res 23, no. 5 (March 1, 2017): 1346–57. https://doi.org/10.1158/1078-0432.CCR-16-1211.Full Text Link to Item
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Ward-Caviness, Cavin K., Lucas M. Neas, Colette Blach, Carol S. Haynes, Karen LaRocque-Abramson, Elizabeth Grass, Z Elaine Dowdy, et al. “A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic.” Plos One 12, no. 3 (2017): e0173880. https://doi.org/10.1371/journal.pone.0173880.Full Text Link to Item
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Inoue, Makoto, Po-Han Chen, Stephen Siecinski, Qi-Jing Li, Chunlei Liu, Lawrence Steinman, Simon G. Gregory, Eric Benner, and Mari L. Shinohara. “An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage.” Nat Neurosci 19, no. 12 (December 2016): 1599–1609. https://doi.org/10.1038/nn.4421.Full Text Link to Item
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Sullivan, Lori L., Kristin A. Maloney, Aaron J. Towers, Simon G. Gregory, and Beth A. Sullivan. “Human centromere repositioning within euchromatin after partial chromosome deletion.” Chromosome Res 24, no. 4 (December 2016): 451–66. https://doi.org/10.1007/s10577-016-9536-6.Full Text Link to Item
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Zeng, Yi, Huashuai Chen, Ting Ni, Rongping Ruan, Chao Nie, Xiaomin Liu, Lei Feng, et al. “Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.” Rejuvenation Res 19, no. 3 (June 2016): 195–203. https://doi.org/10.1089/rej.2015.1737.Full Text Open Access Copy Link to Item
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Zeng, Yi, Chao Nie, Junxia Min, Xiaomin Liu, Mengmeng Li, Huashuai Chen, Hanshi Xu, et al. “Novel loci and pathways significantly associated with longevity.” Sci Rep 6 (February 25, 2016): 21243. https://doi.org/10.1038/srep21243.Full Text Open Access Copy Link to Item
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Dungan, Jennifer R., Xuejun Qin, Benjamin D. Horne, John F. Carlquist, Abanish Singh, Melissa Hurdle, Elizabeth Grass, et al. “Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship.” Plos One 11, no. 5 (2016): e0154856. https://doi.org/10.1371/journal.pone.0154856.Full Text Link to Item
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Ward-Caviness, Cavin K., Lucas M. Neas, Colette Blach, Carol S. Haynes, Karen LaRocque-Abramson, Elizabeth Grass, Elaine Dowdy, et al. “Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease.” Plos One 11, no. 4 (2016): e0152670. https://doi.org/10.1371/journal.pone.0152670.Full Text Link to Item
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Kraus, William E., Deborah M. Muoio, Robert Stevens, Damian Craig, James R. Bain, Elizabeth Grass, Carol Haynes, et al. “Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.” Plos Genet 11, no. 11 (November 2015): e1005553. https://doi.org/10.1371/journal.pgen.1005553.Full Text Open Access Copy Link to Item
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Riley, Ronald T., Olga Torres, Jorge Matute, Simon G. Gregory, Allison E. Ashley-Koch, Jency L. Showker, Trevor Mitchell, Kenneth A. Voss, Joyce R. Maddox, and Janee B. Gelineau-van Waes. “Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala.” Mol Nutr Food Res 59, no. 11 (November 2015): 2209–24. https://doi.org/10.1002/mnfr.201500499.Full Text Link to Item
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Ward-Caviness, Cavin K., William E. Kraus, Colette Blach, Carol S. Haynes, Elaine Dowdy, Marie Lynn Miranda, Robert B. Devlin, et al. “Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients.” Environ Health Perspect 123, no. 10 (October 2015): 1007–14. https://doi.org/10.1289/ehp.1306980.Full Text Link to Item
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Shah, Asad A., Simon G. Gregory, Deidre Krupp, Sheng Feng, Allison Dorogi, Carol Haynes, Elizabeth Grass, et al. “Epigenetic profiling identifies novel genes for ascending aortic aneurysm formation with bicuspid aortic valves.” Heart Surg Forum 18, no. 4 (August 30, 2015): E134–39. https://doi.org/10.1532/hsf.1247.Full Text Link to Item
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Cope, Heidi, Melanie E. Garrett, Simon Gregory, and Allison Ashley-Koch. “Pregnancy continuation and organizational religious activity following prenatal diagnosis of a lethal fetal defect are associated with improved psychological outcome.” Prenat Diagn 35, no. 8 (August 2015): 761–68. https://doi.org/10.1002/pd.4603.Full Text Link to Item
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Roberson, Elle C., William E. Dowdle, Aysegul Ozanturk, Francesc R. Garcia-Gonzalo, Chunmei Li, Jan Halbritter, Nadia Elkhartoufi, et al. “TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.” J Cell Biol 209, no. 1 (April 13, 2015): 129–42. https://doi.org/10.1083/jcb.201411087.Full Text Link to Item
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Winnike, Jason H., Xiaoli Wei, Kevin J. Knagge, Steven D. Colman, Simon G. Gregory, and Xiang Zhang. “Comparison of GC-MS and GC×GC-MS in the analysis of human serum samples for biomarker discovery.” J Proteome Res 14, no. 4 (April 3, 2015): 1810–17. https://doi.org/10.1021/pr5011923.Full Text Link to Item
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Shah, Asad A., Carol Haynes, Damian M. Craig, Jacqueline Sebek, Elizabeth Grass, Karen Abramson, Elizabeth Hauser, et al. “Genetic variants associated with vein graft stenosis after coronary artery bypass grafting.” Heart Surg Forum 18, no. 1 (February 27, 2015): E1–5. https://doi.org/10.1532/hsf.1214.Full Text Link to Item
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Lock, Eric F., Karen L. Soldano, Melanie E. Garrett, Heidi Cope, Christina A. Markunas, Herbert Fuchs, Gerald Grant, David B. Dunson, Simon G. Gregory, and Allison E. Ashley-Koch. “Joint eQTL assessment of whole blood and dura mater tissue from individuals with Chiari type I malformation.” Bmc Genomics 16, no. 1 (January 22, 2015): 11. https://doi.org/10.1186/s12864-014-1211-8.Full Text Open Access Copy Link to Item
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Li, Jing, Simon G. Gregory, Mariano A. Garcia-Blanco, and Andrew J. Armstrong. “Using circulating tumor cells to inform on prostate cancer biology and clinical utility.” Crit Rev Clin Lab Sci 52, no. 4 (2015): 191–210. https://doi.org/10.3109/10408363.2015.1023430.Full Text Link to Item
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Riley, Ronald T., Jency L. Showker, Christine M. Lee, Cody E. Zipperer, Trevor R. Mitchell, Kenneth A. Voss, Nicholas C. Zitomer, et al. “A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans.” Food Addit Contam Part a Chem Anal Control Expo Risk Assess 32, no. 6 (2015): 934–49. https://doi.org/10.1080/19440049.2015.1027746.Full Text Link to Item
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Torres, O., J. Matute, J. Gelineau-Van Waes, J. R. Maddox, S. G. Gregory, A. E. Ashley-Koch, J. L. Showker, K. A. Voss, and R. T. Riley. “Human health implications from co-exposure to aflatoxins and fumonisins in maize-based foods in Latin America: Guatemala as a case study.” World Mycotoxin Journal 8, no. 2 (January 1, 2015): 143–59. https://doi.org/10.3920/WMJ2014.1736.Full Text
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Krupp, Deidre R., Karen L. Soldano, Melanie E. Garrett, Heidi Cope, Allison E. Ashley-Koch, and Simon G. Gregory. “Missing genetic risk in neural tube defects: can exome sequencing yield an insight?” Birth Defects Res a Clin Mol Teratol 100, no. 8 (August 2014): 642–46. https://doi.org/10.1002/bdra.23276.Full Text Link to Item
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Markunas, Christina A., Eric Lock, Karen Soldano, Heidi Cope, Chien-Kuang C. Ding, David S. Enterline, Gerald Grant, Herbert Fuchs, Allison E. Ashley-Koch, and Simon G. Gregory. “Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics.” Bmc Med Genomics 7 (June 25, 2014): 39. https://doi.org/10.1186/1755-8794-7-39.Full Text Open Access Copy Link to Item
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Li, Yi-Ju, Mollie A. Minear, Xuejun Qin, Jacqueline Rimmler, Michael A. Hauser, R Rand Allingham, Robert P. Igo, et al. “Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy.” Invest Ophthalmol Vis Sci 55, no. 7 (June 10, 2014): 4577–84. https://doi.org/10.1167/iovs.13-13517.Full Text Link to Item
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Miranda, Marie Lynn, Rebecca Anthopolos, and Simon G. Gregory. “Association of autism with induced or augmented childbirth.” Am J Obstet Gynecol 210, no. 5 (May 2014): 492–93. https://doi.org/10.1016/j.ajog.2013.12.038.Full Text Link to Item
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Torres, Olga, Jorge Matute, Janee Gelineau-van Waes, Joyce R. Maddox, Simon G. Gregory, Allison E. Ashley-Koch, Jency L. Showker, Nicholas C. Zitomer, Kenneth A. Voss, and Ronald T. Riley. “Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala.” Mol Nutr Food Res 58, no. 5 (May 2014): 973–83. https://doi.org/10.1002/mnfr.201300481.Full Text Link to Item
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McGarrah, Robert, Damian M. Craig, Carol Haynes, Elizabeth Hauser, Christopher B. Newgard, Simon G. Gregory, William Kraus, and Svati Shah. “OMICS PROFILING HIGHLIGHTS ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION AND UBIQUITIN PROTEASOME PATHWAYS IN INSULIN RESISTANCE AND GLYCEMIC CONTROL.” Journal of the American College of Cardiology 63, no. 12 (April 2014): A1600–A1600. https://doi.org/10.1016/s0735-1097(14)61603-x.Full Text
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Gregory, Simon G. “Genetic predisposition of behavioral response.” Proc Natl Acad Sci U S A 111, no. 5 (February 4, 2014): 1672–73. https://doi.org/10.1073/pnas.1323421111.Full Text Link to Item
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Miranda, Marie Lynn, Rebecca Anthopolos, and Simon G. Gregory. “Induction or augmentation of labor and autism--reply.” Jama Pediatr 168, no. 2 (February 2014): 191–92. https://doi.org/10.1001/jamapediatrics.2013.4792.Full Text Link to Item
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Gregory, Simon G., Rebecca Anthopolos, Claire E. Osgood, Chad A. Grotegut, and Marie Lynn Miranda. “Association of Autism With Induced or Augmented Childbirth in North Carolina Birth Record (1990–1998) and Education Research (1997–2007) Databases.” Obstetrical &Amp; Gynecological Survey 69, no. 1 (January 2014): 7–9. https://doi.org/10.1097/01.ogx.0000442814.50107.fa.Full Text
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Markunas, Christina A., David S. Enterline, Kaitlyn Dunlap, Karen Soldano, Heidi Cope, Jeffrey Stajich, Gerald Grant, Herbert Fuchs, Simon G. Gregory, and Allison E. Ashley-Koch. “Genetic evaluation and application of posterior cranial fossa traits as endophenotypes for Chiari type I malformation.” Ann Hum Genet 78, no. 1 (January 2014): 1–12. https://doi.org/10.1111/ahg.12041.Full Text Link to Item
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Connelly, Jessica J., Olga A. Cherepanova, Jennifer F. Doss, Themistoclis Karaoli, Travis S. Lillard, Christina A. Markunas, Sarah Nelson, et al. “Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis.” Hum Mol Genet 22, no. 25 (December 20, 2013): 5107–20. https://doi.org/10.1093/hmg/ddt365.Full Text Link to Item
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Ward-Caviness, Cavin, Carol Haynes, Colette Blach, Elaine Dowdy, Simon G. Gregory, Svati H. Shah, Benjamin D. Horne, William E. Kraus, and Elizabeth R. Hauser. “Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort.” Hum Genet 132, no. 12 (December 2013): 1371–82. https://doi.org/10.1007/s00439-013-1339-7.Full Text Link to Item
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Gregory, Simon G., Rebecca Anthopolos, Claire E. Osgood, Chad A. Grotegut, and Marie Lynn Miranda. “Association of autism with induced or augmented childbirth in North Carolina Birth Record (1990-1998) and Education Research (1997-2007) databases.” Jama Pediatr 167, no. 10 (October 2013): 959–66. https://doi.org/10.1001/jamapediatrics.2013.2904.Full Text Link to Item
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Soldano, Karen L., Melanie E. Garrett, Heidi L. Cope, J Michael Rusnak, Nathen J. Ellis, Kaitlyn L. Dunlap, Marcy C. Speer, Simon G. Gregory, and Allison E. Ashley-Koch. “Genetic association analyses of nitric oxide synthase genes and neural tube defects vary by phenotype.” Birth Defects Res B Dev Reprod Toxicol 98, no. 5 (October 2013): 365–73. https://doi.org/10.1002/bdrb.21079.Full Text Link to Item
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Zeng, Yi, Lingguo Cheng, Ling Zhao, Qihua Tan, Qiushi Feng, Huashuai Chen, Ke Shen, et al. “Interactions between social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China.” Bmc Geriatr 13 (September 9, 2013): 91. https://doi.org/10.1186/1471-2318-13-91.Full Text Open Access Copy Link to Item
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Cope, Heidi, Kelly McMahon, Elizabeth Heise, Sonja Eubanks, Melanie Garrett, Simon Gregory, and Allison Ashley-Koch. “Outcome and life satisfaction of adults with myelomeningocele.” Disabil Health J 6, no. 3 (July 2013): 236–43. https://doi.org/10.1016/j.dhjo.2012.12.003.Full Text Link to Item
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Evsyukova, Irina, Shelton S. Bradrick, Simon G. Gregory, and Mariano A. Garcia-Blanco. “Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.” Rna 19, no. 1 (January 2013): 103–15. https://doi.org/10.1261/rna.035410.112.Full Text Link to Item
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Markunas, Christina A., Karen Soldano, Kaitlyn Dunlap, Heidi Cope, Edgar Asiimwe, Jeffrey Stajich, David Enterline, et al. “Stratified whole genome linkage analysis of Chiari type I malformation implicates known Klippel-Feil syndrome genes as putative disease candidates.” Plos One 8, no. 4 (2013): e61521. https://doi.org/10.1371/journal.pone.0061521.Full Text Open Access Copy Link to Item
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Minear, Mollie A., Yi-Ju Li, Jacqueline Rimmler, Elmer Balajonda, Shera Watson, R Rand Allingham, Michael A. Hauser, Gordon K. Klintworth, Natalie A. Afshari, and Simon G. Gregory. “Genetic screen of African Americans with Fuchs endothelial corneal dystrophy.” Mol Vis 19 (2013): 2508–16.Link to Item
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Nolan, Daniel, William E. Kraus, Elizabeth Hauser, Yi-Ju Li, Dana K. Thompson, Jessica Johnson, Hsiang-Cheng Chen, et al. “Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.” Plos One 8, no. 8 (2013): e71779. https://doi.org/10.1371/journal.pone.0071779.Full Text Open Access Copy Link to Item
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Shah, Svati H., Sheng Feng, Elizabeth Grass, Carol Haynes, Megan Chryst-Ladd, Damian Craig, Elizabeth R. Hauser, Christopher B. Newgard, William E. Kraus, and Simon G. Gregory. “Integration of Whole Genome Methylation with Metabolomics Identifies Novel Cardiovascular Disease Genes.” Circulation 126, no. 21 (November 20, 2012).Link to Item
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Ward-Caviness, Cavin, Lucas Neas, Carol Haynes, Colette Blach, Elizabeth Burns, Karen LaRocque-Abramson, Elaine Dowdy, et al. “Genetic Variants in the Bone Morphogenic Protein (BMP) Family of Genes Interact with Mobile Source Air Pollution to Increase Risk of Peripheral Arterial Disease.” Circulation 126, no. 21 (November 20, 2012).Link to Item
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Krupp, Deidre R., Pu-Ting Xu, Sophie Thomas, Andrew Dellinger, Heather C. Etchevers, Michel Vekemans, John R. Gilbert, et al. “Transcriptome profiling of genes involved in neural tube closure during human embryonic development using long serial analysis of gene expression (long-SAGE).” Birth Defects Res a Clin Mol Teratol 94, no. 9 (September 2012): 683–92. https://doi.org/10.1002/bdra.23040.Full Text Link to Item
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Riley, Ronald T., Olga Torres, Jency L. Showker, Nicholas C. Zitomer, Jorge Matute, Kenneth A. Voss, Janee Gelineau-van Waes, Joyce R. Maddox, Simon G. Gregory, and Allison E. Ashley-Koch. “The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets.” Mol Nutr Food Res 56, no. 9 (September 2012): 1445–55. https://doi.org/10.1002/mnfr.201200166.Full Text Link to Item
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Markunas, Christina A., R Shane Tubbs, Roham Moftakhar, Allison E. Ashley-Koch, Simon G. Gregory, W Jerry Oakes, Marcy C. Speer, and Bermans J. Iskandar. “Clinical, radiological, and genetic similarities between patients with Chiari Type I and Type 0 malformations.” J Neurosurg Pediatr 9, no. 4 (April 2012): 372–78. https://doi.org/10.3171/2011.12.PEDS11113.Full Text Link to Item
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Nolan, Daniel K., Beth Sutton, Carol Haynes, Jessica Johnson, Jacqueline Sebek, Elaine Dowdy, David Crosslin, et al. “Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5.” Bmc Genet 13 (February 27, 2012): 12. https://doi.org/10.1186/1471-2156-13-12.Full Text Link to Item
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Lin, Ningjing, Chunhui Di, Kathy Bortoff, Jinrong Fu, Peter Truszkowski, Patrick Killela, Chris Duncan, et al. “Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma.” Mol Cancer Res 10, no. 2 (February 2012): 208–17. https://doi.org/10.1158/1541-7786.MCR-10-0109.Full Text Link to Item
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Feng, Jie, Jianyi Zhang, Ming Liu, Gang Wan, Keyan Qi, Chenguang Zheng, Zeping Lv, et al. “Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China.” Exp Gerontol 46, no. 12 (December 2011): 987–93. https://doi.org/10.1016/j.exger.2011.09.001.Full Text Link to Item
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Hara, Makoto R., Jeffrey J. Kovacs, Erin J. Whalen, Sudarshan Rajagopal, Ryan T. Strachan, Wayne Grant, Aaron J. Towers, et al. “A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.” Nature 477, no. 7364 (August 21, 2011): 349–53. https://doi.org/10.1038/nature10368.Full Text Link to Item
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Minear, Mollie A., David R. Crosslin, Beth S. Sutton, Jessica J. Connelly, Sarah C. Nelson, Shera Gadson-Watson, Tianyuan Wang, et al. “Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease.” Hum Genet 129, no. 6 (June 2011): 641–54. https://doi.org/10.1007/s00439-011-0959-z.Full Text Link to Item
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Li, Yi-Ju, Mollie A. Minear, Jacqueline Rimmler, Bei Zhao, Elmer Balajonda, Michael A. Hauser, R Rand Allingham, et al. “Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy.” Plos One 6, no. 4 (April 20, 2011): e18044. https://doi.org/10.1371/journal.pone.0018044.Full Text Link to Item
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Sun, Albert Y., Jason I. Koontz, Svati H. Shah, Jonathan P. Piccini, Kent R. Nilsson, Damian Craig, Carol Haynes, Simon G. Gregory, Patrick M. Hranitzky, and Geoffrey S. Pitt. “The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction.” Circ Cardiovasc Genet 4, no. 2 (April 2011): 163–68. https://doi.org/10.1161/CIRCGENETICS.110.958652.Full Text Link to Item
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Jin, Genglin, Stephen Cook, Bo Cui, William C. Chen, Stephen T. Keir, Patrick Killela, Chunhui Di, et al. “HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea.” Neuro Oncol 12, no. 9 (September 2010): 956–66. https://doi.org/10.1093/neuonc/noq045.Full Text Link to Item
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Duncan, Christopher G., Patrick J. Killela, Cathy A. Payne, Benjamin Lampson, William C. Chen, Jeff Liu, David Solomon, et al. “Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes.” Oncotarget 1, no. 4 (August 2010): 265–77. https://doi.org/10.18632/oncotarget.137.Full Text Link to Item
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Zhang, Lisheng, Jessica J. Connelly, Karsten Peppel, Leigh Brian, Svati H. Shah, Sarah Nelson, David R. Crosslin, et al. “Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies.” Hum Mol Genet 19, no. 14 (July 15, 2010): 2754–66. https://doi.org/10.1093/hmg/ddq172.Full Text Link to Item
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Vogazianou, Artemis P., Raymond Chan, L Magnus Bäcklund, Danita M. Pearson, Lu Liu, Cordelia F. Langford, Simon G. Gregory, V Peter Collins, and Koichi Ichimura. “Distinct patterns of 1p and 19q alterations identify subtypes of human gliomas that have different prognoses.” Neuro Oncol 12, no. 7 (July 2010): 664–78. https://doi.org/10.1093/neuonc/nop075.Full Text Link to Item
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Fraser, Heather I., Calliope A. Dendrou, Barry Healy, Daniel B. Rainbow, Sarah Howlett, Luc J. Smink, Simon Gregory, et al. “Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene.” J Immunol 184, no. 9 (May 1, 2010): 5075–84. https://doi.org/10.4049/jimmunol.0903734.Full Text Link to Item
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Chen, Hsiang-Cheng, Virginia Byers Kraus, Yi-Ju Li, Sarah Nelson, Carol Haynes, Jessica Johnson, Thomas Stabler, et al. “Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family.” Arthritis Rheum 62, no. 3 (March 2010): 781–90. https://doi.org/10.1002/art.27288.Full Text Link to Item
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Evsyukova, Irina, Jason A. Somarelli, Simon G. Gregory, and Mariano A. Garcia-Blanco. “Alternative splicing in multiple sclerosis and other autoimmune diseases.” Rna Biol 7, no. 4 (2010): 462–73. https://doi.org/10.4161/rna.7.4.12301.Full Text Open Access Copy Link to Item
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Riazuddin, S Amer, Norann A. Zaghloul, Amr Al-Saif, Lisa Davey, Bill H. Diplas, Danielle N. Meadows, Allen O. Eghrari, et al. “Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p.” Am J Hum Genet 86, no. 1 (January 2010): 45–53. https://doi.org/10.1016/j.ajhg.2009.12.001.Full Text Link to Item
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Gregory, Simon G., Jessica J. Connelly, Aaron J. Towers, Jessica Johnson, Dhani Biscocho, Christina A. Markunas, Carla Lintas, et al. “Genomic and epigenetic evidence for oxytocin receptor deficiency in autism.” Bmc Med 7 (October 22, 2009): 62. https://doi.org/10.1186/1741-7015-7-62.Full Text Link to Item
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McCauley, J. L., R. L. Zuvich, Y. Bradford, S. J. Kenealy, N. Schnetz-Boutaud, S. G. Gregory, S. L. Hauser, et al. “Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.” Genes Immun 10, no. 7 (October 2009): 624–30. https://doi.org/10.1038/gene.2009.53.Full Text Link to Item
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Wang, Tianyuan, Terrence S. Furey, Jessica J. Connelly, Shihao Ji, Sarah Nelson, Steffen Heber, Simon G. Gregory, and Elizabeth R. Hauser. “A general integrative genomic feature transcription factor binding site prediction method applied to analysis of USF1 binding in cardiovascular disease.” Hum Genomics 3, no. 3 (April 2009): 221–35. https://doi.org/10.1186/1479-7364-3-3-221.Full Text Link to Item
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Afshari, Natalie A., Yi-Ju Li, Margaret A. Pericak-Vance, Simon Gregory, and Gordon K. Klintworth. “Genome-wide linkage scan in fuchs endothelial corneal dystrophy.” Invest Ophthalmol Vis Sci 50, no. 3 (March 2009): 1093–97. https://doi.org/10.1167/iovs.08-1839.Full Text Link to Item
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Crosslin, David R., Svati H. Shah, Sarah C. Nelson, Carol S. Haynes, Jessica J. Connelly, Shera Gadson, Pascal J. Goldschmidt-Clermont, et al. “Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.” Hum Genet 125, no. 2 (March 2009): 217–29. https://doi.org/10.1007/s00439-008-0619-0.Full Text Link to Item
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Maier, Lisa M., Christopher E. Lowe, Jason Cooper, Kate Downes, David E. Anderson, Christopher Severson, Pamela M. Clark, et al. “IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.” Plos Genet 5, no. 1 (January 2009): e1000322. https://doi.org/10.1371/journal.pgen.1000322.Full Text Link to Item
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Shah, Svati H., Neil J. Freedman, Lisheng Zhang, David R. Crosslin, David H. Stone, Carol Haynes, Jessica Johnson, et al. “Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.” Plos Genet 5, no. 1 (January 2009): e1000318. https://doi.org/10.1371/journal.pgen.1000318.Full Text Open Access Copy Link to Item
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Gregory, S. G. “Mapping techniques,” December 1, 2008, 291–310. https://doi.org/10.1007/978-1-60327-375-6_20.Full Text
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Shah, Svati H., Elizabeth R. Hauser, David Crosslin, Liyong Wang, Carol Haynes, Jessica Connelly, Sarah Nelson, et al. “ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention.” Atherosclerosis 201, no. 1 (November 2008): 148–54. https://doi.org/10.1016/j.atherosclerosis.2008.01.011.Full Text Link to Item
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Goswami, Robi, Beth S. Sutton, Cynthia Rouf, Sarah Nelson, Carol Haynes, Jessica Johnson, Pascal Goldschmidt-Clermont, et al. “Biliverdin Reductase Genetic Polymorphisms are Associated with Early-Onset Coronary Artery Disease In Two Datasets.” Circulation 118, no. 18 (October 28, 2008): S389–90.Link to Item
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Deak, Kristen L., Deborah G. Siegel, Timothy M. George, Simon Gregory, Allison Ashley-Koch, Marcy C. Speer, and Marcy C. NTD Collaborative Group. “Further evidence for a maternal genetic effect and a sex-influenced effect contributing to risk for human neural tube defects.” Birth Defects Res a Clin Mol Teratol 82, no. 10 (October 2008): 662–69. https://doi.org/10.1002/bdra.20511.Full Text Link to Item
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Wang, L., E. R. Hauser, S. H. Shah, D. Seo, P. Sivashanmugam, S. T. Exum, S. G. Gregory, et al. “Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease.” Ann Hum Genet 72, no. Pt 4 (July 2008): 443–53. https://doi.org/10.1111/j.1469-1809.2008.00433.x.Full Text Link to Item
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Kennerly, Erin, Anne Ballmann, Stanton Martin, Russ Wolfinger, Simon Gregory, Michael Stoskopf, and Greg Gibson. “A gene expression signature of confinement in peripheral blood of red wolves (Canis rufus).” Mol Ecol 17, no. 11 (June 2008): 2782–91. https://doi.org/10.1111/j.1365-294X.2008.03775.x.Full Text Link to Item
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Stamm, Demetra S., Deborah G. Siegel, Lorraine Mehltretter, Jessica J. Connelly, Alison Trott, Nathen Ellis, Victoria Zismann, et al. “Refinement of 2q and 7p loci in a large multiplex NTD family.” Birth Defects Res a Clin Mol Teratol 82, no. 6 (June 2008): 441–52. https://doi.org/10.1002/bdra.20462.Full Text Link to Item
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Sutton, Beth S., David R. Crosslin, Svati H. Shah, Sarah C. Nelson, Anthony Bassil, A Brent Hale, Carol Haynes, et al. “Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets.” Hum Mol Genet 17, no. 9 (May 1, 2008): 1318–28. https://doi.org/10.1093/hmg/ddn020.Full Text Link to Item
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Connelly, Jessica J., Svati H. Shah, Jennifer F. Doss, Shera Gadson, Sarah Nelson, David R. Crosslin, A Brent Hale, et al. “Genetic and functional association of FAM5C with myocardial infarction.” Bmc Med Genet 9 (April 22, 2008): 33. https://doi.org/10.1186/1471-2350-9-33.Full Text Link to Item
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Ichimura, K., A. P. Vogazianou, L. Liu, D. M. Pearson, L. M. Bäcklund, K. Plant, K. Baird, C. F. Langford, S. G. Gregory, and V. P. Collins. “1p36 is a preferential target of chromosome 1 deletions in astrocytic tumours and homozygously deleted in a subset of glioblastomas.” Oncogene 27, no. 14 (March 27, 2008): 2097–2108. https://doi.org/10.1038/sj.onc.1210848.Full Text Link to Item
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Gregory, Simon G., Silke Schmidt, Puneet Seth, Jorge R. Oksenberg, John Hart, Angela Prokop, Stacy J. Caillier, et al. “Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.” Nat Genet 39, no. 9 (September 2007): 1083–91. https://doi.org/10.1038/ng2103.Full Text Link to Item
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International Multiple Sclerosis Genetics Consortium, Stephen L., David A. Hafler, Alastair Compston, Stephen Sawcer, Eric S. Lander, Mark J. Daly, Philip L. De Jager, et al. “Risk alleles for multiple sclerosis identified by a genomewide study.” N Engl J Med 357, no. 9 (August 30, 2007): 851–62. https://doi.org/10.1056/NEJMoa073493.Full Text Link to Item
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McCauley, Jacob L., Shannon J. Kenealy, Elliott H. Margulies, Nathalie Schnetz-Boutaud, Simon G. Gregory, Stephen L. Hauser, Jorge R. Oksenberg, Margaret A. Pericak-Vance, Jonathan L. Haines, and Douglas P. Mortlock. “SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach.” Bmc Genomics 8 (August 6, 2007): 266. https://doi.org/10.1186/1471-2164-8-266.Full Text Link to Item
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Wang, Liyong, Elizabeth R. Hauser, Svati H. Shah, Margaret A. Pericak-Vance, Carol Haynes, David Crosslin, Marco Harris, et al. “Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.” Am J Hum Genet 80, no. 4 (April 2007): 650–63. https://doi.org/10.1086/512981.Full Text Link to Item
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Yeo, Tai Wai, Philip L. De Jager, Simon G. Gregory, Lisa F. Barcellos, Amie Walton, An Goris, Chiara Fenoglio, et al. “A second major histocompatibility complex susceptibility locus for multiple sclerosis.” Ann Neurol 61, no. 3 (March 2007): 228–36. https://doi.org/10.1002/ana.21063.Full Text Link to Item
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Motsinger, Alison A., David Brassat, Stacy J. Caillier, Henry A. Erlich, Karen Walker, Lori L. Steiner, Lisa F. Barcellos, et al. “Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes.” Neurogenetics 8, no. 1 (January 2007): 11–20. https://doi.org/10.1007/s10048-006-0058-9.Full Text Link to Item
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Gregory, S. G., K. F. Barlow, K. E. McLay, R. Kaul, D. Swarbreck, A. Dunham, C. E. Scott, et al. “Erratum: The DNA sequence and biological annotation of human chromosome 1 (Nature (2006) 441 (315-321)).” Nature 443, no. 7114 (October 26, 2006): 1013. https://doi.org/10.1038/nature05152.Full Text
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Bakker, Paul I. W. de, Gil McVean, Pardis C. Sabeti, Marcos M. Miretti, Todd Green, Jonathan Marchini, Xiayi Ke, et al. “A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.” Nat Genet 38, no. 10 (October 2006): 1166–72. https://doi.org/10.1038/ng1885.Full Text Link to Item
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Natrajan, R., R. D. Williams, S. N. Hing, A. Mackay, J. S. Reis-Filho, K. Fenwick, M. Iravani, et al. “Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse.” J Pathol 210, no. 1 (September 2006): 49–58. https://doi.org/10.1002/path.2021.Full Text Link to Item
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Connelly, J. J., T. Wang, J. E. Cox, C. Haynes, L. Wang, S. H. Shah, D. R. Crosslin, et al. “GATA2 is associated with familial early-onset coronary artery disease.” Plos Genetics 2, no. 8 (August 25, 2006). https://doi.org/10.1371/journal.pgen.0020139.Full Text
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Connelly, Jessica J., Tianyuan Wang, Julie E. Cox, Carol Haynes, Liyong Wang, Svati H. Shah, David R. Crosslin, et al. “GATA2 is associated with familial early-onset coronary artery disease.” Plos Genet 2, no. 8 (August 25, 2006): e139. https://doi.org/10.1371/journal.pgen.0020139.Full Text Link to Item
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Schmidt, S., M. A. Pericak-Vance, S. Sawcer, L. F. Barcellos, J. Hart, J. Sims, A. M. Prokop, et al. “Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis.” Genes Immun 7, no. 5 (July 2006): 384–92. https://doi.org/10.1038/sj.gene.6364311.Full Text Link to Item
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Brassat, D., A. A. Motsinger, S. J. Caillier, H. A. Erlich, K. Walker, L. L. Steiner, B. A. C. Cree, et al. “Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans.” Genes Immun 7, no. 4 (June 2006): 310–15. https://doi.org/10.1038/sj.gene.6364299.Full Text Link to Item
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Gregory, S. G., K. F. Barlow, K. E. McLay, R. Kaul, D. Swarbreck, A. Dunham, C. E. Scott, et al. “The DNA sequence and biological annotation of human chromosome 1.” Nature 441, no. 7091 (May 18, 2006): 315–21. https://doi.org/10.1038/nature04727.Full Text Link to Item
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Jarbo, Caroline, Patrick G. Buckley, Arkadiusz Piotrowski, Kiran K. Mantripragada, Magdalena Benetkiewicz, Teresita Diaz de Ståhl, Cordelia F. Langford, et al. “Detailed assessment of chromosome 22 aberrations in sporadic pheochromocytoma using array-CGH.” Int J Cancer 118, no. 5 (March 1, 2006): 1159–64. https://doi.org/10.1002/ijc.21385.Full Text Link to Item
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Kenealy, S. J., L. A. Herrel, Y. Bradford, N. Schnetz-Boutaud, J. R. Oksenberg, S. L. Hauser, L. F. Barcellos, et al. “Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44.” Genes Immun 7, no. 1 (January 2006): 73–76. https://doi.org/10.1038/sj.gene.6364275.Full Text Link to Item
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Xu, Hong, Simon G. Gregory, Elizabeth R. Hauser, Judith E. Stenger, Margaret A. Pericak-Vance, Jeffery M. Vance, Stephan Züchner, and Michael A. Hauser. “SNPselector: a web tool for selecting SNPs for genetic association studies.” Bioinformatics 21, no. 22 (November 15, 2005): 4181–86. https://doi.org/10.1093/bioinformatics/bti682.Full Text Link to Item
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Kresse, Stine H., Jeanne-Marie Berner, Leonardo A. Meza-Zepeda, Simon G. Gregory, Wen-Lin Kuo, Joe W. Gray, Anne Forus, and Ola Myklebost. “Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH.” Mol Cancer 4 (November 7, 2005): 39. https://doi.org/10.1186/1476-4598-4-39.Full Text Link to Item
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Sawcer, Stephen, Maria Ban, Mel Maranian, Tai Wai Yeo, Alastair Compston, Andrew Kirby, Mark J. Daly, et al. “A high-density screen for linkage in multiple sclerosis.” Am J Hum Genet 77, no. 3 (September 2005): 454–67. https://doi.org/10.1086/444547.Full Text Link to Item
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White, Peter S., Patricia M. Thompson, Takahiro Gotoh, Erin R. Okawa, Jun Igarashi, Marleen Kok, Cynthia Winter, et al. “Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma.” Oncogene 24, no. 16 (April 14, 2005): 2684–94. https://doi.org/10.1038/sj.onc.1208306.Full Text Link to Item
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Buckley, Patrick G., Caroline Jarbo, Uwe Menzel, Tiit Mathiesen, Carol Scott, Simon G. Gregory, Cordelia F. Langford, and Jan P. Dumanski. “Comprehensive DNA copy number profiling of meningioma using a chromosome 1 tiling path microarray identifies novel candidate tumor suppressor loci.” Cancer Res 65, no. 7 (April 1, 2005): 2653–61. https://doi.org/10.1158/0008-5472.CAN-04-3651.Full Text Link to Item
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Ross, Mark T., Darren V. Grafham, Alison J. Coffey, Steven Scherer, Kirsten McLay, Donna Muzny, Matthias Platzer, et al. “The DNA sequence of the human X chromosome.” Nature 434, no. 7031 (March 17, 2005): 325–37. https://doi.org/10.1038/nature03440.Full Text Link to Item
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Redon, R., M. Rio, S. G. Gregory, R. A. Cooper, H. Fiegler, D. Sanlaville, R. Banerjee, et al. “Tiling path resolution mapping of constitutional 1p36 deletions by array-CGH: contiguous gene deletion or "deletion with positional effect" syndrome?” J Med Genet 42, no. 2 (February 2005): 166–71. https://doi.org/10.1136/jmg.2004.023861.Full Text Link to Item
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Wicker, Linda S., Carolyn L. Moule, Heather Fraser, Carlos Penha-Goncalves, Dan Rainbow, Valerie E. S. Garner, Giselle Chamberlain, et al. “Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse.” Novartis Found Symp 267 (2005): 57–65. https://doi.org/10.1002/047002139x.ch6.Full Text Link to Item
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Stover, Cordula M., Nicholas J. Lynch, Steven J. Hanson, Michaela Windbichler, Simon G. Gregory, and Wilhelm J. Schwaeble. “Organization of the MASP2 locus and its expression profile in mouse and rat.” Mamm Genome 15, no. 11 (November 2004): 887–900. https://doi.org/10.1007/s00335-004-3006-8.Full Text Link to Item
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International Human Genome Sequencing Consortium, Geraldine. “Finishing the euchromatic sequence of the human genome.” Nature 431, no. 7011 (October 21, 2004): 931–45. https://doi.org/10.1038/nature03001.Full Text Link to Item
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Mallon, Ann-Marie, Laurens Wilming, Joseph Weekes, James G. R. Gilbert, Jennifer Ashurst, Sandrine Peyrefitte, Lucy Matthews, et al. “Organization and evolution of a gene-rich region of the mouse genome: a 12.7-Mb region deleted in the Del(13)Svea36H mouse.” Genome Res 14, no. 10A (October 2004): 1888–1901. https://doi.org/10.1101/gr.2478604.Full Text Link to Item
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Sawcer, Stephen J., Mel Maranian, Sara Singlehurst, TaiWai Yeo, Alastair Compston, Mark J. Daly, Philip L. De Jager, et al. “Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.” Hum Mol Genet 13, no. 17 (September 1, 2004): 1943–49. https://doi.org/10.1093/hmg/ddh202.Full Text Link to Item
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Wicker, Linda S., Giselle Chamberlain, Kara Hunter, Dan Rainbow, Sarah Howlett, Paul Tiffen, Jan Clark, et al. “Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.” J Immunol 173, no. 1 (July 1, 2004): 164–73. https://doi.org/10.4049/jimmunol.173.1.164.Full Text Link to Item
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Penha-Gonçalves, Carlos, Carolyn Moule, Luc J. Smink, Joanna Howson, Simon Gregory, Jane Rogers, Paul A. Lyons, et al. “Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice.” Diabetes 52, no. 6 (June 2003): 1551–56. https://doi.org/10.2337/diabetes.52.6.1551.Full Text Link to Item
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Ueda, Hironori, Joanna M. M. Howson, Laura Esposito, Joanne Heward, Hywel Snook, Giselle Chamberlain, Daniel B. Rainbow, et al. “Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.” Nature 423, no. 6939 (May 29, 2003): 506–11. https://doi.org/10.1038/nature01621.Full Text Link to Item
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Hoffman, Hal M., Simon G. Gregory, James L. Mueller, Mark Tresierras, David H. Broide, Alan A. Wanderer, and Richard D. Kolodner. “Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P.” Hum Genet 112, no. 2 (February 2003): 209–16. https://doi.org/10.1007/s00439-002-0860-x.Full Text Link to Item
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Mouse Genome Sequencing Consortium, Eric S., Robert H. Waterston, Kerstin Lindblad-Toh, Ewan Birney, Jane Rogers, Josep F. Abril, Pankaj Agarwal, et al. “Initial sequencing and comparative analysis of the mouse genome.” Nature 420, no. 6915 (December 5, 2002): 520–62. https://doi.org/10.1038/nature01262.Full Text Link to Item
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Ewens, Kathryn G., Lindsey N. Johnson, Beth Wapelhorst, Kristin O’Brien, Sarah Gutin, V Anne Morrison, Craig Street, Simon G. Gregory, Richard S. Spielman, and Patrick Concannon. “Linkage and association with type 1 diabetes on chromosome 1q42.” Diabetes 51, no. 11 (November 2002): 3318–25. https://doi.org/10.2337/diabetes.51.11.3318.Full Text
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Parvari, Ruti, Eli Hershkovitz, Nili Grossman, Rafael Gorodischer, Bart Loeys, Alexandra Zecic, Geert Mortier, et al. “Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism and autosomal recessive Kenny-Caffey syndrome.” Nat Genet 32, no. 3 (November 2002): 448–52. https://doi.org/10.1038/ng1012.Full Text Link to Item
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Gregory, Simon G., Mandeep Sekhon, Jacqueline Schein, Shaying Zhao, Kazutoyo Osoegawa, Carol E. Scott, Richard S. Evans, et al. “A physical map of the mouse genome.” Nature 418, no. 6899 (August 15, 2002): 743–50. https://doi.org/10.1038/nature00957.Full Text Link to Item
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McMullan, Tristan W., John A. Crolla, Simon G. Gregory, Nigel P. Carter, Rachel A. Cooper, Gareth R. Howell, and David O. Robinson. “A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation.” Hum Genet 110, no. 3 (March 2002): 244–50. https://doi.org/10.1007/s00439-002-0679-5.Full Text Link to Item
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Watanabe, Y., J. C. Murray, B. C. Bjork, C. P. Bird, P. W. Chiang, S. G. Gregory, D. M. Kurnit, and B. C. Schutte. “Matroshka and ectopic polymorphisms: Two new classes of DNA sequence variation identified at the Van der Woude syndrome locus on 1q32-q41.” Hum Mutat 18, no. 5 (November 2001): 422–34. https://doi.org/10.1002/humu.1213.Full Text Link to Item
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Cai, W. W., C. W. Chow, S. Damani, S. G. Gregory, M. Marra, and A. Bradley. “An SSLP marker-anchored BAC framework map of the mouse genome.” Nat Genet 29, no. 2 (October 2001): 133–34. https://doi.org/10.1038/ng1001-133.Full Text Link to Item
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Lander, E. S., L. M. Linton, B. Birren, C. Nusbaum, M. C. Zody, J. Baldwin, K. Devon, et al. “Erratum: Initial sequencing and analysis of the human genome: International Human Genome Sequencing Consortium (Nature (2001) 409 (860-921)).” Nature 412, no. 6846 (August 2, 2001): 565–66. https://doi.org/10.1038/35087627.Full Text
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Stover, C., Y. Endo, M. Takahashi, N. J. Lynch, C. Constantinescu, T. Vorup-Jensen, S. Thiel, et al. “The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.” Genes Immun 2, no. 3 (May 2001): 119–27. https://doi.org/10.1038/sj.gene.6363745.Full Text Link to Item
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Doudney, K., J. N. Murdoch, C. Paternotte, L. Bentley, S. Gregory, A. J. Copp, and P. Stanier. “Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23.” Genomics 72, no. 2 (March 1, 2001): 180–92. https://doi.org/10.1006/geno.2000.6463.Full Text Link to Item
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Bentley, D. R., P. Deloukas, A. Dunham, L. French, S. G. Gregory, S. J. Humphray, A. J. Mungall, et al. “The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X.” Nature 409, no. 6822 (February 15, 2001): 942–43. https://doi.org/10.1038/35057165.Full Text Link to Item
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Lander, E. S., L. M. Linton, B. Birren, C. Nusbaum, M. C. Zody, J. Baldwin, K. Devon, et al. “Initial sequencing and analysis of the human genome.” Nature 409, no. 6822 (February 15, 2001): 860–921. https://doi.org/10.1038/35057062.Full Text Link to Item
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McPherson, J. D., M. Marra, L. Hillier, R. H. Waterston, A. Chinwalla, J. Wallis, M. Sekhon, et al. “A physical map of the human genome.” Nature 409, no. 6822 (February 15, 2001): 934–41. https://doi.org/10.1038/35057157.Full Text Link to Item
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Schutte, B. C., J. D. Carpten, A. Forus, S. G. Gregory, A. Horii, and P. S. White. “Report of the sixth international workshop on human chromosome 1 mapping 2000.” Cytogenetics and Cell Genetics 92, no. 1–2 (2001): 24–40.Link to Item
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White, P. S., P. M. Thompson, B. A. Seifried, E. P. Sulman, S. J. Jensen, C. Guo, J. M. Maris, et al. “Detailed molecular analysis of 1p36 in neuroblastoma.” Med Pediatr Oncol 36, no. 1 (January 2001): 37–41. https://doi.org/10.1002/1096-911X(20010101)36:1<37::AID-MPO1010>3.0.CO;2-L.Full Text Link to Item
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Carpten, J. D., I. Makalowska, C. M. Robbins, N. Scott, R. Sood, T. D. Connors, T. I. Bonner, et al. “A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region.” Genomics 64, no. 1 (February 15, 2000): 1–14. https://doi.org/10.1006/geno.1999.6051.Full Text Link to Item
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Shackleton, S., D. J. Lloyd, S. N. Jackson, R. Evans, M. F. Niermeijer, B. M. Singh, H. Schmidt, et al. “LMNA, encoding lamin A/C, is mutated in partial lipodystrophy.” Nat Genet 24, no. 2 (February 2000): 153–56. https://doi.org/10.1038/72807.Full Text Link to Item
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Schutte, B. C., B. C. Bjork, K. B. Coppage, M. I. Malik, S. G. Gregory, D. J. Scott, L. M. Brentzell, Y. Watanabe, M. J. Dixon, and J. C. Murray. “A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41.” Genome Res 10, no. 1 (January 2000): 81–94.Link to Item
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White, P. S., A. Forus, T. C. Matise, B. C. Schutte, N. Spieker, P. Stanier, J. M. Vance, and S. G. Gregory. “Fifth International Workshop on Human Chromosome 1 Mapping 1999, the Sanger Centre, Cambridge, UK, August 5-7 1999: Report.” Cytogenetics and Cell Genetics 87, no. 3–4 (December 1, 1999): 143–63.
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Labay, V., T. Raz, D. Baron, H. Mandel, H. Williams, T. Barrett, R. Szargel, et al. “Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness.” Nat Genet 22, no. 3 (July 1999): 300–304. https://doi.org/10.1038/10372.Full Text Link to Item
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Gregory, S. G., M. Vaudin, R. Wooster, M. Coleman, D. Mischke, C. Porter, B. C. Schutte, P. White, and J. M. Vance. “Fourth International Workshop on Human Chromosome 1 Mapping 1998, Sanger Centre, Cambridge, United Kingdom, June 25-27 1998: Report.” Cytogenetics and Cell Genetics 83, no. 3–4 (December 1, 1998): 147–67.
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Gregory, S. G., M. Vaudin, R. Wooster, M. Coleman, D. Mischke, C. Porter, B. C. Schutte, P. White, and J. M. Vance. “Report of the fourth international workshop on human chromosome 1 mapping 1998.” Cytogenetics and Cell Genetics 83, no. 3–4 (January 1, 1998): 148–67.Link to Item
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Gregory, S. G., G. R. Howell, and D. R. Bentley. “Genome mapping by fluorescent fingerprinting.” Genome Res 7, no. 12 (December 1997): 1162–68. https://doi.org/10.1101/gr.7.12.1162.Full Text Link to Item
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Roest Crollius, H., M. T. Ross, A. Grigoriev, C. J. Knights, E. Holloway, J. Misfud, K. Li, et al. “An integrated YAC map of the human X chromosome.” Genome Res 6, no. 10 (October 1996): 943–55. https://doi.org/10.1101/gr.6.10.943.Full Text Link to Item
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Forbes, S. A., L. Brennan, M. Richardson, A. Coffey, C. G. Cole, S. G. Gregory, D. R. Bentley, S. Mumm, G. E. Moore, and P. Stanier. “Refined mapping and YAC contig construction of the X-linked cleft palate and ankyloglossia locus (CPX) including the proximal X-Y homology breakpoint within Xq21.3.” Genomics 31, no. 1 (January 1, 1996): 36–43. https://doi.org/10.1006/geno.1996.0006.Full Text Link to Item
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Van de Vosse, E., A. A. Bergen, E. J. Meershoek, J. C. Oosterwijk, S. Gregory, B. Bakker, J. Weissenbach, A. J. Coffey, G. J. van Ommen, and J. T. Den Dunnen. “An Xp22.1-p22.2 YAC contig encompassing the disease loci for RS, KFSD, CLS, HYP and RP15: refined localization of RS.” Eur J Hum Genet 4, no. 2 (1996): 101–4. https://doi.org/10.1159/000472177.Full Text Link to Item
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Wooster, R., G. Bignell, J. Lancaster, S. Swift, S. Seal, J. Mangion, N. Collins, et al. “Addendum: Identification of the breast cancer susceptibility gene BRCA2 (Nature (1995) 378 (789-792)).” Nature 379, no. 6567 (January 1, 1996): 749. https://doi.org/10.1038/379749a0.Full Text
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Wooster, R., G. Bignell, J. Lancaster, S. Swift, S. Seal, J. Mangion, N. Collins, S. Gregory, C. Gumbs, and G. Micklem. “Identification of the breast cancer susceptibility gene BRCA2.” Nature 378, no. 6559 (December 21, 1995): 789–92. https://doi.org/10.1038/378789a0.Full Text Link to Item
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Fantes, J. A., K. Oghene, S. Boyle, S. Danes, J. M. Fletcher, E. A. Bruford, K. Williamson, A. Seawright, A. Schedl, and I. Hanson. “A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1.” Genomics 25, no. 2 (January 20, 1995): 447–61. https://doi.org/10.1016/0888-7543(95)80045-n.Full Text Link to Item
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Redeker, E., J. M. Hoovers, M. Alders, C. J. van Moorsel, A. C. Ivens, S. Gregory, L. Kalikin, J. Bliek, L. de Galan, and R. van den Bogaard. “An integrated physical map of 210 markers assigned to the short arm of human chromosome 11.” Genomics 21, no. 3 (June 1994): 538–50. https://doi.org/10.1006/geno.1994.1312.Full Text Link to Item
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Heding, I. J., A. C. Ivens, J. Wilson, M. Strivens, S. Gregory, J. M. Hoovers, M. Mannens, B. Redeker, D. Porteous, and V. van Heyningen. “The generation of ordered sets of cosmid DNA clones from human chromosome region 11p.” Genomics 13, no. 1 (May 1992): 89–94. https://doi.org/10.1016/0888-7543(92)90206-8.Full Text Link to Item
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Book Sections
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Markunas, C. A., A. E. Ashley-Koch, and S. G. Gregory. “Genetics of the chiari I and II malformations.” In The Chiari Malformations, 289–97, 2020. https://doi.org/10.1007/978-3-030-44862-2_23.Full Text
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Gregory, S. G. “The epigenetics of Autism-Running beyond the bases.” In Frontiers in Autism Research: New Horizons for Diagnosis and Treatment, 303–33, 2014. https://doi.org/10.1142/9789814602167_0013.Full Text
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Markunas, C. A., A. E. Ashley-Koch, and S. G. Gregory. “Genetics of the Chiari i and II malformations.” In The Chiari Malformations, 9781461463696:93–101, 2013. https://doi.org/10.1007/978-1-4614-6369-6_7.Full Text
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Gregory, S. G. “Genomic Rearrangements in Autism: The Contribution of Copy Number Loss and Gain to the Etiology of Autism Spectrum Disorders.,” 52:S17–S17. WILEY-BLACKWELL, 2011.Link to Item
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Gregory, Simon, and John Gilbert. “Strategies for genotype generation.,” Chapter 1:Unit-1.3, 2005. https://doi.org/10.1002/0471142905.hg0103s47.Full Text Link to Item
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Stenger, J. E., and S. G. Gregory. “Genomics and Bioinformatics.” In Genetic Analysis of Complex Diseases: Second Edition, 423–54, 2005. https://doi.org/10.1002/9780471781141.ch15.Full Text
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Coffey, A., S. Gregory, and C. G. Cole. “Alu-PCR fingerprinting of YACs.,” 54:97–114, 1996. https://doi.org/10.1385/0-89603-313-9:97.Full Text Link to Item
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Reports
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Schutte, B. C., J. D. Carpten, A. Forus, S. G. Gregory, A. Horii, and P. S. White. “Report and abstracts of the sixth international workshop on human chromosome 1 mapping 2000. Iowa City, Iowa, USA. 30 September-3 October 2000.,” 2001. https://doi.org/10.1159/000056867.Full Text Link to Item
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White, P. S., A. Forus, T. C. Matise, B. C. Schutte, N. Spieker, P. Stanier, J. M. Vance, and S. G. Gregory. “Report of the fifth international workshop on human chromosome 1 mapping 1999.,” 1999. https://doi.org/10.1159/000015458.Full Text Link to Item
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Gregory, S. G., M. Vaudin, R. Wooster, M. Coleman, D. Mischke, C. Porter, B. C. Schutte, P. White, and J. M. Vance. “Report of the fourth international workshop on human chromosome 1 mapping 1998.,” 1998. https://doi.org/10.1159/000015174.Full Text Link to Item
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Vance, J. M., T. C. Matise, R. Wooster, B. C. Schutte, G. A. P. Bruns, N. Van Roy, G. M. Brodeur, et al. “Third International Chromosome 1 Maping Workshop, Duke University, Durham, NC, USA, 25-27 April 1997: Report of the third international workshop on human chromosome 1 mapping 1997,” December 1, 1997.
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Vance, J. M., T. C. Matise, R. Wooster, B. C. Schutte, G. A. Bruns, N. van Roy, G. M. Brodeur, et al. “Report and abstracts of the third international workshop on human chromosome 1 mapping 1997.,” 1997.Link to Item
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Conference Papers
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Chen, Tianyi, George Dalton, Seh-Hoon Oh, Raquel Maeso-Diaz, Kuo Du, Rachel A. Meyers, Cynthia Guy, et al. “Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease.” In Cellular and Molecular Gastroenterology and Hepatology, S2352-345X(22)00256-9, 2022. https://doi.org/10.1016/j.jcmgh.2022.12.008.Full Text
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Patierno, Brendon M., Wen-Chi Foo, Tyler Allen, Jason A. Somarelli, Kathryn E. Ware, Santosh Gupta, Sandra Wise, et al. “Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.” In Prostate Cancer Prostatic Dis, 25:513–23, 2022. https://doi.org/10.1038/s41391-021-00460-y.Full Text Open Access Copy Link to Item
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Gregory, S. G., S. Arvai, G. D. Dalton, K. Pegram, M. Kanayama, A. S. Chao, G. K. Matsushima, M. L. Shinohara, and E. J. Benner. “Characterizing the immunomodulation and remyelination efficacy of 20-aHydroxycholesterol in pre-clinical models of multiple sclerosis.” In Multiple Sclerosis Journal, 28:247–247, 2022.Link to Item
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Gupta, Santosh, Susan Halabi, Gabor Kemeny, Monika Anand, Paraskevi Giannakakou, David M. Nanus, Daniel J. George, Simon G. Gregory, and Andrew J. Armstrong. “Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer.” In Mol Cancer Res, 19:1040–50, 2021. https://doi.org/10.1158/1541-7786.MCR-20-0975.Full Text Link to Item
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Chen, Tianyi, George D. Dalton, Seh-Hoon Oh, Raquel Maeso Diaz, Kuo Du, Rachel A. Myers, Simon G. Gregory, et al. “SINGLE CELL RNA SEQUENCING DATA FROM MICE IDENTIFIES INHIBITED HEDGEHOG SIGNALING IN HEPATOCYTES AS A CRITICAL EARLY EVENT IN HUMAN NAFLD.” In Hepatology, 74:142A-142A, 2021.Link to Item
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Chen, Tianyi, Seh-Hoon Oh, Simon G. Gregory, Xiling Shen, and Anna Mae Diehl. “DYNAMIC EPIGENETIC REPROGRAMMING ENABLES FUNCTIONAL DIVERSIFICATION OF HEPATOCYTES DURING LIVER REGENERATION.” In Hepatology, 72:119A-120A, 2020.Link to Item
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Lee, M., J. Shannon, V. Jain, S. Joost, M. Kasper, D. L. Corcoran, S. G. Gregory, and A. S. MacLeod. “Skin epidermal keratinocyte differentiation-associated processes regulate homeostatic antiviral protein expression.” In Journal of Investigative Dermatology, 140:S29–S29, 2020.Link to Item
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Oh, Seh-Hoon, Mark Jewell, Richard T. Premont, Jason Gibson, Wayne Glover, Simon G. Gregory, David Hsu, Cynthia D. Guy, and Anna Mae Diehl. “Yap1 AS A THERAPEUTIC TARGET IN FIBROLAMELLAR CARCINOMA.” In Hepatology, 70:888A-889A. WILEY, 2019.Link to Item
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Jewell, Mark, Richard T. Premont, Jason Gibson, Wayne Glover, Timothy A. Dinh, Eliane L. Wauthier, Lola M. Reid, et al. “Yap1 As a Therapeutic Target in Fibrolamellar Carcinoma.” In Hepatology, 68:1243A-1243A. WILEY, 2018.Link to Item
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Kanayama, Masashi, Shengjie Xu, Keiko Danzaki, Jason R. Gibson, Makoto Inoue, Simon G. Gregory, and Mari L. Shinohara. “Skewing the population balance between lymphoid and myeloid cells by osteopontin isoforms.” In Cytokine, 100:161–161. ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2017.Link to Item
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Cote, Sabrina A., Simon G. Gregory, Jason Winnike, Kevin Knagge, Olga Ilkayeva, Thomas O’Connell, James Bain, et al. “Integrated metabolomic and transcriptomic profiles of males with multiple sclerosis.” In Multiple Sclerosis Journal, 22:9–10. SAGE PUBLICATIONS LTD, 2016.Link to Item
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Shah, Svati H., Lydia Kwee, Nathan Stitziel, Elizabeth R. Hauser, Carol Haynes, Sekar Kathiresan, Simon G. Gregory, and William E. Kraus. “Rare Variants Identified With Whole Exome Chip Genotyping Are Associated With Insulin Resistance and Glycemic Control.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.Link to Item
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Kraus, William E., Sheng Feng, Elizabeth R. Hauser, Simon G. Gregory, Carol Haynes, Z. E. Dowdy, Damian M. Craig, and Svati H. Shah. “Association of Gene Expression Signatures with Small Molecule Metabolic Intermediates that Predict Cardiovascular Mortality in CATHGEN.” In Circulation, Vol. 127. LIPPINCOTT WILLIAMS & WILKINS, 2013.Link to Item
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Shah, Asad A., Damian M. Craig, Carol Haynes, Jacqueline K. Sebek, Elizabeth Grass, Karen Abramson, Peter K. Smith, et al. “Genome-Wide Association Identifies Genetic Variants Associated With Vein Graft Stenosis After Coronary Artery Bypass Grafting.” In Circulation, Vol. 124. LIPPINCOTT WILLIAMS & WILKINS, 2011.Link to Item
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Minear, M. A., N. A. Afshari, E. Balajonda, B. Zhao, J. Rimmler, Y. -. J. Li, G. K. Klintworth, and S. G. Gregory. “Analysis of SLC4A11 and COL8A2 Mutations in Fuchs Endothelial Corneal Dystrophy (FECD).” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.Link to Item
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Wang, Liyong, Elizabeth R. Hauser, David Crosslin, Sarah Nelson, A. B. Hale, Simon G. Gregory, Svati H. Shah, William E. Kraus, Pascal J. Goldschmidt-Clermont, and Jeffery M. Vance. “Genomic convergence identified CAPG and VAMP8 as candidate genes for CAD.” In Circulation, 116:807–807. LIPPINCOTT WILLIAMS & WILKINS, 2007.Link to Item
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Wang, Liyong, Elizabeth R. Hauser, Svati H. Shah, Carol Haynes, Jason M. Rose, Marco Harris, Julie Rombaut, et al. “Identification of kalirin gene as a novel coronary artery disease gene through peak-wide association mapping on chromosome 3q13-21.” In Circulation, 114:887–887. LIPPINCOTT WILLIAMS & WILKINS, 2006.Link to Item
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Gregory, S. G., N. V. Johnson, J. J. Connelly, J. Virgadamo, R. E. McLendon, J. M. Vance, and D. D. Bigner. “Characterizing genomic rearrangements in oligodendroglioma using whole genome tilepath hrCGH arrays.” In Neuro Oncology, 8:421–421. DUKE UNIV PRESS, 2006.Link to Item
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Johnson, Nicole V., Jessica J. Connelly, Josh Virigadamo, Roger E. McLendon, Jeffrey M. Vance, Darell D. Bigner, and Simon G. Gregory. “Characterizing oligodendroglioma rearrangements using whole genome hrCGH arrays.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.Link to Item
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Meza-Zepeda, Leonardo A., Stine H. Kresse, Ana H. Barragan-Polania, Junbai Wang, Bjorn E. Kristiansen, Wen-Lin Kuo, Simon G. Gregory, Joe W. Gray, and Ola Myklebost. “Profiling of DNA copy number changes in sarcomas by array comparative genomic hybridization.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.Link to Item
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Wang, L. Y., E. R. Hauser, S. H. Shah, W. E. Kraus, D. Seo, L. L. Huang, J. M. Rose, et al. “Identification of a novel locus for left main coronary artery disease.” In Circulation, 112:U413–U413. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Haines, J. L., S. Schmidt, S. Sawcer, L. F. Barcellos, S. G. Gregory, J. Sims, M. Booze, et al. “Comprehensive analysis of candidate modifier genes for multiple sclerosis (MS) on chromosome 19q13.” In American Journal of Human Genetics, 73:368–368. UNIV CHICAGO PRESS, 2003.Link to Item
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Maris, J. M., C. Guo, D. Blake, P. S. White, M. D. Hogarty, P. M. Thompson, V. Rajalingam, et al. “Comprehensive analysis of chromosome 1p deletions in neuroblastoma.” In Med Pediatr Oncol, 36:32–36, 2001. https://doi.org/10.1002/1096-911X(20010101)36:1<32::AID-MPO1009>3.0.CO;2-0.Full Text Link to Item
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Little, D., C. L. Wu, R. D’Amico, D. Corcoran, S. Gregory, and F. Guilak. “Epigenetic Analysis of Adipose Stem Cells in Obesity Identifies Dysregulation of Critical Pathways in Musculoskeletal Regeneration and Disease.,” n.d.
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- Teaching & Mentoring
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Recent Courses
- MGM 593: Research Independent Study 2022
- UPGEN 778C: University Program in Genetics and Genomics Biological Solutions Module Ill 2022
- CRP 243: Introduction to Medical Genetics 2021
- MGM 593: Research Independent Study 2021
- UPGEN 778D: University Program in Genetics and Genomics Biological Solutions Module IV 2021
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Advising & Mentoring
- Dr. Gregory is/has mentored high school (12), undergraduate (14), graduate candidate rotation (9), graduate candidate thesis committee (14), graduate candidate primary mentor (6), Masters candidate (1), Post-doctoral fellow (4) and junior faculty (5) trainees.
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Characterizing oxysterol regulation of inflamation and mediators of remyelination in MS. 10x Genomics User Group Meeting. October 2018 2018
- Characterizing Oxysterols as moderators of inflammation and mediators of remyelination in MS. Duke - National University of Singapore. July 2018 2018
- Characterizing Oxysterols as moderators of inflammation and mediators of remyelination in MS. University of Sydney. July 2018 2018
- Epistatic interaction with IL7R and the development of MS. Epigenetics and Stem Cell Biology Laboratory Seminar Series. NIEHS. September 2017 2017
- Developing biomarkers and mechanisms of oxytocin use in autism. University of Sydney. February 2017 2017
- Developing biomarkers and mechanisms of oxytocin use in autism. Autism Symposium. Duke - National University of Singapore. January 2017 2017
- Molecular profiling of an Oxytocin Treatment trial - a first pass view. University of Sydney. February 2016 2016
- MicroRNA profiling in an animal model of multiple sclerosis. Epigenomics of Common Diseases. Wellcome Trust. November 2015 2015
- The identification of genetic association and regulation of IL7R in an autoimmune disease. Pfizer. September 2015 2015
- Autoimmune Genes: Discovery & Function. ASHG Annual Meeting. October 2014 2014
- Genetics of Multiple Sclerosis - current state and future developments. University of Basel. July 2014 2014
- The functional characterization of a multiple sclerosis associated variant in IL7Ra. University of North Carolina - Chapel Hill. June 2014 2014
- Leveraging epigenomics to understand the etiology of CVD. Duke Cardiovascular Research Center Seminar Series. June 2013 2013
- In Pursuit of Mechanism - From Association to Function in Multiple Sclerosis. Spring Seminar Series. The Jackson Laboratory. March 2013 2013
- The role of IL7R splicing in the etiology of MS. Carolinas Research Symposium. National Multiple Sclerosis Society. August 2012 2012
- Epigenetic Association of OXTR with Autism. 67th Annual Meeting. Society of Biological Psychiatry. May 2012 2012
- Epigenetic Profiling in Autism – The Case for Targeted and Discovery Approaches. Investigator Forum Series. University of North Carolina - Chapel Hill. March 2012 2012
- Genetic Variation and Multiple Sclerosis. National MS Society - Greater Delaware Valley Chapter. November 2011 2011
- Genomic rearrangements in autism. Environmental Mutagen Society. October 2011 2011
- Genetics of Chiari Type 1 Malformation. American Syringommyelia & Chiari Alliance Project. July 2011 2011
- Genomic and epigenetic signatures of OXTR and autism. World Congress on Neurophysical Hormones. July 2011 2011
- The Genetics and Genomic Sciences of Neurological Disease. Transcending the Boundaries Workshop on Neurodevelopment. Duke University Institute of Brain Science. May 2010 2010
- Epigenetic Evidence of Oxytocin Receptor Deficiency in Autism. Autism Research Institute. April 2010 2010
- Establishing the role of IL-7R in the development of MS. University of California San Francisco. April 2010 2010
- Epigenetic evidence of oxytocin receptor deficiency in autism. Think Tank Meeting. Autism Research Institute. January 2010 2010
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Outreach & Engaged Scholarship
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Service to the Profession
- Academic and Scientific Advisor. David H. Murdock Research Institute. 2018 - 2020 2018 - 2020
- Reviewer. Research Development Grant Program. Kansas City Area Life Sciences Institute (KCALSI). 2018 2018
- International Review Committee Member. Multiple Sclerosis Society Research Foundation, Canada. 2016 - 2017 2016 - 2017
- Member. Pilot Grant Review Committee. National Multiple Sclerosis Society. 2016 - 2017 2016 - 2017
- Standing Member. Special Emphasis Panel/Scientific Review Group 2015/05 NSD-C Neurological Sciences and Disorders C. National Institutes of Health, Center for Scientific Review. 2015 - 2020 2015 - 2020
- Ad Hoc Reviewer. Research Competitiveness Program. American Association for the Advancement of Science. 2014 2014
- Ad Hoc Reviewer. Cancer, Cardiovascular, and Sleep Epidemiology Panel B (CASE). National Institutes of Health, Center for Scientific Review. 2013 - 2016 2013 - 2016
- Ad Hoc Reviewer. National Priorities Research Program. Quatar National Research Foundation. 2013 - 2015 2013 - 2015
- Awards Reviewer. Charles J. Epstein Trainee Awards for Excellence in Human Genetics. American Society of Human Genetics. 2013 - 2016 2013 - 2016
- Editorial Board Member. Frontiers in Neurogenomics. 2013 - 2017 2013 - 2017
- Director, Genomics Core Facility. David H. Murdock Research Institute. 2010 - 2018 2010 - 2018
- Member. American Society of Human Genetics. 2003 - 2020 2003 - 2020
- Editor, Chromosome 1. Human Genome Organization. 1996 - 2003 1996 - 2003
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Service to Duke
- Duke University Center for Neurodegeneration and Neurotherapeutics. 2018 - 2022 2018 - 2022
- Research Planning Committee, Duke School of Medicine. Chair, Precision Medicine and Genetics and Genomics Subcommittee. 2018 2018
- Duke University School of Medicine. Research Planning Committee. 2017 - 2018 2017 - 2018
- Duke Institute of Brain Sciences. Director Search Committee. 2015 - 2017 2015 - 2017
- Duke Pathway to Independence and K-club Review Panel. 2015 - 2020 2015 - 2020
- Executive Counsel of Core Directors. 2015 - 2022 2015 - 2022
- Charter Member. Duke University Cardiovascular Research Center. 2011 - 2022 2011 - 2022
- Co-Leader. Epigenetics and Epigenomics Focus Group (Genetics and Genomics Basic Sciences Program). Duke University Cancer Institute. 2011 - 2014 2011 - 2014
- Executive Committee Member. Duke Epigenetics and Epigenomics Program (DEEP). 2011 - 2020 2011 - 2020
- Executive Committee Member. Program in Genetics and Genomics. 2011 - 2020 2011 - 2020
- Program in Genetics and Genomics. Chair, Admissions Committee. 2011 - 2014 2011 - 2014
- Program in Genetics and Genomics. Seminar Committee. 2010 - 2014 2010 - 2014
- Program in Genetics and Genomics. Admissions Committee. 2003 - 2020 2003 - 2020
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