Simon Gray Gregory
Professor in Neurology
My principal area of research involves elucidating the molecular mechanisms underlying multi-factorial diseases. My lab is primarily interested identifying the complex genetic factors that give rise to multiple sclerosis, autism and cardiovascular disease. We are using targeted approaches to identify differential methylation of the oxytocin receptor gene (OXTR) in individuals with autism, and applying these data to an NICHD funded ACE award, SOARS-B, to assess long term use of oxytocin nasal spray to improve social reciprocity in 300 children with autism, and for which we are developing e/genetic and transcriptomic predictors of response and effects of long term drug exposure. My MS laboratories at Duke University and the David H Murdock Research Institute (DHMRI) are using cell signaling and immune cell flow sorting to establish the role of IL7R signaling in the development of MS; we have developed three novel mouse strains to induce EAE susceptibility and to investigate allele and splicing specific effects of IL7R in these novel MS models; I am PI of the MURDOCK-MS collection, a cross sectional MS cohort of ~1000 MS patients that will provide the basis for genetic, genomic and metabolomic biomarker identification of MS disease development and progression. I am also Director of the nascent Duke Center for Research in Autoimmunity and MS within the Duke Department of Neurology.
Current Research Interests
Multiple Sclerosis
Autism
Coronary Artery Disease
Prostate and Lung cancer
Epigenetics of human diseaseApplication of single cell technologies to basic and translational research
Precision medicine of neurological disease
Current Appointments & Affiliations
- Professor in Neurology, Neurology, MS & Neuroimmunology, Neurology 2016
- Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2016
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2003
- Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2013
Contact Information
- 300 N. Duke Street, Room 51-102, Duke Molecular Physiology Institute, Durham, NC 27701
- Duke Box 104775, Durham, NC 27701
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simon.gregory@duke.edu
(919) 684-0726
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https://dmpi.duke.edu/faculty/simon-gregory-phd
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https://genome.duke.edu/directory/cbb-faculty/simon-gregory-phd
- Background
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Education, Training, & Certifications
- Ph.D., Open University, Milton Keynes (U.K.) 2003
- B.A.Sc., RMIT University (Australia) 1990
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Duke Appointment History
- Professor - TrackV of Medicine, Medicine, Medical Genetics, Medicine 2016
- Associate Research Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2010 - 2016
- Associate Professor in Medicine, Medicine, Medical Genetics, Medicine 2013 - 2016
- Associate Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2010 - 2013
- Assistant Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2006 - 2010
- Assistant Research Professor in Medicine, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2004 - 2006
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Academic Positions Outside Duke
- Adjunct Graduate Faculty, Department of Biological and Biomedical Sciences, North Carolina Central University. 2018 - 2019
- Recognition
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In the News
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MAR 23, 2017 Duke Health News -
NOV 7, 2016 -
JUN 26, 2015 -
JUN 11, 2015 NPR -
NOV 21, 2014 -
SEP 25, 2013 WRAL -
AUG 13, 2013 CNN -
AUG 13, 2013 BBC News -
AUG 13, 2013 -
AUG 13, 2013 Wall Street Journal
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Awards & Honors
- Nominated, Outstanding Postdoc Mentor. Duke University. 2015
- Inducted into Volunteer Hall of Fame for contribution as Scientific Researcher. National Multiple Sclerosis Society. 2014
- Breakthrough Research Award. North Carolina Health & Life Science. 2010
- Axons in Action Award for Cutting Edge Research. National Multiple Sclerosis Society (Eastern North Carolina chapter). 2007
- Research
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Selected Grants
- The role of gastrin in esophageal submucosal gland acinar ductal metaplasia awarded by National Institutes of Health 2018 - 2023
- The role of gastrin in esophageal submucosal gland acinar ductal metaplasia awarded by National Institutes of Health 2018 - 2023
- Social Relationship Qualities as Predictors of Health & Aging from Adolescence thru Midlife 2018 - 2023
- Social Relationship Qualities as Predictors of Health & Aging from Adolescence thru Midlife 2018 - 2023
- Dynamic Control of Innate Antiviral Immunity in Skin Homeostasis and Inflammation awarded by National Institutes of Health 2018 - 2023
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2022
- Copper Homeostasis in Mammals awarded by National Institutes of Health 2004 - 2022
- Characterizing the (epi)genetics of oxytocin response in clinical and animal models awarded by National Institutes of Health 2017 - 2022
- Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
- Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
- Development of Circulating Molecular Predictors of Chemotherapy and Novel Hormonal Therapy Benefit in Men with Metastatic Castration Resistant Prostate Cancer (mCRPC) 2014 - 2020
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Specific and Pervasive Symptoms in Adults with Multiple Sclerosis Using the MURDOCK-MS Dataset: A Secondary Analysis awarded by National Institutes of Health 2017 - 2020
- 10X Single Cell Paired B/TCR Alpha and Beta Receptor and Transcriptome Pilot 2019 - 2020
- Networks of nutritional stress in human pancreatic islet cells 2018 - 2019
- Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution awarded by Department of Defense 2015 - 2019
- Systems Biology Approaches for Predicting Cardiometabolic Risk in Persons Living with HIV awarded by National Institutes of Health 2015 - 2018
- Identifying Genetic and Epigenetic Signatures of Treatment Response to Oxytocin in Humans and Mice 2016 - 2018
- SOARS-B awarded by National Institutes of Health 2012 - 2018
- Integration of CT imaging features with cell-free plasma DNA as biomarkers for early lung cancer detection in patients with indeterminate pulmonary nodules 2016 - 2018
- SRA for Stephanie Arvai awarded by University of Texas Medical Branch 2016
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD awarded by National Institutes of Health 2009 - 2016
- A role for pathogen-induced IL-10 production in susceptibility to MS awarded by National Multiple Sclerosis Society 2014 - 2015
- Study of Oxytocin in Autism to improve Reciprocal Social Behaviors (SOARS-B) awarded by University of North Carolina - Chapel Hill 2012 - 2015
- Defining the Functional Role of a Novel MS Susceptibility Gene, IL7R alpha chain awarded by National Institutes of Health 2009 - 2015
- Linkage and candidate gene analysis in non-syndromic Chiari type I awarded by National Institutes of Health 2009 - 2015
- Study of Genetic Basis of Fuchs Corneal Dystrophy awarded by National Institutes of Health 2007 - 2013
- Genetic Mediators of Metabolic Cardiovascular Disease Risk awarded by National Institutes of Health 2009 - 2012
- Candidate Genes and Longitudinal Disability Phenotypes awarded by National Institutes of Health 2006 - 2012
- Molecular mechanisms of altered calcium sensing in human parathyroid disease awarded by National Institutes of Health 2010 - 2012
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- Hereditary basis of neural tube defects awarded by National Institutes of Health 1999 - 2010
- Genotyping - Illumina Methylation Analysis of DNA Samples awarded by National Institute of Environmental Health Sciences 2008 - 2010
- Genotyping - Methlylation Infinium Chips awarded by National Institute of Environmental Health Sciences 2008 - 2010
- Molecular Dissection of Cardiovascular Disease: From Genes to Models to Function awarded by National Institutes of Health 2007 - 2009
- GENECARD: Gene identification in Early-Onset CAD awarded by National Institutes of Health 2003 - 2009
- Molecular Genetics of Coronary Artery Disease awarded by National Institutes of Health 2006 - 2007
- High-Resolution CGH Characterization of Brain Tumors awarded by National Institutes of Health 2004 - 2006
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Industry Relationships
- David H Murdock Research Institute
- Tellus Therapeutics
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Kwee, Lydia Coulter, Megan L. Neely, Elizabeth Grass, Simon G. Gregory, Matthew T. Roe, E Magnus Ohman, Keith A. A. Fox, et al. “Associations of Osteopontin and NT-proBNP with Circulating miRNA Levels in Acute Coronary Syndrome..” Physiol Genomics, September 18, 2019. https://doi.org/10.1152/physiolgenomics.00033.2019.Full Text Link to Item
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Andersen, S. L., F. B. S. Briggs, J. H. Winnike, Y. Natanzon, S. Maichle, K. J. Knagge, L. K. Newby, and S. G. Gregory. “Metabolome-based signature of disease pathology in MS..” Mult Scler Relat Disord 31 (June 2019): 12–21. https://doi.org/10.1016/j.msard.2019.03.006.Full Text Link to Item
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Kousa, Youssef A., Huiping Zhu, Walid D. Fakhouri, Yunping Lei, Akira Kinoshita, Raeuf R. Roushangar, Nicole K. Patel, et al. “The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation..” Hum Mol Genet 28, no. 10 (May 15, 2019): 1726–37. https://doi.org/10.1093/hmg/ddz010.Full Text Link to Item
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Armstrong, Andrew J., Susan Halabi, Jun Luo, David M. Nanus, Paraskevi Giannakakou, Russell Z. Szmulewitz, Daniel C. Danila, et al. “Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study..” J Clin Oncol 37, no. 13 (May 1, 2019): 1120–29. https://doi.org/10.1200/JCO.18.01731.Full Text Link to Item
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Armstrong, Andrew J., Santosh Gupta, Patrick Healy, Gabor Kemeny, Beth Leith, Michael R. Zalutsky, Charles Spritzer, et al. “Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer..” Plos One 14, no. 5 (2019). https://doi.org/10.1371/journal.pone.0216934.Full Text Link to Item
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Dhingra, Radhika, Lydia Coulter Kwee, David Diaz-Sanchez, Robert B. Devlin, Wayne Cascio, Elizabeth R. Hauser, Simon Gregory, et al. “Evaluating DNA methylation age on the Illumina MethylationEPIC Bead Chip..” Plos One 14, no. 4 (2019). https://doi.org/10.1371/journal.pone.0207834.Full Text Link to Item
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Perkeybile, Allison M., C Sue Carter, Kelly L. Wroblewski, Meghan H. Puglia, William M. Kenkel, Travis S. Lillard, Themistoclis Karaoli, et al. “Early nurture epigenetically tunes the oxytocin receptor..” Psychoneuroendocrinology 99 (January 2019): 128–36. https://doi.org/10.1016/j.psyneuen.2018.08.037.Full Text Link to Item
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Tailor, Tina D., Xiayu Rao, Michael J. Campa, Jing Wang, Simon G. Gregory, and Edward F. Patz. “Whole Exome Sequencing of Cell-Free DNA for Early Lung Cancer: A Pilot Study to Differentiate Benign From Malignant CT-Detected Pulmonary Lesions..” Front Oncol 9 (2019). https://doi.org/10.3389/fonc.2019.00317.Full Text Link to Item
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Ward-Caviness, Cavin K., William E. Kraus, Colette Blach, Carol S. Haynes, Elaine Dowdy, Marie Lynn Miranda, Robert Devlin, et al. “Associations Between Residential Proximity to Traffic and Vascular Disease in a Cardiac Catheterization Cohort..” Arterioscler Thromb Vasc Biol 38, no. 1 (January 2018): 275–82. https://doi.org/10.1161/ATVBAHA.117.310003.Full Text Link to Item
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Kanayama, Masashi, Shengjie Xu, Keiko Danzaki, Jason R. Gibson, Makoto Inoue, Simon G. Gregory, and Mari L. Shinohara. “Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin..” Nat Immunol 18, no. 9 (September 2017): 973–84. https://doi.org/10.1038/ni.3791.Full Text Open Access Copy Link to Item
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Wang, Alice, Lydia Coulter Kwee, Elizabeth Grass, Megan L. Neely, Simon G. Gregory, Keith A. A. Fox, Paul W. Armstrong, et al. “Whole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome..” Atherosclerosis 261 (June 2017): 19–25. https://doi.org/10.1016/j.atherosclerosis.2017.03.041.Full Text Link to Item
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Afshari, Natalie A., Robert P. Igo, Nathan J. Morris, Dwight Stambolian, Shiwani Sharma, V Lakshmi Pulagam, Steven Dunn, et al. “Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy..” Nat Commun 8 (March 30, 2017). https://doi.org/10.1038/ncomms14898.Full Text Link to Item
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Galarza-Muñoz, Gaddiel, Farren B. S. Briggs, Irina Evsyukova, Geraldine Schott-Lerner, Edward M. Kennedy, Tinashe Nyanhete, Liuyang Wang, et al. “Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk..” Cell 169, no. 1 (March 23, 2017): 72-84.e13. https://doi.org/10.1016/j.cell.2017.03.007.Full Text Link to Item
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Gupta, Santosh, Jing Li, Gabor Kemeny, Rhonda L. Bitting, Joshua Beaver, Jason A. Somarelli, Kathryn E. Ware, Simon Gregory, and Andrew J. Armstrong. “Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer..” Clin Cancer Res 23, no. 5 (March 1, 2017): 1346–57. https://doi.org/10.1158/1078-0432.CCR-16-1211.Full Text Link to Item
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Ward-Caviness, Cavin K., Lucas M. Neas, Colette Blach, Carol S. Haynes, Karen LaRocque-Abramson, Elizabeth Grass, Z Elaine Dowdy, et al. “A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic..” Plos One 12, no. 3 (2017). https://doi.org/10.1371/journal.pone.0173880.Full Text Link to Item
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Inoue, Makoto, Po-Han Chen, Stephen Siecinski, Qi-Jing Li, Chunlei Liu, Lawrence Steinman, Simon G. Gregory, Eric Benner, and Mari L. Shinohara. “An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage..” Nat Neurosci 19, no. 12 (December 2016): 1599–1609. https://doi.org/10.1038/nn.4421.Full Text Link to Item
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Sullivan, Lori L., Kristin A. Maloney, Aaron J. Towers, Simon G. Gregory, and Beth A. Sullivan. “Human centromere repositioning within euchromatin after partial chromosome deletion..” Chromosome Res 24, no. 4 (December 2016): 451–66. https://doi.org/10.1007/s10577-016-9536-6.Full Text Link to Item
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Zeng, Yi, Huashuai Chen, Ting Ni, Rongping Ruan, Chao Nie, Xiaomin Liu, Lei Feng, et al. “Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages..” Rejuvenation Res 19, no. 3 (June 2016): 195–203. https://doi.org/10.1089/rej.2015.1737.Full Text Open Access Copy Link to Item
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Zeng, Yi, Chao Nie, Junxia Min, Xiaomin Liu, Mengmeng Li, Huashuai Chen, Hanshi Xu, et al. “Novel loci and pathways significantly associated with longevity..” Sci Rep 6 (February 25, 2016). https://doi.org/10.1038/srep21243.Full Text Open Access Copy Link to Item
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Dungan, Jennifer R., Xuejun Qin, Benjamin D. Horne, John F. Carlquist, Abanish Singh, Melissa Hurdle, Elizabeth Grass, et al. “Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship..” Plos One 11, no. 5 (2016). https://doi.org/10.1371/journal.pone.0154856.Full Text Link to Item
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Ward-Caviness, Cavin K., Lucas M. Neas, Colette Blach, Carol S. Haynes, Karen LaRocque-Abramson, Elizabeth Grass, Elaine Dowdy, et al. “Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease..” Plos One 11, no. 4 (2016). https://doi.org/10.1371/journal.pone.0152670.Full Text Link to Item
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Kraus, William E., Deborah M. Muoio, Robert Stevens, Damian Craig, James R. Bain, Elizabeth Grass, Carol Haynes, et al. “Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis..” Plos Genet 11, no. 11 (November 2015). https://doi.org/10.1371/journal.pgen.1005553.Full Text Open Access Copy Link to Item
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Riley, Ronald T., Olga Torres, Jorge Matute, Simon G. Gregory, Allison E. Ashley-Koch, Jency L. Showker, Trevor Mitchell, Kenneth A. Voss, Joyce R. Maddox, and Janee B. Gelineau-van Waes. “Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala..” Mol Nutr Food Res 59, no. 11 (November 2015): 2209–24. https://doi.org/10.1002/mnfr.201500499.Full Text Link to Item
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Ward-Caviness, Cavin K., William E. Kraus, Colette Blach, Carol S. Haynes, Elaine Dowdy, Marie Lynn Miranda, Robert B. Devlin, et al. “Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients..” Environ Health Perspect 123, no. 10 (October 2015): 1007–14. https://doi.org/10.1289/ehp.1306980.Full Text Link to Item
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Shah, Asad A., Simon G. Gregory, Deidre Krupp, Sheng Feng, Allison Dorogi, Carol Haynes, Elizabeth Grass, et al. “Epigenetic profiling identifies novel genes for ascending aortic aneurysm formation with bicuspid aortic valves..” Heart Surg Forum 18, no. 4 (August 30, 2015): E134–39. https://doi.org/10.1532/hsf.1247.Full Text Link to Item
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Cope, Heidi, Melanie E. Garrett, Simon Gregory, and Allison Ashley-Koch. “Pregnancy continuation and organizational religious activity following prenatal diagnosis of a lethal fetal defect are associated with improved psychological outcome..” Prenat Diagn 35, no. 8 (August 2015): 761–68. https://doi.org/10.1002/pd.4603.Full Text Link to Item
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Roberson, Elle C., William E. Dowdle, Aysegul Ozanturk, Francesc R. Garcia-Gonzalo, Chunmei Li, Jan Halbritter, Nadia Elkhartoufi, et al. “TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone..” J Cell Biol 209, no. 1 (April 13, 2015): 129–42. https://doi.org/10.1083/jcb.201411087.Full Text Link to Item
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Winnike, Jason H., Xiaoli Wei, Kevin J. Knagge, Steven D. Colman, Simon G. Gregory, and Xiang Zhang. “Comparison of GC-MS and GC×GC-MS in the analysis of human serum samples for biomarker discovery..” J Proteome Res 14, no. 4 (April 3, 2015): 1810–17. https://doi.org/10.1021/pr5011923.Full Text Link to Item
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Shah, Asad A., Carol Haynes, Damian M. Craig, Jacqueline Sebek, Elizabeth Grass, Karen Abramson, Elizabeth Hauser, et al. “Genetic variants associated with vein graft stenosis after coronary artery bypass grafting..” Heart Surg Forum 18, no. 1 (February 27, 2015): E1–5. https://doi.org/10.1532/hsf.1214.Full Text Link to Item
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Lock, Eric F., Karen L. Soldano, Melanie E. Garrett, Heidi Cope, Christina A. Markunas, Herbert Fuchs, Gerald Grant, David B. Dunson, Simon G. Gregory, and Allison E. Ashley-Koch. “Joint eQTL assessment of whole blood and dura mater tissue from individuals with Chiari type I malformation..” Bmc Genomics 16 (January 22, 2015). https://doi.org/10.1186/s12864-014-1211-8.Full Text Open Access Copy Link to Item
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Li, Jing, Simon G. Gregory, Mariano A. Garcia-Blanco, and Andrew J. Armstrong. “Using circulating tumor cells to inform on prostate cancer biology and clinical utility..” Crit Rev Clin Lab Sci 52, no. 4 (2015): 191–210. https://doi.org/10.3109/10408363.2015.1023430.Full Text Link to Item
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Riley, Ronald T., Jency L. Showker, Christine M. Lee, Cody E. Zipperer, Trevor R. Mitchell, Kenneth A. Voss, Nicholas C. Zitomer, et al. “A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans..” Food Addit Contam Part a Chem Anal Control Expo Risk Assess 32, no. 6 (2015): 934–49. https://doi.org/10.1080/19440049.2015.1027746.Full Text Link to Item
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Torres, O., J. Matute, J. Gelineau-Van Waes, J. R. Maddox, S. G. Gregory, A. E. Ashley-Koch, J. L. Showker, K. A. Voss, and R. T. Riley. “Human health implications from co-exposure to aflatoxins and fumonisins in maize-based foods in Latin America: Guatemala as a case study.” World Mycotoxin Journal 8, no. 2 (January 1, 2015): 143–59. https://doi.org/10.3920/WMJ2014.1736.Full Text
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Krupp, Deidre R., Karen L. Soldano, Melanie E. Garrett, Heidi Cope, Allison E. Ashley-Koch, and Simon G. Gregory. “Missing genetic risk in neural tube defects: can exome sequencing yield an insight?.” Birth Defects Res a Clin Mol Teratol 100, no. 8 (August 2014): 642–46. https://doi.org/10.1002/bdra.23276.Full Text Link to Item
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Markunas, Christina A., Eric Lock, Karen Soldano, Heidi Cope, Chien-Kuang C. Ding, David S. Enterline, Gerald Grant, Herbert Fuchs, Allison E. Ashley-Koch, and Simon G. Gregory. “Identification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics..” Bmc Med Genomics 7 (June 25, 2014). https://doi.org/10.1186/1755-8794-7-39.Full Text Link to Item
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Li, Yi-Ju, Mollie A. Minear, Xuejun Qin, Jacqueline Rimmler, Michael A. Hauser, R Rand Allingham, Robert P. Igo, et al. “Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy..” Invest Ophthalmol Vis Sci 55, no. 7 (June 10, 2014): 4577–84. https://doi.org/10.1167/iovs.13-13517.Full Text Link to Item
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Miranda, Marie Lynn, Rebecca Anthopolos, and Simon G. Gregory. “Association of autism with induced or augmented childbirth..” Am J Obstet Gynecol 210, no. 5 (May 2014): 492–93. https://doi.org/10.1016/j.ajog.2013.12.038.Full Text Link to Item
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Torres, Olga, Jorge Matute, Janee Gelineau-van Waes, Joyce R. Maddox, Simon G. Gregory, Allison E. Ashley-Koch, Jency L. Showker, Nicholas C. Zitomer, Kenneth A. Voss, and Ronald T. Riley. “Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala..” Mol Nutr Food Res 58, no. 5 (May 2014): 973–83. https://doi.org/10.1002/mnfr.201300481.Full Text Link to Item
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McGarrah, Robert, Damian M. Craig, Carol Haynes, Elizabeth Hauser, Christopher B. Newgard, Simon G. Gregory, William Kraus, and Svati Shah. “OMICS PROFILING HIGHLIGHTS ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION AND UBIQUITIN PROTEASOME PATHWAYS IN INSULIN RESISTANCE AND GLYCEMIC CONTROL.” Journal of the American College of Cardiology 63, no. 12 (April 2014): A1600–A1600. https://doi.org/10.1016/s0735-1097(14)61603-x.Full Text
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Gregory, Simon G. “Genetic predisposition of behavioral response..” Proc Natl Acad Sci U S A 111, no. 5 (February 4, 2014): 1672–73. https://doi.org/10.1073/pnas.1323421111.Full Text Link to Item
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Miranda, Marie Lynn, Rebecca Anthopolos, and Simon G. Gregory. “Induction or augmentation of labor and autism--reply..” Jama Pediatr 168, no. 2 (February 2014): 191–92. https://doi.org/10.1001/jamapediatrics.2013.4792.Full Text Link to Item
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Gregory, Simon G., Rebecca Anthopolos, Claire E. Osgood, Chad A. Grotegut, and Marie Lynn Miranda. “Association of Autism With Induced or Augmented Childbirth in North Carolina Birth Record (1990–1998) and Education Research (1997–2007) Databases.” Obstetrical & Gynecological Survey 69, no. 1 (January 2014): 7–9. https://doi.org/10.1097/01.ogx.0000442814.50107.fa.Full Text
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Markunas, Christina A., David S. Enterline, Kaitlyn Dunlap, Karen Soldano, Heidi Cope, Jeffrey Stajich, Gerald Grant, Herbert Fuchs, Simon G. Gregory, and Allison E. Ashley-Koch. “Genetic evaluation and application of posterior cranial fossa traits as endophenotypes for Chiari type I malformation..” Ann Hum Genet 78, no. 1 (January 2014): 1–12. https://doi.org/10.1111/ahg.12041.Full Text Link to Item
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Connelly, Jessica J., Olga A. Cherepanova, Jennifer F. Doss, Themistoclis Karaoli, Travis S. Lillard, Christina A. Markunas, Sarah Nelson, et al. “Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis..” Hum Mol Genet 22, no. 25 (December 20, 2013): 5107–20. https://doi.org/10.1093/hmg/ddt365.Full Text Link to Item
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Ward-Caviness, Cavin, Carol Haynes, Colette Blach, Elaine Dowdy, Simon G. Gregory, Svati H. Shah, Benjamin D. Horne, William E. Kraus, and Elizabeth R. Hauser. “Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort..” Hum Genet 132, no. 12 (December 2013): 1371–82. https://doi.org/10.1007/s00439-013-1339-7.Full Text Link to Item
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Gregory, Simon G., Rebecca Anthopolos, Claire E. Osgood, Chad A. Grotegut, and Marie Lynn Miranda. “Association of autism with induced or augmented childbirth in North Carolina Birth Record (1990-1998) and Education Research (1997-2007) databases..” Jama Pediatr 167, no. 10 (October 2013): 959–66. https://doi.org/10.1001/jamapediatrics.2013.2904.Full Text Link to Item
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Soldano, Karen L., Melanie E. Garrett, Heidi L. Cope, J Michael Rusnak, Nathen J. Ellis, Kaitlyn L. Dunlap, Marcy C. Speer, Simon G. Gregory, and Allison E. Ashley-Koch. “Genetic association analyses of nitric oxide synthase genes and neural tube defects vary by phenotype..” Birth Defects Res B Dev Reprod Toxicol 98, no. 5 (October 2013): 365–73. https://doi.org/10.1002/bdrb.21079.Full Text Link to Item
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Zeng, Yi, Lingguo Cheng, Ling Zhao, Qihua Tan, Qiushi Feng, Huashuai Chen, Ke Shen, et al. “Interactions between social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China..” Bmc Geriatr 13 (September 9, 2013). https://doi.org/10.1186/1471-2318-13-91.Full Text Open Access Copy Link to Item
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Cope, Heidi, Kelly McMahon, Elizabeth Heise, Sonja Eubanks, Melanie Garrett, Simon Gregory, and Allison Ashley-Koch. “Outcome and life satisfaction of adults with myelomeningocele..” Disabil Health J 6, no. 3 (July 2013): 236–43. https://doi.org/10.1016/j.dhjo.2012.12.003.Full Text Link to Item
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Evsyukova, Irina, Shelton S. Bradrick, Simon G. Gregory, and Mariano A. Garcia-Blanco. “Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6..” Rna 19, no. 1 (January 2013): 103–15. https://doi.org/10.1261/rna.035410.112.Full Text Link to Item
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Markunas, Christina A., Karen Soldano, Kaitlyn Dunlap, Heidi Cope, Edgar Asiimwe, Jeffrey Stajich, David Enterline, et al. “Stratified whole genome linkage analysis of Chiari type I malformation implicates known Klippel-Feil syndrome genes as putative disease candidates..” Plos One 8, no. 4 (2013). https://doi.org/10.1371/journal.pone.0061521.Full Text Link to Item
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Minear, Mollie A., Yi-Ju Li, Jacqueline Rimmler, Elmer Balajonda, Shera Watson, R Rand Allingham, Michael A. Hauser, Gordon K. Klintworth, Natalie A. Afshari, and Simon G. Gregory. “Genetic screen of African Americans with Fuchs endothelial corneal dystrophy..” Mol Vis 19 (2013): 2508–16.Link to Item
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Nolan, Daniel, William E. Kraus, Elizabeth Hauser, Yi-Ju Li, Dana K. Thompson, Jessica Johnson, Hsiang-Cheng Chen, et al. “Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family..” Plos One 8, no. 8 (2013). https://doi.org/10.1371/journal.pone.0071779.Full Text Open Access Copy Link to Item
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Gregory, Simon G., Mandeep Sekhon, Jacqueline Schein, Shaying Zhao, Kazutoyo Osoegawa, Carol E. Scott, Richard S. Evans, et al. “A physical map of the mouse genome..” Nature 418, no. 6899 (August 15, 2002): 743–50. https://doi.org/10.1038/nature00957.Full Text Link to Item
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McMullan, Tristan W., John A. Crolla, Simon G. Gregory, Nigel P. Carter, Rachel A. Cooper, Gareth R. Howell, and David O. Robinson. “A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation..” Hum Genet 110, no. 3 (March 2002): 244–50. https://doi.org/10.1007/s00439-002-0679-5.Full Text Link to Item
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Watanabe, Y., J. C. Murray, B. C. Bjork, C. P. Bird, P. W. Chiang, S. G. Gregory, D. M. Kurnit, and B. C. Schutte. “Matroshka and ectopic polymorphisms: Two new classes of DNA sequence variation identified at the Van der Woude syndrome locus on 1q32-q41..” Hum Mutat 18, no. 5 (November 2001): 422–34. https://doi.org/10.1002/humu.1213.Full Text Link to Item
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Cai, W. W., C. W. Chow, S. Damani, S. G. Gregory, M. Marra, and A. Bradley. “An SSLP marker-anchored BAC framework map of the mouse genome..” Nat Genet 29, no. 2 (October 2001): 133–34. https://doi.org/10.1038/ng1001-133.Full Text Link to Item
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Lander, E. S., L. M. Linton, B. Birren, C. Nusbaum, M. C. Zody, J. Baldwin, K. Devon, et al. “Erratum: Initial sequencing and analysis of the human genome: International Human Genome Sequencing Consortium (Nature (2001) 409 (860-921)).” Nature 412, no. 6846 (August 2, 2001): 565–66. https://doi.org/10.1038/35087627.Full Text
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Stover, C., Y. Endo, M. Takahashi, N. J. Lynch, C. Constantinescu, T. Vorup-Jensen, S. Thiel, et al. “The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3..” Genes Immun 2, no. 3 (May 2001): 119–27. https://doi.org/10.1038/sj.gene.6363745.Full Text Link to Item
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Doudney, K., J. N. Murdoch, C. Paternotte, L. Bentley, S. Gregory, A. J. Copp, and P. Stanier. “Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23..” Genomics 72, no. 2 (March 1, 2001): 180–92. https://doi.org/10.1006/geno.2000.6463.Full Text Link to Item
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Bentley, D. R., P. Deloukas, A. Dunham, L. French, S. G. Gregory, S. J. Humphray, A. J. Mungall, et al. “The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X..” Nature 409, no. 6822 (February 15, 2001): 942–43. https://doi.org/10.1038/35057165.Full Text Link to Item
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Lander, E. S., L. M. Linton, B. Birren, C. Nusbaum, M. C. Zody, J. Baldwin, K. Devon, et al. “Initial sequencing and analysis of the human genome..” Nature 409, no. 6822 (February 15, 2001): 860–921. https://doi.org/10.1038/35057062.Full Text Link to Item
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McPherson, J. D., M. Marra, L. Hillier, R. H. Waterston, A. Chinwalla, J. Wallis, M. Sekhon, et al. “A physical map of the human genome..” Nature 409, no. 6822 (February 15, 2001): 934–41. https://doi.org/10.1038/35057157.Full Text Link to Item
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Schutte, B. C., J. D. Carpten, A. Forus, S. G. Gregory, A. Horii, and P. S. White. “Report of the sixth international workshop on human chromosome 1 mapping 2000.” Cytogenetics and Cell Genetics 92, no. 1–2 (January 1, 2001): 23–48.
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White, P. S., P. M. Thompson, B. A. Seifried, E. P. Sulman, S. J. Jensen, C. Guo, J. M. Maris, et al. “Detailed molecular analysis of 1p36 in neuroblastoma..” Med Pediatr Oncol 36, no. 1 (January 2001): 37–41. https://doi.org/10.1002/1096-911X(20010101)36:1<37::AID-MPO1010>3.0.CO;2-L.Full Text Link to Item
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White, P. S., P. M. Thompson, B. A. Seifried, E. P. Sulman, S. J. Jensen, C. Guo, J. M. Maris, et al. “Comprehensive analysis of chromosome 1p deletions in neuroblastoma.” Medical and Pediatric Oncology 36, no. 1 (2001): 32–36. https://doi.org/10.1002/1096-911X(20010101)36:1<32::AID-MPO1009>3.0.CO;2-0.Full Text
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Carpten, J. D., I. Makalowska, C. M. Robbins, N. Scott, R. Sood, T. D. Connors, T. I. Bonner, et al. “A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region..” Genomics 64, no. 1 (February 15, 2000): 1–14. https://doi.org/10.1006/geno.1999.6051.Full Text Link to Item
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Shackleton, S., D. J. Lloyd, S. N. Jackson, R. Evans, M. F. Niermeijer, B. M. Singh, H. Schmidt, et al. “LMNA, encoding lamin A/C, is mutated in partial lipodystrophy..” Nat Genet 24, no. 2 (February 2000): 153–56. https://doi.org/10.1038/72807.Full Text Link to Item
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Schutte, B. C., B. C. Bjork, K. B. Coppage, M. I. Malik, S. G. Gregory, D. J. Scott, L. M. Brentzell, Y. Watanabe, M. J. Dixon, and J. C. Murray. “A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41..” Genome Res 10, no. 1 (January 2000): 81–94.Link to Item
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White, P. S., A. Forus, T. C. Matise, B. C. Schutte, N. Spieker, P. Stanier, J. M. Vance, and S. G. Gregory. “Fifth International Workshop on Human Chromosome 1 Mapping 1999, the Sanger Centre, Cambridge, UK, August 5-7 1999: Report.” Cytogenetics and Cell Genetics 87, no. 3–4 (December 1, 1999): 143–63.
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Labay, V., T. Raz, D. Baron, H. Mandel, H. Williams, T. Barrett, R. Szargel, et al. “Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness..” Nat Genet 22, no. 3 (July 1999): 300–304. https://doi.org/10.1038/10372.Full Text Link to Item
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Gregory, S. G., M. Vaudin, R. Wooster, M. Coleman, D. Mischke, C. Porter, B. C. Schutte, P. White, and J. M. Vance. “Fourth International Workshop on Human Chromosome 1 Mapping 1998, Sanger Centre, Cambridge, United Kingdom, June 25-27 1998: Report.” Cytogenetics and Cell Genetics 83, no. 3–4 (December 1, 1998): 147–67.
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Gregory, S. G., M. Vaudin, R. Wooster, M. Coleman, D. Mischke, C. Porter, B. C. Schutte, P. White, and J. M. Vance. “Report of the fourth international workshop on human chromosome 1 mapping 1998.” Cytogenetics and Cell Genetics 83, no. 3–4 (January 1, 1998): 148–67.Link to Item
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Gregory, S. G., G. R. Howell, and D. R. Bentley. “Genome mapping by fluorescent fingerprinting..” Genome Res 7, no. 12 (December 1997): 1162–68. https://doi.org/10.1101/gr.7.12.1162.Full Text Link to Item
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Roest Crollius, H., M. T. Ross, A. Grigoriev, C. J. Knights, E. Holloway, J. Misfud, K. Li, et al. “An integrated YAC map of the human X chromosome..” Genome Res 6, no. 10 (October 1996): 943–55. https://doi.org/10.1101/gr.6.10.943.Full Text Link to Item
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Forbes, S. A., L. Brennan, M. Richardson, A. Coffey, C. G. Cole, S. G. Gregory, D. R. Bentley, S. Mumm, G. E. Moore, and P. Stanier. “Refined mapping and YAC contig construction of the X-linked cleft palate and ankyloglossia locus (CPX) including the proximal X-Y homology breakpoint within Xq21.3..” Genomics 31, no. 1 (January 1, 1996): 36–43. https://doi.org/10.1006/geno.1996.0006.Full Text Link to Item
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Van de Vosse, E., A. A. Bergen, E. J. Meershoek, J. C. Oosterwijk, S. Gregory, B. Bakker, J. Weissenbach, A. J. Coffey, G. J. van Ommen, and J. T. Den Dunnen. “An Xp22.1-p22.2 YAC contig encompassing the disease loci for RS, KFSD, CLS, HYP and RP15: refined localization of RS..” Eur J Hum Genet 4, no. 2 (1996): 101–4. https://doi.org/10.1159/000472177.Full Text Link to Item
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Wooster, R., G. Bignell, J. Lancaster, S. Swift, S. Seal, J. Mangion, N. Collins, et al. “Addendum: Identification of the breast cancer susceptibility gene BRCA2 (Nature (1995) 378 (789-792)).” Nature 379, no. 6567 (January 1, 1996).
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Wooster, R., G. Bignell, J. Lancaster, S. Swift, S. Seal, J. Mangion, N. Collins, S. Gregory, C. Gumbs, and G. Micklem. “Identification of the breast cancer susceptibility gene BRCA2..” Nature 378, no. 6559 (December 21, 1995): 789–92. https://doi.org/10.1038/378789a0.Full Text Link to Item
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Fantes, J. A., K. Oghene, S. Boyle, S. Danes, J. M. Fletcher, E. A. Bruford, K. Williamson, A. Seawright, A. Schedl, and I. Hanson. “A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1..” Genomics 25, no. 2 (January 20, 1995): 447–61. https://doi.org/10.1016/0888-7543(95)80045-n.Full Text Link to Item
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Redeker, E., J. M. Hoovers, M. Alders, C. J. van Moorsel, A. C. Ivens, S. Gregory, L. Kalikin, J. Bliek, L. de Galan, and R. van den Bogaard. “An integrated physical map of 210 markers assigned to the short arm of human chromosome 11..” Genomics 21, no. 3 (June 1994): 538–50. https://doi.org/10.1006/geno.1994.1312.Full Text Link to Item
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Heding, I. J., A. C. Ivens, J. Wilson, M. Strivens, S. Gregory, J. M. Hoovers, M. Mannens, B. Redeker, D. Porteous, and V. van Heyningen. “The generation of ordered sets of cosmid DNA clones from human chromosome region 11p..” Genomics 13, no. 1 (May 1992): 89–94. https://doi.org/10.1016/0888-7543(92)90206-8.Full Text Link to Item
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Book Sections
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Gregory, S. G. “The epigenetics of Autism-Running beyond the bases.” In Frontiers in Autism Research: New Horizons for Diagnosis and Treatment, 303–33, 2014. https://doi.org/10.1142/9789814602167_0013.Full Text
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Markunas, C. A., A. E. Ashley-Koch, and S. G. Gregory. “Genetics of the Chiari i and II malformations.” In The Chiari Malformations, 9781461463696:93–101, 2013. https://doi.org/10.1007/978-1-4614-6369-6_7.Full Text
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Gregory, S. G. “Genomic Rearrangements in Autism: The Contribution of Copy Number Loss and Gain to the Etiology of Autism Spectrum Disorders.,” 52:S17–S17. WILEY-BLACKWELL, 2011.Link to Item
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Gregory, Simon, and John Gilbert. “Strategies for genotype generation.,” Chapter 1:Unit-1.3, 2005. https://doi.org/10.1002/0471142905.hg0103s47.Full Text Link to Item
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Stenger, J. E., and S. G. Gregory. “Genomics and Bioinformatics.” In Genetic Analysis of Complex Diseases: Second Edition, 423–54, 2005. https://doi.org/10.1002/9780471781141.ch15.Full Text
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Coffey, A., S. Gregory, and C. G. Cole. “Alu-PCR fingerprinting of YACs.,” 54:97–114, 1996. https://doi.org/10.1385/0-89603-313-9:97.Full Text Link to Item
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Reports
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Schutte, B. C., J. D. Carpten, A. Forus, S. G. Gregory, A. Horii, and P. S. White. “Report and abstracts of the sixth international workshop on human chromosome 1 mapping 2000. Iowa City, Iowa, USA. 30 September-3 October 2000.,” 2001. https://doi.org/10.1159/000056867.Full Text Link to Item
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White, P. S., A. Forus, T. C. Matise, B. C. Schutte, N. Spieker, P. Stanier, J. M. Vance, and S. G. Gregory. “Report of the fifth international workshop on human chromosome 1 mapping 1999.,” 1999. https://doi.org/10.1159/000015458.Full Text Link to Item
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Gregory, S. G., M. Vaudin, R. Wooster, M. Coleman, D. Mischke, C. Porter, B. C. Schutte, P. White, and J. M. Vance. “Report of the fourth international workshop on human chromosome 1 mapping 1998,” 1998. https://doi.org/10.1159/000015174.Full Text Link to Item
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Vance, J. M., T. C. Matise, R. Wooster, B. C. Schutte, G. A. P. Bruns, N. Van Roy, G. M. Brodeur, et al. “Third International Chromosome 1 Maping Workshop, Duke University, Durham, NC, USA, 25-27 April 1997: Report of the third international workshop on human chromosome 1 mapping 1997,” December 1, 1997.
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Vance, J. M., T. C. Matise, R. Wooster, B. C. Schutte, G. A. Bruns, N. van Roy, G. M. Brodeur, et al. “Report and abstracts of the third international workshop on human chromosome 1 mapping 1997.,” 1997.Link to Item
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Conference Papers
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Jewell, Mark, Richard T. Premont, Jason Gibson, Wayne Glover, Timothy A. Dinh, Eliane L. Wauthier, Lola M. Reid, et al. “Yap1 As a Therapeutic Target in Fibrolamellar Carcinoma.” In Hepatology, 68:1243A-1243A. WILEY, 2018.Link to Item
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Kanayama, Masashi, Shengjie Xu, Keiko Danzaki, Jason R. Gibson, Makoto Inoue, Simon G. Gregory, and Mari L. Shinohara. “Skewing the population balance between lymphoid and myeloid cells by osteopontin isoforms.” In Cytokine, 100:161–161. ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2017.Link to Item
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Cote, Sabrina A., Simon G. Gregory, Jason Winnike, Kevin Knagge, Olga Ilkayeva, Thomas O’Connell, James Bain, et al. “Integrated metabolomic and transcriptomic profiles of males with multiple sclerosis.” In Multiple Sclerosis Journal, 22:9–10. SAGE PUBLICATIONS LTD, 2016.Link to Item
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Shah, Svati H., Lydia Kwee, Nathan Stitziel, Elizabeth R. Hauser, Carol Haynes, Sekar Kathiresan, Simon G. Gregory, and William E. Kraus. “Rare Variants Identified With Whole Exome Chip Genotyping Are Associated With Insulin Resistance and Glycemic Control.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.Link to Item
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Kraus, William E., Sheng Feng, Elizabeth R. Hauser, Simon G. Gregory, Carol Haynes, Z. E. Dowdy, Damian M. Craig, and Svati H. Shah. “Association of Gene Expression Signatures with Small Molecule Metabolic Intermediates that Predict Cardiovascular Mortality in CATHGEN.” In Circulation, Vol. 127. LIPPINCOTT WILLIAMS & WILKINS, 2013.Link to Item
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Shah, Asad A., Damian M. Craig, Carol Haynes, Jacqueline K. Sebek, Elizabeth Grass, Karen Abramson, Peter K. Smith, et al. “Genome-Wide Association Identifies Genetic Variants Associated With Vein Graft Stenosis After Coronary Artery Bypass Grafting.” In Circulation, Vol. 124. LIPPINCOTT WILLIAMS & WILKINS, 2011.Link to Item
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Minear, M. A., N. A. Afshari, E. Balajonda, B. Zhao, J. Rimmler, Y. -. J. Li, G. K. Klintworth, and S. G. Gregory. “Analysis of SLC4A11 and COL8A2 Mutations in Fuchs Endothelial Corneal Dystrophy (FECD).” In Investigative Ophthalmology & Visual Science, Vol. 51. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2010.Link to Item
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Wang, Liyong, Elizabeth R. Hauser, David Crosslin, Sarah Nelson, A. B. Hale, Simon G. Gregory, Svati H. Shah, William E. Kraus, Pascal J. Goldschmidt-Clermont, and Jeffery M. Vance. “Genomic convergence identified CAPG and VAMP8 as candidate genes for CAD.” In Circulation, 116:807–807. LIPPINCOTT WILLIAMS & WILKINS, 2007.Link to Item
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Wang, Liyong, Elizabeth R. Hauser, Svati H. Shah, Carol Haynes, Jason M. Rose, Marco Harris, Julie Rombaut, et al. “Identification of kalirin gene as a novel coronary artery disease gene through peak-wide association mapping on chromosome 3q13-21.” In Circulation, 114:887–887. LIPPINCOTT WILLIAMS & WILKINS, 2006.Link to Item
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Gregory, S. G., N. V. Johnson, J. J. Connelly, J. Virgadamo, R. E. McLendon, J. M. Vance, and D. D. Bigner. “Characterizing genomic rearrangements in oligodendroglioma using whole genome tilepath hrCGH arrays.” In Neuro Oncology, 8:421–421. DUKE UNIV PRESS, 2006.Link to Item
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Johnson, Nicole V., Jessica J. Connelly, Josh Virigadamo, Roger E. McLendon, Jeffrey M. Vance, Darell D. Bigner, and Simon G. Gregory. “Characterizing oligodendroglioma rearrangements using whole genome hrCGH arrays.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.Link to Item
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Meza-Zepeda, Leonardo A., Stine H. Kresse, Ana H. Barragan-Polania, Junbai Wang, Bjorn E. Kristiansen, Wen-Lin Kuo, Simon G. Gregory, Joe W. Gray, and Ola Myklebost. “Profiling of DNA copy number changes in sarcomas by array comparative genomic hybridization.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.Link to Item
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Wang, L. Y., E. R. Hauser, S. H. Shah, W. E. Kraus, D. Seo, L. L. Huang, J. M. Rose, et al. “Identification of a novel locus for left main coronary artery disease.” In Circulation, 112:U413–U413. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Haines, J. L., S. Schmidt, S. Sawcer, L. F. Barcellos, S. G. Gregory, J. Sims, M. Booze, et al. “Comprehensive analysis of candidate modifier genes for multiple sclerosis (MS) on chromosome 19q13.” In American Journal of Human Genetics, 73:368–368. UNIV CHICAGO PRESS, 2003.Link to Item
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Maris, J. M., C. Guo, D. Blake, P. S. White, M. D. Hogarty, P. M. Thompson, V. Rajalingam, et al. “Comprehensive analysis of chromosome 1p deletions in neuroblastoma..” In Med Pediatr Oncol, 36:32–36, 2001. https://doi.org/10.1002/1096-911X(20010101)36:1<32::AID-MPO1009>3.0.CO;2-0.Full Text Link to Item
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Little, D., C. L. Wu, R. D’Amico, D. Corcoran, S. Gregory, and F. Guilak. “Epigenetic Analysis of Adipose Stem Cells in Obesity Identifies Dysregulation of Critical Pathways in Musculoskeletal Regeneration and Disease.,” n.d.
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- Teaching & Mentoring
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Recent Courses
- BIOLOGY 728A: University Program in Genetics and Genomics Biological Solutions Module I 2019
- CMB 778A: University Program in Genetics and Genomics Biological Solutions Module I 2019
- CRP 243: Introduction to Medical Genetics 2019
- MGM 593: Research Independent Study 2019
- MGM 778A: University Program in Genetics and Genomics Biological Solutions Module I 2019
- UPGEN 778A: University Program in Genetics and Genomics Biological Solutions Module I 2019
- NEUROSCI 496: Research Independent Study 4 2018
- NEUROSCI 494: Research Independent Study 2 2017
- NEUROSCI 495: Research Independent Study 3 2017
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Advising & Mentoring
- Dr. Gregory is/has mentored high school (12), undergraduate (14), graduate candidate rotation (9), graduate candidate thesis committee (14), graduate candidate primary mentor (6), Masters candidate (1), Post-doctoral fellow (4) and junior faculty (5) trainees.
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Teaching Activities
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2003, 2004 and 2011 Lecturer, “Molecules and Cells” (IND100B),
2004 and 2005 Co-Director, Lecturer, “Fundamentals in Genetics” (MGTP),
2004 – 2013 Director and Instructor, Duke Bioinformatics Workshop
2005 Lecturer, “Algorithms in computational biology” (BGT 203)
2005 – 2010, 2012 – present Lecturer, "Human Genetics" (MGM/UPGG 732)2006 – 2008, 2014, 2016 Lecturer, Open Door Workshop, Montevideo, Uruguay
2006 – present Director, Lecturer, Clinical Research Training Program, “Introduction to Medical Genetics” (CRTP 243)
2010-11, 2013-14, 2016 Guest Lecturer, “Genetic Engineer/Biotech” (BIO 280S)
2011 Lecturer, Open Door Workshop, Dubai, UAE.
2012 Lecturer, “Applied Genomics and Personalized Medicine” (N562)
2012 Lecturer, Open Door Workshop, Ho Chi Minh City, Vietnam, 2012
2013 – present Lecturer, "Genome Technologies" (MGM/UPGG 778)2015 – present Faculty reviewer, “Grant writing” (UPGEN 702)
2016 Lecturer, Open Door Workshop, Bangkok, Thailand
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2003, 2004 and 2011 Lecturer, “Molecules and Cells” (IND100B),
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Characterizing oxysterol regulation of inflamation and mediators of remyelination in MS. 10x Genomics User Group Meeting. October 2018 2018
- Characterizing Oxysterols as moderators of inflammation and mediators of remyelination in MS. Duke - National University of Singapore. July 2018 2018
- Characterizing Oxysterols as moderators of inflammation and mediators of remyelination in MS. University of Sydney. July 2018 2018
- Epistatic interaction with IL7R and the development of MS. Epigenetics and Stem Cell Biology Laboratory Seminar Series. NIEHS. September 2017 2017
- Developing biomarkers and mechanisms of oxytocin use in autism. University of Sydney. February 2017 2017
- Developing biomarkers and mechanisms of oxytocin use in autism. Autism Symposium. Duke - National University of Singapore. January 2017 2017
- Molecular profiling of an Oxytocin Treatment trial - a first pass view. University of Sydney. February 2016 2016
- MicroRNA profiling in an animal model of multiple sclerosis. Epigenomics of Common Diseases. Wellcome Trust. November 2015 2015
- The identification of genetic association and regulation of IL7R in an autoimmune disease. Pfizer. September 2015 2015
- Autoimmune Genes: Discovery & Function. ASHG Annual Meeting. October 2014 2014
- Genetics of Multiple Sclerosis - current state and future developments. University of Basel. July 2014 2014
- The functional characterization of a multiple sclerosis associated variant in IL7Ra. University of North Carolina - Chapel Hill. June 2014 2014
- Leveraging epigenomics to understand the etiology of CVD. Duke Cardiovascular Research Center Seminar Series. June 2013 2013
- In Pursuit of Mechanism - From Association to Function in Multiple Sclerosis. Spring Seminar Series. The Jackson Laboratory. March 2013 2013
- The role of IL7R splicing in the etiology of MS. Carolinas Research Symposium. National Multiple Sclerosis Society. August 2012 2012
- Epigenetic Association of OXTR with Autism. 67th Annual Meeting. Society of Biological Psychiatry. May 2012 2012
- Epigenetic Profiling in Autism – The Case for Targeted and Discovery Approaches. Investigator Forum Series. University of North Carolina - Chapel Hill. March 2012 2012
- Genetic Variation and Multiple Sclerosis. National MS Society - Greater Delaware Valley Chapter. November 2011 2011
- Genomic rearrangements in autism. Environmental Mutagen Society. October 2011 2011
- Genetics of Chiari Type 1 Malformation. American Syringommyelia & Chiari Alliance Project. July 2011 2011
- Genomic and epigenetic signatures of OXTR and autism. World Congress on Neurophysical Hormones. July 2011 2011
- The Genetics and Genomic Sciences of Neurological Disease. Transcending the Boundaries Workshop on Neurodevelopment. Duke University Institute of Brain Science. May 2010 2010
- Epigenetic Evidence of Oxytocin Receptor Deficiency in Autism. Autism Research Institute. April 2010 2010
- Establishing the role of IL-7R in the development of MS. University of California San Francisco. April 2010 2010
- Epigenetic evidence of oxytocin receptor deficiency in autism. Think Tank Meeting. Autism Research Institute. January 2010 2010
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Outreach & Engaged Scholarship
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Service to the Profession
- Academic and Scientific Advisor. David H. Murdock Research Institute. 2018 - 2020 2018 - 2020
- Reviewer. Research Development Grant Program. Kansas City Area Life Sciences Institute (KCALSI). 2018 2018
- International Review Committee Member. Multiple Sclerosis Society Research Foundation, Canada. 2016 - 2017 2016 - 2017
- Member. Pilot Grant Review Committee. National Multiple Sclerosis Society. 2016 - 2017 2016 - 2017
- Standing Member. Special Emphasis Panel/Scientific Review Group 2015/05 NSD-C Neurological Sciences and Disorders C. National Institutes of Health, Center for Scientific Review. 2015 - 2020 2015 - 2020
- Ad Hoc Reviewer. Research Competitiveness Program. American Association for the Advancement of Science. 2014 2014
- Ad Hoc Reviewer. Cancer, Cardiovascular, and Sleep Epidemiology Panel B (CASE). National Institutes of Health, Center for Scientific Review. 2013 - 2016 2013 - 2016
- Ad Hoc Reviewer. National Priorities Research Program. Quatar National Research Foundation. 2013 - 2015 2013 - 2015
- Awards Reviewer. Charles J. Epstein Trainee Awards for Excellence in Human Genetics. American Society of Human Genetics. 2013 - 2016 2013 - 2016
- Editorial Board Member. Frontiers in Neurogenomics. 2013 - 2017 2013 - 2017
- Director, Genomics Core Facility. David H. Murdock Research Institute. 2010 - 2018 2010 - 2018
- Member. American Society of Human Genetics. 2003 - 2020 2003 - 2020
- Editor, Chromosome 1. Human Genome Organization. 1996 - 2003 1996 - 2003
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Service to Duke
- Duke University Center for Neurodegeneration and Neurotherapeutics. 2018 - 2020 2018 - 2020
- Research Planning Committee, Duke School of Medicine. Chair, Precision Medicine and Genetics and Genomics Subcommittee. 2018 2018
- Duke University School of Medicine. Research Planning Committee. 2017 - 2018 2017 - 2018
- Duke Institute of Brain Sciences. Director Search Committee. 2015 - 2017 2015 - 2017
- Duke Pathway to Independence and K-club Review Panel. 2015 - 2020 2015 - 2020
- Executive Counsel of Core Directors. 2015 - 2020 2015 - 2020
- Charter Member. Duke University Cardiovascular Research Center. 2011 - 2020 2011 - 2020
- Co-Leader. Epigenetics and Epigenomics Focus Group (Genetics and Genomics Basic Sciences Program). Duke University Cancer Institute. 2011 - 2014 2011 - 2014
- Executive Committee Member. Duke Epigenetics and Epigenomics Program (DEEP). 2011 - 2020 2011 - 2020
- Executive Committee Member. Program in Genetics and Genomics. 2011 - 2020 2011 - 2020
- Program in Genetics and Genomics. Chair, Admissions Committee. 2011 - 2014 2011 - 2014
- Program in Genetics and Genomics. Seminar Committee. 2010 - 2014 2010 - 2014
- Program in Genetics and Genomics. Admissions Committee. 2003 - 2020 2003 - 2020
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Academic & Administrative Activities
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Director and Instructor
- Duke Bioinformatics Workshop 2004-2013
Founding Co-Director - Duke Epigenetics an Epigenomics Program (DEEP) 2011-present
Co-Director - Genetics and Genomics Basic Sciences Program 2014-2017
Director - Duke Center for Research in Autoimmunity and Multiple Sclerosis (DREAMS), Department of Neurology.
Organizer of DREAMS Seminar Speaker Series 2015-present
Director of Graduate Studies - Duke University Program of Genetics and Genomics 2017-Present
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Director and Instructor
- Duke Bioinformatics Workshop 2004-2013
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