Research Interests
Brain tumors
Multiple Sclerosis
Autism
Alzheimer Disease
Application of single cell and spatial technologies to basic and translational research
Selected Grants
Targeting Hepatocyte Senescence to Improve NAFLD
ResearchAdvisor · Awarded by National Institutes of Health · 2024 - 2029Pathways of Injury and Repair in Barrett's Carcinogenesis
ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2023 - 2028Identifying and exploiting therapeutic vulnerabilities of tumor-host interactions that drive bone-to-meninges breast cancer metastasis
ResearchCollaborator · Awarded by National Institutes of Health · 2023 - 2028IMAGINE: Intestinal Metaplasia And Gastritis INtErception Study
ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2028Elucidating the role of vascular dysfunction in LATE, LATE-AD, and FTLD-TDP
ResearchCo Investigator · Awarded by Alzheimer's Association · 2024 - 2027Harnessing treatment-induced tumor evolution and collateral sensitivities using a human rectal cancer co-clinical platform
ResearchAdvisor · Awarded by National Cancer Institute · 2022 - 2027Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATM
ResearchCollaborator · Awarded by National Cancer Institute · 2022 - 2027Characterizing Spatial Variations in RNA Isoform Expression with Alzheimer's Disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2026Heterogeneous immune responses of the alveolar macrophage population during pulmonary fungal infections
ResearchCollaborator · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026Deciphering Immunological Biomarkers in Myasthenia Gravis by Using Multi-omics
ResearchSignificant Contributor · Awarded by Myasthenia Gravis Foundation · 2024 - 2026Deciphering the role of noncoding variation in the pathogenesis of multiple sclerosis
ResearchCollaborator · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026Hematology & Transfusion Medicine (T32)
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1975 - 2026Pericyte-Macrophage Interactions Maintain CNS Immune Tolerance
ResearchCo Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2021 - 2026Examining the physical toll of marginalizing experiences in emerging adulthood and exploring resilience possibilities
ResearchPrincipal Investigator · Awarded by University of Virginia - Charlottesville · 2021 - 2025Modulation of tumor microenvironment to hinder cancer progression and therapeutic resistance
ResearchCo Investigator · Awarded by Department of Defense · 2022 - 2025Immunovascular interactions in postoperative delirium superimposed on dementia (DSD).
ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2025Investigating the Role of a Novel Dendritic Cell Subset within Sentinel Lymph Node Tissues in Immune Evasion and Melanomagenesis
ResearchCollaborator · Awarded by Department of Defense · 2021 - 2025A spatial transcriptional analsysis of Chlamydia-mediated upper genital tract pathology
ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2025Genomic and Spatial Expression Analysis of Oligodendroglioma to Identify Novel Therapeutic and Prognostic Targets
ResearchMentor · Awarded by Doris Duke Charitable Foundation, Inc. · 2022 - 2025Reviving cancer immune surveillance with CD4 T cell help
ResearchCollaborator · Awarded by National Cancer Institute · 2022 - 2025Dissecting the evolutionary landscape of treatment resistance in rectal cancer using patient-derived models.
ResearchCollaborator · Awarded by American Gastroenterological Association · 2022 - 2025Genetic and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025NINDS Research Education Programs for Residents and Fellows in Neurosurgery
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Neurological Disorders and Stroke · 2009 - 2025Investigating the Impact of ABL Kinase Signaling on Epigenetic Reprogramming in Metastatic Triple Negative Breast Cancer
FellowshipCollaborator · Awarded by National Institutes of Health · 2022 - 2025ABL-regulated transcriptional and epigenetic networks promote outgrowth of breast cancer metastases revealing novel therapeutic targets
ResearchCollaborator · Awarded by Department of Defense · 2022 - 2024ABL-regulated transcriptional and epigenetic networks promote outgrowth of breast cancer metastases revealing novel therapeutic targets
ResearchCollaborator · Awarded by Department of Defense · 2022 - 2024Characterizing the oxysterol, 20-hydroxycholesterol, as a mediator of remyelination in multiple sclerosis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2024Kriya - MGC Addendum #2
ResearchPrincipal Investigator · Awarded by Kriya Therapeutics · 2024 - 2024Mechanisms of oxysterol-induced oligodendrogenesis
ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2024Hepatic Lipotoxicity, Metabolic Homeostasis and NAFLD Pathogenesis
ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2024Kriya - MGC: Spatial Transcriptomics Assay Development
ResearchPrincipal Investigator · Awarded by Kriya Therapeutics · 2024 - 2024The role of gastrin in esophageal submucosal gland acinar ductal metaplasia
ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 202410x Genomics scRNAseq and bulk RNAseq as part of the Role of Macrophages in Age-Related Macular Degeneration project
ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2022 - 2024Characterizing the serum metabolome in Multiple Sclerosis
ResearchPrincipal Investigator · Awarded by University of Miami · 2023 - 2024VA agreement - 10x Genomics - 48 samples - Molecular Genomics Core & the GCB Sequencing Core
ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2022 - 2024Targeting Wnt-signaling to prevent sudden death in pediatric arrhythmic cardiomyopathyTBD
ResearchCollaborator · Awarded by Doris Duke Charitable Foundation, Inc. · 2020 - 2024ITN Subaward Agreement: FY23ITN633 - B Cell Immunophenotyping and EBV Detection in STAyCIS ITN020AI / STAyCIS
ResearchPrincipal Investigator · Awarded by Benaroya Research Institute at Virginia Mason · 2019 - 2024Characterizing the (epi)genetics of oxytocin response in clinical and animal models
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2024VA agreement - Specialized analysis of spatial -omics data
ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2022 - 2023Characterizing the serum metabolome in multiple sclerosis
ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2021 - 2023Reviving cancer immune surveillance with CD4 T cell help
ResearchCo-Mentor · Awarded by National Institutes of Health · 2021 - 2023Postdoctoral Training in Genomic Medicine Research
Inst. Training Prgm or CMECo-Mentor · Awarded by National Institutes of Health · 2017 - 2023Biomarkers predicting response to eculizumab in myasthenia gravis (fed)
ResearchMentor · Awarded by The George Washington University · 2021 - 2023Single cell RNA-Seq of stored RBC to detect Autologous Blood Transfusion
ResearchCo Investigator · Awarded by Partnership for Clean Competition · 2021 - 2023Biomarkers predicting response to eculizumab in MG (NonFed)
ResearchMentor · Awarded by The George Washington University · 2021 - 2023Magnetically directed single cell transcriptome analysis in HIV latency
ResearchCollaborator · Awarded by National Institutes of Health · 2014 - 2023Copper Homeostasis in Mammals
ResearchCollaborator · Awarded by National Institutes of Health · 2004 - 2023MGC- 10x Genomics scRNAseq library generation.
ResearchPrincipal Investigator · Awarded by Sensei Biotherapeutics · 2021 - 2022VA Contract - Visium data analysis - 10x Genomics
ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2021 - 2022VA Contract - 10x Genomics - Molecular Genomics Core
ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2021 - 2022Biomarkers predicting response to eculizumab in MG (NonFed)
ResearchMentor · Awarded by The George Washington University · 2021 - 2022Biomarkers predicting response to eculizumab in myasthenia gravis
ResearchMentor · Awarded by The George Washington University · 2021 - 2022Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma?
ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2022ITN 385- Stage 2 - Run 1 Gene Expression Slide - 2 Lesion and 2 Non-lesion Samples
ResearchPrincipal Investigator · Awarded by Benaroya Research Institute at Virginia Mason · 2021 - 2022TCRCure Biopharma Corp - NC Biotechnology - 10X Genomics TCR V(D)J Library Generation
ResearchPrincipal Investigator · Awarded by TCRCure Biopharma Corp. · 2020 - 2021Gregory - 10x Genomics Gene Expression slides
ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2020 - 2021Bioinformatics and Computational Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2021PASC Autopsy (NYU)
ResearchCo Investigator · Awarded by New York University School of Medicine · 2021 - 2021Metabolic Pathways Of Pathogenic Th17 Cells In Myasthenia Gravis
ResearchCo Investigator · Awarded by Myasthenia Gravis Foundation · 2020 - 2021Networks of nutritional stress in human pancreatic islet cells
ResearchInvestigator · Awarded by Merck Sharp & Dohme · 2018 - 2020Genetics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1979 - 2020Development of Circulating Molecular Predictors of Chemotherapy and Novel Hormonal Therapy Benefit in Men with Metastatic Castration Resistant Prostate Cancer (mCRPC)
ResearchInvestigator · Awarded by Prostate Cancer Foundation · 2014 - 2020Specific and Pervasive Symptoms in Adults with Multiple Sclerosis Using the MURDOCK-MS Dataset: A Secondary Analysis
FellowshipSignificant Contributor · Awarded by National Institutes of Health · 2017 - 2020Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution
ResearchCo Investigator · Awarded by Department of Defense · 2015 - 2019Systems Biology Approaches for Predicting Cardiometabolic Risk in Persons Living with HIV
ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2018Identifying Genetic and Epigenetic Signatures of Treatment Response to Oxytocin in Humans and Mice
FellowshipPrincipal Investigator · Awarded by Autism Speaks · 2016 - 2018Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors (SOARS-B)
ResearchCo Investigator · Awarded by National Institutes of Health · 2012 - 2018Integration of CT imaging features with cell-free plasma DNA as biomarkers for early lung cancer detection in patients with indeterminate pulmonary nodules
FellowshipCollaborator · Awarded by Society of Thoracic Radiology · 2016 - 2018SRA for Stephanie Arvai
ResearchPrincipal Investigator · Awarded by University of Texas Medical Branch · 2016 - 2016Research Training In Neuro-Oncology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1998 - 2016Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD
ResearchCo Investigator · Awarded by National Institutes of Health · 2009 - 2016A role for pathogen-induced IL-10 production in susceptibility to MS
ResearchCo Investigator · Awarded by National Multiple Sclerosis Society · 2014 - 2015Study of Oxytocin in Autism to improve Reciprocal Social Behaviors (SOARS-B)
ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2012 - 2015Defining the Functional Role of a Novel MS Susceptibility Gene, IL7R alpha chain
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2015Linkage and candidate gene analysis in non-syndromic Chiari type I
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2009 - 2015Study of Genetic Basis of Fuchs Corneal Dystrophy
ResearchCollaborator · Awarded by National Institutes of Health · 2007 - 2013Genetic Mediators of Metabolic Cardiovascular Disease Risk
ResearchCo Investigator · Awarded by National Institutes of Health · 2009 - 2012Candidate Genes and Longitudinal Disability Phenotypes
ResearchMentor · Awarded by National Institutes of Health · 2006 - 2012Molecular mechanisms of altered calcium sensing in human parathyroid disease
ResearchConsultant · Awarded by National Institutes of Health · 2010 - 2012Research Training In Neuro-Oncology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2010Hereditary basis of neural tube defects
ResearchCo Investigator · Awarded by National Institutes of Health · 1999 - 2010Genotyping - Illumina Methylation Analysis of DNA Samples
ResearchPrincipal Investigator · Awarded by National Institute of Environmental Health Sciences · 2008 - 2010Genotyping - Methlylation Infinium Chips
ResearchPrincipal Investigator · Awarded by National Institute of Environmental Health Sciences · 2008 - 2010Molecular Dissection of Cardiovascular Disease: From Genes to Models to Function
ResearchMentor · Awarded by National Institutes of Health · 2007 - 2009GENECARD: Gene identification in Early-Onset CAD
ResearchCo Investigator · Awarded by National Institutes of Health · 2003 - 2009Molecular Genetics of Coronary Artery Disease
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2007High-Resolution CGH Characterization of Brain Tumors
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2004 - 2006External Relationships
- 10x Genomics Inc.
- Autoimmunity Biologic Solutions, Inc
- Cellarity Inc.
- David H Murdock Research Institute
- Tellus Therapeutics
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.