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The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.

Publication ,  Journal Article
Stover, C; Endo, Y; Takahashi, M; Lynch, NJ; Constantinescu, C; Vorup-Jensen, T; Thiel, S; Friedl, H; Hankeln, T; Hall, R; Gregory, S ...
Published in: Genes Immun
May 2001

The proteases of the lectin pathway of complement activation, MASP-1 and MASP-2, are encoded by two separate genes. The MASP1 gene is located on chromosome 3q27, the MASP2 gene on chromosome 1p36.23-31. The genes for the classical complement activation pathway proteases, C1r and C1s, are linked on chromosome 12p13. We have shown that the MASP2 gene encodes two gene products, the 76 kDa MASP-2 serine protease and a plasma protein of 19 kDa, termed MAp19 or sMAP. Both gene products are components of the lectin pathway activation complex. We present the complete primary structure of the human MASP2 gene and the tight cluster that this locus forms with non-complement genes. A comparison of the MASP2 gene with the previously characterised C1s gene revealed identical positions of introns separating orthologous coding sequences, underlining the hypothesis that the C1s and MASP2 genes arose by exon shuffling from one ancestral gene.

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Published In

Genes Immun

DOI

ISSN

1466-4879

Publication Date

May 2001

Volume

2

Issue

3

Start / End Page

119 / 127

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Serine Endopeptidases
  • RNA Splicing
  • Promoter Regions, Genetic
  • Multigene Family
  • Molecular Sequence Data
  • Mannose-Binding Protein-Associated Serine Proteases
  • Immunology
  • Humans
  • Genetic Linkage
 

Citation

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Stover, C., Endo, Y., Takahashi, M., Lynch, N. J., Constantinescu, C., Vorup-Jensen, T., … Schwaeble, W. (2001). The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. Genes Immun, 2(3), 119–127. https://doi.org/10.1038/sj.gene.6363745
Stover, C., Y. Endo, M. Takahashi, N. J. Lynch, C. Constantinescu, T. Vorup-Jensen, S. Thiel, et al. “The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.Genes Immun 2, no. 3 (May 2001): 119–27. https://doi.org/10.1038/sj.gene.6363745.
Stover C, Endo Y, Takahashi M, Lynch NJ, Constantinescu C, Vorup-Jensen T, Thiel S, Friedl H, Hankeln T, Hall R, Gregory S, Fujita T, Schwaeble W. The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. Genes Immun. 2001 May;2(3):119–127.

Published In

Genes Immun

DOI

ISSN

1466-4879

Publication Date

May 2001

Volume

2

Issue

3

Start / End Page

119 / 127

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Serine Endopeptidases
  • RNA Splicing
  • Promoter Regions, Genetic
  • Multigene Family
  • Molecular Sequence Data
  • Mannose-Binding Protein-Associated Serine Proteases
  • Immunology
  • Humans
  • Genetic Linkage