Synaptic vesicle biogenesis, docking, and fusion: a molecular description.

Journal Article (Journal Article;Review)

Secretion of neurotransmitter is the primary means of intercellular communication within the nervous system. This process is regulated by a highly orchestrated cycle of membrane trafficking within the presynaptic nerve terminal. Characterization of proteins localized to the synaptic vesicle and the subsequent studies of their properties have led to a model for the biochemical pathway that underlies vesicle docking, activation, and fusion. The proteins found to function in the synapse are related to those in yeast and other organisms, demonstrating that the mechanisms that mediate vesicle trafficking are conserved in all eukaryotic species.

Full Text

Duke Authors

Cited Authors

  • Calakos, N; Scheller, RH

Published Date

  • January 1996

Published In

Volume / Issue

  • 76 / 1

Start / End Page

  • 1 - 29

PubMed ID

  • 8592726

International Standard Serial Number (ISSN)

  • 0031-9333

Digital Object Identifier (DOI)

  • 10.1152/physrev.1996.76.1.1


  • eng

Conference Location

  • United States