Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Resident in Neurology, Medicine, University of California, San Francisco, School of Medicine 1997 - 2000
  • Intern in Medicine, Medicine, University of California, San Francisco, School of Medicine 1996 - 1997
  • M.D., Stanford University 1996
  • Ph.D., Stanford University 1995
• 

  Duke Appointment History

  • Associate Professor of Neurology, Neurology, Movement Disorders, Neurology 2013 - 2015
  • Assistant Professor of Medicine, Neurology, Clinical Science Departments 2005 - 2013
  • Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 2005 - 2013
• Recognition
• 

  In the News

  • SEP 6, 2017

    One Powerful Cell Makes or Breaks Your Habits

  • AUG 1, 2016

    Fox News, Health.com

    New study suggests brain glitch may cause OCD

  • JUL 29, 2016

    Psych Central

    Commentary: OCD and exciting research

  • JAN 22, 2016

    CBC News

    Breaking bad habits relies on 'stop' and 'go' brain signals

  • JAN 22, 2016

    The Daily Mail

    Repetitive behaviors rewire the brain and cause lasting damage

  • JAN 21, 2016

    Why Are Habits So Hard to Break?

  • JUN 26, 2015

    Allen Song Named Interim Director of Brain Institute

  • JAN 6, 2015

    Study Pinpoints Autism-Linked Protein for Sculpting Brain Connections

  • DEC 17, 2013

    Neuroscientists Win McKnight Endowment Award
• Expertise
• 

  Subject Headings

  • Animals
  • Basal Ganglia
  • Brain
  • Cannabinoid Receptor Modulators
  • Cattle
  • Chromosomes, Artificial, Bacterial
  • Compulsive Behavior
  • Corpus Striatum
  • Disease Models, Animal
  • Dopamine
  • Drug Discovery
  • Dystonia
  • Dystonic Disorders
  • Electrophysiology
  • Endocannabinoids
  • Exocytosis
  • Grooming
  • High-Throughput Screening Assays
  • Inclusion Bodies
  • Learning
  • Luminescent Proteins
  • Memory
  • Mice, Knockout
  • Mice, Transgenic
  • Microscopy, Fluorescence
  • Molecular Chaperones
  • Movement Disorders
  • Mutation
  • Nerve Tissue Proteins
  • Neural Pathways
  • Neuronal Plasticity
  • Neurons
  • Obsessive-Compulsive Disorder
  • Patch-Clamp Techniques
  • Presynaptic Terminals
  • R-SNARE Proteins
  • Receptors, Dopamine D1
  • Receptors, Metabotropic Glutamate
  • Receptors, N-Methyl-D-Aspartate
  • Self-Injurious Behavior
  • Synapses
  • Synaptic Transmission
  • Synaptic Vesicles
  • Syntaxin 1
  • Tourette Syndrome
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • Calakos, N. "From Good Habit to Bad: Corticostriatal Synaptic and Circuit Mechanisms in Habit and Compulsion." December 2015.  Link to Item
    • Calakos, N, Fischbein, N, Estanol, B, Baringer, JR, and Jay, C. "Cortical manifestations of the osmotic myelinolysis syndrome identified by MRI." April 1999.  Link to Item
    • Jay, CA, and Calakos, N. "Heroin inhalation and leukoencephalopathy: A case series from California." April 1999.  Link to Item
    • PEVSNER, J, HSU, SC, BRAUN, JEA, CALAKOS, N, TING, AE, BENNETT, MK, and SCHELLER, RH. "MOLECULAR MECHANISMS OF SYNAPTIC TRANSMISSION." April 24, 1995.  Link to Item
    • CALAKOS, N, TRIMBLE, WS, and SCHELLER, RH. "PROTEIN DOMAINS IMPORTANT FOR TARGETING OF THE SYNAPTIC VESICLE PROTEIN, VAMP." January 26, 1993.  Link to Item
    • BENNETT, MK, CALAKOS, N, MILLER, KG, and SCHELLER, RH. "SYNTAXIN - A SYNAPTIC PROTEIN IMPLICATED IN DOCKING OF SYNAPTIC VESICLES AT PRESYNAPTIC ACTIVE ZONES." September 1992.  Link to Item

  • Journal Articles

    • O'Hare, J, Calakos, N, and Yin, HH. "Recent Insights into Corticostriatal Circuit Mechanisms underlying Habits: Invited review for Current Opinions in Behavioral Sciences." Current opinion in behavioral sciences 20 (April 2018): 40-46.  Full Text
    • Wang, X, Gallegos, DA, Pogorelov, VM, O'Hare, JK, Calakos, N, Wetsel, WC, and West, AE. "Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 43, no. 5 (April 2018): 953-963.  Full Text
    • O'Hare, JK, Li, H, Kim, N, Gaidis, E, Ade, K, Beck, J, Yin, H, and Calakos, N. "Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior." eLife 6 (September 5, 2017).  Full Text
    • Hernandez-Martinez, R, and Calakos, N. "Seq-ing the Circuit Logic of the Basal Ganglia." Trends in neurosciences 40, no. 6 (June 2017): 325-327.  Full Text
    • Rittiner, JE, Caffall, ZF, Hernández-Martinez, R, Sanderson, SM, Pearson, JL, Tsukayama, KK, Liu, AY, Xiao, C, Tracy, S, Shipman, MK, Hickey, P, Johnson, J, Scott, B, Stacy, M, Saunders-Pullman, R, Bressman, S, Simonyan, K, Sharma, N, Ozelius, LJ, Cirulli, ET, and Calakos, N. "Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2α Signaling as a Generalizable Mechanism for Dystonia." Neuron 92, no. 6 (December 5, 2016): 1238-1251.  Full Text
    • Ade, KK, Wan, Y, Hamann, HC, O'Hare, JK, Guo, W, Quian, A, Kumar, S, Bhagat, S, Rodriguiz, RM, Wetsel, WC, Conn, PJ, Dzirasa, K, Huber, KM, and Calakos, N. "Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice." Biological psychiatry 80, no. 7 (October 2016): 522-533.  Full Text
    • Bhagat, SL, Qiu, S, Caffall, ZF, Wan, Y, Pan, Y, Rodriguiz, RM, Wetsel, WC, Badea, A, Hochgeschwender, U, and Calakos, N. "Mouse model of rare TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models." Neurobiology of disease 93 (September 2016): 137-145.  Full Text
    • O'Hare, JK, Ade, KK, Sukharnikova, T, Van Hooser, SD, Palmeri, ML, Yin, HH, and Calakos, N. "Pathway-Specific Striatal Substrates for Habitual Behavior." Neuron 89, no. 3 (February 2016): 472-479.  Full Text
    • Rossi, MA, Calakos, N, and Yin, HH. "Spotlight on movement disorders: What optogenetics has to offer." Movement disorders : official journal of the Movement Disorder Society 30, no. 5 (April 2015): 624-631.  Full Text
    • Bohorquez, DV, Shahid, RA, Erdmann, A, Kreger, AM, Wang, Y, Calakos, N, Wang, F, and Liddle, RA. "Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells." JOURNAL OF CLINICAL INVESTIGATION 125, no. 2 (February 2015): 782-786.  Full Text  Link to Item
    • Bohórquez, DV, Shahid, RA, Erdmann, A, Kreger, AM, Wang, Y, Calakos, N, Wang, F, and Liddle, RA. "Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells." J Clin Invest 125, no. 2 (February 2015): 782-786.  Full Text  Open Access Copy  Link to Item
    • Risher, WC, Patel, S, Kim, IH, Uezu, A, Bhagat, S, Wilton, DK, Pilaz, L-J, Singh Alvarado, J, Calhan, OY, Silver, DL, Stevens, B, Calakos, N, Soderling, SH, and Eroglu, C. "Astrocytes refine cortical connectivity at dendritic spines." eLife 3 (December 17, 2014).  Full Text  Open Access Copy
    • Wan, Y, Ade, KK, Caffall, Z, Ilcim Ozlu, M, Eroglu, C, Feng, G, and Calakos, N. "Circuit-selective striatal synaptic dysfunction in the sapap3 knockout mouse model of obsessive-compulsive disorder." Biological Psychiatry 75, no. 8 (April 15, 2014): 623-630.  Full Text
    • Wan, Y, Ade, KK, Caffall, Z, Ilcim Ozlu, M, Eroglu, C, Feng, G, and Calakos, N. "Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder." Biol Psychiatry 75, no. 8 (April 15, 2014): 623-630.  Full Text  Link to Item
    • Deng, JV, Wan, Y, Wang, X, Cohen, S, Wetsel, WC, Greenberg, ME, Kenny, PJ, Calakos, N, and West, AE. "MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity." The Journal of neuroscience : the official journal of the Society for Neuroscience 34, no. 13 (March 2014): 4519-4527.  Full Text
    • Yang, Y, and Calakos, N. "Presynaptic long-term plasticity. (Published online)" Front Synaptic Neurosci 5 (October 17, 2013): 8-. (Review)  Full Text  Link to Item
    • Farrell, MS, Pei, Y, Wan, Y, Yadav, PN, Daigle, TL, Urban, DJ, Lee, H-M, Sciaky, N, Simmons, A, Nonneman, RJ, Huang, X-P, Hufeisen, SJ, Guettier, J-M, Moy, SS, Wess, J, Caron, MG, Calakos, N, and Roth, BL. "A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons." Neuropsychopharmacology 38, no. 5 (April 2013): 854-862.  Full Text  Link to Item
    • Dufour, S, Lavertu, G, Dufour-Beauséjour, S, Juneau-Fecteau, A, Calakos, N, Deschênes, M, Vallée, R, and De Koninck, Y. "A multimodal micro-optrode combining field and single unit recording, multispectral detection and photolabeling capabilities." PLoS One 8, no. 2 (2013): e57703-.  Full Text  Link to Item
    • Wan, Y, Feng, G, and Calakos, N. "Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses." J Neurosci 31, no. 46 (November 16, 2011): 16685-16691.  Full Text  Link to Item
    • Yang, Y, and Calakos, N. "Munc13-1 is required for presynaptic long-term potentiation." J Neurosci 31, no. 33 (August 17, 2011): 12053-12057.  Full Text  Link to Item
    • Chen, M, Wan, Y, Ade, K, Ting, J, Feng, G, and Calakos, N. "Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity." J Neurosci 31, no. 26 (June 29, 2011): 9563-9573.  Full Text  Link to Item
    • Ade, KK, Wan, Y, Chen, M, Gloss, B, and Calakos, N. "An Improved BAC Transgenic Fluorescent Reporter Line for Sensitive and Specific Identification of Striatonigral Medium Spiny Neurons. (Published online)" Front Syst Neurosci 5 (2011): 32-.  Full Text  Link to Item
    • Calakos, N, Patel, VD, Gottron, M, Wang, G, Tran-Viet, K-N, Brewington, D, Beyer, JL, Steffens, DC, Krishnan, RR, and Züchner, S. "Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia." J Med Genet 47, no. 9 (September 2010): 646-650.  Full Text  Link to Item
    • Yang, Y, and Calakos, N. "Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation." J Neurosci 30, no. 7 (February 17, 2010): 2542-2546.  Full Text  Link to Item
    • Zhang, Z-W, Burke, MW, Calakos, N, Beaulieu, J-M, and Vaucher, E. "Confocal Analysis of Cholinergic and Dopaminergic Inputs onto Pyramidal Cells in the Prefrontal Cortex of Rodents. (Published online)" Front Neuroanat 4 (2010): 21-.  Full Text  Link to Item
    • Welch, JM, Lu, J, Rodriguiz, RM, Trotta, NC, Peca, J, Ding, J-D, Feliciano, C, Chen, M, Adams, JP, Luo, J, Dudek, SM, Weinberg, RJ, Calakos, N, Wetsel, WC, and Feng, G. "Synaptic and circuitry mechanisms of obsessive compulsive-like behaviors in mice." INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 26, no. 8 (December 2008): 835-835.  Full Text  Link to Item
    • Shuen, JA, Chen, M, Gloss, B, and Calakos, N. "Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia." J Neurosci 28, no. 11 (March 12, 2008): 2681-2685.  Full Text  Link to Item
    • Welch, JM, Lu, J, Rodriguiz, RM, Trotta, NC, Peca, J, Ding, J-D, Feliciano, C, Chen, M, Adams, JP, Luo, J, Dudek, SM, Weinberg, RJ, Calakos, N, Wetsel, WC, and Feng, G. "Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice." Nature 448, no. 7156 (August 23, 2007): 894-900.  Full Text  Link to Item
    • Marie, H, Morishita, W, Yu, X, Calakos, N, and Malenka, RC. "Generation of silent synapses by acute in vivo expression of CaMKIV and CREB." Neuron 45, no. 5 (March 3, 2005): 741-752.  Full Text  Link to Item
    • Calakos, N, Schoch, S, Südhof, TC, and Malenka, RC. "Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release." Neuron 42, no. 6 (June 24, 2004): 889-896.  Full Text  Link to Item
    • Calakos, N, Fischbein, N, Baringer, JR, and Jay, C. "Cortical MRI findings associated with rapid correction of hyponatremia." Neurology 55, no. 7 (October 10, 2000): 1048-1051.  Link to Item
    • CALAKOS, N. "Synaptic vesicle biogenesis, docking, and fusion : A Molecular Description." Physiol Rev 76 (1996): 1-29.
    • Calakos, N, and Scheller, RH. "Synaptic vesicle biogenesis, docking, and fusion: a molecular description." Physiol Rev 76, no. 1 (January 1996): 1-29. (Review)  Full Text  Link to Item
    • Meffert, MK, Calakos, NC, Scheller, RH, and Schulman, H. "Nitric oxide modulates synaptic vesicle docking/fusion reactions." Neuron 16, no. 6 (1996): 1229-1236.  Full Text
    • Calakos, N, and Scheller, RH. "Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle." J Biol Chem 269, no. 40 (October 7, 1994): 24534-24537.  Link to Item
    • Pevsner, J, Hsu, SC, Braun, JE, Calakos, N, Ting, AE, Bennett, MK, and Scheller, RH. "Specificity and regulation of a synaptic vesicle docking complex." Neuron 13, no. 2 (August 1994): 353-361.  Link to Item
    • Calakos, N, Bennett, MK, Peterson, KE, and Scheller, RH. "Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking." Science 263, no. 5150 (February 25, 1994): 1146-1149.  Link to Item
    • CALAKOS, N. "Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking." Science 263 (1994): 1446-1149.  Full Text
    • Bennett, MK, Calakos, N, and Scheller, RH. "Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones." Science 257, no. 5067 (July 10, 1992): 255-259.  Link to Item
    • Bennett, MK, Calakos, N, Kreiner, T, and Scheller, RH. "Synaptic vesicle membrane proteins interact to form a multimeric complex." J Cell Biol 116, no. 3 (February 1992): 761-775.  Link to Item
    • Ngsee, JK, Trimble, WS, Elferink, LA, Wendland, B, Miller, K, Calakos, N, and Scheller, RH. "Molecular analysis of proteins associated with the synaptic vesicle membrane." Cold Spring Harb Symp Quant Biol 55 (1990): 111-118. (Review)  Link to Item
    • Okuhn, SP, Connelly, DP, Calakos, N, Ferrell, L, Pan, MX, and Goldstone, J. "Does compliance mismatch alone cause neointimal hyperplasia?." J Vasc Surg 9, no. 1 (January 1989): 35-45.  Link to Item
• Teaching & Mentoring
• 

  Recent Courses

  • NEUROBIO 393: Research Independent Study 2018
  • NEUROBIO 719E: Neural Plasticity 2018
  • NEUROBIO 793: Research in Neurobiology 2017
  • NEUROSCI 150: Research Practicum 2017
• 

  Advising & Mentoring

  Available to mentor:

  • Faculty
  • PhD
  • Post-Doc
  • Undergraduate

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