Nicole Calakos | Scholars@Duke

Nicole Calakos
Professor in Neurology

Current Appointments & Affiliations

Professor in Neurology, Neurology, Movement Disorders, Neurology 2018
Professor in Neurobiology, Neurobiology, Basic Science Departments 2018
Professor of Cell Biology, Cell Biology, Basic Science Departments 2018
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2008
Associate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2017

Contact Information

201E Bryan Res Bldg, Durham, NC 27710
Duke Box 2900, Durham, NC 27710
nicole.calakos@duke.edu (919) 684-2423
Lab Website

Background
Education, Training, & Certifications
- Resident in Neurology, Medicine, University of California, San Francisco, School of Medicine 1997 - 2000
- Intern in Medicine, Medicine, University of California, San Francisco, School of Medicine 1996 - 1997
- M.D., Stanford University 1996
- Ph.D., Stanford University 1995
Duke Appointment History
- Associate Professor of Neurology, Neurology, Movement Disorders, Neurology 2015 - 2018
- Associate Professor in the Department of Neurobiology, Neurobiology, Basic Science Departments 2016 - 2018
- Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 2013 - 2015
- Associate Professor of Neurology, Neurology, Movement Disorders, Neurology 2013 - 2015
- Assistant Professor of Medicine, Neurology, Clinical Science Departments 2005 - 2013
- Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 2005 - 2013
Recognition
In the News
- SEP 6, 2017
  
  One Powerful Cell Makes or Breaks Your Habits
- AUG 1, 2016 Fox News, Health.com
  
  New study suggests brain glitch may cause OCD
- JUL 29, 2016 Psych Central
  
  Commentary: OCD and exciting research
- JAN 22, 2016 CBC News
  
  Breaking bad habits relies on 'stop' and 'go' brain signals
- JAN 22, 2016 The Daily Mail
  
  Repetitive behaviors rewire the brain and cause lasting damage
- JAN 21, 2016
  
  Why Are Habits So Hard to Break?
- JUN 26, 2015
  
  Allen Song Named Interim Director of Brain Institute
- JAN 6, 2015
  
  Study Pinpoints Autism-Linked Protein for Sculpting Brain Connections
- DEC 17, 2013
  
  Neuroscientists Win McKnight Endowment Award
Expertise
Subject Headings
Publications & Artistic Works
Selected Publications
- Academic Articles
  - O’Hare, Justin, Nicole Calakos, and Henry H. Yin. “Recent Insights into Corticostriatal Circuit Mechanisms underlying Habits: Invited review for Current Opinions in Behavioral Sciences..” Current Opinion in Behavioral Sciences 20 (April 2018): 40–46. https://doi.org/10.1016/j.cobeha.2017.10.001.
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  - Wang, Xiaoting, David A. Gallegos, Vladimir M. Pogorelov, Justin K. O’Hare, Nicole Calakos, William C. Wetsel, and Anne E. West. “Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference..” Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 43, no. 5 (April 2018): 953–63. https://doi.org/10.1038/npp.2017.178.
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  - O’Hare, Justin K., Haofang Li, Namsoo Kim, Erin Gaidis, Kristen Ade, Jeff Beck, Henry Yin, and Nicole Calakos. “Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior..” Elife 6 (September 5, 2017). https://doi.org/10.7554/eLife.26231.
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  - Hernandez-Martinez, Ricardo, and Nicole Calakos. “Seq-ing the Circuit Logic of the Basal Ganglia..” Trends in Neurosciences 40, no. 6 (June 2017): 325–27. https://doi.org/10.1016/j.tins.2017.04.006.
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  - Rittiner, Joseph E., Zachary F. Caffall, Ricardo Hernández-Martinez, Sydney M. Sanderson, James L. Pearson, Kaylin K. Tsukayama, Anna Y. Liu, et al. “Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2α Signaling as a Generalizable Mechanism for Dystonia..” Neuron 92, no. 6 (December 8, 2016): 1238–51. https://doi.org/10.1016/j.neuron.2016.11.012.
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  - Ade, Kristen K., Yehong Wan, Harold C. Hamann, Justin K. O’Hare, Weirui Guo, Anna Quian, Sunil Kumar, et al. “Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice..” Biological Psychiatry 80, no. 7 (October 2016): 522–33. https://doi.org/10.1016/j.biopsych.2016.04.023.
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  - Bhagat, Srishti L., Sunny Qiu, Zachary F. Caffall, Yehong Wan, Yuanji Pan, Ramona M. Rodriguiz, William C. Wetsel, Alexandra Badea, Ute Hochgeschwender, and Nicole Calakos. “Mouse model of rare TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models..” Neurobiology of Disease 93 (September 2016): 137–45. https://doi.org/10.1016/j.nbd.2016.05.003.
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  - O’Hare, Justin K., Kristen K. Ade, Tatyana Sukharnikova, Stephen D. Van Hooser, Mark L. Palmeri, Henry H. Yin, and Nicole Calakos. “Pathway-Specific Striatal Substrates for Habitual Behavior..” Neuron 89, no. 3 (February 2016): 472–79. https://doi.org/10.1016/j.neuron.2015.12.032.
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  - Rossi, Mark A., Nicole Calakos, and Henry H. Yin. “Spotlight on movement disorders: What optogenetics has to offer..” Movement Disorders : Official Journal of the Movement Disorder Society 30, no. 5 (April 2015): 624–31. https://doi.org/10.1002/mds.26184.
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  - Bohorquez, Diego V., Rafiq A. Shahid, Alan Erdmann, Alex M. Kreger, Yu Wang, Nicole Calakos, Fan Wang, and Rodger A. Liddle. “Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells.” Journal of Clinical Investigation 125, no. 2 (February 2015): 782–86. https://doi.org/10.1172/JCI78361.
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  - Bohórquez, Diego V., Rafiq A. Shahid, Alan Erdmann, Alex M. Kreger, Yu Wang, Nicole Calakos, Fan Wang, and Rodger A. Liddle. “Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells..” J Clin Invest 125, no. 2 (February 2015): 782–86. https://doi.org/10.1172/JCI78361.
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  - Risher, W Christopher, Sagar Patel, Il Hwan Kim, Akiyoshi Uezu, Srishti Bhagat, Daniel K. Wilton, Louis-Jan Pilaz, et al. “Astrocytes refine cortical connectivity at dendritic spines..” Elife 3 (December 17, 2014). https://doi.org/10.7554/eLife.04047.
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  - Wan, Y., K. K. Ade, Z. Caffall, M. Ilcim Ozlu, C. Eroglu, G. Feng, and N. Calakos. “Circuit-selective striatal synaptic dysfunction in the sapap3 knockout mouse model of obsessive-compulsive disorder.” Biological Psychiatry 75, no. 8 (April 15, 2014): 623–30. https://doi.org/10.1016/j.biopsych.2013.01.008.
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  - Wan, Yehong, Kristen K. Ade, Zachary Caffall, M. Ilcim Ozlu, Cagla Eroglu, Guoping Feng, and Nicole Calakos. “Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder..” Biological Psychiatry 75, no. 8 (April 2014): 623–30. https://doi.org/10.1016/j.biopsych.2013.01.008.
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  - Deng, Jie V., Yehong Wan, Xiaoting Wang, Sonia Cohen, William C. Wetsel, Michael E. Greenberg, Paul J. Kenny, Nicole Calakos, and Anne E. West. “MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity..” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 34, no. 13 (March 2014): 4519–27. https://doi.org/10.1523/JNEUROSCI.2821-13.2014.
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  - Yang, Ying, and Nicole Calakos. “Presynaptic long-term plasticity..” Frontiers in Synaptic Neuroscience 5 (October 17, 2013). https://doi.org/10.3389/fnsyn.2013.00008.
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  - Farrell, Martilias S., Ying Pei, Yehong Wan, Prem N. Yadav, Tanya L. Daigle, Daniel J. Urban, Hyeong-Min Lee, et al. “A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons..” Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 38, no. 5 (April 2013): 854–62. https://doi.org/10.1038/npp.2012.251.
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  - Dufour, Suzie, Guillaume Lavertu, Sophie Dufour-Beauséjour, Alexandre Juneau-Fecteau, Nicole Calakos, Martin Deschênes, Réal Vallée, and Yves De Koninck. “A multimodal micro-optrode combining field and single unit recording, multispectral detection and photolabeling capabilities..” Plos One 8, no. 2 (January 2013). https://doi.org/10.1371/journal.pone.0057703.
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  - Wan, Yehong, Guoping Feng, and Nicole Calakos. “Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses..” J Neurosci 31, no. 46 (November 16, 2011): 16685–91. https://doi.org/10.1523/JNEUROSCI.2533-11.2011.
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  - Yang, Ying, and Nicole Calakos. “Munc13-1 is required for presynaptic long-term potentiation..” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 31, no. 33 (August 2011): 12053–57. https://doi.org/10.1523/JNEUROSCI.2276-11.2011.
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  - Chen, Meng, Yehong Wan, Kristen Ade, Jonathan Ting, Guoping Feng, and Nicole Calakos. “Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity..” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 31, no. 26 (June 2011): 9563–73. https://doi.org/10.1523/JNEUROSCI.1701-11.2011.
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  - Ade, Kristen K., Yehong Wan, Meng Chen, Bernd Gloss, and Nicole Calakos. “An Improved BAC Transgenic Fluorescent Reporter Line for Sensitive and Specific Identification of Striatonigral Medium Spiny Neurons..” Frontiers in Systems Neuroscience 5 (January 2011). https://doi.org/10.3389/fnsys.2011.00032.
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  - Calakos, Nicole, Viren D. Patel, Melissa Gottron, Gaofeng Wang, Khan-Nhat Tran-Viet, Danielle Brewington, John L. Beyer, David C. Steffens, Ranga R. Krishnan, and Stephan Züchner. “Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia..” Journal of Medical Genetics 47, no. 9 (September 2010): 646–50. https://doi.org/10.1136/jmg.2009.072082.
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  - Yang, Ying, and Nicole Calakos. “Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation..” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 30, no. 7 (February 2010): 2542–46. https://doi.org/10.1523/JNEUROSCI.4285-09.2010.
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  - Zhang, Zi-Wei, Mark W. Burke, Nicole Calakos, Jean-Martin Beaulieu, and Elvire Vaucher. “Confocal Analysis of Cholinergic and Dopaminergic Inputs onto Pyramidal Cells in the Prefrontal Cortex of Rodents..” Frontiers in Neuroanatomy 4 (January 2010). https://doi.org/10.3389/fnana.2010.00021.
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  - Welch, J. M., J. Lu, R. M. Rodriguiz, N. C. Trotta, J. Peca, J. -. D. Ding, C. Feliciano, et al. “Synaptic and circuitry mechanisms of obsessive compulsive-like behaviors in mice.” International Journal of Developmental Neuroscience 26, no. 8 (December 2008): 835–835. https://doi.org/10.1016/j.ijdevneu.2008.09.033.
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  - Shuen, Jessica A., Meng Chen, Bernd Gloss, and Nicole Calakos. “Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia..” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 28, no. 11 (March 2008): 2681–85. https://doi.org/10.1523/jneurosci.5492-07.2008.
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  - Welch, Jeffrey M., Jing Lu, Ramona M. Rodriguiz, Nicholas C. Trotta, Joao Peca, Jin-Dong Ding, Catia Feliciano, et al. “Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice..” Nature 448, no. 7156 (August 2007): 894–900. https://doi.org/10.1038/nature06104.
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  - Marie, Hélène, Wade Morishita, Xiang Yu, Nicole Calakos, and Robert C. Malenka. “Generation of silent synapses by acute in vivo expression of CaMKIV and CREB..” Neuron 45, no. 5 (March 2005): 741–52. https://doi.org/10.1016/j.neuron.2005.01.039.
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  - Calakos, Nicole, Susanne Schoch, Thomas C. Südhof, and Robert C. Malenka. “Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release..” Neuron 42, no. 6 (June 2004): 889–96. https://doi.org/10.1016/j.neuron.2004.05.014.
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  - Calakos, N., N. Fischbein, J. R. Baringer, and C. Jay. “Cortical MRI findings associated with rapid correction of hyponatremia..” Neurology 55, no. 7 (October 2000): 1048–51. https://doi.org/10.1212/wnl.55.7.1048.
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  - Meffert, M. K., N. C. Calakos, R. H. Scheller, and H. Schulman. “Nitric oxide modulates synaptic vesicle docking fusion reactions..” Neuron 16, no. 6 (June 1996): 1229–36. https://doi.org/10.1016/s0896-6273(00)80149-x.
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  - CALAKOS, N. “Synaptic vesicle biogenesis, docking, and fusion : A Molecular Description.” Physiol Rev 76 (1996): 1–29.
  - Calakos, N., and R. H. Scheller. “Synaptic vesicle biogenesis, docking, and fusion: a molecular description..” Physiological Reviews 76, no. 1 (January 1996): 1–29. https://doi.org/10.1152/physrev.1996.76.1.1.
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  - Calakos, N., and R. H. Scheller. “Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle..” The Journal of Biological Chemistry 269, no. 40 (October 1994): 24534–37.
  - Pevsner, J., S. C. Hsu, J. E. Braun, N. Calakos, A. E. Ting, M. K. Bennett, and R. H. Scheller. “Specificity and regulation of a synaptic vesicle docking complex..” Neuron 13, no. 2 (August 1994): 353–61. https://doi.org/10.1016/0896-6273(94)90352-2.
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  - Calakos, N., M. K. Bennett, K. E. Peterson, and R. H. Scheller. “Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking..” Science (New York, N.Y.) 263, no. 5150 (February 1994): 1146–49. https://doi.org/10.1126/science.8108733.
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  - CALAKOS, N. “Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking.” Science 263 (1994): 1446–1149. https://doi.org/10.1126/science.8108733.
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  - Bennett, M. K., N. Calakos, and R. H. Scheller. “Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones..” Science (New York, N.Y.) 257, no. 5067 (July 1992): 255–59. https://doi.org/10.1126/science.1321498.
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  - Bennett, M. K., N. Calakos, T. Kreiner, and R. H. Scheller. “Synaptic vesicle membrane proteins interact to form a multimeric complex..” The Journal of Cell Biology 116, no. 3 (February 1992): 761–75. https://doi.org/10.1083/jcb.116.3.761.
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  - Ngsee, J. K., W. S. Trimble, L. A. Elferink, B. Wendland, K. Miller, N. Calakos, and R. H. Scheller. “Molecular analysis of proteins associated with the synaptic vesicle membrane..” Cold Spring Harbor Symposia on Quantitative Biology 55 (January 1990): 111–18. https://doi.org/10.1101/sqb.1990.055.01.014.
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  - Okuhn, S. P., D. P. Connelly, N. Calakos, L. Ferrell, M. X. Pan, and J. Goldstone. “Does compliance mismatch alone cause neointimal hyperplasia?.” Journal of Vascular Surgery 9, no. 1 (January 1989): 35–45. https://doi.org/10.1067/mva.1989.vs0090035.
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- Book Sections
  - Calakos, N. “Botulinum toxin: From molecule to clinic.” In Handbook of Dystonia, 343–54, 2006.
- Conference Papers
  - Calakos, Nicole. “From Good Habit to Bad: Corticostriatal Synaptic and Circuit Mechanisms in Habit and Compulsion.” In Neuropsychopharmacology, 40:S38–39. NATURE PUBLISHING GROUP, 2015.
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  - Calakos, N., N. Fischbein, B. Estanol, J. R. Baringer, and C. Jay. “Cortical manifestations of the osmotic myelinolysis syndrome identified by MRI.” In Neurology, 52:A80–81. LIPPINCOTT WILLIAMS & WILKINS, 1999.
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  - Jay, C. A., and N. Calakos. “Heroin inhalation and leukoencephalopathy: A case series from California.” In Neurology, 52:A446–A446. LIPPINCOTT WILLIAMS & WILKINS, 1999.
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  - PEVSNER, J., S. C. HSU, J. E. A. BRAUN, N. CALAKOS, A. E. TING, M. K. BENNETT, and R. H. SCHELLER. “MOLECULAR MECHANISMS OF SYNAPTIC TRANSMISSION.” In Faseb Journal, 9:A1457–A1457. FEDERATION AMER SOC EXP BIOL, 1995.
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  - CALAKOS, N., W. S. TRIMBLE, and R. H. SCHELLER. “PROTEIN DOMAINS IMPORTANT FOR TARGETING OF THE SYNAPTIC VESICLE PROTEIN, VAMP.” In Journal of Cellular Biochemistry, 279–279. WILEY-LISS, 1993.
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  - BENNETT, M. K., N. CALAKOS, K. G. MILLER, and R. H. SCHELLER. “SYNTAXIN - A SYNAPTIC PROTEIN IMPLICATED IN DOCKING OF SYNAPTIC VESICLES AT PRESYNAPTIC ACTIVE ZONES.” In Molecular Biology of the Cell, 3:A3–A3. AMER SOC CELL BIOLOGY, 1992.
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Teaching & Mentoring
Recent Courses
- NEUROBIO 393: Research Independent Study 2019
- NEUROBIO 719D: Brain Development 2019
- NEUROSCI 494: Research Independent Study 2 2019
- NEUROBIO 719E: Neural Development 2018
- NEUROSCI 493: Research Independent Study 1 2018
- NEUROBIO 793: Research in Neurobiology 2017
- NEUROSCI 150: Research Practicum 2017
Advising & Mentoring
Available to mentor:
- Faculty
- PhD
- Post-Doc
- Undergraduate

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Education, Training, & Certifications

Duke Appointment History

In the News

Subject Headings

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses

Advising & Mentoring

Available to mentor: