Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones.

Journal Article (Journal Article)

Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Two 35-kilodalton proteins (p35 or syntaxins) were identified that interact with the synaptic vesicle protein p65 (synaptotagmin). The p35 proteins are expressed only in the nervous system, are 84 percent identical, include carboxyl-terminal membrane anchors, and are concentrated on the plasma membrane at synaptic sites. An antibody to p35 immunoprecipitated solubilized N-type calcium channels. The p35 proteins may function in docking synaptic vesicles near calcium channels at presynaptic active zones.

Full Text

Duke Authors

Cited Authors

  • Bennett, MK; Calakos, N; Scheller, RH

Published Date

  • July 10, 1992

Published In

Volume / Issue

  • 257 / 5067

Start / End Page

  • 255 - 259

PubMed ID

  • 1321498

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1321498


  • eng

Conference Location

  • United States