Anti-angiogenic therapy in renal cell cancer.
Journal Article (Journal Article;Review)
Angiogenesis is an important hallmark of RCC, reflected in the natural history, Histology, genetics and now therapeutics of this disease. Clearly, the pro-angiogenic growth factor VEGF is a functional drug target in RCC and many strategies to inhibit this biology have shown clinical benefit. Multi-targeted TKI that inhibit VEGFRs have been approved by the FDA as standard treatment for advanced RCC. Pharmacodynamyc studies suggest that these agents and others also have anti-angiogenic effects. Currently, studies combining VEGFR-targeted strategies with other anti-angiogenic agents, including anti-VEGF antibodies, IFN or mTOR inhibitors, are underway. However, to what extent the clinical benefit of anti-angiogenic strategies in RCC can be built upon is unknown.
- Srinivasan, R; Armstrong, AJ; Dahut, W; George, DJ
- May 2007
Volume / Issue
- 99 / 5 Pt B
Start / End Page
- 1296 - 1300
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)