A longitudinal analysis of serum cytokines in the Hartley guinea pig model of osteoarthritis.

Journal Article

OBJECTIVE: To evaluate chosen serum cytokines and their association with osteoarthritis (OA) in the guinea pig. METHODS: The levels of 18 cytokines were measured in Hartley guinea pig serum at time points ranging from 3 weeks to 18 months of age. These levels were then tested for any correlation with total histology, and a comprehensive evaluation of these statistics was conducted using data previously collected from OA-resistant Strain 13 guinea pigs. RESULTS: After all cytokines demonstrating a significant association with weight or age were excluded, IL-6 (p=0.016) and G-CSF (p=0.024) were found to correlate positively with total histological score. Models involving each of these cytokines paired independently with weight explained 43-44% of the variance in total histology. CONCLUSIONS: Only the age and weight-independent associations of IL-6 and G-CSF with histological OA were significant under the conditions imposed by the Holm step-down adjustment for multiple comparisons. Though the observed changes of these cytokine levels may be due to a correlation with age, it is highly unlikely given the significant difference between Hartley and Strain 13 age-matched cohorts.

Full Text

Duke Authors

Cited Authors

  • Huebner, JL; Seifer, DR; Kraus, VB

Published Date

  • March 2007

Published In

Volume / Issue

  • 15 / 3

Start / End Page

  • 354 - 356

PubMed ID

  • 17208467

International Standard Serial Number (ISSN)

  • 1063-4584

Digital Object Identifier (DOI)

  • 10.1016/j.joca.2006.10.014

Language

  • eng

Conference Location

  • England