How to manage drug interactions.

Journal Article (Journal Article)

Multiple drugs are used to provide anaesthesia. On average, four to six drugs are used during anaesthesia and, therefore, drug interactions are common. These interactions are primarily either pharmacokinetic or pharmacodynamic. Due to the relatively short duration of drug administration for anaesthesia, pharmacokinetic drug interactions resulting from alterations in drug metabolism do not generally produce clinically significant effects. Pharmacodynamic-drug interactions between anaesthetic drugs, however, are potentially serious. This may reflect that anaesthesia is not a single entity, but a process provided by a combination of drugs; i.e. loss of consciousness, analgesia and neuromuscular blockade. An understanding of each drug's pharmacokinetics, pharmacodynamics and drug interactions will allow clinicians to administer drugs to provide a more optimal anaesthetic.

Full Text

Duke Authors

Cited Authors

  • Glass, PS; Howell, S; Gan, TJ; Ginsberg, B

Published Date

  • May 1997

Published In

Volume / Issue

  • 15 /

Start / End Page

  • 33 - 39

PubMed ID

  • 9202936

International Standard Serial Number (ISSN)

  • 0952-1941

Digital Object Identifier (DOI)

  • 10.1097/00003643-199705001-00007


  • eng

Conference Location

  • England