Brian Ginsberg | Scholars@Duke

Brian Ginsberg
Associate Professor Emeritus of Anesthesiology

My research activities, which are totally clinical and are closely intertwined with my clinical endeavors in the fields of acute pain management and pediatric anesthesia. Research in acute pain management will involve the introduction of both new drugs and techniques into the routine armamentarium of the acute pain team. Another beneficial avenue of research is the use of non invasive and lower cost technologies such as transmucosal fentanyl in the management of pain states. Studies will determine dosing equivalence and therapeutic effectiveness of transmucosal fentanyl. The focus of acute pain therapy is shifting from intermittent analgesia to around the clock medication The development of slow release formulations of potent opioids allows for the study of these agents to optimize postoperative pain. Continuous monitoring of the effectiveness of pain therapy is required to justify the time and expense of therapy. Studies are underway to determine patient satisfaction with these newer modalities of pain care.

One of the clinical challenges in pediatric anesthesia is to overcome some of the trauma associated with pediatric anesthesia. This entails the use of new pharmacological agents and psychological preparation of children prior to surgery.

Current Appointments & Affiliations

Associate Professor Emeritus of Anesthesiology, Anesthesiology, Regional, Anesthesiology 2017
Medical Director, Acute Pain Service, Anesthesiology, Pain Management, Anesthesiology 1993

Contact Information

201 Trent Drive, 4314 Duke South, Orange Zone, Durham, NC 27710
Box 3094 Med Ctr, Durham, NC 27710
ginsb001@mc.duke.edu (919) 668-6208

Background
Education, Training, & Certifications
- M.B.B.Ch., University of Witwatersrand (South Africa) 1975
Duke Appointment History
- Associate Professor of Anesthesiology, Anesthesiology, Regional, Anesthesiology 1997 - 2017
- Associate Professor of Anesthesiology, Anesthesiology, Pain Management, Anesthesiology 1996 - 1997
- Assistant Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 1987 - 1995
Research
Selected Grants
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1993 - 1995
Publications & Artistic Works
Selected Publications
- Books
  - Sinatra, R. S., O. A. De Leon-Casasola, B. Ginsberg, E. R. Viscusi, and H. McQuay. Acute pain management, 2009. https://doi.org/10.1017/CBO9780511576706.
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- Academic Articles
  - Mischel, Nicholas, Christian Bjerre-Real, Jonathan Komisar, Brian Ginsberg, Steven T. Szabo, and Xavier PreudʼHomme. “Intravenous Ketamine Relieves Pain and Depression After Traumatic Suicide Attempts: A Case Series.” J Clin Psychopharmacol 38, no. 2 (April 2018): 149–50. https://doi.org/10.1097/JCP.0000000000000852.
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  - Esper, Stephen A., Brandi A. Bottiger, Brian Ginsberg, J Mauricio Del Rio, Donald D. Glower, Jeffrey G. Gaca, Mark Stafford-Smith, Peter J. Neuburger, and Mark A. Chaney. “CASE 8--2015. Paravertebral Catheter-Based Strategy for Primary Analgesia After Minimally Invasive Cardiac Surgery.” J Cardiothorac Vasc Anesth 29, no. 4 (August 2015): 1071–80. https://doi.org/10.1053/j.jvca.2015.02.018.
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  - Prewitt, Judy, Susan Schneider, Monica Horvath, Julia Hammond, Jason Jackson, and Brian Ginsberg. “PCA safety data review after clinical decision support and smart pump technology implementation.” J Patient Saf 9, no. 2 (June 2013): 103–9. https://doi.org/10.1097/PTS.0b013e318281b866.
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  - Liu, Spencer S., Christopher L. Wu, Jane C. Ballantyne, Asokumar Buvanendran, James P. Rathmell, Daniel T. Warren, Eugene R. Viscusi, et al. “Where in the world is ASRA AcutePOP?” Reg Anesth Pain Med 34, no. 3 (May 2009): 269–74. https://doi.org/10.1097/aap.0b013e3181a39597.
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  - Keck, Sherry, Catherine Glennon, and Brian Ginsberg. “DepoDur extended-release epidural morphine: reshaping postoperative care. What perioperative nurses need to know.” Orthop Nurs 26, no. 2 (March 2007): 86–93. https://doi.org/10.1097/01.NOR.0000265863.78103.78.
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  - Liu, S. S., G. A. Liguori, C. L. Wu, J. C. Ballantyne, J. P. Rathmell, B. Ginsberg, R. W. Rosenquist, E. R. Viscusi, and D. T. Warren. “Announcing the Official Formation of ASRA AcutePOP (Acute Postoperative Pain) Initiative.” Regional Anesthesia and Pain Medicine 32, no. 3 (January 1, 2007): 265–66. https://doi.org/10.1016/j.rapm.2007.03.002.
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  - Liu, Spencer S., Daniel T. Warren, Christopher L. Wu, Jane C. Ballantyne, Brian Ginsberg, James P. Rathmell, Richard W. Rosenquist, and Eugene R. Viscusi. “A lovely idea: forming an ASRA Acute Postoperative Pain (AcutePOP) database.” Reg Anesth Pain Med 31, no. 4 (July 2006): 291–93. https://doi.org/10.1016/j.rapm.2006.05.006.
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  - Rathmell, James P., Christopher L. Wu, Raymond S. Sinatra, Jane C. Ballantyne, Brian Ginsberg, Debra B. Gordon, Spencer S. Liu, et al. “Acute post-surgical pain management: a critical appraisal of current practice, December 2-4, 2005.” Reg Anesth Pain Med 31, no. 4 Suppl 1 (July 2006): 1–42. https://doi.org/10.1016/j.rapm.2006.05.002.
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  - Aronoff, Gerald M., Michael J. Brennan, Douglas D. Pritchard, and Brian Ginsberg. “Evidence-based oral transmucosal fentanyl citrate (OTFC) dosing guidelines.” Pain Med 6, no. 4 (July 2005): 305–14. https://doi.org/10.1111/j.1526-4637.2005.00045.x.
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  - Ginsberg, Brian, Raymond S. Sinatra, Lauri J. Adler, James C. Crews, Allen H. Hord, Charles E. Laurito, and Michael A. Ashburn. “Conversion to oral controlled-release oxycodone from intravenous opioid analgesic in the postoperative setting.” Pain Med 4, no. 1 (March 2003): 31–38. https://doi.org/10.1046/j.1526-4637.2003.03004.x.
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  - Eck, John B., Guy De Lisle Dear, Barbara G. Phillips-Bute, and Brian Ginsberg. “Prediction of tracheal tube size in children using multiple variables.” Paediatr Anaesth 12, no. 6 (July 2002): 495–98. https://doi.org/10.1046/j.1460-9592.2002.00894.x.
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  - Glasson, Joel C., William T. Sawyer, Celeste M. Lindley, and Brian Ginsberg. “Patient-specific factors affecting patient-controlled analgesia dosing.” J Pain Palliat Care Pharmacother 16, no. 2 (2002): 5–21. https://doi.org/10.1080/j354v16n02_02.
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  - Latta, Kenneth S., Brian Ginsberg, and Robert L. Barkin. “Meperidine: a critical review.” Am J Ther 9, no. 1 (January 2002): 53–68. https://doi.org/10.1097/00045391-200201000-00010.
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  - Ross, A. K., P. J. Davis, G. L. Dear Gd, B. Ginsberg, F. X. McGowan, R. D. Stiller, L. G. Henson, C. Huffman, and K. T. Muir. “Pharmacokinetics of remifentanil in anesthetized pediatric patients undergoing elective surgery or diagnostic procedures.” Anesth Analg 93, no. 6 (December 2001): 1393–1401. https://doi.org/10.1097/00000539-200112000-00008.
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  - Ginsberg, B. “Pain management in knee surgery.” Orthop Nurs 20, no. 2 (March 2001): 37–41. https://doi.org/10.1097/00006416-200103000-00010.
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  - Denman, W. T., R. F. Kaplan, N. G. Goudsouzian, T. Uejima, S. L. Barcelona, C. J. Cote, B. Ginsberg, and R. S. Hannallah. “Intramuscular rapacuronium in infants and children: a comparative multicenter study to confirm the efficacy and safety of the age-related tracheal intubating doses of intramuscular rapacuronium (ORG 9487) in two groups of pediatric subjects.” Anesthesiology 94, no. 1 (January 2001): 3–7. https://doi.org/10.1097/00000542-200101000-00006.
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  - Klein, S. M., T. F. Slaughter, P. T. Vail, B. Ginsberg, H. E. El-Moalem, R. Alexander, F. D’Ercole, et al. “Thromboelastography as a perioperative measure of anticoagulation resulting from low molecular weight heparin: a comparison with anti-Xa concentrations.” Anesth Analg 91, no. 5 (November 2000): 1091–95. https://doi.org/10.1097/00000539-200011000-00009.
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  - Iselin-Chaves, I. A., H. E. El Moalem, T. J. Gan, B. Ginsberg, and P. S. Glass. “Changes in the auditory evoked potentials and the bispectral index following propofol or propofol and alfentanil.” Anesthesiology 92, no. 5 (May 2000): 1300–1310. https://doi.org/10.1097/00000542-200005000-00018.
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  - Brandom, B. W., J. O. Margolis, G. B. Bikhazi, A. K. Ross, B. Ginsberg, G. Dear, C. A. Kenaan, J. B. Eck, S. K. Woelfel, and M. E. Lloyd. “Neuromuscular effects of rapacuronium in pediatric patients during nitrous oxide-halothane anesthesia: comparison with mivacurium.” Can J Anaesth 47, no. 2 (February 2000): 143–49. https://doi.org/10.1007/BF03018850.
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  - Ginsberg, B. “Duke pain initiative takes proactive role for patient relief: An interview with Brian Ginsberg M.D.” Disease Management 3, no. 4 (January 1, 2000): 159–62. https://doi.org/10.1089/dis.2000.3.159.
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  - Ginsberg, B., G. Martin, T. J. Gan, K. P. Grichnik, R. Jhaveri, K. Sibert, F. L. Sullivan, M. R. Muir, and P. S. A. Glass. “Assessment of the relative clinical utility of sufentanil and morphine administered by patient controlled analgesia pumps following abdominal hysterectomy.” Journal of Pharmaceutical Care in Pain and Symptom Control 8, no. 4 (January 1, 2000): 5–17. https://doi.org/10.1300/J088v08n04_02.
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  - Soppitt, A. J., P. S. Glass, H. el-Moalem, B. Ginsberg, K. Weatherwax, and T. J. Gan. “Duration and recovery profile of cisatracurium after succinylcholine during propofol or isoflurane anesthesia.” J Clin Anesth 11, no. 8 (December 1999): 652–56. https://doi.org/10.1016/s0952-8180(99)00118-x.
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  - Kaplan, R. F., T. Uejima, G. Lobel, N. Goudsouzian, B. Ginsberg, R. Hannallah, C. J. Coté, et al. “Intramuscular rocuronium in infants and children: a multicenter study to evaluate tracheal intubating conditions, onset, and duration of action.” Anesthesiology 91, no. 3 (September 1999): 633–38. https://doi.org/10.1097/00000542-199909000-00012.
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  - Lichtor, J. L., F. B. Sevarino, G. P. Joshi, M. A. Busch, E. Nordbrock, and B. Ginsberg. “The relative potency of oral transmucosal fentanyl citrate compared with intravenous morphine in the treatment of moderate to severe postoperative pain.” Anesth Analg 89, no. 3 (September 1999): 732–38. https://doi.org/10.1097/00000539-199909000-00038.
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  - Miaskowski, C., J. Crews, L. B. Ready, S. M. Paul, and B. Ginsberg. “Anesthesia-based pain services improve the quality of postoperative pain management.” Pain 80, no. 1–2 (March 1999): 23–29. https://doi.org/10.1016/s0304-3959(98)00192-4.
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  - Ross, A. K., G. L. Dear, R. B. Dear, J. O. Margolis, and B. Ginsberg. “Onset and recovery of neuromuscular blockade after two doses of rocuronium in children.” J Clin Anesth 10, no. 8 (December 1998): 631–35. https://doi.org/10.1016/s0952-8180(98)00098-1.
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  - Iselin-Chaves, I. A., R. Flaishon, P. S. Sebel, S. Howell, T. J. Gan, J. Sigl, B. Ginsberg, and P. S. Glass. “The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index.” Anesth Analg 87, no. 4 (October 1998): 949–55. https://doi.org/10.1097/00000539-199810000-00038.
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  - Ginsberg, B., R. B. Dear, J. O. Margolis, G. D. Dear, and A. K. Ross. “Oral transmucosal fentanyl citrate as an anaesthetic premedication when dosed to an opioid effect vs total opioid consumption.” Paediatr Anaesth 8, no. 5 (1998): 413–18. https://doi.org/10.1046/j.1460-9592.1998.00276.x.
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  - Margolis, J. O., B. Ginsberg, G. L. Dear, A. K. Ross, J. E. Goral, and A. G. Bailey. “Paediatric preoperative teaching: effects at induction and postoperatively.” Paediatr Anaesth 8, no. 1 (1998): 17–23. https://doi.org/10.1046/j.1460-9592.1998.00698.x.
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  - Gan, T. J., B. Ginsberg, P. S. Glass, J. Fortney, R. Jhaveri, and R. Perno. “Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate.” Anesthesiology 87, no. 5 (November 1997): 1075–81. https://doi.org/10.1097/00000542-199711000-00011.
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  - Gan, T. J., P. S. Glass, S. T. Howell, A. T. Canada, A. P. Grant, and B. Ginsberg. “Determination of plasma concentrations of propofol associated with 50% reduction in postoperative nausea.” Anesthesiology 87, no. 4 (October 1997): 779–84. https://doi.org/10.1097/00000542-199710000-00010.
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  - Glass, P. S., T. J. Gan, S. Howell, and B. Ginsberg. “Drug interactions: volatile anesthetics and opioids.” J Clin Anesth 9, no. 6 Suppl (September 1997): 18S-22S. https://doi.org/10.1016/s0952-8180(97)00122-0.
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  - Muir, M. R., F. L. Sullivan, G. Dear, and B. Ginsberg. “Monitoring practices following epidural analgesics for pain management: a follow-up survey.” J Pain Symptom Manage 14, no. 1 (July 1997): 36–44. https://doi.org/10.1016/S0885-3924(97)00039-0.
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  - Ashley, D. M., R. E. Coleman, H. Fuchs, G. Dear, B. Ginsberg, F. M. Zalduondo, H. S. Friedman, and D. Longee. “Chronic CSF leak into the peritoneal cavity shown by radionuclide cisternography. Successful treatment with an epidural blood patch.” Clin Nucl Med 22, no. 6 (June 1997): 390–92. https://doi.org/10.1097/00003072-199706000-00010.
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  - Glass, P. S., S. Howell, T. J. Gan, and B. Ginsberg. “How to manage drug interactions.” Eur J Anaesthesiol Suppl 15 (May 1997): 33–39. https://doi.org/10.1097/00003643-199705001-00007.
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  - Lubarsky, D. A., I. C. Sanderson, W. C. Gilbert, K. P. King, B. Ginsberg, G. L. Dear, R. L. Coleman, T. D. Pafford, and J. G. Reves. “Using an anesthesia information management system as a cost containment tool. Description and validation.” Anesthesiology 86, no. 5 (May 1997): 1161–69. https://doi.org/10.1097/00000542-199705000-00020.
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  - Lubarsky, D. A., P. S. Glass, B. Ginsberg, G. L. Dear, M. E. Dentz, T. J. Gan, I. C. Sanderson, et al. “The successful implementation of pharmaceutical practice guidelines. Analysis of associated outcomes and cost savings. SWiPE Group. Systematic Withdrawal of Perioperative Expenses.” Anesthesiology 86, no. 5 (May 1997): 1145–60. https://doi.org/10.1097/00000542-199705000-00019.
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  - Ginsberg, B., S. Howell, P. S. Glass, J. O. Margolis, A. K. Ross, G. L. Dear, and S. L. Shafer. “Pharmacokinetic model-driven infusion of fentanyl in children.” Anesthesiology 85, no. 6 (December 1996): 1268–75. https://doi.org/10.1097/00000542-199612000-00007.
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  - Gan, T. J., B. Ginsberg, A. P. Grant, and P. S. Glass. “Double-blind, randomized comparison of ondansetron and intraoperative propofol to prevent postoperative nausea and vomiting.” Anesthesiology 85, no. 5 (November 1996): 1036–42. https://doi.org/10.1097/00000542-199611000-00011.
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  - Khalil, S., A. Rodarte, B. C. Weldon, M. Weinstein, Z. Grunwald, B. Ginsberg, R. Kaye, et al. “Intravenous ondansetron in established postoperative emesis in children. S3A-381 Study Group.” Anesthesiology 85, no. 2 (August 1996): 270–76. https://doi.org/10.1097/00000542-199608000-00007.
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  - Jowell, P. S., G. Eisen, J. Onken, B. P. Bute, and B. Ginsberg. “Patient-controlled analgesia for conscious sedation during endoscopic retrograde cholangiopancreatography: a randomized controlled trial.” Gastrointest Endosc 43, no. 5 (May 1996): 490–94. https://doi.org/10.1016/s0016-5107(96)70292-4.
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  - Ginsberg, B. “Patient controlled analgesia used to assess the efficacy and potency of a new opioid.” Pain Research and Management 1, no. 4 (January 1, 1996): 227–31. https://doi.org/10.1155/1996/874063.
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  - Ginsberg, B., K. M. Gil, M. Muir, F. Sullivan, D. A. Williams, and P. S. Glass. “The influence of lockout intervals and drug selection on patient-controlled analgesia following gynecological surgery.” Pain 62, no. 1 (July 1995): 95–100. https://doi.org/10.1016/0304-3959(94)00255-d.
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  - Sullivan, F. L., M. R. Muir, and B. Ginsberg. “A survey on the clinical use of epidural catheters for acute pain management.” J Pain Symptom Manage 9, no. 5 (July 1994): 303–7. https://doi.org/10.1016/0885-3924(94)90188-0.
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  - Grichnik, K. P., B. Ginsberg, T. Gan, and W. J. Richardson. “Epidural analgesia after lumbar laminectomy.” Regional Anesthesia 19, no. 2 (January 1, 1994).
  - Lineberger, C. K., B. Ginsberg, R. J. Franiak, and P. S. A. Glass. “Narcotic agonists and antagonists.” Anesthesiology Clinics of North America 12, no. 1 (January 1, 1994): 65–89.
  - Glass, P. S., R. M. Jhaveri, B. Ginsberg, and K. Ossey. “Evaluation of flumazenil for reversing the effects of midazolam-induced conscious sedation or general anesthesia.” South Med J 86, no. 11 (November 1993): 1238–47. https://doi.org/10.1097/00007611-199311000-00011.
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  - Bloch, E. C., B. Ginsberg, and R. A. Binner. “The esophageal temperature gradient in anesthetized children.” J Clin Monit 9, no. 2 (April 1993): 73–77. https://doi.org/10.1007/BF01616917.
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  - Bloch, E. C. “Anaesthetic death of a child with a cold.” Anaesthesia 48, no. 2 (February 1993): 171. https://doi.org/10.1111/j.1365-2044.1993.tb06870.x.
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  - ESTES, R., B. GINSBERG, and E. C. BLOCH. “Anaesthesia and the Kearns‐Sayre syndrome.” Pediatric Anesthesia 3, no. 5 (January 1, 1993): 307–11. https://doi.org/10.1111/j.1460-9592.1993.tb00094.x.
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  - Hubbard, L. “More on epidural fentanyl analgesia.” Anesth Analg 75, no. 5 (November 1992): 865–66. https://doi.org/10.1213/00000539-199211000-00051.
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  - Gil, K. M., B. Ginsberg, M. Muir, F. Sullivan, and D. A. Williams. “Patient controlled analgesia: the relation of psychological factors to pain and analgesic use in adolescents with postoperative pain.” Clin J Pain 8, no. 3 (September 1992): 215–21.
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  - Binner, R. A., B. Ginsberg, E. C. Bloch, and D. G. Mason. “Anesthetic management of a pediatric Wada test.” Anesth Analg 74, no. 4 (April 1992): 621–22. https://doi.org/10.1213/00000539-199204000-00033.
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  - Bloch, E. C., B. Ginsberg, R. A. Binner, and D. I. Sessler. “Limb tourniquets and central temperature in anesthetized children.” Anesth Analg 74, no. 4 (April 1992): 486–89. https://doi.org/10.1213/00000539-199204000-00002.
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  - Glass, P. S., P. Estok, B. Ginsberg, J. S. Goldberg, and R. N. Sladen. “Use of patient-controlled analgesia to compare the efficacy of epidural to intravenous fentanyl administration.” Anesth Analg 74, no. 3 (March 1992): 345–51. https://doi.org/10.1213/00000539-199203000-00005.
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  - Ginsberg, B. “Acute pain management.” Problems in Urology 6, no. 1 (January 1, 1992): 174–94.
  - Bloch, E. C., and B. Ginsberg. “Short trachea and endotracheal tube placement.” Pediatr Neurol 7, no. 2 (March 1991): 150–51. https://doi.org/10.1016/0887-8994(91)90015-d.
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  - Quill, T. J., M. Begin, P. S. Glass, B. Ginsberg, and M. S. Gorback. “Clinical responses to ORG 9426 during isoflurane anesthesia.” Anesth Analg 72, no. 2 (February 1991): 203–6. https://doi.org/10.1213/00000539-199102000-00011.
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  - Glass, P. S., J. R. Jacobs, L. R. Smith, B. Ginsberg, T. J. Quill, S. A. Bai, and J. G. Reves. “Pharmacokinetic model-driven infusion of fentanyl: assessment of accuracy.” Anesthesiology 73, no. 6 (December 1990): 1082–90. https://doi.org/10.1097/00000542-199012000-00004.
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  - Gil, K. M., B. Ginsberg, M. Muir, D. Sykes, and D. A. Williams. “Patient-controlled analgesia in postoperative pain: the relation of psychological factors to pain and analgesic use.” Clin J Pain 6, no. 2 (June 1990): 137–42. https://doi.org/10.1097/00002508-199006000-00012.
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  - Ginsberg, B., and P. S. A. Glass. “Should vecuronium be used for rapid sequence induction? (I: Reply).” Anesthesiology 72, no. 1 (January 1, 1990): 212. https://doi.org/10.1097/00000542-199001000-00041.
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  - Ginsberg, B., P. S. Glass, T. Quill, D. Shafron, and K. D. Ossey. “Onset and duration of neuromuscular blockade following high-dose vecuronium administration.” Anesthesiology 71, no. 2 (August 1989): 201–5. https://doi.org/10.1097/00000542-198908000-00006.
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  - Bloch, E. C., K. Ossey, and B. Ginsberg. “Tracheal intubation in children: a new method for assuring correct depth of tube placement.” Anesth Analg 67, no. 6 (June 1988): 590–92.
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  - “Anesthesia for caesarean section.” S Afr Med J 63, no. 14 (April 2, 1983): 512–13.
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- Book Sections
  - Flanagan, E., and B. Ginsberg. “Meperidine.” In The Essence of Analgesia and Analgesics, 94–98, 2010. https://doi.org/10.1017/CBO9780511841378.017.
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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Books

Academic Articles

Book Sections