Brian Ginsberg | Scholars@Duke

Brian Ginsberg
Associate Professor Emeritus of Anesthesiology

My research activities, which are totally clinical and are closely intertwined with my clinical endeavors in the fields of acute pain management and pediatric anesthesia. Research in acute pain management will involve the introduction of both new drugs and techniques into the routine armamentarium of the acute pain team. Another beneficial avenue of research is the use of non invasive and lower cost technologies such as transmucosal fentanyl in the management of pain states. Studies will determine dosing equivalence and therapeutic effectiveness of transmucosal fentanyl. The focus of acute pain therapy is shifting from intermittent analgesia to around the clock medication The development of slow release formulations of potent opioids allows for the study of these agents to optimize postoperative pain. Continuous monitoring of the effectiveness of pain therapy is required to justify the time and expense of therapy. Studies are underway to determine patient satisfaction with these newer modalities of pain care.

One of the clinical challenges in pediatric anesthesia is to overcome some of the trauma associated with pediatric anesthesia. This entails the use of new pharmacological agents and psychological preparation of children prior to surgery.

Current Appointments & Affiliations

Associate Professor Emeritus of Anesthesiology, Anesthesiology, Regional, Anesthesiology 2017
Medical Director, Acute Pain Service, Anesthesiology, Pain Management, Anesthesiology 1993

Contact Information

201 Trent Drive, 4314 Duke South, Orange Zone, Durham, NC 27710
Box 3094 Med Ctr, Durham, NC 27710
ginsb001@mc.duke.edu (919) 668-6208

Background
Education, Training, & Certifications
- M.B.B.Ch., University of Witwatersrand (S. Africa) 1975
Duke Appointment History
- Associate Professor of Anesthesiology, Anesthesiology, Regional, Anesthesiology 1997 - 2017
- Associate Professor of Anesthesiology, Anesthesiology, Pain Management, Anesthesiology 1996 - 1997
- Assistant Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 1987 - 1995
Research
Selected Grants
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1993 - 1995
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Mischel, N, Bjerre-Real, C, Komisar, J, Ginsberg, B, Szabo, ST, and PreudʼHomme, X. "Intravenous Ketamine Relieves Pain and Depression After Traumatic Suicide Attempts: A Case Series." Journal of clinical psychopharmacology (February 8, 2018). Full Text
  - Esper, SA, Bottiger, BA, Ginsberg, B, Del Rio, JM, Glower, DD, Gaca, JG, Stafford-Smith, M, Neuburger, PJ, and Chaney, MA. "CASE 8--2015. Paravertebral Catheter-Based Strategy for Primary Analgesia After Minimally Invasive Cardiac Surgery." Journal of cardiothoracic and vascular anesthesia 29, no. 4 (August 2015): 1071-1080. Full Text
  - Prewitt, J, Schneider, S, Horvath, M, Hammond, J, Jackson, J, and Ginsberg, B. "PCA safety data review after clinical decision support and smart pump technology implementation." J Patient Saf 9, no. 2 (June 2013): 103-109. Full Text Link to Item
  - Liu, SS, Wu, CL, Ballantyne, JC, Buvanendran, A, Rathmell, JP, Warren, DT, Viscusi, ER, Ginsberg, B, Rosenquist, RW, Yadeau, JT, and Liguori, GA. "Where in the world is ASRA acute pop?." Regional Anesthesia and Pain Medicine 34, no. 3 (2009): 269-274. Full Text
  - Liu, SS, Liguori, GA, Wu, CL, Ballantyne, JC, Rathmell, JP, Ginsberg, B, Rosenquist, RW, Viscusi, ER, and Warren, DT. "Announcing the Official Formation of ASRA AcutePOP (Acute Postoperative Pain) Initiative." Regional Anesthesia and Pain Medicine 32, no. 3 (May 2007): 265-266. Full Text
  - Keck, S, Glennon, C, and Ginsberg, B. "DepoDur extended-release epidural morphine: reshaping postoperative care. What perioperative nurses need to know." Orthopedic Nursing 26, no. 2 (March 2007): 86-93. Full Text
  - Rathmell, JP, Wu, CL, Sinatra, RS, Ballantyne, JC, Ginsberg, B, Gordon, DB, Liu, SS, Perkins, FM, Reuben, SS, Rosenquist, RW, and Viscusi, ER. "Acute post-surgical pain management: a critical appraisal of current practice, December 2-4, 2005." Regional Anesthesia and Pain Medicine 31, no. 4 Suppl 1 (July 2006): 1-42. Full Text
  - Liu, SS, Warren, DT, Wu, CL, Ballantyne, JC, Ginsberg, B, Rathmell, JP, Rosenquist, RW, and Viscusi, ER. "A Lovely Idea: Forming an ASRA Acute Postoperative Pain (AcutePOP) Database." Regional Anesthesia and Pain Medicine 31, no. 4 (2006): 291-293. Full Text
  - Aronoff, GM, Brennan, MJ, Pritchard, DD, and Ginsberg, B. "Evidence-based oral transmucosal fentanyl citrate (OTFC®) dosing guidelines." Pain Medicine 6, no. 4 (2005): 305-314. Full Text
  - Ginsberg, B, Sinatra, RS, Adler, LJ, Crews, JC, Hord, AH, Laurito, CE, and Ashburn, MA. "Conversion to oral controlled-release oxycodone from intravenous opioid analgesic in the postoperative setting." Pain Medicine (Malden, Mass.) 4, no. 1 (March 2003): 31-38. Full Text
  - Eck, JB, De Lisle Dear, G, Phillips-Bute, BG, and Ginsberg, B. "Prediction of tracheal tube size in children using multiple variables." Paediatr Anaesth 12, no. 6 (July 2002): 495-498. Link to Item
  - Glasson, JC, Sawyer, WT, Lindley, CM, and Ginsberg, B. "Patient-specific factors affecting patient-controlled analgesia dosing." Journal of Pain & Palliative Care Pharmacotherapy 16, no. 2 (January 2002): 5-21. Full Text
  - Latta, KS, Ginsberg, B, and Barkin, RL. "Meperidine: a critical review." American Journal of Therapeutics 9, no. 1 (January 2002): 53-68. (Review) Full Text
  - Ross, AK, Davis, PJ, Dear Gd, GL, Ginsberg, B, McGowan, FX, Stiller, RD, Henson, LG, Huffman, C, and Muir, KT. "Pharmacokinetics of remifentanil in anesthetized pediatric patients undergoing elective surgery or diagnostic procedures." Anesthesia and Analgesia 93, no. 6 (December 2001): 1393-1401. Full Text
  - Ginsberg, B. "Pain management in knee surgery." Orthop Nurs 20, no. 2 (March 2001): 37-41. Link to Item
  - Denman, WT, Kaplan, RF, Goudsouzian, NG, Uejima, T, Barcelona, SL, Cote, CJ, Ginsberg, B, and Hannallah, RS. "Intramuscular rapacuronium in infants and children: A comparative multicenter study to confirm the efficacy and safety of the age-related tracheal intubating doses of intramuscular rapacuronium (ORG 9487) in two groups of pediatric subjects." Anesthesiology 94, no. 1 (2001): 3-7.
  - Klein, SM, Slaughter, TF, Vail, PT, Ginsberg, B, El-Moalem, HE, Alexander, R, D'Ercole, F, Greengrass, RA, Perumal, TT, Welsby, I, and Gan, TJ. "Thromboelastography as a perioperative measure of anticoagulation resulting from low molecular weight heparin: a comparison with anti-Xa concentrations." Anesth Analg 91, no. 5 (November 2000): 1091-1095. Link to Item
  - Iselin-Chaves, IA, El Moalem, HE, Gan, TJ, Ginsberg, B, and Glass, PS. "Changes in the auditory evoked potentials and the bispectral index following propofol or propofol and alfentanil." Anesthesiology 92, no. 5 (May 2000): 1300-1310. Link to Item
  - Brandom, BW, Margolis, JO, Bikhazi, GB, Ross, AK, Ginsberg, B, Dear, G, Kenaan, CA, Eck, JB, Woelfel, SK, and Lloyd, ME. "Neuromuscular effects of rapacuronium in pediatric patients during nitrous oxide-halothane anesthesia: comparison with mivacurium." Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie 47, no. 2 (February 2000): 143-149. Full Text
  - "Duke Pain Initiative Takes Proactive Role for Patient Relief: An Interview with Brian Ginsberg, M.D." Disease Management 3, no. 4 (January 2000): 159-162. Full Text
  - Ginsberg, B, Martin, G, Gan, TJ, Grichnik, KP, Jhaveri, R, Sibert, K, Sullivan, FL, Muir, MR, and Glass, PSA. "Assessment of the relative clinical utility of sufentanil and morphine administered by patient controlled analgesia pumps following abdominal hysterectomy." Journal of Pharmaceutical Care in Pain and Symptom Control 8, no. 4 (2000): 5-17.
  - Soppitt, AJ, Glass, PS, el-Moalem, H, Ginsberg, B, Weatherwax, K, and Gan, TJ. "Duration and recovery profile of cisatracurium after succinylcholine during propofol or isoflurane anesthesia." J Clin Anesth 11, no. 8 (December 1999): 652-656. Link to Item
  - Kaplan, RF, Uejima, T, Lobel, G, Goudsouzian, N, Ginsberg, B, Hannallah, R, Coté, CJ, Denman, W, Griffith, R, Clarke, C, and Hummer, K. "Intramuscular rocuronium in infants and children: a multicenter study to evaluate tracheal intubating conditions, onset, and duration of action." Anesthesiology 91, no. 3 (September 1999): 633-638. Full Text
  - Miaskowski, C, Crews, J, Ready, LB, Paul, SM, and Ginsberg, B. "Anesthesia-based pain services improve the quality of postoperative pain management." Pain 80, no. 1-2 (March 1999): 23-29. Full Text
  - Lichtor, JL, Sevarino, FB, Joshi, GP, Busch, MA, Nordbrock, E, and Ginsberg, B. "The relative potency of oral transmucosal fentanyl citrate compared with intravenous morphine in the treatment of moderate to severe postoperative pain." Anesthesia and Analgesia 89, no. 3 (1999): 732-738. Full Text
  - Ross, AK, Dear, GL, Dear, RB, Margolis, JO, and Ginsberg, B. "Onset and recovery of neuromuscular blockade after two doses of rocuronium in children." Journal of Clinical Anesthesia 10, no. 8 (December 1998): 631-635. Full Text
  - Iselin-Chaves, IA, Flaishon, R, Sebel, PS, Howell, S, Gan, TJ, Sigl, J, Ginsberg, B, and Glass, PS. "The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index." Anesthesia and Analgesia 87, no. 4 (October 1998): 949-955. Full Text
  - Ginsberg, B, Dear, RB, Margolis, JO, Dear, GD, and Ross, AK. "Oral transmucosal fentanyl citrate as an anaesthetic premedication when dosed to an opioid effect vs total opioid consumption." Paediatr Anaesth 8, no. 5 (1998): 413-418. Link to Item
  - Margolis, JO, Ginsberg, B, Dear, GL, Ross, AK, Goral, JE, and Bailey, AG. "Paediatric preoperative teaching: effects at induction and postoperatively." Paediatric Anaesthesia 8, no. 1 (January 1998): 17-23. Full Text
  - Gan, TJ, Ginsberg, B, Glass, PS, Fortney, J, Jhaveri, R, and Perno, R. "Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate." Anesthesiology 87, no. 5 (November 1997): 1075-1081. Full Text
  - Gan, TJ, Glass, PS, Howell, ST, Canada, AT, Grant, AP, and Ginsberg, B. "Determination of plasma concentrations of propofol associated with 50% reduction in postoperative nausea." Anesthesiology 87, no. 4 (October 1997): 779-784. Full Text
  - Glass, PS, Gan, TJ, Howell, S, and Ginsberg, B. "Drug interactions: volatile anesthetics and opioids." Journal of Clinical Anesthesia 9, no. 6 Suppl (September 1997): 18S-22S. (Review) Full Text
  - Muir, MR, Sullivan, FL, Dear, G, and Ginsberg, B. "Monitoring practices following epidural analgesics for pain management: a follow-up survey." J Pain Symptom Manage 14, no. 1 (July 1997): 36-44. Full Text Link to Item
  - Ashley, DM, Coleman, RE, Fuchs, H, Dear, G, Ginsberg, B, Zalduondo, FM, Friedman, HS, and Longee, D. "Chronic CSF leak into the peritoneal cavity shown by radionuclide cisternography. Successful treatment with an epidural blood patch." Clin Nucl Med 22, no. 6 (June 1997): 390-392. Link to Item
  - Glass, PS, Howell, S, Gan, TJ, and Ginsberg, B. "How to manage drug interactions." Eur J Anaesthesiol Suppl 15 (May 1997): 33-39. Link to Item
  - Lubarsky, DA, Sanderson, IC, Gilbert, WC, King, KP, Ginsberg, B, Dear, GL, Coleman, RL, Pafford, TD, and Reves, JG. "Using an anesthesia information management system as a cost containment tool. Description and validation." Anesthesiology 86, no. 5 (May 1997): 1161-1169. Link to Item
  - Glass, PSA, Gan, TJ, Howell, S, and Ginsberg, B. "Drug interactions: Volatile anesthetics and opioids." Journal of Clinical Anesthesia 9, no. 6 SUPPL. (1997): 18S-22S. Full Text
  - Lubarsky, DA, Glass, PSA, Ginsberg, B, Dear, GDL, Dentz, ME, Gan, TJ, Sanderson, IC, Mythen, MG, Dufore, S, Pressley, CC, Gilbert, WC, White, WD, Alexander, ML, Coleman, RL, Rogers, M, and Reves, JG. "The successful implementation of pharmaceutical practice guidelines: Analysis of associated outcomes and cost savings." Anesthesiology 86, no. 5 (1997): 1145-1160.
  - Ginsberg, B, Howell, S, Glass, PS, Margolis, JO, Ross, AK, Dear, GL, and Shafer, SL. "Pharmacokinetic model-driven infusion of fentanyl in children." Anesthesiology 85, no. 6 (December 1996): 1268-1275. Link to Item
  - Gan, TJ, Ginsberg, B, Grant, AP, and Glass, PS. "Double-blind, randomized comparison of ondansetron and intraoperative propofol to prevent postoperative nausea and vomiting." Anesthesiology 85, no. 5 (November 1996): 1036-1042. Link to Item
  - Jowell, PS, Eisen, G, Onken, J, Bute, BP, and Ginsberg, B. "Patient-controlled analgesia for conscious sedation during endoscopic retrograde cholangiopancreatography: a randomized controlled trial." Gastrointest Endosc 43, no. 5 (May 1996): 490-494. Link to Item
  - Ginsberg, B. "Patient controlled analgesia used to assess the efficacy and potency of a new opioid." Pain Research and Management 1, no. 4 (1996): 227-231.
  - Khalil, S, Rodarte, A, Weldon, BC, Weinstein, M, Grunwald, Z, Ginsberg, B, Kaye, R, Otto, A, Wheeler, M, Lawhorn, CD, Prillaman, BA, and Creed, M. "Intravenous ondansetron in established postoperative emesis in children." Anesthesiology 85, no. 2 (1996): 270-276.
  - Ginsberg, B, Gil, KM, Muir, M, Sullivan, F, Williams, DA, and Glass, PS. "The influence of lockout intervals and drug selection on patient-controlled analgesia following gynecological surgery." Pain 62, no. 1 (July 1995): 95-100. Full Text
  - Sullivan, FL, Muir, MR, and Ginsberg, B. "A survey on the clinical use of epidural catheters for acute pain management." J Pain Symptom Manage 9, no. 5 (July 1994): 303-307. Link to Item
  - Grichnik, KP, Ginsberg, B, Gan, T, and Richardson, WJ. "Epidural analgesia after lumbar laminectomy." Regional Anesthesia 19, no. 2 SUPPL. (1994): 83--.
  - Lineberger, CK, Ginsberg, B, Franiak, RJ, and Glass, PSA. "Narcotic agonists and antagonists." Anesthesiology Clinics of North America 12, no. 1 (1994): 65-89.
  - Glass, PS, Jhaveri, RM, Ginsberg, B, and Ossey, K. "Evaluation of flumazenil for reversing the effects of midazolam-induced conscious sedation or general anesthesia." South Med J 86, no. 11 (November 1993): 1238-1247. Link to Item
  - ESTES, R, GINSBERG, B, and BLOCH, E. "Anaesthesia and the Kearns-Sayre syndrome." Pediatric Anesthesia 3, no. 5 (September 1993): 307-311. Full Text
  - Bloch, EC, Ginsberg, B, and Binner, RA. "The esophageal temperature gradient in anesthetized children." J Clin Monit 9, no. 2 (April 1993): 73-77. Link to Item
  - Bloch, EC, Ossey, K, and Ginsberg, B. "Intubation guide marks for correct tube placement [7]." Anaesthesia 48, no. 2 (1993): 171--.
  - Gil, KM, Ginsberg, B, Muir, M, Sullivan, F, and Williams, DA. "Patient controlled analgesia: the relation of psychological factors to pain and analgesic use in adolescents with postoperative pain." The Clinical journal of pain 8, no. 3 (September 1992): 215-221.
  - Bloch, EC, Ginsberg, B, Binner, RA, and Sessler, DI. "Limb tourniquets and central temperature in anesthetized children." Anesth Analg 74, no. 4 (April 1992): 486-489. Link to Item
  - Glass, PS, Estok, P, Ginsberg, B, Goldberg, JS, and Sladen, RN. "Use of patient-controlled analgesia to compare the efficacy of epidural to intravenous fentanyl administration." Anesthesia and Analgesia 74, no. 3 (March 1992): 345-351. Full Text
  - Ginsberg, B. "Acute pain management." Problems in Urology 6, no. 1 (1992): 174-194.
  - Hubbard, L, Nicholson, BD, Rowlingson, J, Glass, PSA, Ginsberg, B, and Sladen, RN. "More on epidural fentanyl analgesia [7]." Anesthesia and Analgesia 75, no. 5 (1992): 865-867. Full Text
  - Jr, RAB, Ginsberg, B, Bloch, EC, and Mason, DG. "Anesthetic management of a pediatric Wada test [6]." Anesthesia and Analgesia 74, no. 4 (1992): 621-622.
  - Quill, TJ, Begin, M, Glass, PS, Ginsberg, B, and Gorback, MS. "Clinical responses to ORG 9426 during isoflurane anesthesia." Anesth Analg 72, no. 2 (February 1991): 203-206. Link to Item
  - Bloch, EC, and Ginsberg, B. "Short trachea and endotracheal tube placement." Pediatric Neurology 7, no. 2 (1991): 150--.
  - Glass, PS, Jacobs, JR, Smith, LR, Ginsberg, B, Quill, TJ, Bai, SA, and Reves, JG. "Pharmacokinetic model-driven infusion of fentanyl: assessment of accuracy." Anesthesiology 73, no. 6 (December 1990): 1082-1090. Link to Item
  - Gil, KM, Ginsberg, B, Muir, M, Sykes, D, and Williams, DA. "Patient-controlled analgesia in postoperative pain: the relation of psychological factors to pain and analgesic use." The Clinical Journal of Pain 6, no. 2 (June 1990): 137-142.
  - Ginsberg, B, and Glass, PSA. "Should vecuronium be used for rapid sequence induction? (I: Reply)." Anesthesiology 72, no. 1 (1990): 212--.
  - Ginsberg, B, Glass, PS, Quill, T, Shafron, D, and Ossey, KD. "Onset and duration of neuromuscular blockade following high-dose vecuronium administration." Anesthesiology 71, no. 2 (August 1989): 201-205. Link to Item
  - Bloch, EC, Ossey, K, and Ginsberg, B. "Tracheal intubation in children: a new method for assuring correct depth of tube placement." Anesth Analg 67, no. 6 (June 1988): 590-592. Link to Item
  - Sischy, S, Ginsberg, B, and Downing, JW. "Anaesthesia for caesarean section." South African Medical Journal 63, no. 14 (1983): 512-513.
- Books
  - Sinatra, RS, De Leon-Casasola, OA, Ginsberg, B, Viscusi, ER, and McQuay, H. Acute pain management. January 1, 2009. Full Text
- Book Sections
  - Flanagan, E, and Ginsberg, B. "Meperidine." In The Essence of Analgesia and Analgesics, 94-98. January 1, 2010. Full Text

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Books

Book Sections