The human fungal pathogen Cryptococcus can complete its sexual cycle during a pathogenic association with plants.

Published

Journal Article

Cryptococcus is a globally distributed human fungal pathogen that primarily afflicts immunocompromised individuals. How and why this human fungal pathogen associates with plants and how this environmental niche influences its life cycle remains a mystery. We established Cryptococcus-Arabidopsis and Cryptococcus-Eucalyptus systems and discovered that Cryptococcus proliferates and mates on plant surfaces. Mating efficiency of C. gattii was markedly enhanced on plants and myo-inositol and indole acetic acid were specific plant products that stimulated mating. On Arabidopsis, dwarfing and chlorosis were observed following infection with a fungal mixture of two opposite mating-type strains, but not with either mating-type alone. This infection process is countered by the plant jasmonate-mediated defense mechanism. These findings reveal that Cryptococcus can parasitically interact with plants to complete its sexual cycle, which may impact an understanding of the origin and evolution of both plant and animal fungal pathogens in nature.

Full Text

Duke Authors

Cited Authors

  • Xue, C; Tada, Y; Dong, X; Heitman, J

Published Date

  • June 14, 2007

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 263 - 273

PubMed ID

  • 18005707

Pubmed Central ID

  • 18005707

Electronic International Standard Serial Number (EISSN)

  • 1934-6069

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2007.05.005

Language

  • eng

Conference Location

  • United States