Distinguishing the neural correlates of episodic memory encoding and semantic memory retrieval.

Journal Article (Journal Article)

Episodic memory and semantic memory interact very closely. In particular, episodic memory encoding (EE) tends to elicit semantic memory retrieval (SR), and vice versa. Thus, similar activations for EE and SR in functional neuroimaging studies may reflect shared memory processes, or they may reflect the fact that EE and SR are usually confounded. To address this issue, we used a factorial functional magnetic resonance imaging approach to disentangle the neural correlates of EE and SR. Within the left temporal lobe, the hippocampus was associated with successful EE, whereas a posterior lateral region was associated with successful SR. Within the left inferior prefrontal cortex, a posterior region was involved in SR, a mid region was involved in both SR and EE, and an anterior region was involved in EE, but only when SR was also high. Thus, the neural correlates of EE and SR are dissociable but interact in specific brain regions.

Full Text

Duke Authors

Cited Authors

  • Prince, SE; Tsukiura, T; Cabeza, R

Published Date

  • February 2007

Published In

Volume / Issue

  • 18 / 2

Start / End Page

  • 144 - 151

PubMed ID

  • 17425535

Electronic International Standard Serial Number (EISSN)

  • 1467-9280

International Standard Serial Number (ISSN)

  • 0956-7976

Digital Object Identifier (DOI)

  • 10.1111/j.1467-9280.2007.01864.x


  • eng