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Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertension.

Publication ,  Journal Article
Hinderliter, A; Sherwood, A; Gullette, ECD; Babyak, M; Waugh, R; Georgiades, A; Blumenthal, JA
Published in: Arch Intern Med
June 24, 2002

BACKGROUND: Hypertrophy and concentric remodeling of the left ventricle are important manifestations of hypertension that are associated with increased morbidity and mortality. Although lifestyle interventions are efficacious in lowering blood pressure, evidence that they have a beneficial effect on target organs has been lacking. OBJECTIVE: To assess the effects of regular aerobic exercise or exercise plus weight management counseling on left ventricular mass and geometry in overweight, sedentary men and women with high-normal or mildly elevated blood pressure. METHODS: Eighty-two participants in a randomized, controlled trial were assigned to supervised aerobic exercise only, a behavioral weight management program that included exercise, or a waiting-list control group for 6 months. Blood pressure and echocardiographic measures of left ventricular structure were measured at baseline and at the conclusion of the treatment phase. RESULTS: The 45 women and 37 men had a mean +/- SD age of 47 +/- 9 years and had a mean +/- SD blood pressure of 140 +/- 10/93 +/- 5 mm Hg. Blood pressure fell by 7/6 mm Hg in the weight management group and by 3/4 mm Hg in the aerobic exercise group. In association with these decreases in blood pressure, participants in the intervention groups exhibited significant decreases in left ventricular relative wall thickness (P =.003), posterior wall thickness (P =.05), and septal thickness (P =.004) and a trend toward a decrease in indexed left ventricular mass (P =.08) relative to the control group. CONCLUSIONS: In a cohort of overweight, sedentary men and women, exercise and weight loss reduced blood pressure and induced favorable changes in left ventricular structure.

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Published In

Arch Intern Med

DOI

ISSN

0003-9926

Publication Date

June 24, 2002

Volume

162

Issue

12

Start / End Page

1333 / 1339

Location

United States

Related Subject Headings

  • Weight Loss
  • Waiting Lists
  • Treatment Outcome
  • Time Factors
  • Severity of Illness Index
  • Patient Compliance
  • Obesity
  • Middle Aged
  • Male
  • Hypertrophy, Left Ventricular
 

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Hinderliter, A., Sherwood, A., Gullette, E. C. D., Babyak, M., Waugh, R., Georgiades, A., & Blumenthal, J. A. (2002). Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertension. Arch Intern Med, 162(12), 1333–1339. https://doi.org/10.1001/archinte.162.12.1333
Hinderliter, Alan, Andrew Sherwood, Elizabeth C. D. Gullette, Michael Babyak, Robert Waugh, Anastasia Georgiades, and James A. Blumenthal. “Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertension.Arch Intern Med 162, no. 12 (June 24, 2002): 1333–39. https://doi.org/10.1001/archinte.162.12.1333.
Hinderliter A, Sherwood A, Gullette ECD, Babyak M, Waugh R, Georgiades A, et al. Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertension. Arch Intern Med. 2002 Jun 24;162(12):1333–9.
Hinderliter, Alan, et al. “Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertension.Arch Intern Med, vol. 162, no. 12, June 2002, pp. 1333–39. Pubmed, doi:10.1001/archinte.162.12.1333.
Hinderliter A, Sherwood A, Gullette ECD, Babyak M, Waugh R, Georgiades A, Blumenthal JA. Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertension. Arch Intern Med. 2002 Jun 24;162(12):1333–1339.

Published In

Arch Intern Med

DOI

ISSN

0003-9926

Publication Date

June 24, 2002

Volume

162

Issue

12

Start / End Page

1333 / 1339

Location

United States

Related Subject Headings

  • Weight Loss
  • Waiting Lists
  • Treatment Outcome
  • Time Factors
  • Severity of Illness Index
  • Patient Compliance
  • Obesity
  • Middle Aged
  • Male
  • Hypertrophy, Left Ventricular