Chemokine mediated control of dendritic cell migration and function.

Journal Article (Review)

Dendritic cells (DC) have historically been viewed as a group of functionally homogeneous cell types that act to stimulate Ag-specific immune responses after migrating to secondary lymphoid organs. DC patterns of chemokine responsiveness have generally been viewed as similar among DC subtypes. Here we discuss recent studies that challenge this view by demonstrating that DC subtypes differ in their response to specific chemokines, their migration patterns, and their capacity to stimulate or inhibit immune response. Thus, individual chemokines may act to regulate the character, strength, and duration of Ag-specific immune responses in a manner that has not previously been appreciated.

Full Text

Duke Authors

Cited Authors

  • Gunn, MD

Published Date

  • October 2003

Published In

Volume / Issue

  • 15 / 5

Start / End Page

  • 271 - 276

PubMed ID

  • 15001176

International Standard Serial Number (ISSN)

  • 1044-5323

Digital Object Identifier (DOI)

  • 10.1016/j.smim.2003.08.004

Language

  • eng

Conference Location

  • England