Michael Dee Gunn
Professor of Medicine
The focus of my work is on understanding how dendritic cells, monocytes, and macrophages regulate immune responses, contribute to specific disease pathologies, and can be manipulated to stimulate or inhibit specific immune responses. We are also using our knowledge of immunology to develop diagnostics and therapeutics for a variety of human diseases.
Lab History
The lab started with our discovery of the lymphoid chemokines, which regulate the migration of lymphocytes and dendritic cells to and within secondary lymphoid organs. We identified the chemokine (CCL21) that mediates the entry of naïve T cells and activated dendritic cells into lymph nodes and the chemokine (CXCL13) that mediates the entry of B cells into lymphoid follicles. Our focus then shifted to understanding how specific cell types, primarily dendritic cells, and cell migration events regulate immune responses. We identified murine plasmacytoid dendritic cells; the cell type that causes pulmonary immune pathology during influenza infection; the dendritic cell type that stimulates Th1 immune responses; the cell type that induces neuronal injury in Alzheimer's disease, and the macrophage type that stimulates pulmonary hypertension. Our current work continues these basic studies while applying our findings to models of human disease.
Current Research
Tumor immune therapeutics – We have developed a novel cellular vaccine strategy for the treatment of cancer. This strategy is much simpler, more cost effective, more clinically feasible, and much more efficacious than classic dendritic cell vaccines. We are now determining the mechanisms by which this vaccine induces such potent immune responses and advancing it to initial human clinical trials.
Development of recombinant antibodies as diagnostic reagents – Our lab has developed novel methods to generate recombinant single chain antibodies using phage display technology. We are currently using these methods to generate pathogen-specific antibodies for use in diagnostic tests for a variety of human bacterial, viral, and fungal infections. In collaboration with Duke Biomedical Engineering, we are deploying our antibodies in a novel diagnostic assay platform to develop point-of-care assays for the diagnosis of a variety of emerging pathogens. Our recently developed point-of-care assay for Ebola virus displays a sensitivity superior to PCR at a fraction of the per assay cost.
Current Appointments & Affiliations
- Professor of Medicine, Medicine, Cardiology, Medicine 2014
- Associate Professor in Pathology, Pathology, Clinical Science Departments 2014
- Professor in Immunology, Immunology, Basic Science Departments 2014
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018
Contact Information
- CARL Building Room 180B, Durham, NC 27703
- Duke Box 102143, Durham, NC 27710
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michael.gunn@duke.edu
(919) 681-0840
- Background
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Education, Training, & Certifications
- Fellowship in Cardiology, Cardiology, University of California - San Francisco 1989
- Internship and Residency, Internal Medicine, Parkland Health & Hospital System 1986
- M.D., UT Southwestern Medical School 1983
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Previous Appointments & Affiliations
- Assistant Professor in Pathology, Pathology, Clinical Science Departments 2003 - 2014
- Associate Professor in Immunology, Immunology, Basic Science Departments 2005 - 2014
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2008 - 2014
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2005 - 2008
- Assistant Professor in Immunology, Immunology, Basic Science Departments 2001 - 2005
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 1999 - 2005
- Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 1999
- Recognition
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In the News
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APR 21, 2020 -
NOV 13, 2019 Duke Health News
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- Expertise
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Subject Headings
- Acute Lung Injury
- Adjuvants, Immunologic
- Administration, Intranasal
- Adoptive Transfer
- Airway Resistance
- Amino Acid Sequence
- Animals
- Anthrax Vaccines
- Anti-Inflammatory Agents, Non-Steroidal
- Antibodies, Bacterial
- Antibodies, Monoclonal
- Antibodies, Neutralizing
- Antibody Affinity
- Antibody Specificity
- Antigen Presentation
- Antigen-Presenting Cells
- Antigens, Bacterial
- Antigens, CD11b
- Antigens, CD11c
- Antigens, CD18
- Antigens, CD44
- Antigens, CD45
- Apoptosis
- Arachidonate 5-Lipoxygenase
- Arterioles
- Benzhydryl Compounds
- Bleomycin
- Blood Vessels
- Bone Marrow Cells
- Brain Injuries
- Burkitt Lymphoma
- CD4-Positive T-Lymphocytes
- Carbohydrate Sequence
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Migration Inhibition
- Cell Movement
- Cell Proliferation
- Cells, Cultured
- Central Nervous System
- Chemokine CCL19
- Chemokine CCL2
- Chemokine CCL21
- Chemokine CCL22
- Chemokine CXCL12
- Chemokine CXCL13
- Chemokines
- Chemokines, CC
- Chemokines, CXC
- Chemotaxis
- Chemotaxis, Leukocyte
- Chimerism
- Chlorine
- Clonal Anergy
- Coronavirus Infections
- CpG Islands
- Cricetinae
- Cysteine
- DNA, Complementary
- Dendritic Cells
- Diclofenac
- Disease Models, Animal
- Drug Synergism
- E-Selectin
- Encephalomyelitis, Autoimmune, Experimental
- Endothelium, Lymphatic
- Enzyme-Linked Immunosorbent Assay
- Eosinophils
- Epitopes, T-Lymphocyte
- Escherichia coli
- Escherichia coli Infections
- Female
- Fibrosis
- Flow Cytometry
- GTP-Binding Proteins
- Gene Deletion
- Gene Duplication
- Genetic Linkage
- Graft Rejection
- Graft Survival
- Granulocyte-Macrophage Colony-Stimulating Factor
- Heart Transplantation
- Hematopoietic Stem Cell Transplantation
- Histocompatibility Antigens Class II
- Homeodomain Proteins
- Humans
- Hyperalgesia
- Hypertension, Pulmonary
- Immune System
- Immunity, Innate
- Immunoblotting
- Immunoglobulin G
- Immunologic Memory
- Immunosuppressive Agents
- In Situ Hybridization
- Inflammation
- Inflammation Mediators
- Influenza A Virus, H1N1 Subtype
- Injections, Intradermal
- Injections, Spinal
- Integrin alphaXbeta2
- Intercellular Adhesion Molecule-1
- Intercellular Signaling Peptides and Proteins
- Interferon-alpha
- Interleukin-1alpha
- Interleukin-3
- Interleukin-4
- Intracellular Signaling Peptides and Proteins
- Jurkat Cells
- Kidney
- L-Selectin
- Leukocyte Count
- Leukocytes
- Leukotrienes
- Ligands
- Lipopolysaccharides
- Lung
- Lymph Nodes
- Lymphatic System
- Lymphocyte Count
- Lymphocyte Function-Associated Antigen-1
- Lymphocytes
- Lymphotoxin-alpha
- Lysophospholipids
- Macrophage Activation
- Macrophages
- Macrophages, Alveolar
- Macrophages, Peritoneal
- Male
- Manganese
- Mast Cells
- Membrane Proteins
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Inbred Strains
- Mice, Knockout
- Mice, Mutant Strains
- Mice, Nude
- Mice, Transgenic
- Molecular Sequence Data
- Monocytes
- Mucins
- Multidrug Resistance-Associated Proteins
- Multigene Family
- Muramidase
- Muscle, Smooth, Vascular
- Muser Mentor
- Myosin Heavy Chains
- Neovascularization, Pathologic
- Neutrophil Infiltration
- Ovalbumin
- Pain, Postoperative
- Peroxidase
- Phosphoserine
- Plasma Cells
- Pneumonia, Viral
- Propylene Glycols
- RNA, Messenger
- Rats
- Rats, Wistar
- Receptor Protein-Tyrosine Kinases
- Receptors, Antigen, T-Cell
- Receptors, CCR2
- Receptors, CCR7
- Receptors, CXCR5
- Receptors, Cell Surface
- Receptors, Chemokine
- Receptors, Cytokine
- Receptors, G-Protein-Coupled
- Receptors, Growth Factor
- Receptors, Lymphocyte Homing
- Receptors, Lysophospholipid
- Receptors, Metabotropic Glutamate
- Respiratory System
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Analysis, DNA
- Serum
- Skin
- Sphingosine
- Spleen
- Sulfotransferases
- Sulfur
- T-Lymphocyte Subsets
- T-Lymphocytes
- T-Lymphocytes, Helper-Inducer
- Tetradecanoylphorbol Acetate
- Thiophenes
- Toll-Like Receptor 4
- Tumor Necrosis Factor-alpha
- Tumor Suppressor Proteins
- Up-Regulation
- Vaccination
- Vascular Endothelial Growth Factor Receptor-3
- Vesicular Transport Proteins
- Research
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Selected Grants
- Development of point-of-care testing for Lassa and other hemorrhagic fever arenaviruses awarded by National Institutes of Health 2022 - 2027
- Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER) awarded by National Institutes of Health 2022 - 2026
- Synergestic microglial activation and tumor cell killing for improved GBM response awarded by National Institutes of Health 2021 - 2025
- A Fully Integrated Point-of-Care Test for Ebola awarded by National Institutes of Health 2020 - 2025
- NINDS Research Education Programs for Residents and Fellows in Neurosurgery awarded by National Institutes of Health 2009 - 2025
- Basic Immunology Training Program awarded by National Institutes of Health 2020 - 2025
- Adjuvant Comparison for Peanut Allergy Immunotherapy awarded by National Institutes of Health 2022 - 2023
- Duke Resident Physician-Scientist Program - NIAID awarded by National Institutes of Health 2018 - 2023
- Humanized Antibody to Treat Pulmonary Fibrosis awarded by North Carolina Biotechnology Center 2022 - 2023
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2023
- Acquisition of a Biacore T200 Surface Plasmon Resonance Instrument for Shared Use awarded by North Carolina Biotechnology Center 2022 - 2023
- Generation of antibodies specific for optimal non-HRP2 malaria diagnostic antigens awarded by National Institutes of Health 2020 - 2023
- Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease awarded by National Institutes of Health 2017 - 2022
- CCL3 as a Developmental Therapeutic to Enhance Brain Tumor Therapy awarded by National Institutes of Health 2016 - 2021
- BATF3+ Dendritic Cells for the Treatment of Malignant Gliomas awarded by Department of Defense 2020 - 2021
- Role of Resident Monocytes in the Pathogenesis of Pulmonary Arterial Hypertension awarded by National Institutes of Health 2015 - 2021
- Role of Dendritic Cell-mediated T Cell Activation in Salt-sensitive Hypertension awarded by National Institutes of Health 2016 - 2021
- Development of anti-Salmonella Single-chain Abs as serum diagnostics awarded by National Institutes of Health 2012 - 2019
- SO150005: Smartphone Enabled Point-of-care Diagnostics for Operationally Significant Pathogens awarded by United States Army Medical Research Acquisition Activity 2016 - 2019
- Generation of Zika virus-specific recombinant antibodies awarded by National Institutes of Health 2016 - 2018
- Development of therapeutics for chlorine-induced airway and lung injury awarded by National Institutes of Health 2008 - 2018
- Physician-Scientist Institutional Award: Increasing Opportunities for the M.D. Interested in a Research Career awarded by Burroughs Wellcome Fund 2017 - 2018
- The role of dendritic cell-mediated T cell activation in hypertension awarded by National Institutes of Health 2017
- Regulation of Lung Fibrosis by Alternatively Activated Macrophages and Arginase-1 awarded by National Institutes of Health 2012 - 2017
- Enhancing dendritic cell migration to drive potent anti-tumor immune responses awarded by National Institutes of Health 2013 - 2017
- Development of anti-Aspergillus single chain Abs as serum and imaging diagnostics awarded by National Institutes of Health 2010 - 2015
- Role of Vascular Dendritic Cells in Atherosclerosis awarded by National Institutes of Health 2008 - 2013
- Prevention of Immune Pathology during Avian Influenza Infection awarded by National Institutes of Health 2007 - 2011
- Novel TLR Ligand Mimetics as Adjuvants and Therapeutics awarded by National Institutes of Health 2003 - 2009
- The role of chemokines in antigen-specific immunity awarded by National Institutes of Health 2002 - 2006
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External Relationships
- Myeloid Therapeutics
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Cable, Jennifer, Anthony Fauci, William E. Dowling, Stephan Günther, Dennis A. Bente, Pragya Dhruv Yadav, Lawrence C. Madoff, et al. “Lessons from the pandemic: Responding to emerging zoonotic viral diseases-a Keystone Symposia report.” Ann N Y Acad Sci 1518, no. 1 (December 2022): 209–25. https://doi.org/10.1111/nyas.14898.Full Text Open Access Copy Link to Item
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Shahid, Rafiq A., Steven R. Vigna, Min-Nung Huang, Michael D. Gunn, and Rodger A. Liddle. “Nicotinic stimulation of splenic T cells is protective in endoscopic retrograde cholangiopancreatography-induced acute pancreatitis in mice.” Am J Physiol Gastrointest Liver Physiol 323, no. 5 (November 1, 2022): G420–27. https://doi.org/10.1152/ajpgi.00156.2022.Full Text Link to Item
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Tomaszewski, William H., Jessica Waibl-Polania, Molly Chakraborty, Jonathan Perera, Jeremy Ratiu, Alexandra Miggelbrink, Donald P. McDonnell, et al. “Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma.” Nat Commun 13, no. 1 (October 29, 2022): 6483. https://doi.org/10.1038/s41467-022-34175-y.Full Text Link to Item
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Huang, Min-Nung, Vincent M. D’Anniballe, and Michael D. Gunn. “Monocytes as a Cellular Vaccine Platform to Induce Antitumor Immunity.” Methods Mol Biol 2410 (2022): 627–47. https://doi.org/10.1007/978-1-0716-1884-4_34.Full Text Link to Item
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Tomaszewski, W. H., J. Waibl-Polania, A. M. Miggelbrink, M. A. Chakraborty, P. E. Fecci, J. H. Sampson, and M. D. Gunn. “Broad immunophenotyping of the murine brain tumor microenvironment.” J Immunol Methods 499 (December 2021): 113158. https://doi.org/10.1016/j.jim.2021.113158.Full Text Link to Item
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Fontes, Cassio M., Barbara D. Lipes, Jason Liu, Krystle N. Agans, Aiwei Yan, Patricia Shi, Daniela F. Cruz, et al. “Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR.” Sci Transl Med 13, no. 588 (April 7, 2021). https://doi.org/10.1126/scitranslmed.abd9696.Full Text Link to Item
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Yu, Yen-Rei A., Yuryi Malakhau, Chen-Hsin A. Yu, Stefan-Laural J. Phelan, R Ian Cumming, Matthew J. Kan, Lan Mao, Sudarshan Rajagopal, Claude A. Piantadosi, and Michael D. Gunn. “Nonclassical Monocytes Sense Hypoxia, Regulate Pulmonary Vascular Remodeling, and Promote Pulmonary Hypertension.” J Immunol 204, no. 6 (March 15, 2020): 1474–85. https://doi.org/10.4049/jimmunol.1900239.Full Text Link to Item
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Huang, Min-Nung, Lowell T. Nicholson, Kristen A. Batich, Adam M. Swartz, David Kopin, Sebastian Wellford, Vijay K. Prabhakar, et al. “Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses.” J Clin Invest 130, no. 2 (February 3, 2020): 774–88. https://doi.org/10.1172/JCI128267.Full Text Link to Item
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Sampson, John H., Michael D. Gunn, Peter E. Fecci, and David M. Ashley. “Brain immunology and immunotherapy in brain tumours.” Nat Rev Cancer 20, no. 1 (January 2020): 12–25. https://doi.org/10.1038/s41568-019-0224-7.Full Text Link to Item
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Ren, Jiafa, Jiandong Zhang, Nathan P. Rudemiller, Robert Griffiths, Yi Wen, Xiaohan Lu, Jamie R. Privratsky, Michael D. Gunn, and Steven D. Crowley. “Twist1 in Infiltrating Macrophages Attenuates Kidney Fibrosis via Matrix Metallopeptidase 13-Mediated Matrix Degradation.” J Am Soc Nephrol 30, no. 9 (September 2019): 1674–85. https://doi.org/10.1681/ASN.2018121253.Full Text Link to Item
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Chandramohan, Vidyalakshmi, Xuhui Bao, Xin Yu, Scott Parker, Charlotte McDowall, Yen-Rei Yu, Patrick Healy, et al. “Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations.” J Immunother Cancer 7, no. 1 (May 29, 2019): 142. https://doi.org/10.1186/s40425-019-0614-0.Full Text Open Access Copy Link to Item
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Rivera, Phillip D., Richa Hanamsagar, Matthew J. Kan, Phuong K. Tran, David Stewart, Young Chan Jo, Michael Gunn, and Staci D. Bilbo. “Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors.” Brain Behav Immun 76 (February 2019): 104–15. https://doi.org/10.1016/j.bbi.2018.11.010.Full Text Link to Item
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Smith, Jeffrey S., Lowell T. Nicholson, Jutamas Suwanpradid, Rachel A. Glenn, Nicole M. Knape, Priya Alagesan, Jaimee N. Gundry, et al. “Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation.” Sci Signal 11, no. 555 (November 6, 2018). https://doi.org/10.1126/scisignal.aaq1075.Full Text Link to Item
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Chongsathidkiet, Pakawat, Christina Jackson, Shohei Koyama, Franziska Loebel, Xiuyu Cui, S Harrison Farber, Karolina Woroniecka, et al. “Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors.” Nat Med 24, no. 9 (September 2018): 1459–68. https://doi.org/10.1038/s41591-018-0135-2.Full Text Link to Item
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Privratsky, Jamie R., Jiandong Zhang, Xiaohan Lu, Nathan Rudemiller, Qingqing Wei, Yen-Rei Yu, Michael D. Gunn, and Steven D. Crowley. “Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury.” Am J Physiol Renal Physiol 315, no. 3 (September 1, 2018): F682–91. https://doi.org/10.1152/ajprenal.00104.2018.Full Text Link to Item
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Tata, Aleksandra, Yoshihiko Kobayashi, Ryan D. Chow, Jasmine Tran, Avani Desai, Abdull J. Massri, Timothy J. McCord, Michael Dee Gunn, and Purushothama Rao Tata. “Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury.” Cell Stem Cell 22, no. 5 (May 3, 2018): 668-683.e6. https://doi.org/10.1016/j.stem.2018.03.018.Full Text Link to Item
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Mastria, Eric M., Leon Y. Cai, Matthew J. Kan, Xinghai Li, Jeffrey L. Schaal, Steven Fiering, Michael D. Gunn, Mark W. Dewhirst, Smita K. Nair, and Ashutosh Chilkoti. “Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.” J Control Release 269 (January 10, 2018): 364–73. https://doi.org/10.1016/j.jconrel.2017.11.021.Full Text Link to Item
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Baek, Amy E., Yen-Rei A. Yu, Sisi He, Suzanne E. Wardell, Ching-Yi Chang, Sanghoon Kwon, Ruchita V. Pillai, et al. “The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.” Nat Commun 8, no. 1 (October 11, 2017): 864. https://doi.org/10.1038/s41467-017-00910-z.Full Text Link to Item
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Rudemiller, Nathan P., Mehul B. Patel, Jian-Dong Zhang, Alexander D. Jeffs, Norah S. Karlovich, Robert Griffiths, Matthew J. Kan, Anne F. Buckley, Michael D. Gunn, and Steven D. Crowley. “C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration.” Am J Pathol 186, no. 11 (November 2016): 2846–56. https://doi.org/10.1016/j.ajpath.2016.07.015.Full Text Open Access Copy Link to Item
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Izykowski, Nicole, Mark Kuehnel, Kais Hussein, Kristin Mitschke, Michael Gunn, Sabina Janciauskiene, Axel Haverich, et al. “Organizing pneumonia in mice and men.” J Transl Med 14, no. 1 (June 10, 2016): 169. https://doi.org/10.1186/s12967-016-0933-6.Full Text Link to Item
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Tighe, Robert M., Zhuowei Li, Erin N. Potts, Sarah Frush, Ningshan Liu, Michael D. Gunn, W Michael Foster, Paul W. Noble, and John W. Hollingsworth. “Correction: Ozone Inhalation Promotes CX3CR1-Dependent Maturation of Resident Lung Macrophages That Limit Oxidative Stress and Inflammation.” J Immunol 196, no. 5 (March 1, 2016): 2424. https://doi.org/10.4049/jimmunol.1600002.Full Text Link to Item
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Yu, Yen-Rei A., Danielle F. Hotten, Yuryi Malakhau, Ellen Volker, Andrew J. Ghio, Paul W. Noble, Monica Kraft, John W. Hollingsworth, Michael D. Gunn, and Robert M. Tighe. “Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues.” Am J Respir Cell Mol Biol 54, no. 1 (January 2016): 13–24. https://doi.org/10.1165/rcmb.2015-0146OC.Full Text Link to Item
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Yu, Yen-Rei A., Emily G. O’Koren, Danielle F. Hotten, Matthew J. Kan, David Kopin, Erik R. Nelson, Loretta Que, and Michael D. Gunn. “A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.” Plos One 11, no. 3 (2016): e0150606. https://doi.org/10.1371/journal.pone.0150606.Full Text Open Access Copy Link to Item
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Kan, Matthew J., Jennifer E. Lee, Joan G. Wilson, Angela L. Everhart, Candice M. Brown, Andrew N. Hoofnagle, Marilyn Jansen, Michael P. Vitek, Michael D. Gunn, and Carol A. Colton. “Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.” J Neurosci 35, no. 15 (April 15, 2015): 5969–82. https://doi.org/10.1523/JNEUROSCI.4668-14.2015.Full Text Link to Item
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Mitchell, Duane A., Kristen A. Batich, Michael D. Gunn, Min-Nung Huang, Luis Sanchez-Perez, Smita K. Nair, Kendra L. Congdon, et al. “Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.” Nature 519, no. 7543 (March 19, 2015): 366–69. https://doi.org/10.1038/nature14320.Full Text Open Access Copy Link to Item
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Martinu, Tereza, Kymberly M. Gowdy, Julia L. Nugent, Jesse Sun, Christine V. Kinnier, Margaret E. Nelson, Matthew A. Lyes, et al. “Role of C-C motif ligand 2 and C-C motif receptor 2 in murine pulmonary graft-versus-host disease after lipopolysaccharide inhalations.” Am J Respir Cell Mol Biol 51, no. 6 (December 2014): 810–21. https://doi.org/10.1165/rcmb.2013-0451OC.Full Text Link to Item
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St John, Ashley L., WX Gladys Ang, Min-Nung Huang, Christian A. Kunder, Elizabeth W. Chan, Michael D. Gunn, and Soman N. Abraham. “S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection.” Immunity 41, no. 3 (September 18, 2014): 440–50. https://doi.org/10.1016/j.immuni.2014.07.013.Full Text Link to Item
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Cain, Derek W., Emily G. O’Koren, Matthew J. Kan, Mandy Womble, Gregory D. Sempowski, Kristen Hopper, Michael D. Gunn, and Garnett Kelsoe. “Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages.” J Immunol 191, no. 9 (November 1, 2013): 4665–75. https://doi.org/10.4049/jimmunol.1300581.Full Text Link to Item
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O’Koren, Emily G., Brigid L. M. Hogan, and Michael Dee Gunn. “Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation.” Am J Respir Cell Mol Biol 49, no. 5 (November 2013): 788–97. https://doi.org/10.1165/rcmb.2012-0369OC.Full Text Link to Item
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Yu, Yen-Rei A., Lan Mao, Claude A. Piantadosi, and Michael D. Gunn. “CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension.” Am J Respir Cell Mol Biol 48, no. 5 (May 2013): 647–54. https://doi.org/10.1165/rcmb.2012-0182OC.Full Text Link to Item
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Gwinn, William M., Brandi T. Johnson, Shaun M. Kirwan, Ashley E. Sobel, Soman N. Abraham, Michael D. Gunn, and Herman F. Staats. “A comparison of non-toxin vaccine adjuvants for their ability to enhance the immunogenicity of nasally-administered anthrax recombinant protective antigen.” Vaccine 31, no. 11 (March 1, 2013): 1480–89. https://doi.org/10.1016/j.vaccine.2013.01.012.Full Text Link to Item
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Keum, Sehoon, Han Kyu Lee, Pei-Lun Chu, Matthew J. Kan, Min-Nung Huang, Carol J. Gallione, Michael D. Gunn, Donald C. Lo, and Douglas A. Marchuk. “Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.” Plos Genet 9, no. 10 (2013): e1003807. https://doi.org/10.1371/journal.pgen.1003807.Full Text Open Access Copy Link to Item
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Inoue, Makoto, Kristi L. Williams, Michael D. Gunn, and Mari L. Shinohara. “NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis.” Proc Natl Acad Sci U S A 109, no. 26 (June 26, 2012): 10480–85. https://doi.org/10.1073/pnas.1201836109.Full Text Link to Item
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Liang, Jiurong, Yoosun Jung, Robert M. Tighe, Ting Xie, Ningshan Liu, Maura Leonard, Michael Dee Gunn, Dianhua Jiang, and Paul W. Noble. “A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury.” Am J Physiol Lung Cell Mol Physiol 302, no. 9 (May 1, 2012): L933–40. https://doi.org/10.1152/ajplung.00256.2011.Full Text Link to Item
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Thompson, Afton L., Brandi T. Johnson, Gregory D. Sempowski, Michael D. Gunn, Baidong Hou, Anthony L. DeFranco, and Herman F. Staats. “Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production.” J Immunol 188, no. 6 (March 15, 2012): 2834–46. https://doi.org/10.4049/jimmunol.1100254.Full Text Link to Item
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Tighe, Robert M., Zhuowei Li, Erin N. Potts, Sarah Frush, Ningshan Liu, Michael D. Gunn, W Michael Foster, Paul W. Noble, and John W. Hollingsworth. “Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation.” J Immunol 187, no. 9 (November 1, 2011): 4800–4808. https://doi.org/10.4049/jimmunol.1101312.Full Text Link to Item
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Tighe, Robert M., Jiurong Liang, Ningshan Liu, Yoosun Jung, Dianhua Jiang, Michael D. Gunn, and Paul W. Noble. “Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury.” Am J Respir Cell Mol Biol 45, no. 4 (October 2011): 781–88. https://doi.org/10.1165/rcmb.2010-0471OC.Full Text Link to Item
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Dolan, Sharron, Mark Donald Gunn, Claire Crossan, and Andrea Mary Nolan. “Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep.” Behav Pharmacol 22, no. 5–6 (September 2011): 582–88. https://doi.org/10.1097/FBP.0b013e3283478802.Full Text Link to Item
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Spesock, April H., Brice E. Barefoot, Caroline A. Ray, Daniel J. Kenan, Michael D. Gunn, Elizabeth A. Ramsburg, and David J. Pickup. “Cowpox virus induces interleukin-10 both in vitro and in vivo.” Virology 417, no. 1 (August 15, 2011): 87–97. https://doi.org/10.1016/j.virol.2011.05.010.Full Text Link to Item
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Cain, Derek W., and Michael D. Gunn. “NUR who? An orphan transcription factor holds promise for monomaniacs.” Nat Immunol 12, no. 8 (July 19, 2011): 727–29. https://doi.org/10.1038/ni.2074.Full Text Link to Item
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Lin, Kaifeng Lisa, Shari Sweeney, Brian Donghoon Kang, Elizabeth Ramsburg, and Michael Dee Gunn. “CCR2-antagonist prophylaxis reduces pulmonary immune pathology and markedly improves survival during influenza infection.” J Immunol 186, no. 1 (January 1, 2011): 508–15. https://doi.org/10.4049/jimmunol.1001002.Full Text Link to Item
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Shelburne, Christopher P., Hideki Nakano, Ashley L. St John, Cheryl Chan, James B. McLachlan, Michael D. Gunn, Herman F. Staats, and Soman N. Abraham. “Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues.” Cell Host Microbe 6, no. 4 (October 22, 2009): 331–42. https://doi.org/10.1016/j.chom.2009.09.004.Full Text Link to Item
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Dolan, Sharron, Mark D. Gunn, Laura Biddlestone, and Andrea M. Nolan. “The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat.” Behav Pharmacol 20, no. 7 (October 2009): 596–604. https://doi.org/10.1097/FBP.0b013e32832ec5d1.Full Text Link to Item
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Nakano, Hideki, Kaifeng Lisa Lin, Manabu Yanagita, Chantal Charbonneau, Donald N. Cook, Terutaka Kakiuchi, and Michael D. Gunn. “Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses.” Nat Immunol 10, no. 4 (April 2009): 394–402. https://doi.org/10.1038/ni.1707.Full Text Link to Item
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Chen, Yu-Hsun, Barbara D. Lipes, Daniel J. Kenan, Herman F. Staats, and Michael D. Gunn. “Identification of recombinant antibodies against multiple distinct toll-like receptors by homolog mining a single immune scFv phage library.” J Immunol Methods 340, no. 2 (January 30, 2009): 144–53. https://doi.org/10.1016/j.jim.2008.10.013.Full Text Link to Item
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Tighe, R. M., D. Jiang, M. D. Gunn, and P. W. Noble. “Arginase-1 Expression in CXCR3 Knockout Mice Identifies Alternatively Activated Macrophages after Non-Infectious Lung Injury.” American Journal of Respiratory and Critical Care Medicine 179 (January 1, 2009).Link to Item
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Schreiber, Olivia, Kathrin Steinwede, Nadine Ding, Mrigank Srivastava, Regina Maus, Florian Länger, Jana Prokein, et al. “Mice that overexpress CC chemokine ligand 2 in their lungs show increased protective immunity to infection with Mycobacterium bovis bacille Calmette-Guérin.” J Infect Dis 198, no. 7 (October 1, 2008): 1044–54. https://doi.org/10.1086/591501.Full Text Link to Item
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Lipes, Barbara D., Yu-Hsun Chen, Hongzheng Ma, Herman F. Staats, Daniel J. Kenan, and Michael Dee Gunn. “An entirely cell-based system to generate single-chain antibodies against cell surface receptors.” J Mol Biol 379, no. 2 (May 30, 2008): 261–72. https://doi.org/10.1016/j.jmb.2008.03.072.Full Text Link to Item
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Kanda, Hidenobu, Rebecca Newton, Russell Klein, Yuka Morita, Michael D. Gunn, and Steven D. Rosen. “Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs.” Nat Immunol 9, no. 4 (April 2008): 415–23. https://doi.org/10.1038/ni1573.Full Text Link to Item
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Lin, Kaifeng Lisa, Yasushi Suzuki, Hideki Nakano, Elizabeth Ramsburg, and Michael Dee Gunn. “CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality.” J Immunol 180, no. 4 (February 15, 2008): 2562–72. https://doi.org/10.4049/jimmunol.180.4.2562.Full Text Link to Item
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Winter, Christine, Katharina Taut, Mrigank Srivastava, Florian Länger, Matthias Mack, David E. Briles, James C. Paton, et al. “Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis.” J Immunol 178, no. 9 (May 1, 2007): 5828–38. https://doi.org/10.4049/jimmunol.178.9.5828.Full Text Link to Item
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Grinnan, Dan, Sun-Sang Sung, Joseph A. Dougherty, Amy Ryce Knowles, Matthew B. Allen, Charles E. Rose, Hideki Nakano, Michael D. Gunn, Shu Man Fu, and C Edward Rose. “Enhanced allergen-induced airway inflammation in paucity of lymph node T cell (plt) mutant mice.” J Allergy Clin Immunol 118, no. 6 (December 2006): 1234–41. https://doi.org/10.1016/j.jaci.2006.07.036.Full Text Link to Item
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Hollingsworth, John W., Gregory S. Whitehead, Kaifeng Lisa Lin, Hideki Nakano, Michael D. Gunn, David A. Schwartz, and Donald N. Cook. “TLR4 signaling attenuates ongoing allergic inflammation.” J Immunol 176, no. 10 (May 15, 2006): 5856–62. https://doi.org/10.4049/jimmunol.176.10.5856.Full Text Link to Item
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Wang, Liqing, Rongxiang Han, Iris Lee, Aidan S. Hancock, Guoxiang Xiong, Michael D. Gunn, and Wayne W. Hancock. “Permanent survival of fully MHC-mismatched islet allografts by targeting a single chemokine receptor pathway.” J Immunol 175, no. 10 (November 15, 2005): 6311–18. https://doi.org/10.4049/jimmunol.175.10.6311.Full Text Link to Item
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Suvarna, Shayela, Lubica Rauova, Emily K. E. McCracken, Christina M. Goss, Bruce S. Sachais, Steven E. McKenzie, Michael P. Reilly, et al. “PF4/heparin complexes are T cell-dependent antigens.” Blood 106, no. 3 (August 1, 2005): 929–31. https://doi.org/10.1182/blood-2004-12-4955.Full Text Link to Item
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Hollingsworth, John W., Benny J. Chen, David M. Brass, Katie Berman, M Dee Gunn, Donald N. Cook, and David A. Schwartz. “The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation.” Am J Respir Crit Care Med 171, no. 8 (April 15, 2005): 806–13. https://doi.org/10.1164/rccm.200407-953OC.Full Text Link to Item
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Gunn, Michael D., and Garnett Kelsoe. “Should we B-leavin' now?” Nat Immunol 5, no. 7 (July 2004): 703–4. https://doi.org/10.1038/ni0704-703.Full Text Link to Item
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Hart, Justin P., Michael D. Gunn, and Salvatore V. Pizzo. “A CD91-positive subset of CD11c+ blood dendritic cells: characterization of the APC that functions to enhance adaptive immune responses against CD91-targeted antigens.” J Immunol 172, no. 1 (January 1, 2004): 70–78. https://doi.org/10.4049/jimmunol.172.1.70.Full Text Link to Item
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McLachlan, James B., Justin P. Hart, Salvatore V. Pizzo, Christopher P. Shelburne, Herman F. Staats, Michael D. Gunn, and Soman N. Abraham. “Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection.” Nat Immunol 4, no. 12 (December 2003): 1199–1205. https://doi.org/10.1038/ni1005.Full Text Link to Item
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Gunn, Michael Dee. “Chemokine mediated control of dendritic cell migration and function.” Semin Immunol 15, no. 5 (October 2003): 271–76. https://doi.org/10.1016/j.smim.2003.08.004.Full Text Link to Item
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Honig, Shaun M., Shuang Fu, Xia Mao, Adam Yopp, Michael D. Gunn, Gwendalyn J. Randolph, and Jonathan S. Bromberg. “FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes.” J Clin Invest 111, no. 5 (March 2003): 627–37. https://doi.org/10.1172/JCI16200.Full Text Link to Item
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Wigle, Jeffrey T., Natasha Harvey, Michael Detmar, Irina Lagutina, Gerard Grosveld, Michael D. Gunn, David G. Jackson, and Guillermo Oliver. “An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.” Embo J 21, no. 7 (April 2, 2002): 1505–13. https://doi.org/10.1093/emboj/21.7.1505.Full Text Link to Item
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Gunn, M. D., M. Yanagita, and H. Nakano. “Identification and characterization of murine plasmacytoid dendritic cells.” Faseb Journal 16, no. 5 (March 22, 2002): A1230–31.Link to Item
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Red-Horse, K., P. M. Drake, M. D. Gunn, and S. J. Fisher. “Chemokine ligand and receptor expression in the pregnant uterus: reciprocal patterns in complementary cell subsets suggest functional roles.” Am J Pathol 159, no. 6 (December 2001): 2199–2213. https://doi.org/10.1016/S0002-9440(10)63071-4.Full Text Link to Item
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Nakano, H., M. Yanagita, and M. D. Gunn. “CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells.” J Exp Med 194, no. 8 (October 15, 2001): 1171–78. https://doi.org/10.1084/jem.194.8.1171.Full Text Link to Item
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Drake, P. M., M. D. Gunn, I. F. Charo, C. L. Tsou, Y. Zhou, L. Huang, and S. J. Fisher. “Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha.” J Exp Med 193, no. 10 (May 21, 2001): 1199–1212. https://doi.org/10.1084/jem.193.10.1199.Full Text Link to Item
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Mori, S., H. Nakano, K. Aritomi, C. R. Wang, M. D. Gunn, and T. Kakiuchi. “Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses.” J Exp Med 193, no. 2 (January 15, 2001): 207–18. https://doi.org/10.1084/jem.193.2.207.Full Text Link to Item
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Nakano, H., and M. D. Gunn. “Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation.” J Immunol 166, no. 1 (January 1, 2001): 361–69. https://doi.org/10.4049/jimmunol.166.1.361.Full Text Link to Item
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Bromley, S. K., D. A. Peterson, M. D. Gunn, and M. L. Dustin. “Cutting edge: hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation.” J Immunol 165, no. 1 (July 1, 2000): 15–19. https://doi.org/10.4049/jimmunol.165.1.15.Full Text Link to Item
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Bromley, S. K., D. A. Peterson, M. D. Gunn, and M. L. Dustin. “Hierarchy of chemokine and antigen signals regulating T cell migration and proliferation.” Faseb Journal 14, no. 6 (April 20, 2000): A1149–A1149.Link to Item
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Stein, J. V., A. Rot, Y. Luo, M. Narasimhaswamy, H. Nakano, M. D. Gunn, A. Matsuzawa, E. J. Quackenbush, M. E. Dorf, and U. H. von Andrian. “The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules.” J Exp Med 191, no. 1 (January 3, 2000): 61–76. https://doi.org/10.1084/jem.191.1.61.Full Text Link to Item
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Bistrup, A., S. Bhakta, J. K. Lee, Y. Y. Belov, M. D. Gunn, F. R. Zuo, C. C. Huang, R. Kannagi, S. D. Rosen, and S. Hemmerich. “Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin.” J Cell Biol 145, no. 4 (May 17, 1999): 899–910. https://doi.org/10.1083/jcb.145.4.899.Full Text Link to Item
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Gunn, M. D., S. Kyuwa, C. Tam, T. Kakiuchi, A. Matsuzawa, L. T. Williams, and H. Nakano. “Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization.” J Exp Med 189, no. 3 (February 1, 1999): 451–60. https://doi.org/10.1084/jem.189.3.451.Full Text Link to Item
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Ngo, V. N., H. Korner, M. D. Gunn, K. N. Schmidt, D. S. Riminton, M. D. Cooper, J. L. Browning, J. D. Sedgwick, and J. G. Cyster. “Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen.” J Exp Med 189, no. 2 (January 18, 1999): 403–12. https://doi.org/10.1084/jem.189.2.403.Full Text Link to Item
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Cyster, J. G., V. N. Ngo, E. H. Ekland, M. D. Gunn, J. D. Sedgwick, and K. M. Ansel. “Chemokines and B-cell homing to follicles.” Curr Top Microbiol Immunol 246 (1999): 87–92. https://doi.org/10.1007/978-3-642-60162-0_11.Full Text Link to Item
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Tangemann, K., M. D. Gunn, P. Giblin, and S. D. Rosen. “A high endothelial cell-derived chemokine induces rapid, efficient, and subset-selective arrest of rolling T lymphocytes on a reconstituted endothelial substrate.” J Immunol 161, no. 11 (December 1, 1998): 6330–37.Link to Item
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Pachynski, R. K., S. W. Wu, M. D. Gunn, and D. J. Erle. “Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow.” J Immunol 161, no. 2 (July 15, 1998): 952–56.Link to Item
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Nielsen, L. B., M. Véniant, J. Borén, M. Raabe, J. S. Wong, C. Tam, L. Flynn, et al. “Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins.” Circulation 98, no. 1 (July 7, 1998): 13–16. https://doi.org/10.1161/01.cir.98.1.13.Full Text Link to Item
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Gunn, M. D., V. N. Ngo, K. M. Ansel, E. H. Ekland, J. G. Cyster, and L. T. Williams. “A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1.” Nature 391, no. 6669 (February 19, 1998): 799–803. https://doi.org/10.1038/35876.Full Text Link to Item
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Gunn, M. D., K. Tangemann, C. Tam, J. G. Cyster, S. D. Rosen, and L. T. Williams. “A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.” Proc Natl Acad Sci U S A 95, no. 1 (January 6, 1998): 258–63. https://doi.org/10.1073/pnas.95.1.258.Full Text Link to Item
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Nielsen, L. B., S. P. McCormick, V. Pierotti, C. Tam, M. D. Gunn, H. Shizuya, and S. G. Young. “Human apolipoprotein B transgenic mice generated with 207- and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine.” J Biol Chem 272, no. 47 (November 21, 1997): 29752–58. https://doi.org/10.1074/jbc.272.47.29752.Full Text Link to Item
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Meiner, V., C. Tam, M. D. Gunn, L. M. Dong, K. H. Weisgraber, S. Novak, H. M. Myers, S. K. Erickson, and R. V. Farese. “Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice.” J Lipid Res 38, no. 9 (September 1997): 1928–33.Link to Item
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Gunn, M. D., N. A. Nelken, X. Liao, and L. T. Williams. “Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation.” J Immunol 158, no. 1 (January 1, 1997): 376–83.Link to Item
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Lauer, M. R., M. D. Gunn, and W. T. Clusin. “Endothelin activates voltage-dependent Ca2+ current by a G protein-dependent mechanism in rabbit cardiac myocytes.” J Physiol 448 (March 1992): 729–47. https://doi.org/10.1113/jphysiol.1992.sp019067.Full Text Link to Item
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Ueno, H., M. Gunn, K. Dell, A. Tseng, and L. Williams. “A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.” J Biol Chem 267, no. 3 (January 25, 1992): 1470–76.Link to Item
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Gunn, M. D., A. Sen, and A. Chang. “Mechanisms of accumulation of arachidonic acid in cultured myocardial cells during ATP depletion.” American Journal of Physiology Heart and Circulatory Physiology 18, no. 6 (December 1, 1985).
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Gunn, M. D., A. Sen, A. Chang, J. T. Willerson, L. M. Buja, and K. R. Chien. “Mechanisms of accumulation of arachidonic acid in cultured myocardial cells during ATP depletion.” Am J Physiol 249, no. 6 Pt 2 (December 1985): H1188–94. https://doi.org/10.1152/ajpheart.1985.249.6.H1188.Full Text Link to Item
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Chien, K. R., A. Sen, R. Reynolds, A. Chang, Y. Kim, M. D. Gunn, L. M. Buja, and J. T. Willerson. “Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. Correlation with the progression of cell injury.” J Clin Invest 75, no. 6 (June 1985): 1770–80. https://doi.org/10.1172/JCI111889.Full Text Link to Item
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Conference Papers
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Chakraborty, Molly Antara, William H. Tomaszewski, Jessica Waibl Polania, Luigi Racioppi, Luis A. Sanchez-Perez, Michael D. Gunn, and John H. Sampson. “CaMKK2 deletion causes increased accumulation of CD4+TILs and an improved ratio of effector memory TILs to Tregs.” In Journal of Immunology, Vol. 206, 2021.Link to Item
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Huang, Hsin-I, Mark L. Jewell, Nourhan Youssef, Min-Nung Huang, Elizabeth R. Hauser, Brian E. Fee, Nathan P. Rudemiller, et al. “Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes.” In Front Immunol, 12:661290, 2021. https://doi.org/10.3389/fimmu.2021.661290.Full Text Link to Item
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Perera, Jonathan J., William H. Tomaszewski, Jessica Waibl Polania, Luigi Racioppi, Luis A. Sanchez-Perez, Michael D. Gunn, and John H. Sampson. “CaMKK2 deletion increases antitumor potential through enhanced MHC-II expression in Macrophages.” In Journal of Immunology, Vol. 206, 2021.Link to Item
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Huang, Min-Nung, Lowell T. Nicholson, Kristen A. Batich, David Kopin, Adam M. Swartz, John H. Sampson, and Michael Dee Gunn. “Monocytes outperform ex vivo generated dendritic cells as cellular vaccines to trigger cytotoxic T lymphocyte responses against cancer in pre-clinical models.” In Journal of Immunology, Vol. 202. AMER ASSOC IMMUNOLOGISTS, 2019.Link to Item
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Achanta, S., B. Liu, M. A. Gentile, A. Caceres, D. J. Behm, M. E. Burgert, M. H. Costell, I. M. Cheifetz, M. D. Gunn, and S. E. Jordt. “TRPV4 Inhibitor Improves Pulmonary Function and Oxygen Saturation in a Pig Translational Model of Chlorine Gas-Induced Acute Lung Injury.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.Link to Item
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Yu, Y. A., J. Daly, S. Phelan, R. I. Cumming, A. Birukova, Y. Malakhau, J. L. Ingram, M. D. Gunn, L. G. Que, and R. M. Tighe. “Replacement of Fetal-Derived with Bone Marrow-Derived Pulmonary Resident Macrophages Reduces House Dust Mite-Induced Airway Hyperresponsiveness.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.Link to Item
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Lu, Xiaohan, Nathan Rudemiller, Jamie Privratsky, Jiafa Ren, Yi Wen, Robert Griffiths, Michael D. Gunn, and Steven D. Crowley. “Classical Dendritic Cells Mediate Hypertension by Promoting Oxidative Stress and Renal Fluid Retention.” In Hypertension, Vol. 74, 2019.Link to Item
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Smith, J. S., L. Nicholson, J. Suwanpradid, R. Glenn, J. Gundry, P. Alagesan, N. Knape, et al. “678 Biased CXCR3 ligands differentially alter allergic contact hypersensitivity and chemotaxis.” In Journal of Investigative Dermatology, 137:S117–S117. Elsevier BV, 2017. https://doi.org/10.1016/j.jid.2017.02.701.Full Text
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Yu, Y. A., M. J. Kan, D. F. Hotten, L. Mao, C. A. Piantadosi, and M. D. Gunn. “Vascular Remodeling Macrophages Arise From Resident Monocytes, Sense Hypoxia Via Hypoxia-Induced Factor-1 alpha (hif-1 alpha), And mediate Hypoxia-Induced Pulmonary Arterial Hypertension.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.Link to Item
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Yu, Y., D. Hotten, A. Birukova, E. Volker, A. J. Ghio, P. W. Noble, M. Kraft, J. W. Hollingsworth, M. D. Gunn, and R. M. Tighe. “Flow Cytometry Of Human Bronchoalveolar Lavage Fluid And Lung Tissue Identifies Interstitial Macrophages.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.Link to Item
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Sampson, J., D. A. Mitchell, K. A. Batich, D. Snyder, W. Xie, E. Reap, X. Cui, et al. “RANDOMIZATION OF PATIENTS WITH GLIOBLASTOMA TO VACCINE SITE PRE-CONDITIONING WITH TETANUS-DIPHTHERIA TOXOID SYSTEMICALLY ENHANCES MIGRATION AND THERAPEUTIC EFFECT OF CYTOMEGALOVIRUS PP65-PULSED DENDRITIC CELL VACCINE IN A MIP-1α-DEPENDENT FASHION.” In Neuro Oncol, 16 Suppl 3:iii39–40, 2014. https://doi.org/10.1093/neuonc/nou208.63.Full Text Link to Item
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Chen, Yu-Hsun, Kaifeng Lisa Lin, and Michael Dee Gunn. “Role of CCR2(+) Monocyte-derived Cells in LPS-induced Acute Lung Injury.” In Journal of Immunology, Vol. 178. AMER ASSOC IMMUNOLOGISTS, 2007.Link to Item
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Wang, L. Q., R. X. Han, A. S. Hancock, M. D. Gunn, and W. W. Hancock. “Location is everything: Permanent survival of fully MHC-mismatched islet allografts without any immunosuppression by targeting of a single chemokine receptor pathway.” In American Journal of Transplantation, 5:543–543. BLACKWELL PUBLISHING, 2005.Link to Item
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Hartig, H. L., S. Hill, and M. D. Gunn. “Differential gene expression in plasmacytoid dendritic cells identified by microarray analysis.” In Faseb Journal, 18:A423–A423. FEDERATION AMER SOC EXP BIOL, 2004.Link to Item
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